• Parasites, Hosts and Diseases
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• v.58 no.4
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• pp.461-466
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• 2020

Toxoplasma gondii is an obligate intracellular protozoan parasite that can invade various organs in the host body, including the central nervous system. Chronic intracranial T. gondii is known to be associated with neuroprotection against neurodegenerative diseases through interaction with host brain cells in various ways. The present study investigated the neuroprotective effects of chronic T. gondii infection in mice with cerebral ischemia experimentally produced by middle cerebral artery occlusion (MCAO) surgery. The neurobehavioral effects of cerebral ischemia were assessed by measurement of Garcia score and Rotarod behavior tests. The volume of brain ischemia was measured by triphenyltetrazolium chloride staining. The expression levels of related genes and proteins were determined. After cerebral ischemia, corrected infarction volume was significantly reduced in T. gondii infected mice, and their neurobehavioral function was significantly better than that of the uninfection control group. Chronic T. gondii infection induced the expression of hypoxia-inducible factor 1-alpha (HIF-1α) in the brain before MCAO. T. gondii infection also increased the expression of vascular endothelial growth factor after the cerebral ischemia. It is suggested that chronic intracerebral infection of T. gondii may be a potential preconditioning strategy to reduce neural deficits associated with cerebral ischemia and induce brain ischemic tolerance through the regulation of HIF-1α expression.

• Korea Trade Review
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• v.48 no.2
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• pp.71-94
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• 2023

The purpose of this study is to prove the effect of psychic distance between home country and host country on overseas foreign direct investment(OFDI) of Spanish companies through panel analysis. The panel data was based on cultural, institutional, economic, and geographical distance data over the past decade between Spain and Spain's OFDI countries. According to the Random Effect Model(REM) analysis, cultural distance(CULD) had a negative effect on OFDI, while institutional distance(INSD) had a positive effect. Among economic distances, income size distance(GDP) had a positive effect on OFDI, but export size distance(EXPO) had a negative effect. Geographic distance(PKM) had a negative impact. Meanwhile, according to the results of quantile regression analysis to prove the psychic distance effect by OFDI size, the effects of CULD and INSD in the quartile (75%) to which Korea belongs were the same as the REM analysis results. In addition, GDP and EXPO had a positive effect, and PKM had a negative effect but EXPO had a positive effect. Therefore, FDI host countries need to establish differentiated strategies through quantile analysis while making continuous efforts to improve the system.

• Journal of Periodontal and Implant Science
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• v.37 no.3
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• pp.511-522
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• 2007

Introduction : The purpose of this study was to evaluate the possibility of the acellular dermal matrix (ADM) as a barrier membrane for bone regeneration, and to evaluate the osteogenic effect of ADM as a carrier system for rhBMP-2 in the rat calvarial defect model. Materials and Methods: An 8-mm, calvarial, critical-size osteotomy defect was created in each of 60 male Spraque-Dawley rats(weight $250{\sim}300g$). Three groups of 20 animals, each received either rhBMP-2(0.025mg/ml) in an ADM carrier, ADM only, or negative surgical control. And each group was divided into 2- and 8-weeks healing intervals. The groups were evaluated by histologic and histomorphometric parameters(10 animals/group/healing intervals). Data were expressed as $means{\pm}standard$ deviations($m{\pm}SD$). Comparisons between experimental and control groups were made using two-way ANOVA and post hoc t-test. Comparisons between 2 weeks and 8 weeks were made using paired t-test. The level of statistical difference was defined as P< 0.05. Results : The ADM group and rhBMP-2/ADM group results in enhanced local bone formation in the rat calvarial defect at both 2 and 8 weeks. The amount of defect closure and new bone formation were significantly greater in the rhBMP-2/ADM group relative to ADM group(P<0.05). At 8 weeks, the majority of ADM in the defect was contracted, and integrated with surrounding host tissues. In addition, host cell infiltration and neovascularization of the ADM in the absence of an inflammatory response were observed, and the newly formed bone around ADM showed a continuous remodeling and consolidation. Conclusion : The results of the present study indicated that ADM may be used as a barrier membrane for bone regeneration and that may be employed as a delivery system for BMPs.

• Food Science of Animal Resources
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• v.39 no.1
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• pp.84-92
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• 2019

Listeria monocytogenes is a major cause of serious foodborne illness in the dairy foods. Although Caenorhabditis elegans model is well established as a virulence model of pathogenic bacteria, its application on L. monocytogenes is critically unclear. The objective of this study was to carry out an evaluation of L. monocytogenes toxicity using C. elegans nematode as a simple host model. We found that C. elegans nematodes have high susceptibility to L. monocytogenes infection, as a consequence of accumulation of bacteria in the worms' intestine. However, L. innocua, which is known to be non-toxic, is not accumulate in the intestine of worms and is not toxic similarly to Escherichia coli OP50 known as the normal feed source of C. elegans. Importantly, immune-associated genes of C. elegans were intensely upregulated more than 3.0-fold when they exposed to L. monocytogenes. In conclusion, we established that C. elegans is an effective model for studying the toxicity of L. monocytogenes and we anticipate that this system will result in the discovery of many potential anti-listeria agents for dairy foods.

• The KIPS Transactions:PartC
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• v.10C no.6
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• pp.727-738
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• 2003

Much research efforts are being exerted for the study of intrusion detection system(IDS). However little work has been for the communication medels and performance eveluation of the IDS. Here we present a communication framework for doing hybrid intrusion detection in which agents are used for local intrusion detections with a centralized data anaysis componenta for a global intrusion detection at multiple domains environment. We also assume the combination of host-based and network-based intrusion detection systems in the oberall framework. From the local domain, a set of information such as alert, and / or log data are reported to the upper level. At the root of the hierarchy, there is a global manager where data coalescing is performed. The global manager delivers a security policy to its lower levels as the result of aggregation and correlation of intrusion detection alerts. In this paper, we model the communication mechanisms for the hybrid IDS and develop a simular using OPNET modeller for the performance evaluation of transmission capabillities for the delivery of data and policy. We present and compare simulation results based on several scenarios focuding on communication delay.

• The Transactions of the Korea Information Processing Society
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• v.5 no.10
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• pp.2627-2640
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• 1998

In this paper, we analyze the performance of the virtual cell system[1] for the transmission of IP datagrams in mobile computer communications. A virtual cell consistsof a group of physical cells shose base stationsl are implemented b recote bridges and interconnected via high speed datagram packet switched networks. Host mobility is supported at the data link layer using the distributed hierachical location information of mobile hosts. Given mobility and communication ptems among physical cells, the problem of deploying virtual cells is equivalent to the optimization cost for the entire system where interclster communication is more expesive than intracluster communication[2]. Once an iptimal partitionof disjoint clusters is obtained, we deploy the virtual cell system according to the topology of the optimal partition such that each virtual cell correspods to a cluser. To analyze the performance of the virtual cell system, we adopt a BCMP open multipel class queueing network model. In addition to mobility and communication patterns, among physical cells, the topology of the virtual cell system is used to determine service transition probabilities of the queueing network model. With various system parameters, we conduct interesting sensitivity analyses to determine network design tradeoffs. The first application of the proposed model is to determine an adequate network bandwidth for base station networking such that the networks would not become an bottleneck. We also evaluate the network vlilization and system response time due to various types of messages. For instance, when the mobile hosts begin moving fast, the migration rate will be increased. This results of the performance analysis provide a good evidence in demonsratc the sysem effciency under different assumptions of mobility and communication patterns.

• Composites Research
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• v.15 no.3
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• pp.18-29
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• 2002

The bending vibration and thermal flutter instability of spacecraft booms modeled as circular thin-walled beams of closed cross-section and subjected to thermal radiation loading is investigated in this paper. The thin-walled beam model incorporates a number of nonclassical effects of transverse shear, primary and secondary warping, rotary inertia and anisotropy of constituent materials. Thermally induced vibration response characteristics of a composite thin walled beam exhibiting the circumferantially uniform system(CUS) configuration are exploited in connection with the structural flapwise bending-lagwise bending coupling resulting from directional properties of fiber reinforced composite materials and from ply stacking sequence. The numerical simulations display deflection time-history as a function of the ply-angle of fibers of the composite materials, damping factor, incident angle of solar heat flux, as well as the boundary of the thermal flutter instability domain. The adaptive control are provided by a system of piezoelectric devices whose sensing and actuating functions are combined and that are bonded or embedded into the host structure.

• The Transactions of the Korea Information Processing Society
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• v.6 no.7
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• pp.1770-1776
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• 1999

Mobile agent technology has received great attention in the last years as a new paradigm for distributed processing systems. Mobile agents are autonomous objects that can migrate from node to node of a computer network. But, due to hosts or communication nodes failures, mobile agents may be blocked or crashes even if there are other nodes available that could continue processing. To cope with above, this paper proposes an efficient policy by introducing the path reordering and backward recovery to ensure the migration of mobile agents. The proposed migration policy will be provided the migration reliability of mobile agents as autonomously as possible, and it is implemented in the MOS, a mobile object system model developed by the Java language.

• IEMEK Journal of Embedded Systems and Applications
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• v.6 no.5
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• pp.263-272
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• 2011

The complexity of flash memory based storage systems is high due to diverse host interfaces and other design choices such as mapping granularity, flash memory controller execution models and so on. Thus, it is possible that the actual performance after implementation is not consistent with the target performance. This paper demonstrates that the performance prediction of flash memory based storage systems is possible through performance modeling that takes into account various design parameters. In the performance modeling, the FTL, which is the core element of flash memory based storage systems, is modeled as a set of (copy-on-write) logs and their interactions. Also, the flash memory controller is modeled based on the classification proposed in the design of the Ozone flash controller. In this study, the performance model has been implemented using Simulink and experimental results are presented and analyzed.

• Journal of Auto-vehicle Safety Association
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• v.11 no.3
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• pp.30-36
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• 2019

This paper suggests a car-following algorithm for urban environment, with multiple target candidates. Until now, advanced driver assistant systems (ADASs) and self-driving technologies have been researched to cope with diverse possible scenarios. Among them, car-following driving has been formed the groundwork of autonomous vehicle for its integrity and flexibility to other modes such as smart cruise system (SCC) and platooning. Although the field has a rich history, most researches has been focused on the shape of target trajectory, such as the order of interpolated polynomial, in simple single-lane situation. However, to introduce the car-following mode in urban environment, realistic situation should be reflected: multi-lane road, target's unstable driving tendency, obstacles. Therefore, the suggested car-following system includes both in-lane preceding vehicle and other factors such as side-lane targets. The algorithm is comprised of three parts: path candidate generation and optimal trajectory selection. In the first part, initial guesses of desired paths are calculated as polynomial function connecting host vehicle's state and vicinal vehicle's predicted future states. In the second part, final target trajectory is selected using quadratic cost function reflecting safeness, control input efficiency, and initial objective such as velocity. Finally, adjusted path and control input are calculated using model predictive control (MPC). The suggested algorithm's performance is verified using off-line simulation using Matlab; the results shows reasonable car-following motion planning.