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http://dx.doi.org/10.15207/JKCS.2018.9.10.093

Convergence study on anticancer and antimetastasis effect by quercetin in human oral cancer cells  

Kang, Hae-Mi (Department of Oral Anatomy, School of Dentistry, Pusan National University)
Kil, Jong-Jin (Department of Oral Anatomy, School of Dentistry, Pusan National University)
Park, Bong-Soo (Department of Oral Anatomy, School of Dentistry, Pusan National University)
Kang, Hyun-Kyung (Department of Dental Hygiene, Silla university)
Kim, In-Ryoung (Department of Oral Anatomy, School of Dentistry, Pusan National University)
Publication Information
Journal of the Korea Convergence Society / v.9, no.10, 2018 , pp. 93-101 More about this Journal
Abstract
This study was conducted to investigate the anticancer and antitumor effects of quercetin, which is a natural flavonoid substance in human oral cancer cell line HSC-2 cells. The results of this study showed that quercetin reduses the cell viability and the cell proliferation rate, and it led to the evidences of cell death through apoptosis pathway. Also, lower concetration quercetin over $100{\mu}M$ were inhibited the cell migration and invasion. In the present study, we conclude that quercetin treatment of more than $200{\mu}M$ induces apoptosis by activating programed cell death and quercetin treatment of $100{\mu}M$ or more inhibits the cell migration and invasion rate in oral cancer cells. Therefore, this study suggests that quercetin is of sufficient value as an anticancer drug to inhibit metastasis and to treat cancer.
Keywords
Convergence; Apoptosis; Epithelial-mesenchymal transition; Metastasis; Oral cancer; Quercetin;
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