• Genomics & Informatics
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• v.21 no.4
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• pp.45.1-45.11
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• 2023

Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH development, which is important for early screening and intervention, remains unclear. Weighted gene co-expression network analysis (WGCNA) is a useful method for identifying hub genes and screening specific targets for diseases. In this study, we utilized an mRNA dataset of the liver tissues of patients with NASH and conducted WGCNA for various stages of liver fibrosis. Subsequently, we employed two additional mRNA datasets for validation purposes. Gene set enrichment analysis (GSEA) was conducted to analyze gene function enrichment. Through WGCNA and subsequent analyses, complemented by validation using two additional datasets, we identified five genes (BICC1, C7, EFEMP1, LUM, and STMN2) as hub genes. GSEA analysis indicated that gene sets associated with liver metabolism and cholesterol homeostasis were uniformly downregulated. BICC1, C7, EFEMP1, LUM, and STMN2 were identified as hub genes of NASH, and were all related to liver metabolism, NAFLD, NASH, and related diseases. These hub genes might serve as potential targets for the early screening and treatment of NASH.

• The Journal of Society for e-Business Studies
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• v.20 no.1
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• pp.23-43
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• 2015

Information and communications technology facilitates collaboration among individuals by functioning as an open platform for open collaboration projects. In this regard, this study aims to understand the network characteristics of participants who contribute greatly to open collaboration by investigating the mutual cooperation network in an open source project, which represents a form of open collaboration based on social network theory. To achieve this objective, this study analyzes the network centrality of developers with a high number of commits, particularly 8,101 developers in 782 repositories in GitHub, a representative open source platform. This study also determines how the relationship between network centrality and number of commits depends on the size of a repository network and the presence of a hub. Consequently, the number of commits by developers with high degree, betweenness, and closeness centrality is increasing. Among which, betweenness centrality has the highest explanatory power. Furthermore, when a hub is present and as network size increases, the relationship between the betweenness centrality of a developer and his/her number of commits continues to grow. This study is expected to provide suggestions for the successful performance of open collaboration projects in the future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.1
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• pp.122-127
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• 2009

In this paper, it is reviewed security architecture and proposed security model about secure aeronautical system, which is considering in the cynical research topics out of aeronautical traffic system. The reviewed contents is treated about security model fur domestic aeronautical system with international security technology trends in the basis of security technology related aeronautical services. In the security framework of aeronautical communication network, it is analyzed data link security technology between air and ground communication, and security architecture in according to aeronautical system, and presented security architecture of U information HUB model. The security architecture of U-information HUB includes the internetworking scope of airline, airport network, airplane network, and related government agency, etc.

• Journal of the Korea Society of Computer and Information
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• v.21 no.1
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• pp.59-64
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• 2016

This paper suggests heuristic algorithm with O(mn) polynomial time complexity using Excel for partially survivable networks optimization problem of cellular telecommunication systems with m cells and n hubs. This problem only can be get the solution using linear programming or LINGO software package. The proposed algorithm connects the cell to hubs in ring network with minimum cost as the connection diversity of each cell. If the traffic of ring network (T) is T>2K for ring capacity (K), we adjust the maximum cost hub to MTSO that has a ascending order of (D/DC)/${\Delta}^+$ cell with each cell traffic demand (D) and ${\Delta}^+$=(MTSO cost-maximum cost hub) than we get the $T{\leq}2K$. Finally, we adjust MTSO to the removed maximum cost hub for the cell with 2K-$T{\geq}$(D/DC) and $_{max}{\Delta}^-$. While we using like this simple method, the proposed algorithm can be get the same optimal solution for experimental data as linear programing and LINGO software package.

• Journal of Korean Institute of Industrial Engineers
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• v.31 no.4
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• pp.303-315
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• 2005

In this paper we address a design problem for hub-and-spoke networks and then consider a capacitated hub locations problem with direct shipment (CHLPwD). We determine the location of hubs, the allocation of nodes to hubs, and direct shipment paths in the network, with the objective of minimizing the total cost in the network. In this paper, CHLPwD is formulated as 0-1 integer programming. We develop an evolutionary algorithm here to solve the large sized CHLPwD. To do this, we present the representation and the genetic operators suitable for the problem and propose a heuristic method for the allocation of nodes to hubs. To enhance the search capability, problem-specific information is used in our evolutionary algorithm. The proposed algorithm is compared with the heuristic method in terms of solution quality and computation time. The experimental results show that our algorithm can provide better solutions than the heuristic.

• Journal of Korea Port Economic Association
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• v.19 no.2
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• pp.159-175
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• 2003

The purpose of this paper is to investigate the development strategy for the Hub of Northeast Asia. Those countries such as Singapore, Taiwan, Hong Kong and China competing us are trying to concentrate on their core capacity. Based on the severe competition surrounding us, we are confronting with a transitional period to upgrade competitiveness. It is acknowledged that the building of economic hub of Northeast Asia is essential to become an advanced country. Therefore, it is becoming an urgent task that Korean government should formulate the development strategy of building efficient transportation network, economic special zone and financial hub.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2005.05a
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• pp.59-71
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• 2005

In this paper we address a design problem for hub and spoke transportation networks and then consider a capacitated hub locations problem with direct shipment (CHLPwD). We determine the location of hubs, the allocation of nodes to hubs, and direct shipment paths in the network, with the objective of minimizing the total cost in the network. An evolutionary algorithm is developed here to solve the CHLPwD. To do this, we propose the representation and the genetic operators suitable for the problem and adopt a heuristic method for the allocation of nodes to hubs. To enhance the search capability, problem-specific information is used in our evolutionary algorithm. The proposed algorithm is compared with the heuristic method in terms of solution quality and computation time. The experimental results show that our algorithm can provide better solutions than the heuristic.

• Journal of Korean Society of Transportation
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• v.26 no.6
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• pp.103-112
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• 2008

Implementing hub networks in logistics is generally attractive and effective because of cost savings derived from economies of scale on network transportation, and objective of the hub network design problem is to decide optimal hub locations, and the transportation route of each origin-destination pair. This problem is generally a NP-complete problem not to solve easily, and it is almost impossible to find optimal solutions considering the big-sized network within a reasonable time. This research tried to find optimal logistics strategy in the given big-sized real network and the freight origin-destination data. The objective function, which was proposed by Honor and O'kelly (2001), that rewards economies of scale on network links with increase of transportation volumes, is applied. This thesis proposed the optimal hub network of korea within a reasonable time based on engineering approaches. And it is expected that this thesis can contribute to plan freight policies which can improve to have competitive power in the level of a company or nation by reducing logistic costs.

• Journal of Distribution Research
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• v.7 no.1
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• pp.1-20
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• 2002

Many of logistics-related research in automobile industry has focused on inbound logistics and procurement. Research into outbound logistics is relatively few. As a starting research into outbound logistics in automobile industry, this paper examined its logistics network problems with three aspects - location strategy, inventory strategy and transportation strategy. We proposed alternatives of logistics network design resolution, and presented three practical scenarios based on those alternatives. Based on interview, on-site visit and internal data collection processes, we identified major domestic outbound logistics problems such as redundant logistics bases, inefficient delivery policy, insufficient inventory capacity, inventory stock quality deterioration, inefficient transportation system, and etc. In order to cope with those problems, we proposed such strategic alternatives as introduction of hub-and-spoke system, integration of logistics bases, introduction of (automatic) parking building, diversification of transportation mode, and etc. At the same time, we constructed three practically executable scenarios based on those ideas. The first is "Center Hub" scenario, the second is "Metropolitan Hub" scenario. The third and last scenario is "Regional Consolidation of Warehouses (distribution centers)".

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.12
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• pp.1908-1918
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• 2022

Recently, ASEAN is not only a new production base but also a consumer market for Korea, and interest in the utilization of production networks in each region is increasing. In particular, urbanization in ASEAN countries is progressing at a relatively fast pace. Each country is promoting smart city projects combined with ICT to improve outdated basic infrastructure facilities such as housing, transportation, logistics, crime prevention, and disaster prevention. The purpose of this study is to develop a web-based smart city export HUB platform so that companies with excellent domestic smart city solutions can participate in smart city construction through networks with ASEAN countries. These platforms can secure the demand for smart city construction in ASEAN countries, and through the establishment of the Korea-ASEAN public-private network, smart cities planned in ASEAN countries can be promoted more innovative. In addition, it is expected to be positioned as a Global smart city platform model by applying to real cities through collaboration with excellent domestic companies.