• Journal of Integrative Natural Science
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• v.5 no.3
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• pp.190-194
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• 2012

Human P-gp is one of the protein responsible for the multidrug resistance (MDR) develpment. MDR is a major cause of the cancer chemotherapy. In this paper, we performed homology modeling, docking study of papayriferic acid into the P-gp nucleotide binding domain (NBD2). For human P-gp, X-ray crystal structure is not known yet. We developed homology model for human NBD2 using HlyB ABC transporter structure (PDB code: 1XEF, resolution 2.5 ${\AA}$). Docking study was performed using Autodock. Docking result was analyzed, which shows that ligand docks into steroid binding site and interacts through hydrophobic and hydrophilic interactions.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.1
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• pp.96-104
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• 2009

An anatomically detailed elderly human body model is under development. Using the anthropometric database of domestic nation-wide size survey, SizeKorea, a standard size and shape of 50th %tile elderly was constructed. Through the local recruitment process, a male volunteer with 71 years of age, 163cm of height and 63kg of weight has been selected. The exterior (skin) and interior (skeleton and organ) geometries were acquired from whole body 3D laser scan and various medical images such as CT, X-ray, and Ultrasonic of the volunteer. A particular attention has been paid into the combining process of exterior and interior geometries especially for joint articulation positions since they were measured at different postures (sitting vs. supine). A whole ribcage of PMHS which possessed similar anthropometry and age of standard 50th %tile elderly was prepared and dissected for the precise gauge of cortical rib bone thickness distributions. After completing the morphological construction of elderly human body, the finite element modeling will be processed by meshing elements and assigning mechanical properties to various biological tissues which reflect the aging effect.

• Interdisciplinary Bio Central
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• v.2 no.3
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• pp.8.1-8.5
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• 2010

Introduction: Recently identified human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Bioinformatics study of hABH2 and hABH3 had led to the discovery of a novel DNA repair mechanism. Very little is known about structure and function of hABH4, one of the members of this superfamily. Therefore, in present study we are intended to predict its structure and function through various bioinformatics tools. Materials and Methods: Modeling was done with modeler 9v7 to predict the 3D structure of the hABH4 protein. This model was validated with the program Procheck using Ramachandran plot statistics and was submitted to PMDB with ID PM0076284. The 3d2GO server was used to predict the functions. Residues at protein ligand and protein RNA binding sites were predicted with 3dLigandSite and KYG programs respectively. Results and Discussion: 3-D model of hABH4, ALKBH4.B99990003.pdb was predicted and evaluated. Validation result showed that 96.4 % residues lies in favored and additional allowed region of Ramachandran plot. Ligand binding residues prediction showed four Ligand clusters, having 24 ligands in cluster 1. Importantly, conserved pattern of Glu196-X-Pro198- Xn-His254 in the functional domain was detected. DNA and RNA binding sites were also predicted in the model. Conclusion and Prospects: The predicted and validated model of human homologue hABH4 resulted from this study may unveil the mechanism of DNA damage repair in human and accelerate the research on designing of appropriate inhibitors aiding in chemotherapy and cancer related diseases.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.47 no.3
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• pp.257-266
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• 2011

Recently, the manufacturers of life-jacket are very interested in the acquisition of USCG(US Coast Guard) approval because the acquisition of USCG approval has an important role in the purchasing decision of the buyer's. Be based on criterion of USCG, we studied how to predict the change of floating position of human model with life-jacket to verify the backside restore. For this, in this study, the human model and the lifejacket was modeled in three dimension, the application program for prediction of floating position was developed, and plugged-in commercial program.

• Journal of Ocean Engineering and Technology
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• v.22 no.5
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• pp.119-125
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• 2008

Musculoskeletal disorders(MSDs) are one of the major issues in shipbuilding industry. Main risk factors of MSDs include manual handling of heavy weight, awkward posture, repetitive tasks, prolonged static muscle contraction, and so on. in this study, Using the three-dimensional digital human modeling and simulation method we made up a worker and work posture on a virtual environment. To verify this simulation we compared both traditional ergonomic analysis on a real worker and digital program analysis on a digital human. And this paper shows that it is possible to reduce the rate of MSDs in the shipbuilding industry because it means we can change poor posture mid surroundings into better ones.

• Archives of design research
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• v.19 no.1 s.63
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• pp.79-88
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• 2006

A human face figure is a visual symbol of identity. Each different face per person is a critical information differentiating each person from others and it directly relates to individual identity. When we look back human history, historical change of recognition for a face led to the change of expression and communication media and it in turn caused many changes in expressing a face. However, there has not been no time period when people pay attention to a face more than this time. Technically, the advent of computer graphics opened new turning point in expressing human face figure. Especially, a visual image which can be produced, saved, and transferred in digital has no limitation in time and space, and its importance in communication is getting higher and higher. Among those visual image information, a face image in digital is getting more applications. Therefore, 3d (3-dimensional) expression of a face using computer graphics can be easily produced without any professional techniques, just like assembling puzzle parts composed of the shape of each part ands texture map, etc. This study presents a method with which a general visual designer can effectively express 3d type face by studying each producing step of 3d face expression and by visualizing case study based on the above-mentioned study result.

• Proceedings of the Safety Management and Science Conference
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• 2003.11a
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• pp.207-214
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• 2003

3D Modeling Solution can reduce projecting error and also make possible to design visually, so that it can minimize human resources. On the other hand, it has defects of operating difficulties caused by too much complex function, thus it consequently prevent user from prompt handling. According to this paper, the developed party S/W will help that user can construct the parts easily, can let everybody use 3D modeling solution readily, and make fast development of new product. This software will carry out prompt development of new product and derive satisfaction of customers from high quality. Also, saving time and expense naturally raise competitive power in consequence.

• Journal of KIISE:Computer Systems and Theory
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• v.30 no.7_8
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• pp.397-407
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• 2003

In the past decade, significant effort has been made toward increasing the accuracy and robustness in the three-dimensional scanning methods. In this paper, we introduce a novel laser-stripe, 3D scanning system which was developed to digitize a whole human body. We also suggest a new semi-automatic contour registration method to generate robust contours from the 3D data points acquired by our scanning system. A contour triangulation based surface modoling method was also introduced. Experimental result shows that our system is very robust and efficient for reconstructing overall 3D surface model of a human body.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.4
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• pp.55-60
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• 2020

This study aims to apply Arduino and 3D printing technology considered as a key subject in the age of 4th industrial revolution which is a step 1 for customizing and applying the process of production by chemical molding companies producing environment-friendly biodegradable packaging materials to the 3D printing teaching in universities. Step 3 is applied to IoT for Arduino application, and 3D printing technology is also used on the basis of teaching creative integrated human resource. Integration of Arduino with 3D printers is based on the assumption that middle- and high-school students can learn it step by step to higher levels and university students majoring or not majoring in computing science can also have computing skills for solving 3D printing-based problems. For IoT application in this study, the 3D printing technology is applied to the external shape of products for producing an Arduino-based lighting fixture. The applied 3D printing technology is further extended to teaching modeling of producing packaging materials by chemical product molding companies in the age of 4th industrial revolution.

• Proceedings of the ESK Conference
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• 1997.04a
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• pp.196-199
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• 1997

This paper describes the implementation process of Virtual Modeling system for a customer-oriented product. The human sense is measured and analyzed by physical design factors and can be applied also for the product design. The first step implementing virtual modeling is to make a human sensibility("Kansei") database. Human sensibility database is constructed with the relational data of Kansei words and design factors. The next step is extraction the design information from the human sensibility database by fuzzy inference algorithm. This design information is used for the input data for the graphic database. Virtual implementation software compounds 3D shape of product. The final product can be modified according to the customer's requirement.quirement.