• BMB Reports
• /
• 제41권10호
• /
• pp.733-738
• /
• 2008

Although previous studies have implicated a role for TC1 (C8orf4) in cancer cell proliferation, the molecular mechanism of its action is still largely unclear. In this study, we showed, for the first time, that the mRNA levels of TC1 were upregulated by mitogens (FBS/thrombin) and at least partially, through the ERK1/2 signaling pathway. Interestingly, the over-expression of TC1 promoted the $G_1$- to S-phase transition of the cell cycle, which was delayed by the deficiency of ERK1/2 signaling in fibroblast cells. Furthermore, the luciferase reporter assay indicated that the over-expression of TC1 significantly increased Cyclin D1 promoter-driven luciferase activity. Taken together, our findings revealed that TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated $G_1$- to S-phase transition of the cell cycle. Our results may provide a novel mechanism of the role of TC1 in the regulation of cell proliferation.

• Journal of Preventive Medicine and Public Health
• /
• 제18권1호
• /
• pp.41-50
• /
• 1985

To find out the differences in medical practice according to the environment of patient care and managerial situation of the medical care institutions, normal spontaneous vaginal delivery and acute appendicitis were selected, which is suitable for comparison because of their high comparability. A total of 473 cases of normal spontaneous vaginal delivery and 408 cases of acute appendicitis was sampled from the claims to Korea Medical Insurance Cooperations during January to June 1984. Complicated cases were excluded from population and sampling was restricted from 40 to 60 percentile for total charges by the type of medical care facility in order to rule out the influence originating from case mix. Important items representing type and quantity of medical care service were compared by type of facility. Major findings are as follows : 1. University hospital shows the highest in charges per case and decrease in order of general hospital, and clinic. 2. In case of normal spontaneous vaginal delivery, average length of stay shows statistically significant difference by type of facility. 3. Charge amount for each service item affected by practice pattern shows statistically significant difference mostly by type of facility. It is suggested that medical practice pattern is different by type of facility for medical services. 4. Difference in total medical expenditure by type of facility is affected more with charges for materials, consumables and drugs than with fee for service activity. 5. In administering drugs to patients, hospital and clinic show higher injection rate than university and general hospital. 6. Clinical Laboratory tests were common in order of uninalysis, hemoglobin, hematocrit, white blood cell count, urine microscopic examination in cases of normal spontaneous vaginal delivery; white blood cell count, urinalysis, hemoglobin, hematocrit, urine microscopic examination, white blood cell differential count, in cases of acute appendicitis. 7. The result for Laboratory test and Radiologic study shows extreme difference by type of facility. Test rate is lowest in clinic and increase hospital, general hospital, and university hospital in order, both in type and frequency.

• 대한소아치과학회지
• /
• 제43권4호
• /
• pp.401-409
• /
• 2016

본 연구는 만 11세에서 18세 사이에 해당하는 소년원 여학생과 대학병원 소아치과에 내원한 동일한 연령대 환자들의 구강 건강상태를 조사하여 차이점을 비교하고자 시행되었다. 최근 5년간 누적된 소년원 여학생과 아주대학교병원 소아치과에 내원한 환자의 치과기록을 수집하여 치과치료에 분석하였다. 소년원 여학생과 대학병원 환자 모두 수복치료가 가장 높은 비중을 차지하였다. 소년원 여학생에서는 치아우식에 의한 영구치의 발거가 중,고등학교 시기에 점차 증가한 반면에 대학병원 환자에서는 영구치의 발거 비율이 적었다. 현재 수용되어있는 만 11부터 18세까지의 소년원 여학생 130명과 최근 1년간 대학 병원 소아치과에 내원한 환자에 대해 구강검진을 시행하여 우식, 상실, 충전 치아 수를 검사하여 구강건강상태를 조사하였다. 우식경험영구치지수가 대학병원에서 4.15인 반면에 소년원 여학생에서는 7.53로 약 2배 높았다.

• 대한방사선방어학회:학술대회논문집
• /
• 대한방사선방어학회 2011년도 추계 학술발표회 및 심포지엄
• /
• pp.368-369
• /
• 2011

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제23권3호
• /
• pp.47-56
• /
• 2017

Purpose : This study is a basic research to establish guidelines for healthcare facility in Korean healthcare market. As a first step, it is a main purpose for making beginning point of ICU guideline to set a basic level of ICU facility size and quality by analysis current ICU facilities and existed domestic guidelines : law, criteria of healthcare insurance review and assessment service, credit of Korea institute for healthcare accreditation. Methods : First of all, the all requirements of existed guidelines are put together and summarized. The summary is compared with that of US, UK, and Australia to know its quality difference with international market. In addition, all hospitals in Korean market are classified based on total bed number and ICU bed number to know the most occupied facility size range in the market. Second of all, by comparing 15 ICUs' current setting of the public general hospital, a general condition of ICU facility would be extracted based on function, floor area per bed, services Results : 72.8% of hospitals in Korea are belonging below 500 beds hospital. Among them 200-299 beds hospitals occupied 35.3% and are shown as the most occupied hospital size. As 15 public general hospitals are analyzed, it is clear that the more bed size and services the more ICU area per bed. As a result it is sure that the 300~500 bed may be a clear line as a general ICU condition whose function and bed number relatively consistent in the range. Implications : to keep the qualified medical environment and contemporary hospital trend, the guideline as a minimum requirement keep naturally out from current healthcare settings and should reflect their limit to reconcile with the new trend in the market.

• 한국병원경영학회지
• /
• 제16권2호
• /
• pp.1-18
• /
• 2011

The research was to investigate the effect of quality cognition(usage, medical information, aesthetic, safety) of the web site of the facility on customer loyalty and moderating role of trust variable. The respondents was 201 patients and caregivers. Data were collected from March 1 to 31, 2010 at C university hospital in G city. In relationship between quality cognition of facility web site and customer loyalty, the results of quality cognition on customer loyalty showed 43.1% (F=36.912) in model 1, 46.3%(F=33.454) in model 2, and 46.8%(F=18.580) in model 3. In relationship between web site quality cognition and customer loyalty, moderate effect of trust was not considerable. As results, quality is the leading fact for customer loyalty more than trust. Therefore, customer loyalty leaves its possibility of increment when facility web site is designated depending on medical information, usage and aesthetic.

• 한국병원경영학회지
• /
• 제2권1호
• /
• pp.65-79
• /
• 1997

This study aims to measure in-patients' willingness to choose the same hospital, and to define the related factors. The willingness was measured by the fact whether in-patients would return to the same hospital for their future hospitalization and can be said as the essence of ascertaining patients' satisfaction. Data was collected from 236 patients hospitalized in two hospitals selected according to its superiority, one being superior in medical technique, the other being superior in facility and equipment. To enhance the comparability between the two hospitals, the department and the diagnosis were matched, and structured questionnaires were self-fill-up. The main findings are as follows. Hospitals were analyzed by their superiority : medical services, facility and equipment. In case of hospitals with superior medical services, the willingness was proportional to positive doctor-patient relationship, to satisfaction with the medical level, and to the acknowledgement of utility in cure. In case of hospitals with superior facility and equipment, the willingness was proportional to the satisfactory state of overall facility. Two types of hospitals were combined and analyzed. The willingness for choosing hospitals with superior medical services was stronger than that for choosing the other hospitals. The satisfaction with overall facility, satisfaction with medical level, acknowledgement of utility in cure, positive doctor-patient relationship, and better consultation produced higher willingness to choose the same hospital. The willingness for the option shows to what degree the hospital suffices patients' expectation. Patients' understanding views were obviously influential. The satisfaction level for medical aspect was more influential than the level for non-medical aspect.

• 한국실내디자인학회논문집
• /
• 제21권2호
• /
• pp.223-230
• /
• 2012

These days, hospitals in Korea have great interests in healthcare accreditation. The criteria of this accreditation has been established by management, but development of the management system without facility improvement has limits. Therefore this study reclassified domestic and foreign healthcare accreditation focusing on facilities and has purpose on proposing facility elements that can be adopted in hospitals. Also, the study is relevant to the study on architecture planning of hospital according to 'Patient safety' which will be suggested in the future and has significance for establishing basis of healthcare facility planning and for improving the existing facilities. The study selected facility lists from 'healthcare accreditation' and reclassified them based on departments in the hospital. Using these lists, the study divided the hospital that has obtained 'healthcare accreditation' into departments and investigated and analyzed them. On the basis of the analysis, the study suggested facility lists involved in hand washing, waste disposal, equipment washing, quarantine, goods-movement, establishing clean/polluted area, emergency exit-way, and restricted zone.

• 한국병원경영학회지
• /
• 제10권2호
• /
• pp.26-44
• /
• 2005

The purpose of this study was to investigate these major factors on patient satisfaction, and to examine the affecting level of major factors in. The subjects in this study was 70 hospitals that were surveyed the hospital evaluation program containing the survey of patient satisfaction by KHIDI(Korea Health Industry Development Institute) from 1997 to 1999. The collected data was analysed SPSS for Windows(Ver 10.0). On basically, frequency analysis, t-test, and ANOVA was performed and, for more analysis, correlation analysis, factor analysis, multiple regression analysis, logistic regression analysis was utilized. According to this study, the major factors of inpatient satisfaction are divided 3 types facility factor, manpower factor, and service factor. And the major factors of outpatient satisfaction are analyzed 5 types; facility factor related direct medical service, facility factor related indirect medical services, manpower factor, pharmacy factor, and facility factor related utilization convenience. The importance of this study lies in the identification of major factors on hospital patient satisfaction.

• 한국식품조리과학회지
• /
• 제19권4호
• /
• pp.477-492
• /
• 2003

The purposes of the study were to establish HACCP-based standards and guidelines for conducting a plan review to build, or renovate, hospital food service establishments, and ensure the safety of foodservice and reduce the risk of food borne illness. The scope of the study included suggestion for the planning of hospital foodservice facilities: layout, design, equipment and modeling. The results of this study can be summarized as follows: 1) The development of a foodservice facility plan based on the results of a survey, literature reviews and the results of interviews with foodservice managers from 9 general hospitals. This was composed of operational policies in foodservices, layout characteristics, space allocation, selection, design, specification standards for equipment and the construction principles of foodservice facilities. 2) Two foodservice facility models were developed, one for general hospitals with 900 beds (2,000 patients and 2,500 employee meals per day) and the other for general hospitals with 300 beds (600 patients and 650 employees meals per day). 3) The suggested kitchen space requirements for the foodservice facility models were 341.2 ㎡ (W 17,100mm x L 23,700mm) and 998.8㎡ (W 35,600mm x L 32,800mm) for the 300 and 900 beds hospitals, respectively, with both designs being rectangular. The space requirements for the equipment, in relation to the total operational area, in terms of ratios were 1:3.5 and 1:3.8 for the 300 and 900 beds hospitals, respectively. The recommended space allowances per bed for the developed foodservice facility models were 1.15 ㎡ and 1.11 ㎡ for the 300 and 900 beds hospitals, respectively, which were increased by more than 30% compared to those suggested in the precedent study, and considered appropriate for the implementation of the HACCP system. 4) The hospital foodservice facilities plans and models were developed based on the general sanitation standards, guidelines and the HACCP system, and included foodservice facility layout, product flow, physical separation between contaminated and sanitary areas, foodservice facility specifications with a 1/300 scale for a 300 bed, and a 1/400 scale for a 900 beds blueprint. 5) The main features of the developed foodservice facility plans and models were; physical separation between contaminated and sanitary areas to prevent cross contamination, product flow in one direction from the arrival of the raw material to the finished product, and separation of different work areas and the process of receiving & preparation of products, refrigeration & storage, cooking, assembly, cleaning & disinfection, employee areas and janitorial facilities. The proposed models from this study were presented as examples for those wanting to build, or renovate, their facility for the production of foods.