• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권1호
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• pp.57-61
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• 2010

Objective: Second primary malignancy (SPM) that occur in various period and region are important factors that deteriorate long-term survival rate in patients who recovered from oral cancer. Researches such as chemoprevention are being tried to reduce occurrence of SPMs. Only if analysis of clinical features of patients who develop SPM such as period, region and factors precedes, adequate prevention and treatment of SPM is possible. But, there are few researches about clinical features of SPMs that have primary lesion in oral cavity. In this study, we analysis that occurrence rates, regions that happen, risk factors and effect to survival rates of 2nd primary malignancies in oral cancer patients. From this survey, we willing to collect basic data for prevention and early diagnosis of SPMs. Methods: The medical records of 139 patients of oral oncology clinic of National Cancer Center who had up to 2-years follow up records after surgical or radiological treatment due to squamus cell carcinoma of oral cavity were reviewed. In these patients, survey of occurrence rate of SPMs, duration, survival rate and risk factors about occurrence of SPMs such as history of smoking, body mass index, age, sex, stage of primary lesion and history of radiologic treatment were achieved. Results: There are 15 patients who developed SPM in 139 cases. The actual occurrence rate of SPM was 10.79% and SPM were more likely to occur in male patients with 11 male Vs 4 female patients. Median age of these patient is 61.47 within 32 to 74 range. The regions that develop SPM are oral cavities (2 cases), stomach (4 cases), esophagus (2 cases), lung (2 cases) and others (1 case each breast, larynx, cervix, liver and kidney). In addition, metachronous cancers were 11 cases which happened more common than 4cases of synchronous cancers. Surveys of risk factors that relate to development of SPMs, such as sex, age, history of radiologic treatment, body mass index, history of smoking and stage of primary disease were done. Among them, factor of sex is only appear statistically significant (P=0.001), but rest are not significant in statistically. Conclusion: Occurrence rates of SPMs were reported from 10% to 20% by precede study. In this study, occurrence rate of SPMs is 10.79% that is similar to results of precede research. In comparison of 5-yr survival rates of groups that develop SPMs or not, there is statistically significance between two groups. Present treatment modalities of SPMs are surgical operation, radiotherapy, chemotherapy and combination of these modalities. In choosing the treatment modality, we must consider the first treatment modality, region of primary disease, region of SPMs and general conditions of patient. Because development of SPMs have big effect on prognosis, prevention of SPMs must regard to important objective of treatments in patients of SCCa in oral cavity.

• 한국기록관리학회지
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• 제8권2호
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• pp.39-60
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• 2008

본 연구는 근 현대 지역사료 수집, DB 구축 및 공동 활용 방안의 네 가지 측면을 다루었다. 첫째, 한국 지역사의 개념은 향토사, 지방사, 지역사 등으로 쓰이는데 근 현대사와 관련해서는 지역사의 개념이 확대되고 있는 추세이다. 둘째, 국가기록원은 1999년에 제정된 공공기관의 기록물관리에 관한 법률에 의거하여 근 현대 지역사료를 체계적으로 수집하여 관리하고 있으며 현재 중앙행정기관, 지방자치단체 및 교육청, 대학, 기타 공공기관의 기록물을 관리하고 있다. 국사편찬위원회는 2004년부터 2010년까지 10개년 계획으로 각 지역에 산재해 있는 근 현대 지역사료를 시군별 자료수집과 더불어 주제별 자료조사도 병행하고 있다. 한국학중앙연구원은 초기에는 현대사연구소를 중심으로 근 현대사사료를 수집하였다. 1997년부터 2005년까지는 수집된 사료는 해방기를 전후한 자료들이다. 셋째, 국가기록원의 중앙기록관리시스템 및 나라기록포털시스템, 국사편찬위원회의 한국사데이터베이스시스템, 한국학중앙연구원의 한국향토문화대전시스템의 특성이 기술되었다. 넷째, 세 기관 사이의 공동협의회의 구성은 국가기록물관리위원회 산하에 '근 현대 지역사료 협의회'를 두고, 국가기록원이 주도적인 역할을 하고 각 기관과 연대해 나가며, 근 현대 사료의 디지털화된 자원의 공유를 위한 기술개발, 콘텐츠의 이용과 개선, 공공의 이용과 참여, 국제적인 이용이 가능하도록 하려면 국가기록원, 국사편찬위원회, 한국학중앙연구원의 분담된 역할이 있어야함을 강조하였다.

• 보존과학회지
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• 제36권1호
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• pp.1-14
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• 2020

This study investigates the crystallinity distribution of ancient silk. Owing to the inherent multi-hierarchical structure of silk protein and the complicated structural changes that occur due to various burial environments, it is challenging but worthwhile to study ancient silk ageing behavior, which is based on the fact that ageing begins with a single fiber and then spreads to a whole fabric. Crystallinity was one of the most effective indicators found to reveal the ageing status of silk. Therefore, a synchrotron radiation-based X-ray diffraction(SR-XRD) method was employed to study the crystallinity distribution of single fibers of ancient silk unearthed from seven archaeological sites in China from historical periods including the warring states, Han dynasty, Song dynasty, and Ming dynasty. In comparison, the conventional X-ray diffraction method, which uses large amounts of samples, was also performed to determine the integral crystallinity of ancient silk. Thermal stability experiments by thermogravimetry(TG) as well as morphology observations by scanning electron microscopy(SEM) and optical microscopy(OM) all confirmed the deterioration of ancient silk. Moreover, the ageing mechanism of ancient silk was proposed with the assistance of an artificial ageing study. The results confirmed the effectiveness of SR-XRD as an ageing indicator, revealing the crystallinity distribution. This research could provide motivation to determine the deterioration status of ancient silk, and would also aid in explaining the fragility of ancient silk due to ageing.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2002년도 춘계공동학술발표회요약집
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• pp.242-242
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• 2002

Two MIMAS MaX fuel rods base-irradiated in a commercial PWR have been reinstrumented and irradiated at a test reactor. The fabrication data for two MOX roda are characterized together with base irradiation information. Both Rods were reinstrumented to be fitted with thermocouple to measure centerline temperature of fuel. One rod was equipped with pressure transducer for rod internal pressure whereas the other with cladding elongation detector. The post irradiation examinations for various items were performed to determine fuel and cladding in-pile behavior after base irradiation. By using well characterized fabrication and re-instrumentation data and power history, the fuel performance code, COSMOS, is verified with measured in-pile and PIE information. The COMaS code shows good agreement for the cladding oxidation and creep, and fission gas release when compared with PIE dad a after base irradiaton. Based on the re-instrumention information and power history measured in-pile, the COSMOS predicts re-instrumented in-pile thermal behaviour during power up-ramp and steady operation with acceptable accuracy. The rod internal pressure is also well simulated by COSMOS code. Therfore, with all the other verification by COSMOS code up to now, it can be concluded that COSMOS fuel performance code is applicable for the design and license for MaX fuel rods up to high burnup.

• 대한약침학회지
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• 제19권2호
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• pp.101-108
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• 2016

Objectives: This study introduces the history and types of Korean pharmacopuncture and reports trends of research on Korean pharmacopuncture. Methods: Pharmacopuncture studies were searched from the first year of each search engine to 2014 by using seven domestic and foreign search databases. Selected studies were divided into the history of pharmacopuncture, kinds and features of pharmacopuncture, research types, and experimental and clinic studies and were then classified by year of publication, type of pharmacopuncture, disease, and topic. Results: Pharmacopuncture can be classified into four large groups: meridian field pharmacopuncture (MFP), eight-principles pharmacopuncture (EPP), animal-based pharmacopuncture (ABP) and mountain-ginseng pharmacopuncture, which is a single-compound pharmacopuncture (SCP). The largest numbers of studies were reported from 1997 to 2006, after which the numbers decreased until 2014. Of experimental studies, 51.9%, 18.7%. 14.3%, 9% and 3.4% were on SCP, ABP, MFP, formula pharmacopuncture (FP), and EPP, respectively. Of clinical studies, 54.7%, 15.3%. 14.9% 10.0% and 1.5% were on ABP, MFP, EPP, SCP, and FP (1.5%), respectively. Among clinical studies, case reports and case series accounted for 76.5%, followed by randomized controlled trials (RCTs, 16.4%) and non-RCT (13.9%). Musculoskeletal diseases, toxicity and safety tests, anti-cancer effects, and nervous system diseases were mainly treated in experimental studies while musculoskeletal diseases, nervous system diseases, toxicity and safety tests, and autonomic nerve function tests were addressed in clinical studies. Bee venom (BV) was the most frequently-used pharmacopuncture in mechanism studies. Pharmacopuncture was mainly used to treat musculoskeletal diseases. Conclusion: Pharmacopuncture and studies of it have made great progress in Korea. Studies on BV pharmacopuncture and musculoskeletal diseases accounted for most of the studies reported during the review period. Research on the types of pharmacopuncture and diseases has to be expanded. Especially, studies on the use of MFP and EPP for treating patients with various diseases are needed.

• 대한한의학원전학회지
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• 제33권4호
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• pp.21-32
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• 2020

Objectives : Pulse descriptions in Korean Medical texts are comprised of combinations of pulse terminology, where various combinations of pulse terminology are used to describe disease symptoms. For Korean Medical doctors and professionals, however, it is impossible to identify the entirety of pulse description combinations, and their understanding is mostly limited to those learned from classical texts studied individually. Methods :This research was carried out by using Access of Microsoft Office 365 in Windows 10 of Microsoft. Pulse descriptions were extracted from the text, 『Euijongsonik』. In the final stages, the automatically extracted list of pulse descriptions was refined through [excluded terminology of pulse description]. Results : The PC environment of this research was Intel Core i7-1065G7 CPU 1.30GHz, with 8GB of RAM and a Windows 10 64bit operation system. Out of 6,115 verses 6,497 descriptions were primarily extracted, and after a refinement process, the final list contained 5,507 pulse descriptions. Conclusions : Based on the assumption that classical texts are available in data form to be processed by programs, current research methodology demonstrated that it was more efficient in regards to time and man power to create a pulse description database compared to when the researcher manually created one.

• 한국콘텐츠학회논문지
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• 제21권3호
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• pp.194-204
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• 2021

본 연구는 역사를 소재로 한 다크투어리즘 방문객들의 방문동기를 도출한 후, 방문목적지에서 경험한 진정성과 감정, 만족, 태도변화 간의 영향관계를 파악하고, 이를 기반으로 방문 후 역사에 대해 어떠한 태도변화를 일으키는지를 파악하고자 하였다. 이를 위해 국내 대표적인 다크투어리즘 장소 중의 하나인 서대문형무소역사관을 방문한 경험이 있는 15세 이상을 대상으로 2020년 8월 3일~20일 동안 온라인조사를 통해 수집된 347부를 최종 활용하였다. 분석결과, 다크투어리즘 방문동기(탐구성, 역사성, 일탈과 자아성찰) 중 탐구성과 역사성은 진정성과 감정에 모두 유의한 영향을 미치며, 만족은 태도변화에 영향을 미치는 것으로 분석되었다. 또한, 진정성과 감정은 태도변화에 유의한 영향력을 갖는 것으로 나타났다. 본 연구는 다크투어리즘 방문경험으로 인해 역사에 대한 태도변화가 나타났음을 실증적으로 규명하였다. 다크투어리즘 방문동기요인 중 역사성은 진정성과 감정을 통해 역사에 대한 태도변화에 유의한 영향을 미치는 것으로 나타난 만큼, 역사의 현장에서 이야기를 기반으로 한 체험프로그램 강화가 요구된다.

• 한국기록관리학회지
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• 제17권1호
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• pp.143-161
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• 2017

본 연구는 개인의 기록이 사회의 공공기록을 보완할 수 있음을 전제로 한다. 대학의 중요 기록물은 행정기록 이외에 대학과 관련된 인물의 개인기록을 통하여 보완될 수 있음을 인식하였다. 대학의 설립자의 생애사를 분석하여, 기록의 분류체계와 수집전략 구축에 활용하였다. 분류체계로 기능 및 주제 분류 그리고 형태분류로 구성되는 다중분류체계를 제안하였고, 수집전략으로는 분류체계에서 도출한 키워드들을 향후 기록 수집을 위한 탐색의 출발점으로 활용하고 잠재적 수집처 및 생산자로 추론할 것을 제안하였다. 모든 개인기록에 대한 표준적인 기준은 만들어 질 수 없지만 개인기록의 다양성을 고려할 때 의미 있는 시도로 생각된다.

• 헤리티지:역사와 과학
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• 제47권3호
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• pp.128-145
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• 2014

일본에는 우리나라 문화재가 다수 소장되어 있으며, 이에 대한 연구도 시기별로 다양하게 이루어졌다. 해방 이후인 1945년부터 1980년대까지 일본 소재 한국 문화재에 대한 연구는 일본과 국내 모두 한국 문화를 소개하는 개설서가 증대되면서 자료 보고서 형식의 논고가 지속적으로 발표되었다. 분야별로 약간의 차이를 보이지만 불교회화에서 두드러진 성과가 나왔다. 조각은 일본 학자들에 의한 한국 불상 연구가 매우 활발히 이루어진 시기였으며 일반회화 분야에서 연구 논문 발표와 저술 활동이 국내와 일본 모두 증가하였다. 도자 분야는 다른 어느 분야 못지않게 관련 저서가 증가된 점이 주목된다. 1980년대 후반부터1990년대 말까지는 국내에서 소장학자의 연구가 활발히 개시되고 신 자료를 발굴하여 소개하는 개별 논고가 많아진 시기이다. 일본의 경우 소수 연구자들의 지속적 활동이 이어지며 국내의 경우 기존 학자에 이어 도일 유학생들에 의한 연구조사가 실시되었다. 나아가 조사 지역 및 연구 범위가 확대되어 연구자의 양적 증가가 이루어진 시기이기도 하다. 일본 소재 한국 문화재의 대여 전시가 활발히 이루어진 결과, 새로운 관심이 더욱 집중되기도 하였고 국가기관(한국국제교류재단)에서의 미흡하지만 처음으로 조사와 보고서 간행이 시작되었다. 2000년 초부터 현재까지는 1990년대 후반부터 이루어진 심화된 연구를 바탕으로 개별 작품에 대한 미시적 접근이 점차 이루어진 시기이다. 미술사 대학원에서 석사 학위 논문 주제로 일본 소재 한국 문화재를 다룬 논문이 증가되었고, 연구가 확장되어 여러 방면에 걸친 연구 인력이 배출되었다. 그러나 일반회화, 불교회화, 소수의 불교공예 정도를 제외하고 연구 분야 간 차별화 현상이 심화되는 경향을 보이게 된다. 도자 분야는 국립문화재 연구소에 의한 본격적인 한국 문화재 보고서가 간행되어 소장처별로 체계적인 보고서가 간행된 점은 괄목한만한 성과이다.

• Fisheries and Aquatic Sciences
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• 제27권3호
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• pp.145-158
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• 2024

Life history characteristics, habitat landscape, and historical events are believed to have shaped the patterns of genetic variation in many taxa. The bony lip barb, Osteohilus vittatus, represent a potamodromous fish that complete all life cycle in freshwater and is widely distributed in Southeast Asia. It usually lives in small rivers and other freshwater habitats, and movement between habitats for either food or reproduction has been typical. These life history characteristics may promote gene flow, leading to less structured populations. However, many freshwater habitats are fragmented, which restricts gene flow. We investigate how this interplay has shaped patterns of genetic variation and phylogeographic structure within this species in the Sundaland, a biodiversity hotspot with a complex geological history, using mitochondrial cytochrome oxidase I (mtCOI) as a genetic marker. Forty-six mtCOI sequences of 506 bp long were collected from ten localities, eight geographically isolated and two connected. The sequences were used for population genetic and phylogeographic analyses. Our results showed a low genetic diversity within populations but high between populations. There was a deep phylogeographic structure among geographically isolated populations but a lack of such structure in the connected habitats. Among geographically isolated populations, sequence divergence was revealed, ranging from 1.8% between Java and Sumatra populations to 12.2% between Malaysia and Vietnam. An indication of structuring was also observed among localities that are geographically closer but without connectivity. We conclude that despite high dispersal capacity, the joint effects of historical events, long-term geographic isolation associated with sea level oscillation during the Pleistocene, and restricted gene flow related to lack of habitat connectivity have shaped the phylogeographic structure within the O. vittatus over the Sundaland.