• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.997-1008
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• 2006

This experiment was designed to investigate the effect of the CMT and PCMT hot water extract & ultra-fine powder on microglia and memory deficit model. The effects of the CMT and PCMT hot water extract on expression of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NOS-II, COX-2, IL-10, $TGF-{\beta}1$ mRNA and production of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NO, ROS in BV2 microglial cell line treated by lipopolysacchaide(LPS) , serum glucose, uric acid, AChE activity of the memory deficit mice induced by scopolamine , behavior of the memory deficit mice induced by scopolamine and were investigated, respectively. The CMT and PCMT hot water extract suppressed the expression of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NOS-11, COX-2 mRNA, production of $IL-l{\beta},\;IL-6,\;TNF-{\alpha}$, NO, ROS and increased the expression of IL-10, $TGF-{\beta}1$ mRNA in BV2 microglial cell line treated by LPS. The PCMT hot water extract & ultra-fine powder increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. The CMT and PCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. According to the above result, it is suggested that the CMT and PCMT hot water extract & ultra-fine powder might be usefully applied for prevention and treatment of dementia.

• Journal of Oriental Neuropsychiatry
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• v.19 no.3
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• pp.69-84
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• 2008

Objective: This experiment was designed to investigate the effects of the KBHT hot water extract & ultra-fine powder on Alzheimer's Disease Model Induced by $\beta$A. Method: The effects of the KBHT hot water extract on expression of proinflammatory cytokine mRNA in BV2 microglial celll cell line treated by lipopolysacchaide(LPS). The effects of the KBHT hot water extract & ultra-fine powder on (1) the behavior (2) AChE in serum (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with $\beta$A were investigated. Results: 1. The KBHT hot water extract suppressed the expression of proinflammatory cytokine mRNA in BV2 microglial cell line treated with LPS. 2. The KBHT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by $\beta$A in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency 3. The KBHT hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by $\alpha$A. 4. The KBHT hot water extract & ultra-fine powder suppressed the expression of TNF-$\alpha$, IL-l$\beta$ protein significantly in the microglial cell of mice with Alzheimer's disease induced by 1$\beta$A. 5. The KBHT ultra-fine powder reduced infarction area of hippocampus significantly in the mice with Alzheimer's disease induced by $\beta$A. Conclusions: These results suggest that the KBHT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the PMCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

• Journal of Oriental Neuropsychiatry
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• v.22 no.2
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• pp.107-128
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• 2011

Objectives : This experiment was designed to investigate the efficacy of DDTCMT hot water extract & ultra-fine powder on Alzheimer's Disease Model. Methods : The effects of the DDTCMT hot water extract on expression of IL-$1{\beta}$, IL-6, TNF-${\alpha}$, COX-2, NOS-II, IL-10, IL-1 receptor antagonist mRNA and production of IL-$1{\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. Expression of NO, ROS in BV2 microglial cell line treated by LPS and AChE activity in PC-12 cell treated by NGF were investigated. anti-AChE was observed through Western blot analysis. The effects of the DDTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated. Results : 1. The DDTCMT hot water extract significantly decreased the production of mIL-6, mNOS-II, mTNF-${\alpha}$, and increased the production of mIL-10, mIL-1 receptor antagonist. 2. The DDTCMT hot water extract significantly suppressed the production of IL-$1{\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line treated by LPS. 3. The DDTCMT hot water extract significantly suppressed the NO and ROS production in BV2 microglial cell line treated by LPS. 4. The DDTCMT hot water extract groups showed inhibition of AChE activity in NGF treated PC-12 cell line. 5. The DDTCMT hot water extract suppressed anti-AChE expression in NGF treated PC-12 cell line was observed by Western blot analysis. 6. The DDTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine -induced impairment of memory in the experiment of Morris water maze. Conclusions : These results suggest that the DDTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease.

• Solar Energy
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• v.19 no.3
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• pp.13-21
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• 1999

Calculation method about the water temperature variable inside hot water pipe had proposed in the past does not correspond with branch pipe system, variable of water volume, variable of entrance water temperature, using and so on. A calculation method proposed in this paper can solve above problems, and calculate the kinds variation of the water temperature inside pipe in the real use state of the hot water pipe.

• Journal of the Korean Solar Energy Society
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• v.27 no.3
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• pp.45-54
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• 2007

For a conventional natural-circulation type solar water heater, the pressure head is limited by the height between the storage tank and hot water tap. Therefore, it is difficult to provide sufficient hot water flow rate for general usage. This study deals with a design modification of the storage tank to utilize the tap-water pressure to increase hot-water supply Based on fluid dynamic and heat transfer theories, a series of modeling and simulation is conducted to achieve practical design requirements. An experimental setup is built and tested and the results are compared with theoretical simulation model. The storage tank capacity is 240 l and the outer diameter of piping was 15 mm. Number of tube turns tested are 5, 10, and 15. Starting with initial storage tank temperature of $80^{\circ}C$, the temperature variation of the supply hot water is investigated against time, while maintaining minimum flow rate of 10 1/min. Typical results show that the hot water supply of minimum $30^{\circ}C$ can be maintained for 34 min with tap-water supply pressure of 2.5 atm, The relative errors between modeling and experiments coincide well within 10% in most cases.

• Journal of the Korean Solar Energy Society
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• v.34 no.6
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• pp.49-56
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• 2014

Research about hybrid solar air-water heater that can make heated air and hot water was conducted as a part of improving efficiency of solar thermal energy. At this experiment, ability of making heating air and hot water was investigated and compared with traditional solar air heater and flat plate solar collector for hot water when air or liquid was heated respectively. Comparing hybrid solar air-water heater that used in this experiment to other solar air heater studied already, it has a lower efficiency at same mass flow rate. Air channel structure, fin's shape and arrangement in the air channel result in these difference then the ability of air heating need to be improved with changing these thing. In case of making hot water, performance was shown as similar with traditional system although the air channels were established beneath absorbing plate. But the heat loss coefficient was shown higher value by installing of air channel. Also the performance of hot water making was shown lower value at same liquid mass flow rate with traditional flat plate solar collector for hot water. So the necessity of performance improvement at lower mass flow rate of each heating medium can be confirmed.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.16 no.3
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• pp.295-304
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• 1987

The purpose of this study is to develop a computer model for simulating the water-lit hium bromide absorption heat transformer (AHT) Including all major components and to find the flexibility in operation. The effect of source hot water temperature, cooling water temperature, useful hot water flow rate, cooling water flow rate and evaporator circulation flow rate were investigated. The coefficient of performance (COP), temperature boost $({\Delta}T\;=\;T_A\;-\;Ti)$ and concentration variations can be predicted. The performance study indicates that the performance of AHT increases for the waste hot water temperature increasing and with a decrease of the cooling water temperature. The effect on performances of useful hot water flow rape is significant except on temperature boost. Also the effects on performance of cooling water flow rate and evaporator circulation flow rate are small. It is shown that the computer program is valuable to predict the performance of absorp-tion heat transformer units at various working corditions.

• Journal of Energy Engineering
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• v.21 no.4
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• pp.435-443
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• 2012

The combination of space shortage and the high population density concentrated in urban areas of South Korea has resulted in the growth of large-scale high-rise residential complexes, naturally affecting water and hot water usage patterns as well. But the current designs for water and hot water supply in South Korea rely mostly on international design standards and data calculated on site due to the severe shortage of basic data in relation to actual use, which result in the frequent problem of the under-or over-design of water and hot water supply. The following study measures the hot water supplier's conditions and the user's heat usage to realize the amount of time required for hot water supply load generation and the pattern of actual use in order to create basic data for effective hot water supply facility design and maintenance.

• Korean journal of food and cookery science
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• v.28 no.1
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• pp.51-55
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• 2012

This study was conducted to investigate the physicochemical properties of citrus peel extracts with different hot water extraction and enzymatic hydrolysis conditions. Enzymatic hydrolysis was also employed using Viscozyme L and results were compared with that of optimized hot water extract. Hot water extraction was performed under different parameters; the sample to solvent ratio(1:20, 1:15, 1:10), extraction time(2, 4 hrs), extraction temperature(85, $95^{\circ}C$) and enzymatic hydrolysis(0, 1%) and the subsequent extracts were used for determining their physicochemical properties, such as total yield, total phenolics, total flavonoids, and electron donating ability (EDA). With the increase in the sample to solvent ratio and extraction time, total yield, total phenolics, total flavonoids and EDA increased. But extraction temperature did not significantly affect the hot water extract. As hot water extract was hydrolyzed by the enzyme, total yield and active ingredients increased rapidly. In the result of total yield, total phenolics, total flavonoids and EDA, the activity of enzyme-treated extract was higher than those of enzyme-untreated extract. Based upon the overall hot water extraction efficiency, it was found that 20 times volume or 120 min at a time at $95^{\circ}C$ after enzyme treatment was optimal.

• Korean Journal of Materials Research
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• v.30 no.12
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• pp.693-700
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• 2020

Direct water quenching technique can be used in hot stamping process to obtain higher cooling rate compared to that of the normal die cooling method. In the direct water quenching process, setting proper water flow rate in consideration of material thickness and the size of the area directly cooled in the component is important to ensure uniform microstructure and mechanical properties. In this study, to derive proper water flow rate conditions that can achieve uniform microstructure and mechanical properties, microstructure and hardness distribution in various water flow rate conditions are measured for 3.2 mm thick boron steel sheet. Hardness distribution is uniform under the flow condition of 1.5 L/min or higher. However, due to the lower cooling rate in that area, the lower flow conditions result in a drastic decrease in hardness in some areas in the hot-stamped part, resulting in low martensite fraction. From these results, it is found that the selection of proper water flow rate is an important factor in hot stamping with direct water quenching process to ensure uniform mechanical properties.