• Food Science and Industry
• /
• v.55 no.2
• /
• pp.154-165
• /
• 2022

Humans have been breeding the mulberry silkworm for the long period of time to obtain silk fabric and nutrient-rich pupae. Currently, silkworm larvae, pupae, and silk-Fibroin hydrolysates are registered as food raw materials, while silkworm feces and Bombyx batryticatus are registered as Korean traditional medicines. Among sericulture products, individually recognized health functional food ingredients include silk-protein acid-hydrolysates for immunity enhancement, Fibroin-hydrolysates for memory improvement, and freeze-dried 5^th instar and 3^rd-day-silkworm powder for lowering-blood sugar. Recently, HongJam produced by steaming and freeze-drying mature silkworms were reported to have various health-promoting effects such as preventing the onset of Alzheimer's disease and Parkinson's disease, enhancing gastro-intestinal functions, improving skin-whitening and hair growth, and extending healthspan. By consuming silkworm products with various health-promoting effects, it is possible to increase the healthspan of human beings, thereby reducing personal and national medical expenses, resulting in increasing the individual's happiness.

• Journal of Internet Computing and Services
• /
• v.23 no.1
• /
• pp.77-86
• /
• 2022

The Republic of Korea is a country in which coastal surveillance is an imperative national task as it is surrounded by seas on three sides under the confrontation between South and North Korea. However, due to Defense Reform 2.0, the number of R/D (Radar) operating personnel has decreased, and the period of service has also been shortened. Moreover, there is always a possibility that a human error will occur. This paper presents specific guidelines for developing an AI learning model for the intelligent coastal surveillance system. We present a three-step strategy to realize the guidelines. The first stage is a typical stage of building an AI learning model, including data collection, storage, filtering, purification, and data transformation. In the second stage, R/D signal analysis is first performed. Subsequently, AI learning model development for classifying real and false images, coastal area analysis, and vulnerable area/time analysis are performed. In the final stage, validation, visualization, and demonstration of the AI learning model are performed. Through this research, the first achievement of making the existing weapon system intelligent by applying the application of AI technology was achieved.

• Animal Bioscience
• /
• v.35 no.1
• /
• pp.126-137
• /
• 2022

Objective: Efficient gene editing technology is critical for successful knock-in in domestic animals. RAD51 recombinase (RAD51) gene plays an important role in strand invasion during homologous recombination (HR) in mammals, and is regulated by checkpoint kinase 1 (CHK1) and CHK2 genes, which are upstream elements of RAD51 recombinase (RAD51). In addition, mismatch repair (MMR) system is inextricably linked to HR-related pathways and regulates HR via heteroduplex rejection. Thus, the aim of this study was to investigate whether clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9)-mediated knock-in efficiency of human lactoferrin (hLF) knock-in vector in the bovine β-casein gene locus can be increased by suppressing DNA MMR-related genes (MSH2, MSH3, MSH6, MLH1, and PMS2) and overexpressing DNA double-strand break (DSB) repair-related genes (RAD51, CHK1, CHK2). Methods: Bovine mammary epithelial (MAC-T) cells were transfected with a knock-in vector, RAD51, CHK1, or CHK2 overexpression vector and CRISPR/sgRNA expression vector to target the bovine β-casein gene locus, followed by treatment of the cells with CdCl₂ for 24 hours. After 3 days of CdCl₂ treatment, the knock-in efficiency was confirmed by polymerase chain reaction (PCR). The mRNA expression levels of DNA MMR-related and DNA DSB repair-related genes were assessed by quantitative real-time PCR (RT-qPCR). Results: Treatment with CdCl₂ decreased the mRNA expression of RAD51 and MMRrelated genes but did not increase the knock-in efficiency in MAC-T cells. Also, the overexpression of DNA DSB repair-related genes in MAC-T cells did not significantly affect the mRNA expression of MMR-related genes and failed to increase the knock-in efficiency. Conclusion: Treatment with CdCl₂ inhibited the mRNA levels of RAD51 and DNA MMR-related genes in MAC-T cells. However, the function of MMR pathway in relation to HR may differ in various cell types or species.

• Journal of Food Hygiene and Safety
• /
• v.37 no.2
• /
• pp.114-120
• /
• 2022

In this study, a comparative dissolution experiment was conducted between an immediate-release and a controlled-release vitamin C tablet applied with a technology to control the dissolution of vitamin C to maintain the vitamin C level in the human body. In order to confirm the dissolution rate (%) of vitamin C tablets, HPLC determination was conducted based on the dissolution test methods in the 'Korean Pharmacopoeia (No. 2020-88),' 'Guidelines on Specifications of Dissolution Tests for Oral dosage Forms,' and 'Standard and Specifications for Health Functional Foods (No. 2020-63)' from Ministry of Food and Drug Safety (MFDS). In addition, the dissolution pattern between the immediate-release tablet and the controlled-release tablet was comparatively analyzed. The analysis result confirmed that the immediate-release vitamin C tablet was 100% dissolved after 45 minutes, while the controlled-release vitamin C tablet was 100% dissolved after 480 minutes (8 hours). Furthermore, the dissolution rate (%) at 60 minutes was slower than that of the immediate-release vitamin C tablet. Based on these results, this study confirmed that the dissolution rate (%) test and development of controlled-release tablets containing vitamin C as the main component a re possible.

• Journal of Space Technology and Applications
• /
• v.1 no.2
• /
• pp.217-240
• /
• 2021

Upon the human exploration era of the Moon, this paper introduces lunar topography and geologic fundamentals to space scientists. The origin of scientific terminology for the lunar topography was briefly summarized, and the extension of the current Korean terminology is suggested. Specifically, we suggest the most representative lunar topography that are useful to laymen as 1 ocean (Oceanus Procellarum), 10 maria (Mare Imbrium, Mare Serenitatis, Mare Tranuillitatis, Mare Nectaris, Mare Fecundatis, Mare Crisium, Mare Vaporium, Mare Cognitum, Mare Humorum, Mare Nubium), 6 great craters (Tyco, Copernicus, Kepler, Aristachus, Stebinus, Langrenus). We also suggest Korean terms for highland, maria, mountains, crater, rille, rima, graben, dome, lava tube, wrinkle ridge, trench, rupes, and regolith. In addition, we introduce the standard model for the lunar interior and typical rocks. According to the standard model on the basis of historical impact events, the lunar geological eras are classified as Pre-Nectarian, Nectarian, Imbrian, Erathostenesian, and Copernican in chronologic order. Finally, we summarize the latest discovery records on the water on the Moon, and introduce the concept of water extraction from the lunar soil, which is to be developed by the Korea Institute of Geoscience and Mineral Resources (KIGAM).

• Journal of Korea Water Resources Association
• /
• v.55 no.6
• /
• pp.461-469
• /
• 2022

It is very important to ensure the reliability of dam inflow data, which is critical in planning and managing the supply and demand of water resources in a basin. However, the simple water balance model sometimes results in negative inflows and does not consider the actual inflow characteristics. In this study, to address these issues, the existing water balance formula was modified by considering evaporation which is available for calculation among other outflows. The modified water balance formula was applied to the Soyang Dam. The results showed that the rate of negative inflows decreased in the re-evaluated dam inflow data and it was possible to secure consistency for the total inflow volume. In addition, investigating the water availability in the Soyang Dam watershed based on the water balance concept considering evaporation, it was found that direct water use in the human aspect was about 60%, and the indirect water use in the natural aspect was about 40%. In drought years, it was also confirmed that the proportion of indirect use of water resources increased.

• Analytical Science and Technology
• /
• v.35 no.3
• /
• pp.93-115
• /
• 2022

Potential impurities in pharmaceuticals could be produced during manufacture, distribution, and storage and affect quality and safety of pharmaceuticals. In particular, highly reactive impurities could result in carcinogenic (mutagenic) effects on human body. International Conference on Harmonisation (ICH) has provided M7(R1) guideline for "Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk" and recommended an adoption of this guideline to the authorities. ICH M7(R1) guideline provides classification, accepted intakes, and controls of potential impurities in pharmaceuticals. However, since appropriate and unified analytical methods for impurities in pharmaceuticals have not been provided in this guideline, most potential impurities in pharmaceuticals are still difficult to manage and supervise by pharmaceutical companies and regulatory authorities, respectively. In this review, we briefly described definition of unintended mutagenic impurities, basic information in ICH M7(R1) guideline, and analytical methods to determine potential impurities. This review would be helpful to manage and supervise potential impurities in pharmaceuticals by pharmaceutical companies and regulatory authorities.

• Trans-
• /
• v.12
• /
• pp.81-106
• /
• 2022

The possibility of metaverse system to be a catalyst for hyper-connected society will be dependent on the speed of connected technological development and its social utilization in the same manner as AI technology. Putting these technical realization processes in brackets, this paper focus on some philosophical-political issues in connection with cognitive-ecological changes in the future cinema which will be influenced by the complexive techno-socio couples of accelerated development of metaverse system. Generally speaking, essence of metaverse system seems to be the degree of immersion by technical accuracy, but is not true. In perspective of cognitive-ecology, flow degree of a picture or photograph is relied not on 'accuracy of representation' but on its message's contextual link-up. In this aspect, real potentiality of metaverse system shall be understood in the context of cognitive-ecological changes of human brain's multi-intelligence networking abilities(intersection of augmentation-simulation and outside-inside) which will be activated in the new structure of natural-social-technological coupling of metaverse system. These cognitive-ecological potentialities have been partially actualized in the cinematic process of tripod mimesis for the longest time, [real contradiction/conflicts (Mimesis-1) -->fictional solutions of cinema (Mimesis-2) --> selective interpretation of spectator's wish fulfillment (Mimesis-3) --> real change (Mimesis-1')]. Therefore metaverse's real potentiality must be considered to be dependent on the possibility of deepening and extending of cinematic circulation between real seperation/problems and ideal connection/solutions. In this context, advanced metaverse system can be compared as a modern technical version of ideal circulation of physics and metaphysics

• The Journal of the Korea Contents Association
• /
• v.22 no.10
• /
• pp.132-142
• /
• 2022

The purpose of this study is to interpret the MCU's universal worldview from the perspective of geometry and to storytell narrative elements with mathematical imagination. For storytelling, data from the Phase 3 series aired from 2016 to 2019 was used. The Phase 3 series stimulates the imagination of the public with the sense of reality shown in the narrative and images based on geometrical theory and various predictions about future technology. Imagination is the driving force for diverse and original thinking about the unexperienced, and the ability to find order in chaos and create new perceptions of matter. The power of imagination is very necessary not only in artistic activities, but also in the scientific field where logic and rationality are important. Bachelard's imagination aims for art, the primitive realm of human beings, and contains sincerity and passion for the wonders of nature and all things. By exploring the MCU's worldview and superhero narrative through geometrical logic and imagination-driven imagery, you can understand the cosmic messages and laws in the film. From a convergence point of view of art and science, various and original techniques based on mathematics and scientific imagination used in MCU video production will help to improve the quality of video analysis.

• Journal of Advanced Navigation Technology
• /
• v.26 no.5
• /
• pp.365-372
• /
• 2022

Compared to sensors mainly used in human activity recognition (HAR) systems, inertial measurement unit (IMU) sensors are small and light, so can achieve lightweight system at low cost. Therefore, in this paper, we propose a binary neural network (BNN) based gait pattern analysis system using IMU sensor, and present the design and implementation results of an FPGA-based accelerator for computational acceleration. Six signals for gait are measured through IMU sensor, and a spectrogram is extracted using a short-time Fourier transform. In order to have a lightweight system with high accuracy, a BNN-based structure was used for gait pattern classification. It is designed as a hardware accelerator structure using FPGA for computation acceleration of binary neural network. The proposed gait pattern analysis system was implemented using 24,158 logics, 14,669 registers, and 13.687 KB of block memory, and it was confirmed that the operation was completed within 1.5 ms at the maximum operating frequency of 62.35 MHz and real-time operation was possible.