• Asian review of World Histories
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• v.3 no.2
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• pp.171-200
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• 2015

At its simplest, this essay provides a narrative of migration in Asia since the arrival of Homo sapiens some 70,000 years ago. More fully, it presents the case for conducting long-term, world-historical interpretation for Asia with attention to multiple perspectives, which has become increasingly central to global historical analysis. Following an introductory articulation of the benefits of long-term interpretation, the second section presents a balance of three perspectives-empire, exchange, and migration-as frameworks for interpreting the Asian past. The third section presents further detail on migration in long-term Asian history. The concluding section identifies four changes in patterns of migration during the past two centuries and emphasizes the underlying importance of cross-community migration in long-term human biological and social evolution.

• Genomics & Informatics
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• v.3 no.3
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• pp.80-85
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• 2005

HExDB is a database for analyzing exon and splicing pattern information in Homo sapiens. HExDB is useful for specific purposes: 1) to design primers for exon amplification from cDNA and 2) to understand the change of ORFs by alternative splicing. HExDB was constructed by integrating data from AltExtron which is the computationally predicted exon database, Ensemble cDNA annotation, and Affymetrix genome tile published recently. Although it may contain false positive data, HExDB is good starting point due to its sensitivity. At present, there areas many as 2,046,519 exons stored in the HExDB. We found that $16.8\%$ of the exons in the database was constitutive exons and $83.1\%$ were novel gene exons.

• The korean journal of orthodontics
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• v.38 no.2
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• pp.133-143
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• 2008

Objective: This study was performed to identify the characteristics of the MSX1 gene (locus chromosome 4p16) in Korean nonsyndromic cleft lip and palate (CL/P), which is assumed to be a major candidate gene acting as a causal factor in nonsyndromic CL/P and missing teeth. Methods: The 36 individuals (23 males and 13 females) who had visited the department of orthodontics at from 1998 to 2002 and who had nonsyndromic CL/P were included in the study. Using a PCR-based assay, the MSX1 gene was amplified, sequenced, and searched for inferred protein products (Reference: Homo sapiens MSX1, accession number AF426432 and NP_002439). The common single nucleotide polymorph isms were observed. Results: In exon 1, nucleotide "A" of the 253 basepair (bp) region was substituted for "G", and in the 255 bp region, nucleotide "G" was inserted. In exon 2, nucleotide "C" of the 11 bp region was substituted for "A", and "T" or "G" was inserted into the 351 bp region whereas "T" or "A" was inserted into the 352 bp region. In protein analysis, "Thr85Ala" missense mutation was found. The "Thr85Ala" missense mutation in this study is different from those of studies using subjects of other races. Conclusions: The results suggest that there is specific mutation of MSX1 in Korean and it plays an important role in Korean nonsyndromic CL/P. However, any distinct genetic polymorphisms between CL/P with missing teeth in the cleft region and CL/P without missing teeth could not be found.

• Bioinformatics and Biosystems
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• v.1 no.2
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• pp.95-98
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• 2006

Recent proteomic studies of protein domains require high-throughput and systematic approaches. Since most experiments using protein domains, the modules of protein-protein interactions, require gene cloning, the first experimental step should be retrieving DNA sequences of domain encoding regions from databases. For a large scale proteomic research, however, it is a laborious task to extract a large number of domain sequences manually from several inter-linked databases. We present a new methodology to retrieve DNA sequences of domain encoding regions through automatic database cross-referencing. To extract protein domain encoding regions, it traverses several inter-connected database with validation process. And we applied this method to retrieve all the EGF domain encoding DNA sequences of homo sapiens. This new algorithm was implemented using Python library PAMIE, which enables to cross-reference across distinct databases automatically.

• CELLMED
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• v.2 no.1
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• pp.4.1-4.13
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• 2012

When medicine is unable to cure, and the end becomes imminent, or when the patient is tired of the side effects associated with chronic use of drugs, the search for alternative and new ways of healing is begun. Coincidentally, sometimes the alternative is the origin, as is the case for traditional Arab medicine and traditional American Indian healing. Traditional healing is the first healing that all people have used for 200,000 years, since the beginning of Homo sapiens. The sources and elements of traditional Arab medicine have been examined in books and by consulting with traditional Arab healers. Arabic medicine is a career combining both elements of science and philosophy based on religion and traditions, and includes a diversity of healing approaches: spiritual, physical, and using natural products. These approaches are discussed with emphasis on wet cupping (Alhijamah), a practice that is undergoing a revival nowadays in Arab countries. American Indian healing is a career based on religion, tradition, an innate healing gift and extensive training, both in a medical school setting and as an apprentice. Arabic healing approaches are compared to American Indian healing approaches.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.1326-1329
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• 2012

전사체(transcript)는 유전자로부터 전사된 DNA 시퀀스 코드를 말한다. 전사체(transcript)의 발현된 형태에 따라 생성되는 단백질의 형태 역시 달라지므로 전사체 모델의 형태는 중요한 의미를 가지며 특정 위치의 전사체가 정상과 다르게 모델이 변할 경우 심각한 경우에는 유전자 질병에 노출될 수 있다. 현재 실험체에 대한 전사체 모형은 SpliceGrapher, Cufflinks와 같은 상용화된 도구들을 사용하여 얻을 수 있다. 하지만 이런 도구 간의 결과 값 및 어노테이션 정보와 결과 값 간의 유사도 비교를 위한 방법론은 현재 알려진 바 없다. 대신 전사체 비교를 위해 모형 간의 차이를 눈으로 하나씩 비교하거나 전사체 위치를 이용한 산수 값을 이용한다. 본 논문에서는 전사체 모형 간의 유사도를 비교하기 위한 방법론을 제시하고 Homo sapiens grch37 어노테이션 파일과 SRR387514 실험 데이터 간의 유사도를 제시한 방법론을 이용하여 측정한 결과 값을 분석하였다.

• Journal of Microbiology and Biotechnology
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• v.31 no.4
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• pp.621-629
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• 2021

Shigella flexneri is a facultative intracellular pathogen that causes bacillary dysentery in humans. Infection with S. flexneri can result in more than a million deaths yearly and most of the victims are children in developing countries. Therefore, identifying novel and unique drug targets against this pathogen is instrumental to overcome the problem of drug resistance to the antibiotics given to patients as the current therapy. In this study, a comparative analysis of the metabolic pathways of the host and pathogen was performed to identify this pathogen's essential enzymes for the survival and propose potential drug targets. First, we extracted the metabolic pathways of the host, Homo sapiens, and pathogen, S. flexneri, from the KEGG database. Next, we manually compared the pathways to categorize those that were exclusive to the pathogen. Further, all enzymes for the 26 unique pathways were extracted and submitted to the Geptop tool to identify essential enzymes for further screening in determining the feasibility of the therapeutic targets that were predicted and analyzed using PPI network analysis, subcellular localization, druggability testing, gene ontology and epitope mapping. Using these various criteria, we narrowed it down to prioritize 5 novel drug targets against S. flexneri and one vaccine drug targets against all strains of Shigella. Hence, we suggest the identified enzymes as the best putative drug targets for the effective treatment of S. flexneri.

• Journal of TMJ Balancing Medicine
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• v.8 no.1
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• pp.6-10
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• 2018

In order to propose a fundamental and appliable theories for balancing therapy of temporomandibular joint (TMBT), evolutionary proofs and up-down theories in evolutionary biology and Korean medicine were investigated. Balancing therapy of temporomandibular joint treats disorder and diseases of the whole body through straightening of the abnormal linking between temporomandibular joint and axis. Although the mechanism of this therapy contains many merits like multicellular integrity and coadjustment, ease of balance and alert forward mobility by the bipedal stepping and evolution to Homo sapiens, increasing disadvantages of balancing pressure of right and left in the lengthened perpendicular axis and the balancing load of temporomandibular joint and axis following the reactional change of dental occlusion are deeply related and considered in this therapy. As for up-down theory, crossing of heavenly qi and earth qi centering on cervical joint is presented as the first mechanism for TMBT, and the other ones like in-out and up-down qi activity of tripple energizer, up-down of essence-qi-spirit in the three backbone barrier and three cinnabar field, up-down of yin-yang-water-fire of viscera and bowels can be related too.

• International Journal of Industrial Entomology and Biomaterials
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• v.12 no.2
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• pp.57-61
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• 2006

Suppressor of cytokine signaling (SOCS) is known to be as a negative feedback regulator in Janus kinase signal transducer and activator of transcription signaling. Highly conserved SOCS box domain was cloned from a Korean malaria vector, Anopheles sinensis. Sequence analysis indicates that it has identity to Anopheles gambiae (96%), Aedes aegypti (94%), Drosophila melanogaster (78%), Mus musculus (72%) and Homo sapiens (72%), respectively. Tissue specificity RT-PCR demonstrated that the expression level of AsSOCS transcript was high at abdomen, midgut, and ovary, whereas developmental expression patterns showed that the level of AsSOCS was high at egg, early pupae, and adult female. On the other hand, RT-PCR analysis after bacterial challenge showed that SOCS mRNA was strongly induced in larvae. In addition, it was also induced by various immune elicitors such as lipoteicoic acid, CpG-DNA, and laminarin. It seems that AsSOCS, repressor of JAK-STAT pathway, is highly conserved in mosquito, and may play an important role in mosquito innate immune response.

• International Journal of Industrial Entomology and Biomaterials
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• v.12 no.2
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• pp.63-67
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• 2006

Suppressor of cytokine signaling (SOCS) is known to playa key role as a negative feedback regulator in JAK/STAT signaling cascade in innate immunity. Our laboratory has recently been interested in elucidating the interactions between Spodoptera exigua (Se) and SeNPV. This context leads us to clone and characterize SeSOCS that may have important functions in response to SeNPV infection. Using the RT-PCR and TA cloning approach, we found a partial fragment (416 bp) of SeSOCS. Blast search and multiple alignment data showed that it has a homology to various insects such as Anopheles gambiae (78%), Aedes aegypti (75%), Drosophila melanogastar (77%), Mus musculus (69%), and Homo sapiens (69%). Temporal induction patterns of SeSOCS were analysed after being immune-challenged with either NPV or laminarin. It showed that the level of SeSOCS mRNA was strongly induced in a biphasic manner in response to SeNPV and laminarin, respectively. It seems that SOCS, a negative regulator of JAK/STAT signaling system is also present in S. exigua and may playa role in innate immunity albeit its precise role should be further elucidated at the molecular and cellular level in the early phase of SeNPV infection in larvae.