• Title/Summary/Keyword: Hugo

Search Result 95, Processing Time 0.036 seconds

How Many SNPs Should Be Used for the Human Phylogeny of Highly Related Ethnicities? A Case of Pan Asian 63 Ethnicities

  • Ghang, Ho-Young;Han, Young-Joo;Jeong, Sang-Jin;Bhak, Jong;Lee, Sung-Hoon;Kim, Tae-Hyung;Kim, Chul-Hong;Kim, Sang-Soo;Al-Mulla, Fahd;Youn, Chan-Hyun;Yoo, Hyang-Sook;The HUGO Pan-Asian SNP Consortium, The HUGO Pan-Asian SNP Consortium
    • Genomics & Informatics
    • /
    • v.9 no.4
    • /
    • pp.181-188
    • /
    • 2011
  • In planning a model-based phylogenic study for highly related ethnic data, the SNP marker number is an important factor to determine for relationship inferences. Genotype frequency data, utilizing a sub sampling method, from 63 Pan Asian ethnic groups was used for determining the minimum SNP number required to establish such relationships. Bootstrap random sub-samplings were done from 5.6K PASNPi SNP data. DA distance was calculated and neighbour-joining trees were drawn with every re-sampling data set. Consensus trees were made with the same 100 sub-samples and bootstrap proportions were calculated. The tree consistency to the one obtained from the whole marker set, improved with increasing marker numbers. The bootstrap proportions became reliable when more than 7,000 SNPs were used at a time. Within highly related ethnic groups, the minimum SNPs number for a robust neighbor-joining tree inference was about 7,000 for a 95% bootstrap support.

Identification of Ethnically Specific Genetic Variations in Pan-Asian Ethnos

  • Yang, Jin Ok;Hwang, Sohyun;Kim, Woo-Yeon;Park, Seong-Jin;Kim, Sang Cheol;Park, Kiejung;Lee, Byungwook;The HUGO Pan-Asian SNP Consortium
    • Genomics & Informatics
    • /
    • v.12 no.1
    • /
    • pp.42-47
    • /
    • 2014
  • Asian populations contain a variety of ethnic groups that have ethnically specific genetic differences. Ethnic variants may be highly relevant in disease and human differentiation studies. Here, we identified ethnically specific variants and then investigated their distribution across Asian ethnic groups. We obtained 58,960 Pan-Asian single nucleotide polymorphisms of 1,953 individuals from 72 ethnic groups of 11 Asian countries. We selected 9,306 ethnic variant single nucleotide polymorphisms (ESNPs) and 5,167 ethnic variant copy number polymorphisms (ECNPs) using the nearest shrunken centroid method. We analyzed ESNPs and ECNPs in 3 hierarchical levels: superpopulation, subpopulation, and ethnic population. We also identified ESNP- and ECNP-related genes and their features. This study represents the first attempt to identify Asian ESNP and ECNP markers, which can be used to identify genetic differences and predict disease susceptibility and drug effectiveness in Asian ethnic populations.

A Diffie-Hellman Key Exchange Protocol in the Standard Model (표준 모델에서 안전한 Diffie-Hellman 키 교환 프로토콜)

  • Jeong, Ik-Rae;Kwon, Jeong-Ok;Lee, Dong-Hoon;Hong, Do-Won
    • Journal of KIISE:Information Networking
    • /
    • v.35 no.6
    • /
    • pp.465-473
    • /
    • 2008
  • The MQV protocol has been regarded as the most efficient authenticated Diffie- Hellman key exchange protocol, and standardized by many organizations including the US NSA. In Crypto 2005, Hugo Krawczyk showed vulnerabilities of MQV to several attacks and suggested a hashed variant of MQV, called HMQV, which provides the same superb performance of MQV and provable security in the random oracle model. In this paper we suggest an efficient authenticated Diffie-Hellman key exchange protocol providing the same functionalities and security of HMQV without random oracles. So far there are no authenticated Diffie-Hellman protocols which are provably secure without using random oracles and achieve the same level of security goals of HMQV efficiently yet.

Ste. Genevieve Library as a Criticism of Classicism

  • Kang, Tae-Woong
    • Architectural research
    • /
    • v.15 no.1
    • /
    • pp.17-23
    • /
    • 2013
  • The purpose of this paper is to reconsider and revaluate Ste. Genevieve Library designed by Henri Labrouste as a criticism of Classicism. Considered as the epitome of the early structural Rationalism the modern historian tried to focus only on the iron structure of the library. Arguably, the structural concern was one of the ideas that the architect wanted to manifest in the library. As a rebel against a view of the Acad$\acute{e}$mie des Beaux-Art the notions of H. Labrouste were radical. He criticized an autistic Classicism with an echoing Claude Perrault's doubt about the myth of classical beauty. These radical ideas firstly showed in his report of the Grand Prix de Rome and must have been developed through several discussions for a novel: Notre-Dame de Paris by V. Hugo. 'Ceci tuera cela', one of the chapter of the novel, was generally known as the death of architecture due to the invention of the printing press around Renaissance period. We, however, consider that even though the historical background of the novel is the Gothic period the ideas, which was discussed with Labrouste, related to the death of architecture was not the architecture itself but classical architecture recomposed during Renaissance period. As the first design work the library must be reflected his ideas, which were developed, and manifested his criticism of the Classicism indirectly.

Personality Traits, Positive Emotions and Psychological Well-Being of Telecommunications Distribution Employees

  • Edwin RAMIREZ-ASIS;Roger Pedro NORABUENA-FIGUEROA;Hugo Walter MALDONADO-LEYVA;Rudecindo Albino PENADILLO-LIRIO;Hugo ESPINOZA-RODRÍGUEZ;Wilber ACOSTA-PONCE
    • Journal of Distribution Science
    • /
    • v.21 no.10
    • /
    • pp.11-19
    • /
    • 2023
  • Purpose: Personality qualities are essential to the prosperity of any contemporary company because they foster the growth of pleasant emotions in telecommunications distribution employees. Research design, data and methodology: Thus improving their overall psychological well-being and productivity. Talent retention is facilitated by mutual respect between management and staff. The success of the company as a whole, including the development and maintenance of emotions with customers, also depends on the psychological well-being of employees. The aim is to demonstrate how a positive and satisfied emotional workforce contributes to psychological well-being in the 21st century. Result: The research aims to better understand the personality traits that influence the psychological well-being of employees. In addition, between January and March 2023, a total of 179 employees in the telecommunications distribution industry in the Peruvian city of Chiclayo were surveyed using structural modelling methods to measure employee satisfaction. It also shows how various ideas, approaches and models can be used in the real world. Conclusion: The significance of the model on the perception of telecommunications workers in Peru is demonstrated by the results, which indicate an R2 value of 0.681 for positive emotions and an R2 value of 0.792 for employees' psychological well-being.

A Case Study of Architectural Design of Hospital based on Substantial Interpretation of Functionalism (기능주의 이론의 존재론적 해석에 입각한 병원건축 설계 사례 - 광주보훈병원을 중심으로 -)

  • Yang, Nae Won
    • Journal of The Korea Institute of Healthcare Architecture
    • /
    • v.9 no.1
    • /
    • pp.25-33
    • /
    • 2003
  • The purpose of this study is not to understand functionalism from a simple program or effectiveness and economic perspective, but to reinterpret from a substantial perspective that modern architects assert commonly and to apply it to hospital design in a new way.

  • PDF