• Korean Journal of Pharmacognosy
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• v.48 no.3
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• pp.202-207
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• 2017

The purpose of this study was to investigate the skin irritation of bee venom (melittin) in human. Skin irritation test was performed at 0.05% bee venom by 48 h single patch test in 30 healthy volunteers with no skin disease and skin sensitization test was performed by local lymph node assay in animal. In single patch test, 28 human subjects showed no reaction and 2 subjects showed 1+ or 3+ grade skin reaction. In a skin sensitization test of bee venom conducted using mice. no erythema was observed on the dorsal side of mice up to 8 days after application of bee venom on the skin. The results of the average stimulation index by ATP values showed that there was no irritation to the mice skin at 0.005% and 0.01% of bee venom. Therefore, bee venom is not likely to induce a significant skin irritation under 0.05% concentration.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.5
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• pp.269-273
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• 2005

In horizontal cells (HCs) that were freshly dissociated from goldfish retina, two types of voltagedependent calcium currents ($I_{Ca}$) were recorded using a patch-clamping configuration: a transient type current and a sustained type current. The cell was held at -40 mV, and the prepulse step of -90 mV was applied before command pulse between -65 and +55 mV. The transient $Ca^{2+}$ current was activated by depolarization to around -50 mV from a prepulse voltage of -90 mV lasting at least 400 ms and reached a maximal value near -25 mV. On the other hand, the sustained $Ca^{2+}$ current was induced by pre-inactivation for less than 10 ms duration. Its activation started near -10 mV and peaked at +20 mV. $Co^{2+}$ (2 mM) suppressed both of these two components, but nifedipine ($20{\mu}M$), L-type $Ca^{2+}$ channel antagonist, blocked only the sustained current. Based on the activation voltage and the pharmacolog$I_{Ca}$l specificity, the sustained current appears to be similar to L-type $I_{Ca}$ and the transient type to T-type $I_{Ca}$. This study is the first to confirm that transient type $I_{Ca}$ together with the sustained one is present in HCs dissociated from goldfish retina.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.2
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• pp.189-197
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• 2001

To investigate propofol's effects on ionic currents induced by ${\gamma}-aminobutyric$ acid (GABA) and glycine as well as on those produced by the nicotinic acetylcholine- and glutamate-responsive channels, rat dorsal raphe neurons were acutely dissociated and the nystatin-perforated patch-clamp technique under voltage-clamp conditions was used to observe their responses to the administration of propofol. Propofol evoked ion currents in a dose-dependent manner, and propofol $(10^{-4}\;M)$ was used to elicit ion currents through the activation of $GABA_A,$ glycine, nicotinic acetylcholine and glutamate receptors. Propofol at a clinically relevant concentration $(10^{-5}\;M)$ potentiated $GABA_A-,$ glycine- and NMDA receptor-mediated currents. The potentiating action of propofol on $GABA_A-,$ glycine- and NMDA receptor-mediated responses involved neither opioid receptors nor G-proteins. Apparently, propofol modulates inhibitory and excitatory neurotransmitter-activated ion channels either by acting directly on the receptors or by potentiating the effects of the neurotransmitters, and this modulation appears to be responsible for the majority of the anaesthetic and/or adverse effects.

• The Korean Journal of Pain
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• v.11 no.2
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• pp.338-342
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• 1998

Postural headache due to spontaneous intracranial hypotension occurs without any diagnostic lumbar puncture, myelography, cranial or spinal injury, or spinal anesthesia. The clinical characteristics of the syndrome are disappearance of the headache or a notable decrease in its severity with recumbency, the finding of meningeal enhancement and subdural fluid collection on brain MRI, the pleocytosis and the increased CSF protein concentration. We report a case of a 40-year-old woman who exhibited the signs and symptoms of postural headache due to low CSF pressure. Her headache started suddenly at the occiput and radiated to frontal head. Magnetic resonance imaging (MRI) of her brain showed enhancement of the meninges and subdural fluid collection. Intrathecal radionuclide cisternography showed the delayed appearance of the isotope in the cranium and the minimal CSF leak at the left upper thoracic region. Her headache was relieved completely after a lumbar (L2-L3) epidural injection of 12 ml of autologous blood and remained asymptomatic.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.8
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• pp.459-466
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• 2014

Fading effect of old pictures and printings is shown up differently according to the ink property, temperature, humidity, illuminants, and so on. Faded image enhancement techniques based on illuminant estimation are proposed such as the gray world algorithm and white patch retinex methods. However, conventional simple operators are not suitable for enhancing faded images because partial fading effect is appeared differently. Thus, this paper presents a color enhancement algorithm based on integrating correction coefficients for faded images. First, the proposed method adopts local process by using multi-scale average mask. The coefficients for each multi-scale average mask are obtained to apply the gray world algorithm. Then, integrating the coefficients with weights is performed to calculate correction ratio for red and blue channels in the gray world assumption. Finally, the enhanced image is obtained by applying the integrated coefficients to the gray world algorithm. In the experimental results, the proposed method reproduces better colors for both wholly and partially faded images compared with the previous methods.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.3 s.357
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• pp.26-32
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• 2007

A simple but accurate equivalent circuit of an aperture-coupled cavity-fed microstrip patch antenna is developed. It consists of ideal transformers, admittance elements, and transmission lines, and the related circuit element values are computed by applying the reciprocity theorem and complex power concept with the spectral-domain immittance approach. After validating by the published design example, a dual-band antenna was designed with the help of a hybrid optimization method. For this purpose, the Genetic Algorithm is applied with the Nelder-Mead simplex method. The obtained good results show that this approach turned out to be a very efficient tool for the design of aperture-coupled cavity-fed microstrip patch antenna having various structural design parameters.

• Asian Journal of Turfgrass Science
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• v.24 no.2
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• pp.161-164
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• 2010

Dollar spot, caused by Sclerotinia homoeocarpa F.T. Bennett, is the most economically important turfgrass disease on golf courses in North America due to its persistent nature. Fungicides, plant growth regulators, and other products were evaluated for preventative control of dollar spot and the secondary effects on brown patch and Pythium in a mixed stand of creeping bentgrass and annual bluegrass golf course putting green. Most fungicides provided excellent control of dollar spot throughout the trial but Rhapsody alone did not provide adequate control. Civitas applied alone and tank-mixed with Banner MAXX(R) and Daconil Ultrex(R) provided acceptable control throughout the study. No phytotoxicity was observed on any of the treatments applied but a darker green color and reduction in turfgrass growth was observed in a treatment with plant growth regulator, Trimmit. Treatments that contained Civitas and the Civitas Harmonizer also exhibited green pigmentation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.1B
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• pp.114-124
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• 2002

In this paper, we proposed the image-based 3D ray tracing indoor propagation model using a patch scattering model for fading analysis of indoor propagation environments. An image-based 3D ray tracing technique is mainly used, which allows the rapid generation of the complex channel impulse response for any given location and polarization of transmitter and receiver. Due to the site specific nature of indoor environment, we took into account the location and the electrical properties of individual walls and objects such as windows, doors and plaster board in our propagation model. Besides, the 3D radiation beam-patterns and polarizations of arbitrary antennas were considered, and using patch scattering model we can consider the change of the polarization due to the scattering from the various indoor objects, like desks, chairs and etc. the are almost impossible to be modeled with the basic image-based ray tracing method. The model will predict the impulse response, the rms delay spread, the fading characteristics of the channel and performances of the polarization diversity schemes.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.1
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• pp.91-97
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• 2005

In the mobile antenna systems for satellite multimedia communications, the active way antenna having a low sidelobe antenna pattern is described in this paper. This designed and fabricated array antenna is satisfied with international beam pattern regulation on moving states. The subarray of the proposed mobile antenna system is arranged with a stair-planar structure and non-periodic array spacing. This subarray is designed with three-layered microstrip patch as both receiving and transmitting radiator of which are improved with antenna gain and bandwidth. Also, the optimum subarray spacing is designed to make the lowest sidelobe pattern by genetic algorithm. In addition, the characteristics of a GA-perturbed array are investigated from simulated and measured beam pattern results.

• Journal of Korean Society of Forest Science
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• v.84 no.2
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• pp.258-265
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• 1995

Regeneration process of edaphic pine(Pinus densiflora) climax forest in Bulyung-gyegog, Uljin-gun, Kyungsangbuk-do, was studied. The height of dominant trees in the stands are 12 15m. Upper layers are highly dominated by pine trees and are randomly distributed. Pine trees in lower layer grow in a patch type. In the upper layer, the age distribution is likely one model type with mode of 60 and 80 years. In the horizontal distribution of these trees, some of the even-aged cluster constituted of several tree were found. For the first 25 years, the stem diameter increment rates in upper layer are higher than those in the middle layer. It could be concluded that after the forest canopy had been broken out, the seedlings established densely in a patch in the gap with the decreasing density and some of them, distributed in random, would constitute the canopy.