• STI Policy Review
• /
• v.5 no.2
• /
• pp.1-19
• /
• 2014

The concept of a holistic innovation policy is defined in this article, with discussions of what it is, why it is relevant, and how it can be implemented to enhance product innovation. It is shown that the innovation systems approach has diffused rapidly during the latest decades and has completely replaced the linear view in the field of innovation research. The majority of European countries are striving in the direction of developing a more holistic innovation policy. However, it is concluded that the innovation policies in European countries are still dominantly linear despite the fact that holistic policy seems to be the driving vision. Innovation policy is behindhand. Why innovation policy is still linear is also preliminarily discussed. Policymakers attending conferences on innovation are practically always in favor of holistic (systemic, broad-based, comprehensive, etc) innovation policies, have abandoned the linear view by learning from innovation research. The division between "linear" and "holistic" seems to be located within the community where innovation policies are designed and implemented, a community composed of policymakers (administrators/bureaucrats) and elected politicians. Perhaps the dividing line is between these two groups in that politicians, who actually make the decisions, may still reflexively believe in the linear view. Nevertheless, there seems to be a failure in communication between researchers and politicians in the field of innovation and there is therefore a strong need to involve innovation researchers in policy design and implementation to a much higher degree. Another way to increase the degree of holism could be to separate innovation policy from research policy, since their integration tends to cement the linear character of innovation policy. The empirical results are based on a questionnaire sent to twenty-three EU Member States, out of which nineteen (83%) responded. Part of the work for this article was carried out for the European Research and Innovation Area Committee (ERAC) of the European Commission (DG RTD).

• International Journal of Advanced Culture Technology
• /
• v.7 no.1
• /
• pp.155-161
• /
• 2019

This study was to identify the effects of home visit intervention program for Holistic Healthcare of multi-culture Couples. It used a non-equivalent control group pretest-posttest design quasi-experimental research. The subjects of this study consist of 20 couples for experimental and control groups. Multi-cultural couples comprised of foreign women married to Korean men in farm and fishery areas. The research tools were used stress index by SA-3000P (Medicare co. Ltd. KOREA), Center for Epidemiologic Studies-Depression Scale (CES-D), and World Health Organization Quality of Life (WHOQOL-Bref). The experimental group of the wives had lower stress index than the control group, the experimental group of the husband showed lower stress index than the control group, (t=-3.14, p=.002). The wife (t=-3.75, p=.001) and husband (t=-4.20, p=.001) of the experimental group showed lower depression scores than the control group. Both the wife (t=3.86, p=.001) and husband (t=5.28, p=.001) showed higher scores for quality of life compared to the control group. It was found that this holistic healthcare home visit program is an effective program to make improvements on stress, depression and quality of life for multi-cultural couples. Therefore, as the intervention program developed in this study is home visits for the holistic health of multi-cultural couples, and it is judged that it can be implemented at the local social health centers or healthcare centers.

• Proceeding of KASS Symposium
• /
• 2005.05a
• /
• pp.52-66
• /
• 2005

Tension and Membrane have the potential to enable the realization of lightweight structures that have the attractive features of structures efficiency and aesthetical expression. Compared with pure (thorough-bred) tension structures such as cable net, air dome and tensegrity, so called hybrid tension structures such as beam string, tensegric system and other mixed structures have Potential still to be realized. After synnaruzubg the simple definition of tensegric structure, some holistic designs for hybrid tension structures completed recently in the author's practice are given.

• Advances in Traditional Medicine
• /
• v.4 no.3
• /
• pp.137-156
• /
• 2004

Altruistic virtuous caring, possibly originated from religion and/or spirituality, is indispensable for holistic health through channeling vital energy with diet, exercise and meditation. This is a participant-observed medical anthropological research of a first generation Korean elderly immigrant health professional woman living in a four generational family. She had hypertension and was concerned about possible attack of stroke. Multi-religious, spiritual, and cosmological vital energy based on holistic Nature-oriented health beliefs and practices influenced by psychosocial, cultural and economic background, education, self- discipline and self-cultivation of individual, and group or family may create health. Self-care beliefs based on confidence in self-control of one's life style for oneself and others influence individual and group health practice. The holistic alternative health beliefs and practices were proved to be efficacious and beneficial by her self-evaluation, evaluation of significant others, biomedical professionals, and laboratory tests. That may have potential application for global health.

• Korean Journal of Adult Nursing
• /
• v.28 no.5
• /
• pp.501-513
• /
• 2016

Purpose: The purpose of this study was to identify attitudes of male baby boomer toward holistic health using Q-methodology. Methods: Q-methodology is analysed through the subjectivity of each type of attitudes. Thirty-five q-statements were selected from a total of 145 statements. These statements were categorized into six areas (Physical, psychological, spiritual, work and leisure, love and friendship, culture). The recruited P-sample consisted of thirty-four male baby boomers from one town and two cities. The 35 selected Q-statements from each of 35 participants were classified into the shape of a normal distribution using a 9-point scale. The collected data were analysed using the PQMethod Program 2.11. Results: Four types of male baby boomer attitudes towards holistic health were identified. The first is a relationship oriented-marital relationship oriented type, the second type is an economic oriented- job seeking type, the third type is a nature friendly oriented-independent living type, and the fourth type is health oriented-physical health seeking type. Conclusion: The results of this study indicated that different approaches to holistic health promotion program could be developed based on the four types of holistic health attitudes among baby boom generation males in Korea.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.9 no.1
• /
• pp.58-66
• /
• 2016

The purpose of this study is to consider of fasting cure as natural healing and holistic medicine. As a study method, this author conducted a literature review to figure out the history and meaning of fasting found in religious thoughts and studied the cases applying fasting to either mental or physical healing analytically. According to the study results, first, in terms of religious thoughts, fasting plays significant roles mentally, and the act of fasting influences mankind's mind considerably. Second, fasting as a means of humans' mental and physical healing has been playing significant roles as the medical act of natural healing that has been transmitted from a long time ago. As a result, this author has found that fasting cure has great value as holistic medicine based on natural healing. Based on the implications of this study, this researcher expects that this study will be used as fundamental material to provide the directions and grounds of fasting cure as efficient healing in the aspects of holistic medicine exerting effects on chronic disease resulted from habits or diseases caused by stress, a factor that results in many different kinds of diseases in this age.

• Journal of Ginseng Research
• /
• v.45 no.4
• /
• pp.465-472
• /
• 2021

Background: Ginseng can help regulate brain excitability, promote learning and memory, and resist cerebral ischemia in the central nervous system. Ginsenosides are the major effective compounds of Ginseng, but their protein targets in the brain have not been determined. Methods: We screened proteins that interact with the main components of ginseng (ginsenosides) by affinity chromatography and identified the 14-3-3 ζ protein as a potential target of ginsenosides in brain tissues. Results: Biolayer interferometry (BLI) analysis showed that 20(S)-protopanaxadiol (PPD), a ginseng saponin metabolite, exhibited the highest direct interaction to the 14-3-3 ζ protein. Subsequently, BLI kinetics analysis and isothermal titration calorimetry (ITC) assay showed that PPD specifically bound to the 14-3-3 ζ protein. The cocrystal structure of the 14-3-3 ζ protein-PPD complex showed that the main interactions occurred between the residues R56, R127, and Y128 of the 14-3-3 ζ protein and a portion of PPD. Moreover, mutating any of the above residues resulted in a significant decrease of affinity between PPD and the 14-3-3 ζ protein. Conclusion: Our results indicate the 14-3-3 ζ protein is the target of PPD, a ginsenoside metabolite. Crystallographic and mutagenesis studies suggest a direct interaction between PPD and the 14-3-3 ζ protein. This finding can help in the development of small-molecular compounds that bind to the 14-3-3 ζ protein on the basis of the structure of dammarane-type triterpenoid.

• Korean Journal of Culture and Social Issue
• /
• v.29 no.2
• /
• pp.253-273
• /
• 2023

This study was conducted to determine how analytic-holistic thinking style, one of the cultural characteristics, affects intentionality judgment and what role the crime typicality plays in the process. To this end, the psychological mechanism of intentionality judgment was confirmed in cases where the criminal typicality was manipulated by the moral characteristics of the crime perpetrator and victim. As a result, higher the criminal typicality lead to higher intentionality judgement. In addition, it was found that people with relatively holistic thinking style (with high causality and perception of change) judge less of the perpetrator intentionality. In particular, it was confirmed that the analytic-holistic thinking style interacts with criminal typicality and affects the intentionality judgment. Specifically, people with a holistic thinking style (high causality) judged the perpetrator to have high intentionality in typical cases, but judged in a reverse way in atypical cases. It means that, holistic thinkers, compared to analytic thinkers, strongly judge intentionality based on criminal typicality considering the moral characteristics of not only the perpetrators but also the victims. Along with the significance of this study, the relationships among analytic-holistic thinking style, criminal typicality and intentionality judgment were discussed.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2013.05a
• /
• pp.459-460
• /
• 2013

• Journal of Ginseng Research
• /
• v.46 no.5
• /
• pp.666-674
• /
• 2022

Background: Ginsenosides and their metabolites have antidepressant-like effects, but the underlying mechanisms remain unclear. We previously identified 14-3-3 ζ as one of the target proteins of 20 (S)-protopanaxadiol (PPD), a fully deglycosylated ginsenoside metabolite. Methods: Corticosterone (CORT) was administered repeatedly to induce the depression model, and PPD was given concurrently. The tail suspension test (TST) and the forced swimming test (FST) were used for behavioral evaluation. All mice were sacrificed. Golgi-cox staining, GSK 3β activity assay, and Western blot analysis were performed. In vitro, the kinetic binding analysis with the Biolayer Interferometry (BLI) was used to determine the molecular interactions. Results: TST and FST both revealed that PPD reversed CORT-induced behavioral deficits. PPD also ameliorated the CORT-induced expression alterations of hippocampal Ser9 phosphorylated glycogen synthase kinase 3β (p-Ser9 GSK 3β), Ser133 phosphorylated cAMP response element-binding protein (p-Ser133 CREB), and brain-derived neurotrophic factor (BDNF). Moreover, PPD attenuated the CORT-induced increase in GSK 3β activity and decrease in dendritic spine density in the hippocampus. In vitro, 14-3-3 ζ protein specifically bound to p-Ser9 GSK 3β polypeptide. PPD promoted the binding and subsequently decreased GSK 3β activity. Conclusion: These findings demonstrated the antidepressant-like effects of PPD on the CORT-induced mouse depression model and indicated a possible target-based mechanism. The combination of PPD with the 14-3-3 ζ protein may promote the binding of 14-3-3 ζ to p-GSK 3β (Ser9) and enhance the inhibition of Ser9 phosphorylation on GSK 3β kinase activity, thereby activating the plasticity-related CREBeBDNF signaling pathway.