• Investigative Magnetic Resonance Imaging
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• v.16 no.2
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• pp.173-176
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• 2012

We report the radiological findings of regional enhancement of the liver adjacent to the right adrenal pheochromocytoma. CT and MRI showed focal strong enhancement of adjacent liver tissue in the arterial phase. However during the delayed phase, the lesion showed iso-attenuation with normal hepatic parenchyma and not delineated. The lesion did not show abnormal signal intensity on neither T1 nor T2 weighted images and indistinguishable from normal parenchyma. The enhancing hepatic lesion was spontaneously regressed on postoperative follow up CT which was taken several months after the adrenalectomy.

• The Journal of Korean Physical Therapy
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• v.21 no.2
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• pp.79-85
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• 2009

Purpose: This study examined the characteristics of gait in patients with chronic low back pain. Methods: The subjects were out-patients suffering from chronic low back pain at the department of physical therapy, B hospital in Seoul. Gait analysis was performed by dividing the subjects into two groups. The study and control group comprised 15 chronic low back pain patients and 14 healthy people, respectively. Gait analysis was performed using a VICON 512 Motion Analysis System to obtain the spatio-temporal and kinematic parameters. Results: First, there was a significant difference in the spatio-temporal parameters between the two groups (p<0.05). Second, the study group showed significant differences in the kinematic parameters during the stance phase (p<0.05). Third, there were significant differences in kinematic parameters in the study group during the swing phase (p<0.05). Conclusion: The gait pattern of patients with chronic low back pain is characterized by more rigid patterns. Compared to the control group, there was a decrease in the spatio-temporal parameters and kinematic parameters in patients with chronic low back pain. These findings are expected to play a role as basic data and to form a rehabilitation program for low back pain patients.

• Clinical Pain
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• v.19 no.1
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• pp.23-27
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• 2020

Our objective is to evaluate the applicability of segmental phase angle (PhA) via bioelectrical impedance analysis (BIA) for post-stroke complex regional pain syndrome (CRPS). Due to its noninvasiveness and convenience, various studies have used BIA in clinical conditions. We measured segmental PhA in 4 patients at the time of CRPS diagnosis and repeated 4 weeks after 2 weeks of steroid pulse therapy. In 3 cases, the affected-to-unaffected ratio of the upper limb PhA decreased at the time of diagnosis. In 2 cases with improvement of more than 5 points in the CRPS severity score (CSS), increased ratios were observed. In other 2 cases with improvement of less than 4 points in the CSS, no remarkable changes in the ratios were found. We suggest that the segmental PhA can be helpful in assessment of post-stroke CRPS and its recovery.

• The Journal of Korean Academy of Prosthodontics
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• v.32 no.4
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• pp.553-564
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• 1994

Using Sirognathograph Analyzing System, the patterns of chewing movement were analyzed into opening phase and closing phase, each phase to frontal plane, horizontal plane, and sagittal plane by maruyama's classification. In opening phase, the chewing patterns of frontal plane were classifed into Chopping Opening, Grinding Opening, Concave Opening, Lateral Shift Opening, Vertical Guide Opening, Convergence Opening. Those of horizontal plane were classified into Chopping Opening, Grinding Opening, Concave Opening, Protrusive Shift Opening, Posterior Guide Opening, Convergence Opening. Those of sagittal plane were classified into Normal Opening, Protrusive Shift Opening, Vertical Guide Opening, Convergence Opening. In closing phase, the chewing patterns of frontal plane were classified into Normal Closure, Concave Closure, Lateral Shift Closure, Lateral Guide Closure, Vertical Guide Closure, Convergence Closure, Those of horzontal plane were classified into Normal Closure, Concave Closure, Lateral Shift Closure, Protrusive Shift Closure, Lateral Guide closure, Posterior Guide Closure, Convergence Closure. Those of sagittal plane were classified into Normal Closure, Protrusive Shift Closure, Vertical Guide. Closure, Convergence Closure. Results were summarized as follows : 1. Opening phase in chewing movement The Normal Openings in 3 planes(frontal, horizontal, sagittal), the Concave Openings in frontal plane and horizontal plane, the Vertical Guide Opening in frontal plane and the Posterior Guide Opening in horizontal plane were many observed. 2. Closing phase in chewing movement The Concave Closure in frontal and horizontal plane, the Normal Closure in 3 planes (frontal, horizontal, sagittal), the Concave Closure in horizontal plane were many observed.

• Radiation Oncology Journal
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• v.21 no.4
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• pp.306-314
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• 2003

Purpose : In our Previous study, we have shown the main cel1 death pattern Induced by irradiation or protein tyrosine kinase (PTK) inhibitors in K562 human myeiogenous leukemic cell line. Death of the cells treated with irradiation alone was characterized by mitotic catastrophe and typical radiation-induced apoptosis was accelerated by herblmycin A (HMA). Both types of cell death were inhibited by genistein. In this study, we investigated the effects of HMA and genistein on cell cycle regulation and its correlation with the alterations of radiation-induced cell death. Materials and Methods: K562 cells In exponential growth phase were used for this study. The cells were Irradiated with 10 Gy using 6 MeV Linac (200-300 cGy/min). Immediately after irradiation, cells were treated with 250 nM of HMA or 25 $\mu$N of genistein. The distributions of cell cycle, the expressions of cell cycle-related protein, the activities of cyclin-dependent kinase, and the yield of senescence and differentiation were analyzed. Results: X-irradiated cells were arrested In the G2 phase of the cell cycle but unlike the p53-positive cells, they were not able to sustain the cell cycle arrest. An accumulation of cells in G2 phase of first ceil-cycle post-treatment and an increase of cyclin Bl were correlated with spontaneous, premature, chromosome condensation and mitotic catastrophe. HMA induced rapid G2 checkpoint abrogation and concomitant p53-independent Gl accumulation. HMA-induced cell cycle modifications correlated with the increase of CDK2 kinase activity, the decrease of the expressions of cyclins I and A and of CDK2 kinase activity, and the enhancement of radiation-induced apoptosis. Genistein maintained cells that were arrested in the G2-phase, decreased the expressions of cyclin Bl and cdc25c and cdc25C kinase activity, increased the expression of pl6, and sustained senescence and megakaryocytic differentiation. Conclusion: The effects of HMA and genistein on the radiation-induced cell death of KS62 cells were closely related to the cell cycle regulatory activities. In this study, we present a unique and reproducible model in which for investigating the mechanisms of various, radiation-induced, cancer cell death patterns. Further evaluation by using this model will provide a potent target for a new strategy of radiotherapy.

• Journal of Korean Foot and Ankle Society
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• v.17 no.3
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• pp.234-238
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• 2013

Osteoarticular tuberculosis is often misdiagnosed as other disease because of a rare incidence and nonspecific clinical and radiographic presentation. Therefore, it is important to know clinical and radiographic presentations of osteoarticular tuberculosis and to diagnose in early phase. Especially, fistula formation is one of the most important clinical features which suspects osteoarticular tuberculosis. We report a case of ankle tuberculosis to be misdiagnosed as subtalar osteoarthritis and performed subtalar arthrodesis.

• Investigative Magnetic Resonance Imaging
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• v.19 no.1
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• pp.52-55
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• 2015

Supradiaphragmatic liver is a rare condition. Establishing an accurate preoperative diagnosis is difficult. Operative exploration is necessary to differentiate this lesion from intrathoracic masses, such as a pleural based tumor, diaphragmatic tumor and peripheral lung tumor. However, with the aid of the hepatocyte-specific magnetic resonance imaging contrast agent, gadoxetic acid (Gd-EOB-DTPA), functional hepatocytes in the lesion can be identified in the hepatobiliary phase, potentially allowing an accurate and non-invasive diagnosis. We report a case of supradiaphragmatic liver diagnosed by Gd-EOB-DTPA-enhanced magnetic resonance imaging.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.2
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• pp.237-243
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• 2002

Uveitis is a comprehensive term that indicates the inflammation of not only the uvea but also its adjacent tissues, and its etiology, clinical features and prognosis are various. We conducted 2 patients with uveitis seen at Won-Kwang University Kwang- Ju Oriental Medical Hospital in 2002. We treated uveitis in a twenty-nine years old man and a thirty years old woman with the complaint of decreased vision, glaring eye, blood-shot eye, pain of eye, tears in one's eye by herbal medicine (Se-An-Myung-Mok-Tang gami) and Acupunture. Usually, uveitis have chronic phase. We had a significant results. So we report this two cases.

• Molecules and Cells
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• v.46 no.6
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• pp.360-373
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• 2023

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein 2 (SKP2) and the prognosis of thyroid cancer. SKP1 is related to apoptosis of PTC cells; however, its role in PTC remains largely elusive. This study aimed to understand the expression and molecular mechanism of SKP2 in PTC. SKP2 expression was upregulated in PTC tissues and closely associated with clinical diagnosis. In vitro and in vivo knockdown of SKP2 expression in PTC cells suppressed cell growth and proliferation and induced apoptosis. SKP2 depletion promoted cell autophagy under glucose deprivation. SKP2 interacted with PH domain leucine-rich repeat protein phosphatase-1 (PHLPP1), triggering its degradation by ubiquitination. Furthermore, SKP2 activates the AKT-related pathways via PHLPP1, which leads to the cytoplasmic translocation of SKP2, indicating a reciprocal regulation between SKP2 and AKT. In conclusion, the upregulation of SKP2 leads to PTC proliferation and survival, and the regulatory network among SKP2, PHLPP1, and AKT provides novel insight into the molecular basis of SKP2 in tumor progression.

• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.546-553
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• 2006

Schizophrenia is a disturbance condition that lasts for at least 6 months and includes at least 1 month of active-phase symptoms(i.e., two [or more] of the following : delusions, hallucinations. disorganized speech, grossly disorganized or catatonic behavior, negative symptoms) In this study, we report one case of schizophrenia with acute cerebral infarction. The patient has been diagnosed with schizophrenia more than 20 years ago, and after this recent cerebral infarction, all of her schizophrenic symptoms such as auditory hallucination, delirium, depression, insomnia were aggravated. Her schizophrenic symptoms, PANSS and NIHSS total scores were considerably reduced after oriental treatment(Guibi-tang(歸脾湯)), so we report this as a potential treatment.