• Steel and Composite Structures
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• 제30권5호
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• pp.417-432
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• 2019

This paper presents the results of axial compression testing and numerical modeling on reinforced concrete columns (RCC) with normal concrete (NC) and high-strength concrete (HSC), RCC confined by glass-fiber reinforced plastic pipes (GRP) casing as well as carbon fiber reinforced polymer (CFRP), The major parameters evaluated in the experiments were the effects of concrete type, GRP casing and CFRP wrapping, as well as the number of CFRP layers. 12 cylindrical RCC ($150{\times}600mm$) were prepared and divided into two groups, NC and HSC. Each group was divided into two parts; with and without GRP casing. In each part, one column was without CFRP strengthening layer, a column was wrapped with one CFRP layer and another column with two CFRP layers. All columns were tested under concentrated compression load. Numerical modeling was performed using ABAQUS software and the results of which were compared with experimental findings. A good agreement was found between the results. Results indicated that the utilization of CFRP wrapping and GRP casing improved compression capacity and ductility of RCC. The addition of one and two layer-FRP wrapping increased capacity in the NC group to an average of 18.5% and 26.5% and in the HSC group to an average of 10.2% and 24.8%. Meanwhile, the utilization of GRP casing increased the capacity of the columns by 3 times in the NC group and 2.38 times in the HSC group. The results indicated that although both CFRP wrapping and GRP casing increased confinement, the GRP casing gave more increase capacity and ductility of the RCC due to higher confinement. Furthermore, the confinement effect was higher on NC group.

• 한국식품과학회지
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• 제41권5호
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• pp.597-601
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• 2009

간성상세포(HSC)는 간섬유화와 간경변에 중요한 역할을 한다고 알려져 있다. 간손상에 의해 둥근 모양의 간성상세포는 활성화되어 세포외기질(ECM)을 생산하는 myofibroblast와 같은 모양으로 활성화 된다. 활성화된 간성상세포의 특징은 빠른 증식 속도와 collagen과 같은 세포외 기질의 생산이다. 활성화된 간성상 세포의 제거방법은 apoptosis를 유도하는 것이다. 가자 추출물은 정상 간세포(rat primary hepatocyte), 간세포주(HepG2) 및 활성화된 간성상세포주인 T-HSC/Cl-6에 $1,000{\mu}g/mL$의 농도까지 처리하여 세포독성을 확인하였다. 그 결과 hepatocyte나 HepG2에서는 최고 농도에서도 독성이 없었으나 T-HSC/Cl-6는 U-shape 모양으로 사멸하는 것을 확인 하였다. T-HSC/Cl-6의 사멸이 apoptosis에 의한 것인지를 Annexin-V/PI double staining을 통하여 확인한 결과 apoptosis에 의해 T-HSC/Cl-6의 사멸이 일어나는 것을 확인하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 추계학술대회 논문집 전기물성,응용부문
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• pp.91-92
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• 2006

The electrical properties of viologen derivatives were studied in terms of the tunneling current characteristics on the length of the viologen derivatives using self-assembling techniques and ultra high vacuum scanning tunneling microscopy (UHV-STM). We fabricated the Au substrate were deposited by thermal evaporation system ($420^{\circ}C$. Self-assembled monolayers (SAMs) were prepared on Au (111), which had been thermally deposited onto freshly cleaved, heated mica. The Au substrate was exposed to a 1 mM solution of viologen derivatives in ethanol for 24 hours to form a monolayer. We measurement of the morphology on the single viologen molecules ($VC_{8}SH$, $VC_{10}SH$, $HSC_{8}VC_{8}SH$, and $HSC_{10}VC_{10}SH$). The current-voltage (I-V) and differential conductance (dl/dV-V) properties were measured while the electrical properties of the formed monolayer were scanned by using a STS. The effective barrier height of viologen derivatives ($VC_{8}SH$, $VC_{10}SH$, $HSC_{8}VC_{8}SH$, and $HSC_{10}VC_{10}SH$) were calculated to be 1.076 eV, 1.56 ${\pm}$ 0.3 eV, 1.85 eV, 2.28 eV, respectively.

• KCI Concrete Journal
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• 제12권1호
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• pp.23-34
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• 2000

Experiments were carried out to investigate the seismic behaviors, such as lateral strength, ductility and energy-dissipation capacity. of high-strength concrete (HSC) square short column confined in thin steel shell. The primary objective of the study was to investigate the suitability of using HSC square columns confined in thin steel shell in region of moderate-to-high seismic risk. A total of six columns, consisting of two ordinarily reinforced concrete square short columns and four reinforced concrete square short columns confined in thin steel shell was tested. Column specimens, short columns in a moment resisting frame with girder. were tested under a constant axial and reversed cyclic lateral loads. To design the specimens. transverse reinforcing methods, level of axial load applied, and the steel tube width-thickness ratio (D/t) were chosen as main parameters. Test results were also discussed and compared in the light of improvements in general behaviors, ductility, and energy-absorption capacities. Compared to conventionally reinforced concrete columns, the HSC columns confined in thin steel shell had similar load-displacement hysteretic behavior but exhibited greater energy-dissipation characteristics . It is concluded that, in strong earthquake areas, the transverse reinforcing method by using a thin steel shell (D/t=125) is quite effective to make HSC short columns with very strong and ductile.

• BMB Reports
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• 제48권12호
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• pp.645-646
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• 2015

The sympathetic nervous system (SNS) or neurotransmitters in the bone marrow microenvironment has been known to regulate hematopoietic stem cell (HSC) functions such as self-renewal, proliferation and differentiation. However, the specific role of neuropeptide Y (NPY) in this process remains relatively unexplored. In this study, we demonstrated that NPY deficient mice have significantly reduced HSC numbers and impaired bone marrow regeneration due to apoptotic destruction of SNS fibers and/or endothelial cells. Moreover, NPY treatment prevented bone marrow impairments in a mouse model of chemotherapy-induced SNS injury, while conditional knockout mice lacking the Y1 receptor in macrophages did not restore bone marrow dysfunction in spite of NPY injection. Transforming growth factor-beta (TGF-β) secreted by NPY-mediated Y1 receptor stimulation in macrophages plays a key role in neuroprotection and HSC survival in the bone marrow. Therefore, this study reveals a new role of NPY in bone marrow HSC microenvironment, and provides an insight into the therapeutic application of this neuropeptide.

• Structural Engineering and Mechanics
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• 제49권1호
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• pp.65-80
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• 2014

This paper reports on the development of a minimum cost design model and its application for obtaining economic designs for reinforced High Strength Concrete (HSC) T-sections in bending under ultimate limit state conditions. Cost objective functions, behavior constraint including material nonlinearities of steel and HSC, conditions on strain compatibility in steel and concrete and geometric design variable constraints are derived and implemented within the Conjugate Gradient optimization algorithm. Particular attention is paid to problem formulation, solution behavior and economic considerations. A typical example problem is considered to illustrate the applicability of the minimum cost design model and solution methodology. Results are confronted to design solutions derived from conventional design office methods to evaluate the performance of the cost model and its sensitivity to a wide range of unit cost ratios of construction materials and various classes of HSC described in Eurocode2. It is shown, among others that optimal solutions achieved using the present approach can lead to substantial savings in the amount of construction materials to be used. In addition, the proposed approach is practically simple, reliable and computationally effective compared to standard design procedures used in current engineering practice.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.918-923
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• 2003

Reinforced concrete deep beams are commonly used in many structural applications, including transfer girders, pile caps, foundation walls, and offshore structures. The existing design methods were developed and calibrated using normal strength concrete test results, and their applicability th HSC deep beams must be assessed. For the shear strength prediction of high-strength concrete(HSC) deep beams, this paper proposed Softened Strut-and-Tie Model(SSTM) considered HSC and bending moment effect. The shear strength predictions of the refined model, the formulas the ACI 318-02 Appendix A STM, and Eq. of ACI 318-99 11.8 are compared with the collected experimental data of 74 HSC deep beams with compressive strength in the range of 49-78MPa . It is shown the shear strength of deep beam calculated by those equations are conservative on comparing test results. The comparison shows that the performance of the proposed SSTM is better than the ACI Code approach for all the parameters under comparison. The parameters reviewed include concrete strength, the shear span-depth ratio, and the ratio of horizontal and vertical reinforcement. The proposed SSTM gave a mean predicted to experimental ratio of 0.99, 32 percent higher than ACI 318-02 Code, however with the low coefficient variation.

• Steel and Composite Structures
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• 제46권1호
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• pp.75-92
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• 2023

The novel composite cold-formed steel (CFS)/engineered cementitious composites (ECC) beams have been recently presented. The new composite section exhibited superior structural performance as a flexural member, benefiting from the lightweight thin-walled CFS sections with improved buckling and torsional properties due to the restraints provided by thinlayered ECC. This paper investigated the shear performance of the new composite CFS/ECC section. Twenty-eight simply supported beams, with a shear span-to-depth ratio of 1.0, were assembled back-to-back and tested under a 3-point loading scheme. Bare CFS, composite CFS/ECC utilising ECC with Polyethylene fibres (PE-ECC), composite CFS/MOR, and CFS/HSC utilising high-strength mortar (MOR) and high-strength concrete (HSC) as replacements for PE-ECC were compared. Different failure modes were observed in tests: shear buckling modes in bare CFS sections, contact shear buckling modes in composite CFS/MOR and CFS/HSC sections, and shear yielding or block shear rupture in composite CFS/ECC sections. As a result, composite CFS/ECC sections showed up to 96.0% improvement in shear capacities over bare CFS, 28.0% improvement over composite CFS/MOR and 13.0% over composite CFS/HSC sections, although MOR and HSC were with higher compressive strength than PE-ECC. Finally, shear strength prediction formulae are proposed for the new composite sections after considering the contributions from the CFS and ECC components.

• Journal of Animal Science and Technology
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• 제57권12호
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• pp.44.1-44.9
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• 2015

Background: Heat shock proteins play an important role in protection from stress stimuli and metabolic insults in almost all organisms. Methods: In this study, computational tools were used to deeply analyse the physicochemical characteristics and, using homology modelling, reliably predict the tertiary structure of the blunt snout bream (Ma-) Hsp70 and Hsc70 proteins. Derived three-dimensional models were then used to predict the function of the proteins. Results: Previously published predictions regarding the protein length, molecular weight, theoretical isoelectric point and total number of positive and negative residues were corroborated. Among the new findings are: the extinction coefficient (33725/33350 and 35090/34840 - Ma-Hsp70/ Ma-Hsc70, respectively), instability index (33.68/35.56 - both stable), aliphatic index (83.44/80.23 - both very stable), half-life estimates (both relatively stable), grand average of hydropathicity (-0.431/-0.473 - both hydrophilic) and amino acid composition (alanine-lysine-glycine/glycine-lysine-aspartic acid were the most abundant, no disulphide bonds, the N-terminal of both proteins was methionine). Homology modelling was performed by SWISS-MODEL program and the proposed model was evaluated as highly reliable based on PROCHECK's Ramachandran plot, ERRAT, PROVE, Verify 3D, ProQ and ProSA analyses. Conclusions: The research revealed a high structural similarity to Hsp70 and Hsc70 proteins from several taxonomically distant animal species, corroborating a remarkably high level of evolutionary conservation among the members of this protein family. Functional annotation based on structural similarity provides a reliable additional indirect evidence for a high level of functional conservation of these two genes/proteins in blunt snout bream, but it is not sensitive enough to functionally distinguish the two isoforms.

• Smart Structures and Systems
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• 제14권5호
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• pp.785-809
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• 2014

In this paper, an Adaptive nerou-based inference system (ANFIS) is being used for the prediction of shear strength of high strength concrete (HSC) beams without stirrups. The input parameters comprise of tensile reinforcement ratio, concrete compressive strength and shear span to depth ratio. Additionally, 122 experimental datasets were extracted from the literature review on the HSC beams with some comparable cross sectional dimensions and loading conditions. A comparative analysis has been carried out on the predicted shear strength of HSC beams without stirrups via the ANFIS method with those from the CEB-FIP Model Code (1990), AASHTO LRFD 1994 and CSA A23.3 - 94 codes of design. The shear strength prediction with ANFIS is discovered to be superior to CEB-FIP Model Code (1990), AASHTO LRFD 1994 and CSA A23.3 - 94. The predictions obtained from the ANFIS are harmonious with the test results not accounting for the shear span to depth ratio, tensile reinforcement ratio and concrete compressive strength; the data of the average, variance, correlation coefficient and coefficient of variation (CV) of the ratio between the shear strength predicted using the ANFIS method and the real shear strength are 0.995, 0.014, 0.969 and 11.97%, respectively. Taking a look at the CV index, the shear strength prediction shows better in nonlinear iterations such as the ANFIS for shear strength prediction of HSC beams without stirrups.