• Journal of Mechanical Science and Technology
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• v.17 no.3
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• pp.400-408
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• 2003

A study on the progressive inelastic deformation behavior of the 316 L stainless steel cylindrical structure with plate-to-shell junction under moving temperature front was carried out by structural test and analysis. The structural test intends to simulate the thermal ratcheting behavior occurring at the reactor baffle of the liquid metal reactor as free surface of hot sodium pool moves up and down under plant transients. The thermal ratchet load that heats the specimen up to 550$^{\circ}C$ was applied repeatedly and residual deformation was measured. The thermal ratcheting test was carried out with two types of cylindrical structures, one with plate to-shell junction and the other without the junction to investigate the effects of the geometric discontinuities on the global ratcheting deformation. The temperature distributions of the test specimens were measured and were used for the ratcheting analysis. The ratchet deformations were analyzed with the constitutive equation of the non-linear combined hardening model. The analysis results were in good agreement with those of the structural tests.

• Journal of Acupuncture Research
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• v.36 no.3
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• pp.147-153
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• 2019

Background: The aim of this study was to investigate the safety and analgesic effects of Datura Flos pharmacopuncture (DFP). Methods: The analgesic effects of DFP were assessed using mechanical (hot plate), chemical (formalin test), and thermal (von Frey filament test) pain tests. Forty male Sprague Dawley rats were assigned randomly into DFP (75 mg/kg, 150 mg/kg), lidocaine 0.5%, or normal saline group for treatment on Kl3. Gross pathology, histopathology, biochemistry and hematology were performed. Results: In the hot plate test, DFP at a high dose (HDDFP; 150 mg/kg) produced a significant analgesic effect, at 10 and 20-minutes post injection (p < 0.01). Low dose DFP (LDDFP; 75 mg/kg) also showed an analgesic effect at 10 minutes post injection (p < 0.01). In the formalin test, HDDFP produced an analgesic effect, for 0-10 and 10-20 minutes (p < 0.01) post treatment, whereas LDDFP showed analgesic effects between 10-20 minutes (p < 0.05). In the von Frey filament test, DF-H produced an analgesic effect, 10 (p < 0.01) and 20 minutes post treatment (p < 0.05). LDDFP showed analgesic effect at 10 minutes (p < 0.05). In the acupuncture response test, HDDFP produced an analgesic effect at 10 minutes post treatment (p < 0.05). DF-H did not cause any anatomical changes to the liver or kidney and there were no abnormalities in biochemistry or hematology. Conclusion: DF-H was not toxic and provided short term analgesia, suggesting it may be useful in the management of pain.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.30 no.4
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• pp.175-185
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• 2018

This research investigates the internal flow and heat transfer in a plate heat exchanger with chevron shape by utilizing the computational fluid dynamics (CFD) software. The basic unit of the plate heat exchanger is generally composed of a hot channel, an intermediate chevron plate, and a cold channel. Several studies have reported experimental and numerical simulation of heat transfer and pressure drop. This study focused on the detailed numerical simulation of flow and heat transfer in the complicated chevron shape channel. The long chevron plate was designed to include 16 chevron patterns. For proper mesh resolution, the number of cells was determined after the grid sensitivity test. The working fluid is water, and its properties are defined as a function of temperature. The Reynolds number ranges from 900 to 9,000 in the simulation. A realizable $k-{\varepsilon}$ model and non-equilibrium wall function are properly considered for the turbulent flow. The friction factors and heat transfer coefficient are validated by comparing them with existing empirical correlations, and other patterned flow phenomena are also investigated.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.6
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• pp.1919-1932
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• 1991

Experimental studies are conducted to investigate the Flow-Induced Vibration mechanism for cantilever plate model with the angle of attack (.alpha.=10.deg., 20.deg., 30.deg.). Research is divided into two parts. First, the flow fields around two dimensional flat plate model are investigated using LDV system. Second, the vortex shedding frequency and response spectra of cantilever plate are obtained experimentally using gap sensor and hot wire anemometer. Finite element method program was used in order to predict the flow field and pressure field around thin flat plate. And some predicted results were compared with the experimental data. The aspect ration of test model is d/t=25 (d; width, t; thickness). From the measurement of the flow field it was found that in the case of small inclined (.alpha.=10.deg., 20.deg.) relatively, the separated boundary layer at sharp leading edge developed smoothly downstream. With increasing the angle of attack of the plate, stagnation region was appeared on the back side of the plate and separated boundary layer was extended downstream. These trends are a good agreement with the computational results. It was found by analysis of response spectra of cantilever plate that the influences of vortex shedding frequency were important at the large of attack (.alpha.=30.deg.), and two peak values appear in entire test model at 24Hz, 150Hz.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.171-183
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• 2005

Objective : The Korean famous medicinal prescription of Subi-jeon was investigated for their antidepressant effects by tail suspension test, hot plate test, reserpine-induced hypothermia test. In addition, the monoamine oxidase activity was determined in vivo. Methods : The methanol extract reduced dose-dependently the duration of immobility in the tail suspension test, by 31.4 and 34%(p<0.05) at doses of 500mg/kg and 1g/kg, respectively, compared with control group. In comparison with this, the effect of the water extract was very weak. Results : 1. In the hot plate test, the methanol extract potently increased the jump latency time(p<0.05) compared to the control group, exhibiting the inhibition rate of 197% and 256% at doses of 500mg/kg and 1g/kg(per os), respectively, which is more effective than the water extract. 2. Both extracts suppressed the fall of body temperature induced by reserpine(reserpine-induced hypothermia) in a dose-dependent manner, showing the less effect at lower doses and better effect at higher doses compared to the water extract. 3. Both extracts inhibited the brain monoamine oxidase activity in an in vivo assay compared to the control group, the activity of water extract was better than that of the methanol extract. Conclusion : The prescription of Subi-jeon can be useful for the prevention and treatment of depression.

• The Korean Journal of Pain
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• v.37 no.2
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• pp.151-163
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• 2024

Background: Galangin, commonly employed in traditional Chinese medicine for its diverse medicinal properties, exhibits potential in treating inflammatory pain. Nevertheless, its mechanism of action remains unclear. Methods: Mice were randomly divided into 4 groups for 7 days: a normal control group, a galangin-treated (25 and 50 mg/kg), and a positive control celecoxib (20 mg/kg). Analgesic and anti-inflammatory effects were evaluated using a hot plate test, acetic acid-induced writhing test, acetic acid-induced vascular permeability test, formalin-induced paw licking test, and carrageenan-induced paw swelling test. The interplay between galangin, transient receptor potential vanilloid 1 (TRPV1), NF-κB, COX-2, and TNF-α proteins was evaluated via molecular docking. COX-2, PGE2, IL-1β, IL-6, and TNF-α levels in serum were measured using ELISA after capsaicin administration (200 nmol/L). TRPV1 expression in the dorsal root ganglion was analyzed by Western blot. The quantities of substance P (SP) and calcitonin gene-related peptide (CGRP) were assessed using qPCR. Results: Galangin reduced hot plate-induced licking latency, acetic acid-induced contortions, carrageenan-triggered foot inflammation, and capillary permeability in mice. It exhibited favorable affinity towards TRPV1, NF-κB, COX-2, and TNF-α, resulting in decreased levels of COX-2, PGE2, IL-1β, IL-6, and TNF-α in serum following capsaicin stimulation. Galangin effectively suppressed the upregulation of TRPV1 protein and associated receptor neuropeptides CGRP and SP mRNA, while concurrently inhibiting the expression of NF-κB, TNF-α, COX-2, and PGE2 mRNA. Conclusions: Galangin exerts its anti-inflammatory pain effects by inhibiting TRPV1 activation and regulating COX-2, NF-κB/TNF-α expression, providing evidence for the use of galangin in the management of inflammatory pain.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.6 no.1
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• pp.20-26
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• 2007

In this study, fatigue strength of load-carrying cruciform fillet welded joints were evaluated using a new method proposed by Yamada, for geometric or structural stress in welded joint, that is, one-millimeter stress below the surface in the direction corresponding to the expected crack path. Validity of the method is verified by analyzing fatigue test results for load-carrying cruciform welded specimens has different size of weld toe radius, leg length and plate thickness reported in literature. Structural stress concentration factor for 1mm below the surface was calculated by finite element analysis for each specimen respectively. When compared to the basic fatigue resistance curve offered by BS7608, the one-millimeter stress method shows conservative evaluation for load-carrying cruciform fillet welded joints.

• The Korean Journal of Pain
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• v.32 no.4
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• pp.256-263
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• 2019

Background: Antinociceptive anti-inflammatory drugs have many adverse effects. The goal of this investigation is to study the probable anti-inflammatory and analgesic effects of verapamil and N-acetylcysteine (NAC) in experimental rats. Methods: Adult male Wistar rats were randomly divided into 4 groups in the antinociceptive study, each containing 6 rats; the normal control group, which received saline (1 mL/kg); the diclofenac group, which received diclofenac sodium (5 mg/kg); the NAC group, which received NAC (125 mg/kg); and the verapamil group, which received verapamil (8 mg/kg). In the anti-inflammatory study, 5 groups were used, the 4 previous groups with the addition of an edema control group, received saline and were subjected to formalin test. Hot plate latency time was recorded for antinociceptive evaluation. Paw edema thickness and biochemical parameters were recorded for anti-inflammatory evaluation. Results: Administration of NAC showed significant prolongation of hot plate latency time at 1 hour when compared to the control group while verapamil showed a significant prolongation of hot plate latency time at 1 and 2 hours when compared to the control group and NAC group values. Administration of NAC and verapamil significantly decreased paw edema thickness at 2, 4, and 8 hours when compared to edema control values. Regarding biochemical markers, NAC and verapamil significantly decreased serum nitric oxide synthase, C-reactive protein, and cyclooxygenase-2 levels compared to the edema control value. In accordance, a marked improvement of histopathological findings was observed with both drugs. Conclusions: NAC and verapamil have antinociceptive and anti-inflammatory effects comparable to diclofenac sodium.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1219-1224
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• 2004

The objective of this study is to propose an experimental calibration facility in which a heat flux sensor can be calibrated under conductive condition by using helium gas. The heat flux calibration facility was designed, simulated and manufactured for use in a high heat transfer condition. It delivers heat fluxes up to a maximum of 35 KW $m^{-2}$. A copper block heated electrically with 3.5 KW power is designed to produce uniform temperature up to 600 K across its face. High heat fluxes are provided between hot plate and cold plate by 1 mm height helium filled gap. A cold plate is maintained around 300 K through pool boiling using a refrigerant and water-cooled heat exchanger. A simulation was conducted to verify the design of the main test section. To verify the performance of calibration facility, a heat flux sensor was examined. The measured heat fluxes were compared to the calculated one.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.12 no.3
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• pp.25-39
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• 2004

An experimental study was quantitatively carried out in order to investigate the influence of flow conditions on a boundary layer in the near-wake of a flat plate. Tripping wires attached at various positions were selected to change flow conditions of a boundary layer in the vicinity of trailing edge. The flows such as laminar, transitional, and turbulent boundary layer at 0.98C from the leading edge are imposed to investigate the evolution of symmetric and asymmetric wake. Measurements were made at freestream velocity of 6.0m/s, and the corresponding Reynolds number is $2.8{\times}10^5$. An x-type hot-wire probe(55P61) was employed to measure at 8 stations in the near-wake region. Test results show that the near-wake of the flat plate for the case of a laminar and transitional boundary layer is sensitive to mean flow shear generated after separation but for the case of turbulent boundary layer is insensitive.