• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.256-257
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• 2006

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.194-195
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• 2006

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2002.04b
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• pp.180-180
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• 2002

• Proceedings of the Korean Society of Crop Science Conference
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• 2005.08a
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• pp.130-131
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• 2005

• Proceedings of the Korean Society of Crop Science Conference
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• 2001.05a
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• pp.98-99
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• 2001

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2001.05a
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• pp.100-101
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• 2001

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2001.05a
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• pp.102-103
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• 2001

• Proceedings of the Korean Society of Crop Science Conference
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• 2004.04a
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• pp.278-279
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• 2004

• Korean Journal of Plant Resources
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• v.36 no.3
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• pp.207-218
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• 2023

Hepatocellular carcinoma (HCC) has a poor prognosis and high metastasis and recurrence rates. Although extracts of Alnus hirsuta (Turcz. ex Spach) Rupr. (AH) have been demonstrated to possess potential anti-inflammatory and anti-cancer activities, the underlying mechanism of AH in HCC treatment remains to be elucidated. We investigated the effects and potential mechanisms of AH on migration and invasion of Hep3B cells. Within the non-cytotoxic concentration range, AH significantly inhibited motility and invasiveness of Hep3B cells in a concentration-dependent manner. Inhibitory effects of AH on cell invasiveness are associated with tightening of tight junctions (TJs), as demonstrated by an increase in transepithelial electrical resistance. Immunoblotting indicated that AH decreased levels of claudins, which form major components of TJs and play key roles in the control and selectivity of paracellular transport. Furthermore, AH inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and simultaneously increased the levels of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. These effects were related to inactivation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in Hep3B cells. Therefore, AH inhibits migration and invasion of Hep3B cells by inhibiting the activity of MMPs and tightening TJs through suppression of claudin expression, possibly by suppressing the PI3K/AKT signaling pathway.

• Korean Journal of Breeding Science
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• v.40 no.3
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• pp.332-335
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• 2008

"Hwangkeumbora" is a new japonica rice cultivar developed from a three way cross of Jinbubyeo, Odaebyeo, Fukei126 at Honam Agricultural Reaserch Institute (HARI), NICS, RDA, in 2006. This cultivar has about 110 days growth duration from transplanting to harvesting under Korean climate condition. The milled kernel of "Hwangkeumbora" is translucent with non- glutinous endosperm. Amylose content of "Hwangkeumbora" is about 19.3%. "Hwangkeumbora" has better palatability of cooked rice compared with "Odaebyeo" and shows high resistant reaction to the blast, but susceptible to major diseases and insect pests. The milled rice yield of "Hwangkeumbora" is about 5.37 MT/ha under the standard fertilizer level of the ordinary transplanting cultivation. "Hwangkeumbora" would be adaptable for ordinary transplanting in northern plain, mid-mountainous, southern mountainous of Korea.