• Proceedings of the Korea Concrete Institute Conference
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• 2009.05a
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• pp.543-544
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• 2009

The fiber(NY, PP) known to the effective material on improvement of the fire-resistance of HSC(high strength concrete) has a difference for fluidity according to the variation of a length and contents of fiber. In this study, to analyze the effect of a length and contents of the fiber on the fluidity of HSC and fheological characteristics, we calculated a viscosity of mortar by mini slump-flow, simple V-lot and viscometer. With the test results, the fluidity characteristic showed a moderate difference by a length and contents of the fiber, but showed a significant difference by increase of the fiber contents. ${\ast}$ AFR Concrete (Advenced Fire Resistant Concrete)

• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.93-101
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• 2018

This study was conducted to investigate the anticancer and antitumor effects of quercetin, which is a natural flavonoid substance in human oral cancer cell line HSC-2 cells. The results of this study showed that quercetin reduses the cell viability and the cell proliferation rate, and it led to the evidences of cell death through apoptosis pathway. Also, lower concetration quercetin over $100{\mu}M$ were inhibited the cell migration and invasion. In the present study, we conclude that quercetin treatment of more than $200{\mu}M$ induces apoptosis by activating programed cell death and quercetin treatment of $100{\mu}M$ or more inhibits the cell migration and invasion rate in oral cancer cells. Therefore, this study suggests that quercetin is of sufficient value as an anticancer drug to inhibit metastasis and to treat cancer.

• Computers and Concrete
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• v.4 no.3
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• pp.187-206
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• 2007

A rational three-dimensional nonlinear finite element model is described and implemented for evaluating the behavior of high strength concrete slabs under transverse load. The concrete was idealized by using twenty-nodded isoparametric brick elements with embedded reinforcements. The concrete material modeling allows for normal (NSC) and high strength concrete (HSC), which was calibrated based on experimental data. The behavior of concrete in compression is simulated by an elastoplastic work-hardening model, and in tension a suitable post-cracking model based on tension stiffening and shear retention models are employed. The nonlinear equations have been solved using the incremental iterative technique based on the modified Newton-Raphson method. The FE formulation and material modeling is implemented into a finite element code in order to carry out the numerical study and to predict the behavior up to ultimate conditions of various slabs under transverse loads. The validity of the theoretical formulations and the program used was verified through comparison with available experimental data, and the agreement has proven to be very good. A parametric study has been also carried out to investigate the influence of different material and geometric properties on the behavior of HSC slabs. Influencing factors, such as concrete strength, steel ratio, aspect ratio, and support conditions on the load-deflection characteristics, concrete and steel stresses and strains were investigated.

• Computers and Concrete
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• v.3 no.1
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• pp.17-28
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• 2006

Replacement of actual stress distribution in a reinforced concrete (RC) flexural member with a simpler geometrical shape, which maintains magnitude and location of the resultant compressive force, is an acceptable conceptual trick. This concept was originally perfected for normal strength concrete. In recent years, high strength concrete (HSC) has been introduced and widely used in modern construction. The stress block parameters require updating to account for special features of HSC in the design of flexural members. In future, more varieties of concrete may be developed and a corresponding design procedure of RC flexural members will be required. The usual practice is to conduct large number of experiments on various sizes of specimen and then evolve an empirical relation. This paper presents a numerical procedure through which the stress block parameters can be numerically derived for a given strain ratio variation. The material model for concrete is presented and computational procedure is described. This procedure is illustrated with several variations of strain ratio. The advantages of numerical procedure are that it costs less and it can be used with new material models for any new variety of concrete.

• Journal of Korea Society of Digital Industry and Information Management
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• v.11 no.1
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• pp.1-8
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• 2015

Recently, a high strength concrete(HSC) in excess of 80 MPa is popular to use in the domestic construction field. But there is no design standard of high strength concrete. It is reason why a study about structural behaviors of thin walls is required. In this paper, the accurate Finite Element Method as a virtual test is suggested considering material properties, which are concrete and steel, and the experimental fractural model suggested by Kupfer. It is conducted the comparison evaluation of the ultimate failure loads, lateral-displacements and crack propagation patterns between the results of experimental approach, which were carried on Saheb's test for normal strength concrete and Lee's test for high strength concrete. Therefore it is suggested to use the accurate virtual simulation test method and Ubiquitous Sensor Network(USN) by Finite Element Method for Internet of Things(IoT).

• Computers and Concrete
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• v.8 no.4
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• pp.445-463
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• 2011

In the design of reinforced concrete (RC) beams, apart from providing adequate strength, it is also necessary to provide a minimum deformability even for beams not located in seismic regions. In most RC design codes, this is achieved by restricting the maximum tension steel ratio or neutral axis depth. However, this empirical deemed-to-satisfy method, which was developed based on beams made of normal-strength concrete (NSC) and normal-strength steel (NSS), would not provide a consistent deformability to beams made of high-strength concrete (HSC) and/or high-strength steel (HSS). More critically, HSC beams would have much lower deformability than that provided previously to NSC beams. To ensure that a consistent deformability is provided to all RC beams, it is proposed herein to set an absolute minimum rotation capacity to all RC beams in the design. Based on this requirement, the respective maximum limits of tension steel ratio and neutral axis depth for different concrete and steel yield strengths are derived based on a formula developed by the authors. Finally for incorporation into design codes, simplified guidelines for designing RC beams having the proposed minimum deformability are developed.

• Steel and Composite Structures
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• v.27 no.2
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• pp.243-253
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• 2018

In recent years, concrete-filled box or tubular columns have been commonly used in high-rise buildings. However, a number of fire test results show that there are significant differences between high strength concrete (HSC) and normal strength concrete (NSC) after being subjected to high temperatures. Therefore, this paper presents an investigation on the fire resistance of HSC filled steel tubular columns (CFTCs) under combined temperature and loading. Two groups of full-size specimens were fabricated to consider the effect of type of concrete infilling (plain and reinforced) and the load level on the fire resistance of CFTCs. Prior to fire test, a constant compressive load (i.e., load level for fire design) was applied to the column specimens. Thermal load was then applied on the column specimens in form of ISO 834 standard fire curve in a large-scale laboratory furnace until the set experiment termination condition was reached. The results demonstrate that the higher the axial load level, the worse the fire resistance. Moreover, in the bar-reinforced concrete-filled steel tubular columns, the presence of rebars not only decreased the spread of cracks and the sudden loss of strength, but also contributed to the load-carrying capacity of the concrete core.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.4
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• pp.379-387
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• 2024

Breast cancer (BC) is most commonly diagnosed worldwide. Liquiritigenin is a flavonoid found in various species of the Glycyrrhiza genus, showing anti-tumor activity. This article was to explore the influences of liquiritigenin on the biological behaviors of BC cells and its underlying mechanism. BC cells were treated with liquiritigenin alone or transfected with oe-HSP90 before liquiritigenin treatment. RT-qPCR and Western blotting were employed to examine the levels of HSP90, Snail, E-cadherin, HSC70, and LAMP-2A. Cell viability, proliferation, migration, and invasion were evaluated by performing MTT, colony formation, scratch, and Transwell assays, respectively. Liquiritigenin treatment reduced HSP90 and Snail levels and enhanced E-cadherin expression as well as inhibiting the proliferation, migration, and invasion of BC cells. Moreover, liquiritigenin treatment decreased the expression of HSC70 and LAMP-2A, proteins related to chaperone-mediated autophagy (CMA). HSP90 overexpression promoted the CMA, invasion, and migration of BC cells under liquiritigenin treatment. Liquiritigenin inhibits HSP90-mediated CMA, thereby suppressing BC cell growth.

• International Journal of Concrete Structures and Materials
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• v.18 no.2E
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• pp.79-87
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• 2006

The main objective of this research is to examine the behavior of high-strength concrete(HSC) columns. Eight test columns in one-third scale were tested under the conditions of cyclic lateral force and a constant axial load equal to 30% of the column axial load capacity. The $200{\times}200mm$ square columns were reinforced with eight DB bars constituting a longitudinal steel ratio of 2.54% of the column cross-sectional area. The main experimental parameters were volumetric ratio of transverse reinforcement(${\rho}_s$=1.58, 2.25 percent), tie configuration(Type H, Type C, Type D) and tie yield strength($f_{yh}$=548.8 and 779.1 MPa). It was found that the hysteretic behaviour and ultimate deformability of HSC columns were influenced by the amount and details of transverse reinforcement in the potential plastic hinge regions. Columns of transverse reinforcement in the amount 42 percent higher than that required by seismic provisions of ACI 318-02 showed ductile behavior. At 30% of the axial load capacity, it is recommended that the yield strength of transverse reinforcement be held equal to or below 548.8 MPa. Correlations between the calculated damage index and the damage progress are proposed.

• BMB Reports
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• v.50 no.8
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• pp.417-422
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• 2017

Cisplatin is the most effective and widely used chemotherapeutic agent for many types of cancer. Unfortunately, its clinical use is limited by its adverse effects, notably bone marrow suppression leading to abnormal hematopoiesis. We previously revealed that neuropeptide Y (NPY) is responsible for the maintenance of hematopoietic stem cell (HSC) function by protecting the sympathetic nervous system (SNS) fibers survival from chemotherapy-induced bone marrow impairment. Here, we show the NPY-mediated protective effect against bone marrow dysfunction due to cisplatin in an ovarian cancer mouse model. During chemotherapy, NPY mitigates reduction in HSC abundance and destruction of SNS fibers in the bone marrow without blocking the anticancer efficacy of cisplatin, and it results in the restoration of blood cells and amelioration of sensory neuropathy. Therefore, these results suggest that NPY can be used as a potentially effective agent to improve bone marrow dysfunction during cisplatin-based cancer therapy.