• 대한안전경영과학회지
• /
• 제6권2호
• /
• pp.1-9
• /
• 2004

The chemical factory deals with dangerous element and more advance, human-error analyzes and becomes effective research for the country and region. This paper analysis the form of work-miss on human-error according to a safety accident for domestic chemical factory from 1999-2002. It include the present contents and raise issues human knowledge, behavior, judgment, sensibility as an important counter plan that makes the safety solution of work miss. For the point of view of human knowledge, it takes color standard for works to be effective in work place. For behavior, the test has been for risk Point of work place and infra worker movement, also the workers performed professional work as classify according to work. For judgement, the valuation sheet is reflected to minimize the human-error and the 3rd supervisor does a cross-check audit beforehand. For sensibility, it is applicable for human relations, information, communication by program to the consciousness and an attitude of worker-supervisor.

• 한국감성과학회:학술대회논문집
• /
• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
• /
• pp.207-211
• /
• 1999

Nowadays human sensibility ergonomics is spotlighted as one of trends which we have pursued for improvement of humanity. Human sensibility ergonomics is a technique making human life more convenient by applying it to many kinds of products and design for environment by measuring and estimating human sensibility more qualitatively and quantitatively. The study of human sensibility can be discovered in oriental philosophy based on human being. Therefore there is an close relationship between human sensibility ergonomics and oriental philosophy. In this study, we research the sensibility factors of diagnostics by Sasang constitutional medicine, Five element properties and biorhythm by human sensibility ergonomics, and will apply the result of this study - the analyses of the difference among reaction time by using ANOVA after measuring the reaction time depending on one's individual temperament and condition- to job design.

• 대한안전경영과학회:학술대회논문집
• /
• 대한안전경영과학회 2004년도 춘계학술대회
• /
• pp.33-39
• /
• 2004

The chemical factory deals with dangerous element and more advance, human-error analyzes and becomes effective research for the country and region, this paper analyes the form of work-miss on human-error according to a safety accident for domestic chemical factory from 1999-2002. It include the present contents and raise issues human knowledge, behavior, judgment, sensibility as an important counterplan that makes the safety solution of work miss. For the point of view of human knowledge, it takes color standard for works to be effective in work place. for behavior, the test has been for risk point of work place and infra worker movement, also the workers performed professional work as classify according to work. for judgement, the valuation sheet is reflected to minimize the human -error and the 3rd supervisor does a cross-check audit beforehand. For sensibility, it is applicable for human relations, information, communication by program to the consciousness and an attitude of worker-supervisor.

• Archives of Pharmacal Research
• /
• 제25권3호
• /
• pp.375-380
• /
• 2002

Cytochrome P4501A2 (CYP1A2) is a member of the cytochrome P450 family of isozymes involved in the phase I drug metabolism of vertebrates. CYP1A2 is responsible for the activation of a number of aromatic amines to mutagenic and carcinogenic forms. Thus, the level of CYP1A2, which varies among different populations, may determine an individual's susceptibility to these chemicals. We have previously reported on the importance of a cis element named PRB (protected region B) in the regulation of human Cytochrome P4501A2 (CYP1A2) gene, which appeared to act as a positive regulatory element. Closer examination of the PRB sequence (-2218 to -2187 bp) revealed a putative AP-1 binding site, TGACTAA, at -2212 bp (Chung and Bresnick, 1997). To elucidate the role of AP-1 in CYP1A2 regulation, we transiently overexpressed c-Jun and c-Fos transcription factors in human hepatoma HepG2 cells, and examined their influence on the CYP1A2 promoter activity by reporter gene assays. Cotransfection of the c-Jun and the c-Fos expression vectors increased the induced transactivation by five to six fold from the CYP1A2 promoter constructs. However, deletion of the PRB element did not affect the degree of activation by the c-Jun and the c-Fos. Therefore, it is unlikely that the c-Jun and the c-Fos activate the CYP1A2 promoter through this AP-1 consensus-like sequence in the PRB region.

• BMB Reports
• /
• 제31권6호
• /
• pp.565-571
• /
• 1998

The expression of the endogenous human apolipoprotein(apo)E gene was significantly induced when HepG2 cells were treated with exogenous 25-hydroxy-cholesterol. This sterol-mediated apoE gene upregulation appears to require the participation of a positive element for the apoE gene transcription (PET) ( -169/ -140), a core sequence of upstream regulatory element (URE)1 enhancer of the human apoE gene. This PET was renamed as sterol regulatory element (SRE)4 based on its new role as a sensor for the level of intracellular sterol. Furthermore, a gel mobility shift analysis showed that binding activity of the SRE4 binding protein (BP) obtained from HepG2 cells was induced by sterol treatment, while that from either MCF7 or BT20 cells remained unchanged. Binding activity of SRE4BP was also induced in mouse macrophage cells, J774A.1, by sterol treatment, but it was drastically reduced when cells were subjected to treatment of AY-9944, a potent inhibitor for sterol synthesis. However, binding activity of Spl, which is a co-binding protein to the SRE4 region, remained the same in either condition, suggesting that SRE4BP (formally known as PETBP) may be mainly responsible for the sterol-mediated regulation of the apoE gene expression. Deletion analysis of the core binding site of SRE4BP by gel mobility shift assays showed that the minimal sequence of the SRE4BP binding appears to reside between -157 and -140, confirming the identity of SRE4 with the previously determined core sequence of URE1.

• 대한의용생체공학회:의공학회지
• /
• 제25권3호
• /
• pp.207-215
• /
• 2004

본 연구에서는 유전 프로그램을 이용하여 6가지 형태의 금속 와이어 배치를 가진 전극을 생성하여 각 전극이 3차원 형태의 달팽이관에 미치는 기계적인 영향과 그 거동을 유한요소법을 이용하여 분석하였다. 그리고 전극이 삽입되는 달팽이관은 helico-spiral 근사방법에 의해 결정된 식을 이용하였으며, 고실계단(scala tympani)의 형태는 실제 고실계단 단면의 영상정보를 추출하여 얻어내었다. 해석결과 금속 와이어가 평행하게 배치될 경우 가장 큰 힘을 달팽이관 외벽에 전달하며, 삽입에도 가장 큰 힘이 필요한 것을 알 수 있었다. 그리고 달팽이관은 3차원 구조이므로 전극이 삽입되면서 삽입 전에 자극 사이트가 바라보도록 설정한 방향보다 조금 돌아감을 확인하였다. 이 연구의 결과로부터 전극의 강성이 외상(trauma)을 줄이는데 중요하다는 것을 알 수 있다.

• 한국생산제조학회지
• /
• 제21권3호
• /
• pp.425-432
• /
• 2012

This paper investigates shape design processes of two implant systems for bone fracture treatment ; Bone plate and Interlocking nail system. These systems can directly fix fractured human bones by surgical operations. The bone plates consist of various shaped plates and implant screws for fixation of fractured human bones with various manual instruments allowing to handle them. The material corresponds to titanium alloy Ti6Al4V because it is harmless material for human body as well as significantly rigid. This system has to be suitably rigid as well as manually bended in orthopedic surgery operations. The Interlocking nail system is a kind of nail implanted inside fractured human bones. The shapes of these systems have to be suitably designed in order to endure various loads as well as avoid any damages. If various shaped prototypes would be fabricated and tested to design the optimal shapes, optimal shapes could be obtained but very long time and expensive costs must be required. In this paper finite element method was applied into these systems. Under various boundary conditions a series of structural analysis was conducted by using ANSYS. Finally important shape factors could be determined on the basis of the analysis results.

• 한국디자인학회:학술대회논문집
• /
• 한국디자인학회 1995년도 디자인 학 연구 1995년 추계 학술연구 발표 대회 개요 집
• /
• pp.6-7
• /
• 1995

• 한국생활과학회:학술대회논문집
• /
• 한국생활과학회 2010년도 하계학술대회
• /
• pp.137-138
• /
• 2010

• 대한기계학회논문집A
• /
• 제31권7호
• /
• pp.764-776
• /
• 2007

On the human-rifle system, the human body is affected by the firing impact. The firing impact will reduce the firing accuracy and change the initial shooting posture. Therefore the study of biomechanical characteristics using human-rifle modeling and numerical investigation is needed. The musculoskeletal model is developed by finite element method using beam and spar elements. In this study structural analysis has been performed in order to investigate the human body impact by firing of 5.56mm small caliber machine gun. The firing experiments with the standing shooting postures were performed to verify analytical results. The result if this study shows analytical displacements of the human-rifle system and experimental displacements of the real firing. As the results, the analytical displacement and stress of human body are presented.