• 한국수자원학회논문집
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• 제43권7호
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• pp.645-655
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• 2010

본 논문에서는 각각의 시점에서의 변화확률을 산정하여 변화시점을 추정하는 Barry and Hartigan (BH)의 베이지안 변화시점 추정방법(Bayesian changing points estimation method)을 이용하여 측우기 관측자료계열(CWK)과 근대우량계 관측자료계열(MRG)간의 변화에 대한 상대확률적 절점의 발생여부를 분석하였다. 어떠한 자연 현상도 완전히 동일하게 재현되지 않기때문에 시간적인 순서를 고려하지못하는 통계적 방법은 구체적인발생시간을 예측하기 어렵다는 점에서 자료의 변화량 파악은 가능하나 변화시점을 명확히 추정하는데 한계가 있다. 이러한 배경에서, 본 논문에서는 각 시점에서의 변화확률을 산정하여 변화시점을 추정하는 BH 베이지안 방법을 적용하여 CWK와 MRG의 각 강우특성별로 상대확률적인 변화시점 분석을 통하여 CWK와 MRG 간의 동질성 분석을 실시하였다. 분석 결과, CWK의 정성적인(본질적인) 통계적 특성은 MRG와 큰 차이가 없는 것으로 나타났다. 다만, 관측정밀도의 한계로 인한 정량적인 차이가 존재하는 것으로 분석되었다.

• Bulletin of the Korean Chemical Society
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• 제26권2호
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• pp.285-291
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• 2005

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is the viral RNA-dependent RNA polymerase (RdRp), which is the essential catalytic enzyme for the viral replication and is an appealing target for the development of new therapeutic agents against HCV infection. A small amount of serum from a single patient with hepatitis C was used to get the genome of a Korean HCV isolate. Sequence analysis of NS5B 1701 nucleotides showed the genotype of a Korean isolate to be subtype 1b. The soluble recombinant HCV NS5B polymerase lacking the C-terminal 24 amino acids was expressed and purified to homogeneity. With the highly purified NS5B protein, we established in vitro systems for RdRp activity to identify potential polymerase inhibitors. The rhodanine family compounds were found to be potent and specific inhibitors of NS5B from high throughput screening (HTS) assay utilizing the scintillation proximity assay (SPA) system. The binding mode of an inhibitor was analyzed by measuring various kinetic parameters. Lineweaver-Burk plots of the inhibitor suggested it binds not to the active site of NS5B polymerase, but to an allosteric site of the enzyme. The activity of NS5B in in vitro polymerase reactions with homopolymeric RNA requires interaction with multiple substrates that include a template/primer and ribonucleotide triphosphate. Steady-state kinetic parameter, such as Km, was determined for the ribonucleotide triphosphate. One of compounds found interacts directly with the viral polymerase and inhibits RNA synthesis in a manner noncompetitively with respect to UTP. Furthermore, we also investigated the ability of the compound to inhibit NS5B-directed viral RNA replication using the Huh7 cell-based HCV replicon system. The investigation is potentially very useful for the utility of such compounds as anti-hepatitic agents.

• Journal of Radiation Protection and Research
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• 제43권3호
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• pp.107-113
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• 2018

Background: The purpose of our study was to compare the dosimetric advantages of Flattening filter free (FFF) beams for trigeminal neuralgia patients using 4 mm conical collimators over previously treated patients with 6 MV SRS beam. Materials and Methods: A retrospective study was conducted for 5 TN patients who had been previously treated at our institution using frame-based, LINAC-based stereotactic radiosurgery (SRS) on Novalis Tx using 6 MV SRS beam were replanned on 6X FFF beams on Edge Linear accelerator with same beam angles and dose constraints using 4 mm conical collimator. The total number of monitor units along with the beam on time was compared for both Edge and Novalis Tx by redelivering the plans in QA mode of LINAC to compare the delivery efficiency. Plan quality was evaluated by homogeneity index (HI) and Paddick gradient index (GI) for each plan. We also analyzed the doses to brainstem and organ at risks (OARs). Results and Discussion: A 28% beam-on time reduction was achieved using 6X FFF when compared with 6X SRS beam of Novalis Tx. A sharp dose fall off with gradient index value of $3.4{\pm}0.27$ for 4 mm Varian conical collimator while $4.17{\pm}0.20$ with BrainLab cone. Among the 5 patients treated with a 4 mm cone, average maximum brainstem dose was 10.24 Gy for Edge using 6X FFF and 14.28 Gy for Novalis Tx using 6X SRS beam. Conclusion: The use of FFF beams improves delivery efficiency and conical collimator reduces dose to OAR's for TN radiosurgery. Further investigation is warranted with larger sample patient data.

• Human Ecology Research
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• 제58권1호
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• pp.105-120
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• 2020

This study helps infant teachers practice a constructivism-based teacher education program that supports infant mathematical inquiry activities and examines improvements in mathematical teaching knowledge, mathematical teaching initiatives, mathematical interaction, constructivism belief and mathematical teaching efficacy. Twenty two experiment group infant teachers and twenty two comparison group infant teachers were chosen at two workforce educare centers. The experiment group infant teachers participated in 18 sessions of a constructivism teacher training program for 8 weeks, but the comparison group infant teachers did not take part in the program. Pretest and post-tests were implemented for the mathematical teaching knowledge, mathematical teaching initiatives, mathematical interactions, constructivism belief and mathematical teaching efficacy in the experiment group. Independent sample t-test and ANCOVA were tested using Windows SPSS statistics 21.0. The homogeneity test for the experiment and comparison group revealed significant differences. ANCOVA was carried out after the pretest score was controlled as a co-variance. Significant differences were indicated in mathematical teaching knowledge, mathematical teaching initiative, mathematical interaction, constructivism belief and mathematical teaching efficacy. The results indicated that a constructivism-based teacher education program to support infant mathematical inquiry activities influenced improvements in mathematical teaching knowledge, mathematical teaching initiative, mathematical interaction, constructivism belief and mathematical teaching efficacy. This study proved the effects of the program based on constructivism theory content for the knowledge, skills and attitude about infant teaching of mathematical initiatives and practiced a program of exploration, investigation, application and assessment for infant teachers. The results can help infant teachers teach mathematical exploration activities and help activate infant mathematical exploration activities.

• 한국의류학회지
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• 제40권6호
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• pp.1150-1163
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• 2016

This study makes use of meta-analysis to statistically integrate the quantitative results of individual research on the influence of fashion product attributes on purchase; in addition, this study utilizes the effect sizes of correlation coefficients. This study was based on 24 individual studies from January 2000 to March 2015. The meta-analysis analyzed 91 effect sizes and 24 studies and calculated the correlation coefficient effect sizes. A random effect model was employed for meta-analysis because the results for the homogeneity test indicated that the effect sizes of each research were heterogeneous. The analysis results are as follows. First, when the total effect sizes of the fashion product attributes that influence clothing purchase decisions were calculated as .256; this indicated that the effect size is slightly below the mid-sized level. Second, upon examining the effect sizes of the categorized fashion product attributes, the intrinsic attributes yielded .222, extrinsic factors yielded .235, and the compiled attributes yielded .420; this demonstrated that the compiled attributes have a larger effect size than individual attributes. Third, when they were measured by the characteristics of study targets, they were larger for a mixed-gender group than women as well as for ordinary citizens than university students. When the effect sizes were measured based on the characteristics of fashion products as suggested in the study, there were significant differences with respect to sportswear, followed by SPA brand clothing, general clothing, fashion accessories, and designer clothing. The cases where the clothing were purchased in non-retail stores were found to have a slightly larger effect size than those of offline retail stores when the effect sizes were measured based on purchase routes; however, the difference was not statistically significant. Next, an investigation of the trend of effect sizes based on published year via the meta regression analysis indicated slightly larger effect sizes as shown in more recent publications, but this was not statistically significant.

• 한국재료학회지
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• 제34권1호
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• pp.21-26
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• 2024

In this investigation, samples of the chemical (Hg_1-xPb_xBa₂Ca_1.8Mg_0.2Cu₃O_8+δ) were prepared utilizing a solid-state reaction technique with a range of lead concentrations (x = 0.0, 0.05, 0.10, and 0.20). Specimens were pressed at 8 tons per square centimeter and then prepared at 1,138 K in the furnace. The crystalline structure and surface topography of all samples were examined using X-ray diffraction (XRD) and atomic force microscopy (AFM). X-ray diffraction results showed that all of the prepared samples had a tetragonal crystal structure. Also, the results showed that when lead was partially replaced with mercury, an increase in the lead value impacted the phase ratio, and lattice parameter values. The AFM results likewise showed excellent crystalline consistency and remarkable homogeneity during processing. The electrical resistivity was calculated as a function of temperature, and the results showed that all samples had a contagious behavior, as the resistivity decreased with decreasing temperature. The critical temperature was calculated and found to change, from 102, 96, 107, and 119 K, when increasing the lead values in the samples from 0.0 to 0.05, 0.10, and 0.20, respectively.

• 대한방사선치료학회지
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• 제23권1호
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• pp.59-66
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• 2011

목 적: 유방 부분 절제술 후 방사선 치료 시 기존의 라이낙을 이용한 치료기법과 비교하여 TOMO Direct를 이용한 접선 치료 기법의 임상적 유용성을 알아보고자 한다. 대상 및 방법: 유방 부분 절제술 후 방사선 치료를 받은 좌측 유방암 환자 3명을 대상으로 라이낙을 이용한 쐐기 접선 조사 기법(Wedged tangential fields technique)과 조사면 내 선량 보강 기법(Field In Field technique, FIF), TOMO Direct, TOMO Direct 세기 변조 방사선 치료(Intensity Modulated Radiation Therapy, IMRT)기법을 이용하여 동일한 처방 조건(CTV 내 $D_{90%}$: 50.4 Gy/28 fx)으로 치료계획을 수립하였다. 선량 분석을 위해 선량 체적 히스토그램(Dose Volume Histogram, DVH)과 등선량 곡선 (Isodose curve)을 이용하여 종양 내 표적체적(Clinical Target Volume, CTV)과 손상위험장기(Organ At Risk, OAR)에 대한 선량을 비교분석 하였다. 표적체적의 선량 인자로는 $D_{99}$, $D_{95}$, 선량 균일 지수(Dose homogeneity index, DHI: $D_{10}/D_{90}$)와 $V_{105}$, $V_{110}$을 손상위험장기의 선량 인자로는 심장의 $V_{10}$, $V_{20}$, $V_{30}$, $V_{40}$과 좌측 폐의 $V_{10}$, $V_{20}$, $V_{30}$을 비교 분석하였다. 결 과: 표적체적의 선량 분석 결과로 $D_{99}$, $D_{95}$의 평균값은 각각 쐐기 접선 조사(W)에서 $47.7{\pm}1.1Gy$, $49.4{\pm}0.1Gy$이었으며, 조사면 내 선량 보강 기법(F)은 각각 $47.1{\pm}0.6Gy$, $49.2{\pm}0.4Gy$, 그리고 TOMO Direct(D)와 TOMO Direct IMRT(I)에서는 각각 $49.2{\pm}0.4$ vs. $48.6{\pm}0.8Gy$, $49.9{\pm}0.4$ vs. $49.5{\pm}0.3Gy$이었다. 선량 균일 지수의 평균값은 W: $1.1{\pm}0.02$, F: $1.07{\pm}0.02$, D: $1.03{\pm}0.001$, I: $1.05{\pm}0.02$이었다. 각각의 치료 기법으로 $V_{105}$, $V_{110}$의 평균값을 비교하였을 때 쐐기 접선 조사 시 각각 $34.6{\pm}9.3%$, $7.5{\pm}7.9%$로 가장 높았고 조사면 내 선량 보강 기법은 $16.5{\pm}14.8%$, $2.1{\pm}3.5%$로, TOMO direct IMRT는 $7.5{\pm}8.3%$, $0.1{\pm}0.1%$로 낮아졌으며 TOMO direct에서는 두 값 모두 0%로 나타났다. 손상 위험 장기에 대한 선량 분석 결과 각각의 치료 기법 사이에 유의한 차이를 보이지 않았다. 결 론: TOMO Direct를 이용한 접선 조사 기법은 기존의 쐐기 접선 치료 기법보다 치료 용적 내에 균일한 선량분포를 얻을 수 있을 뿐만 아니라 IMRT 또는 Tomotherapy와 달리 정상조직의 저 선량 영역의 노출용적을 증가시키지 않았으며 조사면 내선량 보강 기법 보다 용이한 치료계획 절차를 수행하므로 유방 부분 절제술 후 방사선 치료 시 임상적으로 유용하리라 사료된다.

• 보존과학회지
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• 제27권2호
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• pp.211-222
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• 2011

익산 미륵사지 석탑은 백제 무왕대(639년)에 기초부가 조성되면서 창건된 것으로 알려져 왔다. 석탑의 주요 부재는 중생대 쥐라기에 생성된 미륵산의 중조립질 회백색 흑운모화강암으로서 조암광물은 석영, 장석, 흑운모, 백운모와 인회석 및 갈염석 등으로 구성되어 있다. 대부분의 부재는 비교적 강한 물성을 가지고 있으나 장기간 풍화를 거치면서 전체적인 내구성은 중간풍화(MW: $883kgf/cm^3$ 정도까지 약화되었다. 이 과정에서 부재의 강도에 영향을 주는 휨, 전단 및 압축력의 저하에 따라 절단(31%), 결실(57%), 균열(44%) 등의 손상이 발생하였다. 원부재는 보존처리를 통해 재사용율을 약 74%까지 높일 수 있으며, 일부 결실과 절단된 부재를 신석재로 성형할 부재가 약 55개 정도이다. 재사용이 거의 불가능한 26%의 외면석과 적심석 일부는 탑의 구조적 안정성을 유지하기 위해 신석재로의 대체가 불가피하다. 따라서 익산지역의 채석장을 중심으로 석탑과 동일한 암석을 탐색한 결과, 황등지역의 석재가 미륵사지 석탑의 원부재와 가장 유사하고 안정적인 물성을 보였다.

• 대한토목학회논문집
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• 제33권3호
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• pp.833-841
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• 2013

복합재료의 경우 다양한 재료에 따라 제작이 가능하며 이들 완성재료의 경우 다양한 재료특성을 나타낸다. 이 연구는 건설용 FRP복합재료의 재료특성 중 선형거동이 뚜렷이 나타나는 인장, 압축과는 달리 비선형 거동이 발생되는 전단거동 특성에 대한 실험적 연구로서 ASTM D4255 규정에 의한 2-Rail 전단시험 방법을 토대로 각각의 시편들을 제작, 실험결과를 분석하였다. 고려된 실험변수로는 함침 수지류의 종류와 섬유 체적비, 섬유배열 방향 및 온도 특성, 공장용 생산제품의 균질성 등을 고려하였다. 섬유배열 방향에 따른 특성조사의 경우 섬유 배열방향을 $0^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$로 각각 시편을 제작하였으며, 온도에 따른 외부환경 변화에 의한 FRP재료의 전단거동을 조사하기 위하여 실험온도를 $25^{\circ}C$, $40^{\circ}C$, $60^{\circ}C$, $80^{\circ}C$로 각각 고려하여 시험을 수행하였다. 이 연구를 통하여 대부분의 복합재료 시편에서 비선형 전단거동이 확인되었으며 비닐에스테르수지를 사용하고, 높은 섬유체적비와 $45^{\circ}$의 섬유배열방향을 가진 시편에서 비선형 전단거동이 가장 두드러지게 나타나는 것으로 조사되었다. 온도변화에 따른 실험결과의 경우, 온도가 증가함에 따라 전단 내 비선형 거동의 감소가 나타났으며 공장용 제작제품의 경우 hand lay-up 제작시편에 비하여 비선형 전단거동이 비교적 동등하게 나타냈다.

• 품질경영학회지
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• 제5권2호
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• pp.59-120
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• 1977

An antibiotic 'P', which is one of the products of the Gist Brocades N. V. is being tested by its research department as fungicide on seed-potatoes. For this testing they designed experiments, with two control groups, one competitor's product, eight formulations of the antibiotic to be tested in different concentrations and one mercury treatment which can not be used in practice. The treated potatoes were planted in three different regions, where bifferent conditions prevail. After several months the harvested potatoes are divided in groups according to their diameter, potato illness is analysed and counted. These data were summarised in percentage and given to us for Analysis. We approached and analysed the data by following methods: a. Computation of the mean and standard deviation of the percenage of good results in each size group and treatment. b. Computation of the experimental errors by substraction of each treatment mean from observed data. c. Description of the frequency table, plotting of a histogram and a normal curve on same graph to check normality. d. Test of normality paper and chi-sqeare test to check the goodness of fit to a normal curve. e. Test for homogeneity of variance in each treatment with the Cochran's test and Hartley's test. f. Analysis of Variance for testing the means by one way classifications. g. Drawing of graphs with upper and lower confidence limits to show the effect of different treatments. h. T-test and F-test to two Control mean and variance for making one control of Dunnett's test. i. Dunnett's Test and calculations for numerical comarision of different treatments wth one control. In region R, where the potatoes were planted, it was this year very dry and rather bad conditions to grow potatoes prevailed during the experimental period. The results of this investigation show us that treatment No.2, 3 and 4 are significantly different from other treatments and control groups (none treated, just like natural state). Treatment no.2 is the useless mercury formulation. So only No. 3 and 4, which have high concentrations of antibiotic 'P', gave a good effect to the potatoes. As well as the competitors product, middle and low concentrated formulations are not significantly different from control gro-ups of every size. In region w, where the potatoes got the same treatments as in region R, prevailed better weather conditions and was enough water obtainable from the lake. The results in this region showed that treatment No. 2, 3, 4, and 5 are Significantly different from other treatments and the control groups. Again No.2 is the mercury treatmentin this investigation. Not only high concentrated formulation of antibiotic 'P', but also the competitor's poroduct gave good results. But, the effect of 'P', was better than the competitors porduct. In region G, where the potatoes got the same treatments as in the regions R and w. and the climate conditions were equal to region R, the results showed that most of the treatments are not significantly different from the control groups. Only treatment no. 3 was a little bit different from the others. but not Significantly different. It seems to us that the difference between the results in the three regions was caused by certain conditions like, the nature of the soil the degres of moisture and hours of sunshine, but we are not sure of that. As a conclusion, we can say that antibiotic 'P' has a good effect on potatoes, but in most investigations a rather high concentration of 'P' was required in formulations.