• Journal of Sasang Constitutional Medicine
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• v.23 no.3
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• pp.412-418
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• 2011

1. Objectives: The purpose of this study is to evaluate the effect of Hyangbujapalmul-tang(香附子八物湯) for hot flush on the palms and soles of the feet. 2. Methods: The patient was hospitalized from June 4. 2011 to June 18. 2011. The Patient Was treated with herbal medicine. The changes in symptoms can be diagnosed by the help of DITI(Digital Infrared Thermal Imaging) and VAS(Visual analogue Score). 3. Results By the use of Hyangbujapalmul-tang(香附子八物湯), this patient showed a positive response. We compared the temperature of palm with that of sole the feet on DITI. After the treatment, the symptoms and DITI, VAS results improved. The temperature of palms and soles of the feet after treatment were statistically lower than those before treatment. 4. Conclusions: We suggest that Hyangbujapalmul-tang(香附子八物湯) significantly has a curative effect on hot flush on the palms and soles of the feet patient with Soeumin.

• Herbal Formula Science
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• v.20 no.2
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• pp.199-211
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Gamisoyo-san on severe menopausal disorder patients. Methods : We recruited 2 severe menopausal disorder patients who have been suffering from hot flush and heat sensation. The patients had been administrated Gamisoyo-san. The patients of severe menopausal disorder had been estimated with Kupperman's index(KI), Menopause rating scale(MRS), Beck's depression Inventory(BDI), Visual analogue scale(VAS) and Heart rate variability (HRV). Kupperman's index, Menopause rating scale and Beck's depression inventory for every seven days. We measured VAS everyday. Heart rate variability was estimated twice, before and after treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Gamisoyo-san is significantly effective on severe menopausal disorder patients with hot flush and heat sensation.

• 대한상한금궤의학회지
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• v.12 no.1
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• pp.91-99
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• 2020

Objective: The aim of this study was to evaluate the effects of Gyejigamchoyonggolmoryeo-tang on facial flush. Methods: Facial flushwas evaluated using photographs and questionnaires. The (VAS) and investigator's global assessment were used to measure the improvement in facial flush symptoms. Results: The visual findings were. The VAS score decreased from 10 to 0 after administration of Gyejigamchoyonggolmoryeo-tang for 40 days. In addition, accompanying symptoms such as neck pain, palpitation, and insomnia were improved. These results indicated that Gyejigamchoyonggolmoryeo-tang was effective for emotional facial flush. Conclusions: This study shows the effective treatment of facial flush using Gyejigamchoyonggolmoryeo-tang based on the provisions of the Shanghanlun disease pattern identification diagnostic system.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.2
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• pp.193-203
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• 2015

Objectives : The purpose of this study is to evaluate the clinical effects of ascending kidney water and descending heart fire pharmacopuncture treatment for hot flush and sweating. Methods : Ascending kidney water and descending heart fire pharmacopuncture is achieved by injecting pharmacopuncture on a specific acupoint to change from the state of water-fire disharmony to harmonious state. Hwangryunhaedok-tang (黃連解毒湯) pharmacopuncture is injected on both side Gyeonjeong (GB ₂₁ ), Pungji (GB ₂₀ ). Total 0.4 cc was injected by 0.1 cc each point. BUM (Bear’s gall bladder, ox bezoar and musk) pharmacopuncture is injected on both side Jeonjung (CV ₁₇ ), Jungwan (CV ₁₂ ), Gihae (CV ₆ ). Total 0.15 cc was injected by 0.05 cc each point. Treatment was done daily. The method of evaluation are Hot Flush Score (HFS), VAS and sweating areas. Results : In case 1, after treatment hot flush score was reduced from 24 to 4 points. VAS scale was reduced from 7 to 2. It took about two weeks for the symptoms to decrease by half. Associated symptoms almost did not stay at discharge. In case 2, after treatment hot flush score was reduced from 28 to 2 points. VAS scale was reduced from 10 to 3. And emotional symptoms were reduced about 70%. In case 3, after treatment hot flush score was reduced from 8 to 1 points. VAS scale was reduced from 6 to 1. And headache and chest discomfort symptoms have disappeared. Conclusions : Ascending kidney water and descending heart fire pharmacopuncture treatment is effective for improve ascending kidney water and descending heart fire energy. Therefore, it will be used to alleviate hot flush and sweating.

• The Journal of Korean Obstetrics and Gynecology
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• v.36 no.1
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• pp.90-102
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• 2023

Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine treatment on postmenopausal syndrome. Methods: The patient with postmenopausal syndrome with palpitation was treated with Korean medicine treatment during 14 days of hospitalization. The patient received Korean medicine treatment including herbal medicine, acupuncture and moxibustion. The effect of treatment on postmenopausal syndrome was evaluated through the Numeric Rating Scale (NRS) and questionnaire. Palpitation and arrhythmia was evaluated by Electrocardiogram (ECG) and manual pulse diagnosis three times a day. Result: After the treatment, the clinical postmenopausal symptoms of palpitation and hot flush were improved. Also, ECG's result was improved ventricular premature contraction to normal ECG. Conclusions: This case report proved that the Korean medicine treatment may be effective for improving postmenopausal syndrome with palpitation and hot flush. However, further clinical study is needed in the future to prove the effectiveness of Korean medicine treatment for postmenopausal syndrome with palpitation and hot flush.

• Journal of Oriental Medical Thermology
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• v.7 no.1
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• pp.37-43
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• 2009

Purpose: The purpose of this study is to identify the clinical effect of Red Ginseng in the treatment of postmenopausal hot flushes. Methods: We studied 49 women from 45 to 55 years old who complained hot flushes. We randomly divided women into two groups, We treated one group with red ginseng capsule, and treated another group with placebo for 2 months. patients recorded the frequency of the hot flush on an everyday basis. And we measured temperature of patient's face by DITI. Results: Red ginseng and Placebo treated group significantly decreased the frequency of the hot flush. After treatment, the temperature on the cheekbones who treated by red ginseng get lower than before treatment. But there is no statistically difference between red ginseng and placebo. Conclusion: This study shows that both red ginseng and placebo have remarkable effects on patients, but red ginseng is not better than placebo.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.4
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• pp.75-92
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• 2020

Objectives: This clinical trial is performed to investigate the effect of improving the menopausal symptoms and the safety of extract obtained from Pueraria thunbergiana Bentham and Curcuma longa L. in menopausal women Methods: This study was randomized, double blinded, placebo-controlled clinical trial. 110 women with menopausal symptoms were assigned to treatment group (n=55) and control group (n=55). The results of this study were evaluated through changes in Kupperman Index score, Menopause-specific Quality of Life Questionnaire (MENQOL) score, degree of hot flashes and sweating, Body Mass Index(BMI), laboratory test results including female hormones. Results: In the treatment group compared to before baseline, there was significant difference in the Kupperman Index total score, score of each item in the Kupperman Index, MENQOL total score, hot flush and sweating visual analogue scale (VAS), hot flush score, and hot flush duration at one time. However, there was also a significant change compared to baseline in the control group, there was no significant difference between the treatment group and the control group. There was no significant change in female hormone levels in both group, and there were no adverse events associated with the clinical trial product. Conclusions: This clinical trial showed that extract obtained from Pueraria thunbergiana Bentham and Curcuma longa L. was helpful in improving menopausal symptoms in menopausal women without significant side effects.

• Microbiology and Biotechnology Letters
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• v.39 no.3
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• pp.224-237
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• 2011

For establishing the efficacy against breast cancer occurrence, women's mammographic breast density and hot flush remission related to pre and post-menopausal symptoms were selected as biomarkers. Meta analysis applied the final selection of 40 papers from Medline to assess the efficacy of isoflavone-rich soy or supplements versus placebo under randomized controlled trials. Interestingly, the exposure to the purified isoflavones was more effective than the exposure to the crude extract of soy isoflavones for hot flush suppression. The length and the amount of dosage dependency is the most appropriately suggested to be one year long with 50~100 mg/day of isoflavone-rich soy or supplements. Funnel plots was used to interpret the results, overall effect of isoflavones on breast density in post-menopausal women was revealed to be less effect [effect size: 0.062, 95% confidence interval (CI): 0.005 to 0.12], than that of pre-menopausal women (effect size: 0.101, CI: -0.003 to 0.205). The reason why breast density was found higher among the pre-menopausal than the post-menopausal women is that the phytoestrogens of dietary isoflavones were antagonized against estrogen by the basis of estrogen receptor binding affinity. Overall, the Meta analysis reported that isoflavone had limited influence on breast density by suppressing the expansion by only 2%, while it was more effective to suppressing the hot flush, showing a dramatic decrease of 23%.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.1
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• pp.86-103
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• 2020

Objectives: The purpose of this study is to analyse the domestic trends of Traditional Korean Medicine on Hot flush in menopausal women. Methods: We searched six databases and selected relevant papers according to the criteria. Results: 12 papers included case report, literature review, randomized controlled clinical trials (RCTs), Non-RCTs, and retrospective chart analysis study design. 1. The daily diary, Kupperman's Index, Menopause Rating Scale, Menopause-specific Quality of Life Questionnaire, Digital Infrared Thermographic Imaging were used as a measure of the symptoms of hot flush. 2. There were significant correlations between Thermographic images, Pulse energy, Lifestyle Habits, Low frequency power/High frequency power (LF/HF) ratio and certain items of Menopausal Symptoms Measurement. 3. The case report using Er-Xian decoction and Hwangryunhaedoktang-Gamibang showed significant effect. 4. Domestic RCT studies using herbal or acupuncture treatments showed a significant value of 3.4 on average in the quality assessment conducted in the study. However, the number of domestic studies included was five, which is not enough compared to foreign countries. Conclusions: This study examined domestic research trends on hot flushes of menopausal women and found that various evaluation tools and diagnostic methods were applied. It is necessary to conduct various RCT studies in Korea, where the number of studies is insufficient compared to overseas.

• Journal of Sasang Constitutional Medicine
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• v.29 no.3
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• pp.271-279
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• 2017

Objectives The purpose of this study is to investigate the efficacy of Sasang constitutional herb medicine for the treatment in postmenopausal women having various complaints. Methods From December 2016 to July 2017, four cases of women having climacteric complaints were extracted. Results Their main symptoms were hot flush, insomnia, sweating, cold sensation, and excitation. Their Sasang constitutional types were 2 Soyangin and 2 Taeeumin. Main symptomology of Soyangin was Chest-heat congested symptomology and that of Taeeumin was Esophagus-cold symptomology or Esophagus-cold Lung-dry Symptomology. Conclusions Their symptomolgies of Soyangin and Taeeumin lied in the Interior disease rather than Exterior disease, in the Advanced disease rather than Mild disease. It could show that Sasang constitutional medicine and management is possible to be indicated in climacteric disorders.