• 대한한방내과학회지
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• 제40권6호
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• pp.1112-1121
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• 2019

Objectives: FDY003 is a raw material for medicine consisting of a natural product that is expected to have the advantages of low side effects and high efficacy. In this study, we predict the efficacy and the standardization of the drug by method validation of anticipated index compounds and the measurement of antioxidant activity. Methods: FDY003 is prepared by extracting and purifying 70% of ethyl alcohol (EtOH). The method validation of cordycepin and chlorogenic acid was determined by high-performance liquid chromatography-photo diode array (HPLC-PDA) and the content of FDY003 was calculated. In order to monitor the biological activity of FDY003, antioxidant activity was measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric-reducing antioxidant power (FRAP). The equivalent values of antioxidants such as trolox, ascorbic acid, gallic acid, and caffeic acid were measured by ABTS and FRAP. Results: Chlorogenic acid and cordycepin were both found suitable for method validation in HPLC and FDY003 containing 9.92±0.50 and 17.97±0.27 ㎍/g, respectively. In DPPH, the electron donating ability (EDA) value of FDY003 was increased in a concentration dependent manner. FDY003 confirmed antioxidant activity by ABTS and FRAP. Conclusions: FDY003 contains certain components including cordycepin and chlorogenic acid and has antioxidant ability by various mechanisms. Therefore, it is expected that FDY003 is capable of various physiological activities including anti-cancer activity.

• 대한이식학회지
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• 제31권4호
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• pp.170-176
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• 2017

We need to establish an informative guideline to increase inter-institutional and inter-observer reproducibility of renal transplant diagnosis, and to improve the diagnostic ability of pathologists in Korea. A first nation-wide survey for renal transplant pathology was conducted by Renal Pathology Study Group of the Korean Society of Pathologists in 2016, to provide the continued excellence in the transplantation pathology laboratory, and to improve the diagnostic ability for the best treatment of transplant patients. This survey revealed the significant variations in scale, work load and biopsy indications for the renal transplant pathology in various institutions in Korea. The Banff classification were used by all institutions for the diagnosis of renal transplant pathology, but different formats were used: most institutions (70%) used the "2013 Banff classification" while the others were using "2007 Banff classification" (20%) or even older formats. In daily diagnostic practice of the renal allografts, difficulties that pathologists encounter were quite diverse due to different environments they work in. Most respondents agreed that standardized diagnostic practice guidelines, regular education on renal transplant pathology and convenient ways of consultation are further needed. We are currently working toward the enhancement of the expertise of renal pathologists and to increase inter-institutional and inter-observer reproducibility by 1) development of a set of virtual slides of renal allograft biopsies for the training, 2) validation and gathering expert's consensus on the core variables of rejection diagnosis by using virtual slides, and 3) continued education by the developed virtual slide atlas.

• 보건행정학회지
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• 제28권3호
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• pp.251-256
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• 2018

The origin of hospital accreditation in Korea is the Hospital Standardization Program of the Korea Hospital Association. Current accreditation program implemented by the Korea Institute for Healthcare Accreditation has succeeded in stimulating quality improvement activities of participating hospitals since its launching in 2010. However it has been criticized due to some unintended consequences of accreditation. In order to fully enjoy the benefit of the accreditation program in Korea, national efforts to expand accreditation scheme and coverage, upgrade accreditation standards, insure substantiality of accreditation process, provide consumers with more useful information, and strengthen the professional capacity of accreditation organization will be needed.

• 한국간담췌외과학회지
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• 제27권3호
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• pp.227-240
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• 2023

Hilar cholangiocarcinomas are highly aggressive malignancies. They are usually at an advanced stage at initial presentation. Surgical resection with negative margins is the standard of management. It provides the only chance of cure. Liver transplantation has increased the number of 'curative' procedures for cases previously considered to be unresectable. Meticulous and thorough preoperative planning is required to prevent fatal post-operative complications. Extended resection procedures, including hepatic trisectionectomy for Bismuth type IV tumors, hepatopancreaticoduodenectomy for tumors with extensive longitudinal spread, and combined vascular resection with reconstruction for tumors involving hepatic vascular structures, are challenging procedures with surgical indications expanded. Liver transplantation after the standardization of a neoadjuvant protocol described by the Mayo Clinic has increased the number of patients who can undergo operation.

• 셀메드
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• 제11권3호
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• pp.13.1-13.9
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• 2021

Background and Objective: Nux-vomica based traditional Unani formulation, Habb-e-Azaraqi (HAZ) is an important drug used by Unani physicians since several decades. It possesses Muqawwi-i-A'sab (nervine tonic), Muharrik-i-A'sab (nervine stimulant) properties and is an effective treatment option for diseases like Laqwa (facial palsy), Falij (paralysis), Niqris (gout) and Waja'al-Mafasil (arthritis) etc. The aim of the study is to access and provide information of HAZ for its TLC, HPTLC Fingerprinting defining its clear qualitative perspective and acute oral toxicity evaluation for its safety assessment which was not done earlier, thus contributing in the field of research. Materials and Methods: The chief ingredient, nux-vomica was detoxified as per method mentioned in Unani Pharmacopeia before its use in formulation. TLC and HPTLC was developed under four detection system i.e., UV 366nm, UV 254nm, exposure to iodine vapours and after derivatization with anisaldehyde sulphuric acid. Acute toxicity studies were performed as per OECD Guidelines 425 at a limit dose of 2000 mg/kg. Observations were done for signs of toxicity, body weight, and feed consumption at regular intervals followed by haematological and biochemistry evaluation. Results: The generated data proved the authenticity and established the TLC and HPTLC profile of the formulation. Acute toxicity revealed no significant differences in HAZ-treated animals with respect to body weight gain, feed consumption, haematology, clinical biochemistry evaluation. No significant gross pathological observation was noticed in necropsy. Conclusion: Data of the present study is substantial and scientific proof of HAZ in terms of standardization and toxicity study that can be utilize in future research activities.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제11권1호
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• pp.91-99
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• 2000

목 적：주의력결핍 과잉운동 장애의 진단과 치료 효과를 평가하기 위해 전산화된 한국판 주의력 장애 진단 시스템(ADHD Diagnostic System：ADS)을 개발한 후, 연령별 규준을 산출하였다. 방 법：서울, 경기도, 강원도 지역의 유치원, 초등학교, 중학교에 재학중인 5세에서 15세 연령범위의 총 847명(남자 429명, 여자 418명)의 정상 아동 및 청소년이 규준집단으로 연구에 참여하였다. 또한 ADS의 신뢰도와 변별 타당도를 검증하기 위해 서울대학병원 소아정신과에서 DSM-IV 기준에 의해 ADHD로 진단받은 아동 30명이 본 연구에 포함되었다. 정상 집단의 아동들에게는 그들이 다니는 학교의 컴퓨터실에서 ADS를 실시하였고, ADHD 아동들에게는 소아정신과 외래 임상심리실에서 ADS를 실시한 후, 정상 아동의 자료에 입각해서 연령별 규준을 산출하였고, 신뢰도와 타당도 분석을 하였다. 결 과：ADS의 내적 일치도 계수(Cronbach's ${\alpha}$)는 .85이었다. 정상 집단과 ADHD 집단간에 오경보 오류를 제외한 모든 측정치에서 유의미한 차이가 있었다. 요인분석 결과, ADS 시각, 청각 검사에서 모두 3개의 요인이 산출되었다. 요인 1은 '주의력 요인'으로 누락오류, 오경보 오류, 민감도(d')가 포함되었고, 요인 2는 '정보처리 속도 요인'으로 정반응시간, 정반응시간의 표준편차가 여기에 해당되며, 요인 3은'충동성 요인'으로 반응기준(${\beta}$)이 포함되었다. 요인 1, 2, 3은 ADHD의 핵심적 증상과 정확하게 일치하므로, 이상과 같은 요인분석 결과는 ADS가 주의집중력 장애를 도구로써 구성 타당도가 있음을 입증해주었다. 판별분석 결과, 시각, 청각 ADS가 정상 아동과 ADHD 아동의 96.7%를 정확하게 변별해 주는 것으로 나타났다. 논 의：ADS가 주의력 결핍-과잉 운동 장애를 일관성이 있게 평가하는 신뢰롭고, 타당한 검사로 입증되었고, ADS를 통해 정상 집단과 ADHD 집단을 정확하게 분류할 수 있음이 시사되었다.

• Allergy, Asthma & Respiratory Disease
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• 제5권6호
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• pp.307-311
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• 2017

Induced sputum and sputum cell count analysis is a test for the diagnosis of various respiratory diseases. In particular, it has long been used as an important biomarker in the diagnosis or characterization of asthma or eosinophilic bronchitis. Despite a relatively long history of this test, there has been no consensus report for conducting and interpreting the analyses in Korea. Based on this awareness and necessity, the Korean Academy of Asthma, Allergy and Clinical Immunology launched the Standardization Committee to review the international guidelines and the literature and to develop a consensus report on the diagnostic procedure and interpretation of the sputum induction test.

• 디지털융복합연구
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• 제12권1호
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• pp.431-443
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• 2014

본 연구에서는 의료기관인증을 받은 병원과 받지 않은 병원의 내부 구성원을 비교 분석하여 의료기관인증제도가 구성원 만족도와 병원운영효과에 어떤 영향을 미치는지 파악하고자 하였다. 인증제도에 따른 직원만족도 차이는 인증을 받은 병원에서 인센티브 지급, 본인업무 자부심 등에서와 병원운영효과는 업무표준화로 업무수행의 정확성 등의 문항에서 통계적으로 유의미한 차이로 정(+)적 영향을 미치는 것으로 나타났다. 인증을 획득한 병원에서 구성원 만족이 높으며, 만족도가 높을수록 병원운영효과에 영향을 미치는 것으로 나타났다. 인증을 획득한 의료기관에 국가가 의료수가의 차별화나 의료장비를 지원하면, 인증을 받지 않은 병원들의 자발적인 인증 평가를 적극적으로 참여시킬 수 있는 활성화 방안이라고 사료된다.

• 한국병원경영학회지
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• 제7권2호
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• pp.80-98
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• 2002

The purpose of this study was to investigate user satisfaction at Defense Medical Information System as it has been utilized as a part of National Defense Information Strategies since Aug. 2000. The subjects of this study were nurse officers and army surgeons of a hospital with 1,000 beds. The results of this study are as follows; First, according to the characteristics of the subjects, there was statistically significant difference in system satisfaction, job satisfaction and information satisfaction at Military Hospital Information System. Second, according to the intention of participation, there was a statistically significant difference in user satisfaction at Military Hospital Information System. Third, according to a level of dexterity at Military Hospital Information System, there was statistically significant difference only in job satisfaction. Fourth, factors to influence system satisfaction were one's duty, using period of Military Hospital Information System, and a level of dexterity at Military Hospital Information System. Factors to influence job satisfaction were a level of dexterity at Military Hospital Information System, one's duty and intention of participation. Factors to influence information satisfaction were one's duty, a level of dexterity at Military Hospital Information System, and intention of participation. As the first study on user satisfaction at Military Hospital Information System, this study suggests the followings. First, a plan to inspire users with intention of participating in information system should be prepared. Second, it is necessary to provide policy activities for job standardization of Military Hospital Information System and legal system improvement.

• 대한의생명과학회지
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• 제7권3호
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• pp.133-138
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• 2001

The recently proposed Bethesda system for cervical/vaginal cytology has made a standardization related to "atypia". In cellular change due to inflammation or repair, the word "benign cellular change" has been suggested as a substitute for atypia. Terminology related to atypia cells may become standardized, but the cytologic criteria has not been well defined yet Among 8113 cases screened, we evaluated 182 cases as atypia squamous cells undetermined significance (ASCUS) by the Bethesda system (TBS): 52 cases of ASCUS were cytologically diagnosed and 33 cases were histologically verified. ASCUS was diagnosed based on nuclear enlargement and nonclassical signs of condyloma. The results are as follows; Six cases (16.6%) turned out to have benign cellular change. Twenty five cases (69.1%) demonstrated squamous intraepthelial lesion, condyloma was 2 cases (6.0%) and mild dysplasia was not revealed. Moderate and severe dysplasia were 1 case (3.0%) and 16 cases (48.4%), squamous cell carcinoma and adenocarcinoma were 4 (12.1%) and 1 cases (3.0%), respectively. Our data suggested that patients with ASCUS are highly recommended to be examined colposcopic biosy to cornfim.