• Biomolecules & Therapeutics
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• 제6권3호
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• pp.328-336
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• 1998

The subacute oral toxicity study of DWP-311 was carried out in Sprague-Dawley rats of both sexes. We daily examined clinical signs, body weights, hematological and biochemical parameters, and histopathological examinations for 30 days after administration of DWP-311 with different dose levels (0, 0.04, 0.2, and 1.0 g/kg). There were no clinical signs and pathological changes compared with control group except slight decreases in spontaneous motor activities and locomotions at high dose group of DWP-311. Body weights were not significantly changed in animals treated with DWP-311, In histopathological examinations, there were 2 cases of pneumonia in control group for one male and one female, but it was not directly related to DWP-311. These results indicate that subacute oral toxicities of DWP-311 were low and the no-observed a dverse effect level (NOAEL) was considered to be 1.0 g/kg in rats.

• Toxicological Research
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• 제12권2호
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• pp.323-330
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• 1996

Subacute toxicity study was performed in Sprague-Dawley rats after daily oral administration of KDRD-002 0.23, 0.7, 2.1 g/kg for one month. There were no clinical signs and pathological changes compared with control group but slight decrease in spontaneous motor activities and locomotions at high dose group of KDRD-002. Body weights were not significantly changed between control and KDRD-002 treated groups. In histopathological examinations, however, two animals (1 male, 1 female) showed abnormal increases in the weights of spleen tissues at middle dose group of KDRD-002. Also, there were some hemorrhages in lung tissues at low dose group of KDRD-002, but it was not considered to be caused by KDRD-002. These results suggest that KDRD-002 does not induce any significant subacute oral toxicity in Sprague-Dawley rats.

• 한국임상수의학회지
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• 제20권4호
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• pp.458-466
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• 2003

The bone regeneration effects of copper oxide on experimentally induced fibular fracture were examined in 36 New Zealand white male rabbits. They were divided into two groups: non-treated group (control group) and copper oxide treated group (treatment group). A fibular fracture was created by an osteotomy in the middle of the fibula and 62.5 mg/kg of copper oxide was orally administrated during 7 days after operation in the treatment group. Radiological findings, histopathological examinations and hematoserological findings were observed to evaluate the bone regeneration effects of copper oxide on fibula fracture during 9 weeks. In radiological findings, the area of bone regeneration at the fracture site of the treatment group was significantly wider from 3 weeks to 6 weeks after administration of copper oxide than those of the control group (p < 0.05). In histopathological examinations, fracture healing in treatment group was faster than in control group. Also, histopathological responses of thick bony trabeculae and new bone marrow formation were shown in the treatment group, whereas many fibrous tissues and cartilages were mainly observed in the control group. No specific effects of copper oxide on the body was found in hematological and serological test during experimental period. These results showed that the copper oxide had a potential therapeutic application in the treatment of fracture and bone trauma.

• Imaging Science in Dentistry
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• 제49권3호
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• pp.201-208
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• 2019

Purpose: The aim of this study was to evaluate the characteristic features of oral and maxillofacial swellings that could be seen on ultrasonographic examinations. Materials and Methods: Fifty patients with oral and/or maxillofacial swellings were randomly selected, thorough case histories and clinical examinations were done, ultrasonographic examinations with Doppler imaging were performed, and the features of every group were studied. Finally, histopathological evaluations were performed to identify the final diagnosis, according to which patients were classified into 5 groups; group I: inflammatory/space infection and abscess swellings, group II: cystic swellings, group III: lymph node swellings, group IV: benign swellings, and group V: malignant neoplastic swellings. Results: A significant association (P<0.05), with a contingency coefficient of 0.88, was found between the histopathological and ultrasonographic diagnoses, with ultrasonography having a diagnostic accuracy of 89% in diagnosing maxillofacial swellings. The diagnostic accuracy of ultrasonography was 100% for lymph node and malignant swellings, followed by 98% for inflammatory and cystic swellings and 92% for benign swellings. The sensitivity of the ultrasonographic diagnosis was 100% for cystic, lymph node, and malignant swellings, followed by 91% for inflammatory swellings and 86% for benign swellings. Conclusion: Ultrasonographic features with Doppler imaging greatly aid in obtaining accurate diagnoses of oral and maxillofacial swellings. Ultrasonography is a recommended imaging tool for differentiating maxillofacial swellings and classifying them accurately.

• 대한수의사회지
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• 제9권1호
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• pp.4-11
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• 1965

Histopathological examinations were carried out on the swine tonsils from 175 randomely selected pigs at Ist Seoul Abattoir. Macroscopically, tiny miliary or rice size abscesses were recognized on 86 cases(49. 1$\%$) out of examined 175 cases.

• 한국정보통신학회논문지
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• 제18권2호
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• pp.351-356
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• 2014

최근 들어 검체 관리의 부실 및 병리 정보의 불일치 등으로 의료사고가 증가하고 있다. 또한, 향후 불치병 치료와 신약 개발의 결과 검증을 위해 많은 병기 조직의 수요가 예측되며, 환자의 병력, 투약 정보, 검사결과에 따른 맞춤형 의료용 병기 관리가 필요한 실정이다. 본 논문에서는 RFID를 기반하여 U-Healthcare 환경을 지원할 수 있는 바이오 병리조직 통합 프린팅 시스템을 제안하였다. 바이오 병리조직의 검사, 관리 시스템 지원을 통해 효율적 업무와 비용 절감 기대되며, 무엇보다도 의료사고를 원천적으로 방지할 수 있는 시스템으로 활용될 것이다.

• 한국임상수의학회지
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• 제33권5호
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• pp.286-289
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• 2016

Two dogs (Case 1: Poodle, 4 years old, spayed female; Case 2: Bulldog, 3 years old, intact female) were referred to us for treatment of vomiting; Case 1 had a history of acute vomiting that started 1 day prior to presentation, and Case 2 had a history of chronic vomiting that started 2 years prior to presentation. The vomiting did not respond to medication in the local animal hospital. Results from abdominal ultrasound examinations showed that case 1 had gastric wall thickening, and case 2 had no remarkable findings. For both cases, we performed gastrointestinal endoscopic examinations, and several biopsy samples were obtained from different gastric areas. On the basis of the results of histopathological examinations, both dogs were diagnosed with atrophic gastritis concurrent with a Helicobacter infection. Clinical signs improved after antibiotic therapy. This case report describes the clinical, endoscopic, and histopathological findings of atrophic gastritis concurrent with a Helicobacter infection.

• Biomolecules & Therapeutics
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• 제1권2호
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• pp.262-265
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• 1993

Acute toxicities of DWH-01 (Ranitidine : Bismuth : Sucralfate= 1.5: 2 : 6) were investigated in Sprague-Dawley rats. Seven days after oral administration of DWH-01 with different doses (10 g/kg, 5 g/kg, 2.5 g/kg, 1.25 g/kg, 0.625 g/kg), we examined numbers of deaths, general signs, weight measurement and histopathological examination for both sexes of rats. Summaried results are: 1) No deaths were occurred, 2) There were no pathological and clinical differences compared with control group, 3) No significant changes of body weights were observed, and 4) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group for male and female respectively, but it was thought to be caused by environmental factor. The results suggest that toxicity of DWH-01 is low and its $LD_{50}$ is over 10 g/kg in Sprague-Dawley rats.

• Journal of Oral Medicine and Pain
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• 제10권1호
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• pp.41-52
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• 1985

In order to observe the histopathological changes with the progress of time after formation of bite-mark, experimental bite-marks were made in female rats and histopathological examinations were performed in the given sites immediately, 5 minutes, 10 minutes, 30 minutes, I hr., 4 hrs., 8 hrs., 12 hrs., 24 hrs., and 48 hrs, after injury. Results and Summary 1. Subcutaneous loose connective tissues and fatty layers were compressed immediately after formation of bite-marks, injured epithelia showed hydropic degeneration 5 minutes later. 2. Inflammatory cells emigrated into tissues with hemorrhages in the tissues after 10 minutes, and more increased centered around the blood vessels.- These distributed most densely in the tissues, after 12 hrs., thereafter, were decreased and distributed in various groups of crowdy appearances, after 48 hrs. 3. After 10 minutes, neutrophils emigrated into tissues and disappeared gradually with an appearance of monocytes. These disappeared completely, after 24 hrs. Lymphocytes and plasma cells were see n at 48 hrs. later. 4. Adherence of mast cells to injured sites occurred immediately, and which adhered to blood vessel walls of injured sites, after 10 minutes. 8 hrs. later, degranulation in emigrated inflammatory cells showed, and these degranulation disappeared gradually with a progress of time.

• Parasites, Hosts and Diseases
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• 제46권4호
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• pp.229-234
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• 2008

The prevalence of Sarcocystis spp. was investigated by gross and histopathological examinations in 250 camels (Camelus dromedarius) slaughtered from 2002 to 2005 in the Mashhad Slaughterhouse, eastern Iran. Samples were taken from the diaphragm, heart, tongue, esophagus and masseter muscles for histopathological studies. No macroscopic sarcocysts were found in the samples at gross inspection. Sarcocysts were detected in 209 of 250 (83.6%) examined camels at histopathological level. The infection rate of the esophagus, heart, masseter muscles, diaphragm, and tongue was 58.8%, 48.0%, 46.8%, 41.6%, and 28.0%, respectively. There was no significant difference in the rate of infection between male (85.8%) and female (81.0%) camels. The tissue response to vital cysts was minimal; however, reaction to the degenerating cysts was severe and caused tissue damages resulting in hyperemia, hemorrhages, mononuclear cell infiltration, necrotic changes, and fibrosis. The wild and domestic carnivores especially dogs may be the final hosts of Sarcocystis spp. in this area.