• Animal cells and systems
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• 제6권2호
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• pp.167-170
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• 2002

The long terminal repeats (LTRs) of human endogenous retrovirus (HERV) have been found to be coexpressed with sequences of closely located genes. It has been suggested that the LTR elements have contributed to the structural change or genetic variation of human genome connected to various diseases and evolution. We examined the HERV-W LTR elements in various cancer cells (2F7, A43l , A549, HepG2, MIA-PaCa-2, PC-3, RT4, SiHa, U-937, and UO-31). Using genomic DNA from the cancer cells, we performed PCR amplification and identified twelve new HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity (88-99％) with HERV-W LTR (AF072500). A phylogenetic tree obtained by the neighbor-joining method revealed that HERV-W LTR elements could be mainly divided into two groups through evolutionary divergence. Three HERV-W LTR elements (RT4-2, A43l-1, and UO3l-2) belonged to Group 1, whereas nine LTR elements (2F7-2, A549-1, A549-3, HepG2-3, MP2-2, PC3-1, SiHa-8, SiHa-10, and U937-1) belonged to Group 11. Taken together, our new sequence data of the HERV-W LTR elements may contribute to an understanding of tissue-specific cancer by genomic instability of LTR integration.

• 한국실내디자인학회논문집
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• 제14권2호
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• pp.104-111
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• 2005

Environment problem has proposed in the world at large, the desire for environment conservation and one's value change which lay emphasis on lasting human sensibility are increasing. Constant human mind and ecology centered in space is presenting as future space design substitute plan which is based on fundamental material quality in the space such as environment and human ,naturalist or Green Design, pro-environment construction, sense design and etc. So, we intend to anthropocentric value and get out of satisfaction of function as the past physical environment equipment which is applied the elements of ecology based on the organized body and interaction with human. A form of sensitive space is divided into sentient space, expressing method and material, change of space according to the flow of time, and is expressed in a more segmented form of sensuality by being replaced into a new sensitive space through transaction with human, who occupy within the space. The space embodiment which is satisfied human sense regards as alternative plan intention for the future, through two subjects relativity between the elements of ecology and sense, we will find the influence of sense as each space trait of the elements of ecology, examine sense form in the space with the synthetic summary. It is significant presentation for the lasting space based on anthropocentric delightfulness as the design which moves human mind while designing the space for this pattern of sense space.

• 생명과학회지
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• 제11권4호
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• pp.379-384
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• 2001

Long terminal repeats(LTRs) of the human endogenous retrovirus(HERV) heve been found to be coexpresed with genes located nearby. It has been suggested that the LTR elements have contributed to the genetic variation of human genome connected to various diseases. Recently, HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using cHNA library derived from human fetal brain, we performed PCR amplification and identified seven new HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity(98∼99%) with HERV-W (AF072500). A phylogentic tree obtained by the neighbor-joining method revealed that seven new HERV-W LTR elements(FB-1, 2, 4, 8, 9, 10, 12) were closely related to the AX000960, AF072504, and AF072506 from Gen Bank database. Our data suggest that several copy numbers of the HERV-W LTR elements are expressed in human feta brain and may contribute to an understanding of biological function connected to neuropsychiatric diseases.

• Genomics & Informatics
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• 제3권4호
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• pp.133-141
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• 2005

Most of the endogenous retroviral genes integrated into the primate genome after the split of New World monkeys in the Oligocene era, approximately 33 million years ago. Because they can change the structure of adjacent genes and move between and within chromosomes they may play important roles in evolutionas well as in many kinds of disease and the creation of genetic polymorphism. Comparative analysis of HERVs (human endogenous retroviruses) and their LTR (long terminal repeat) elements in the primate genomes will help us to understand the possible impact of HERV elements in the evolution and phylogeny of primates. For example, HERV-K LTR and SINE-R elements have been identified that have been subject to recent change in the course of primate evolution. They are specific elements to the human genome and could be related to biological function. The HERV-M element is related to the superfamily of HERV-K and is integrated into the periphilin gene as the truncated form, 5'LTR-gag-pol-3'LTR. PCR and RT-PCR approaches indicated that the insertion of various retrotransposable elements in a common ancestor genome may make different transcript variants in different primate species. Examination of the HERV-W elementrevealed that env fragments were detected on human chromosomes 1, 3-7, 12, 14, 17, 20, and X, whilst the pol fragments were detected on human chromosomes 2-8, 10-15, 20, 21, X, and Y. Bioinformatic blast search showed that almost full-length of the HERV-W family was identified on human chromosomes 1-8, 11-15, 17, 18, 21, and X. Expression analysis of HERV-W genes (gag, pol, and env) in human tissues by RT-PCR indicated that gag and pol were expressed in specific tissues, whilst env was constituitively expressed in all tissues examined. DNA sequence based phylogenetic analysis indicated that the gag, pol and env genes have evolved independently during primate evolution. It will thus be of considerable interest to expand the current HERV gene information of various primates and disease tissues.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 2001년도 춘계 학술대회 논문집
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• pp.135-140
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• 2001

In the last years there have been some severe accidents with passenger vessels. So, International Maritime Organization(IMO) has recognized that computer stimulation of the evacuation may be required for passenger vessels. Human elements is a key issues of escape analysis on shipboard. There are technical requirements to simulate of escape analysis for human elements. Technical requirements include model of ship structure, evacuation algorithm, human behaviour analysis and influence of ship listing/motion. This paper provides the key issues and technologies of simulation for human escape on shipboard.

• Journal of Applied Biological Chemistry
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• 제60권3호
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• pp.207-211
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• 2017

It is introduced an outstanding book about an important topic in occupational and environmental sciences i.e., the opportunities and challenges that may be connected with increasing the use and distribution of rare earth elements. These chemically similar elements, comprising the lanthanides, scandium, and yttrium, are involved in a number of essential technological applications, and their effects raise a number of human health issues of relevance to the occupational and environmental sciences. The book that I introduced here, "Rare Earth Elements in Human and Environmental Health; At the Crossroads between Toxicity and Safety" edited by Giovanni Pagano (Pan Stanford Publishing Pte. Ltd., Temasek Boulevard, Singapore) represents a break from that situation. It is essential to increase our knowledge about the environmental fate and biological effects of these technologically important metals in order to prevent unforeseen long-term man-made consequences to human health. This book is likely to become an important resource for scientists, engineers, and decision makers who understand the need for sensible exploitation of this resource.

• Journal of Mechanical Science and Technology
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• 제19권3호
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• pp.743-755
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• 2005

Human Sensibility Engineering System (HSES) has been applied to product development for customer's satisfaction based on ergonomic technology. The system is composed of three parts such as human sensibility analysis, inference mechanism, and presentation technologies. Inference mechanism translating human sensibility into design elements plays an important role in the HSES. In this paper, we propose a rule-based inference model for HSES. The rule-based inference model is composed of five rules and two inference approaches. Each of these rules reasons the design elements for selected human sensibility words with the decision variables from regression analysis in terms of forward inference. These results are evaluated by means of backward inference. By comparing the evaluation results, the inference model decides on product design elements which are closer to the customer's feeling and emotion. Finally, simulation results are tested statistically in order to ascertain the validity of the model.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2007년도 추계학술발표대회 논문집
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• pp.169-172
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• 2007

Sustainable interior design elements are related with human health. We know that a demand for environmental-friendly housing and all about the others demanding are for human health. We have to make up basement of natural environment for sustainable space composition. If natural environment is polluted that surrounded by human, we have to effort to revive without any pollution. We have to get accomplished stability, comfortable, security, convenience and organize interior design elements for sustainable space to enhance for the quality of life. Furthermore, it needs to get a respect lifestyle on personal. To study composing of the sustainable interior design, we arranged interior design elements to compose sustainable space of housing. We investigated how to compose energy-efficiency, sustainable, interior tree-planting, alterable of the space.

• Asian-Australasian Journal of Animal Sciences
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• 제22권6호
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• pp.893-899
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• 2009

Few studies have reported the existence of imprinted genes in cattle compared to the human and mouse. Genomic imprinting is expressed in monoallelic form and it depends on a single parent-specific form of the allele. Comparative analysis of mammals other than the human is a valuable tool for explaining the genomic basis of imprinted genes. In this study, we investigated 34 common imprinted genes in the human and mouse as well as 35 known non-imprinted genes in the human. We found short interspersed nuclear elements (SINEs), long interspersed nuclear elements (LINEs), and long terminal repeats (LTRs) in imprinted (human and mouse) and control (cattle) genes. Pair-wise comparisons for the three species were conducted using SINEs, LINEs, and LTRs. We also calculated 95% confidence intervals of frequencies of repetitive sequences for the three species. As a result, most genes had a similar interval between species. We found 11 genes with conserved SINEs, LINEs, and LTRs in the human, mouse, and cattle. In conclusion, eleven genes (CALCR, Grb10, HTR2A, KCNK9, Kcnq1, MEST, OSBPL5, PPP1R9A, Sgce, SLC22A18, and UBE3A) were identified as candidate imprinted genes in cattle.

• 대한의용생체공학회:의공학회지
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• 제2권1호
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• pp.65-76
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• 1981

Human body structure can be considered as a complex of many elements such as head, chest, arm, leg and etc. As the correct classification of human body is basic for the design of all the materials used by mankind and since we cannot consider all the elements simultaneously, there is a need of extracting a Sew elements which can be "most" representative of all those elements. This paper describes the procedure of determining those representative body dimensions utilizing the data obtained from a national project carried out in 1976. Also the relationship of the above determined body dimensions to the other commonly reference body dimensions are given in linear forms.ear forms.