• Title/Summary/Keyword: High-risk group

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Effect of Weight-Related Concerns and Dietary Behavior on Eating Disorder Risk in Korean Women

  • Kim, Jung-Hyun;Lim, Yun-Sook;Jun, In-Kyung
    • International Journal of Human Ecology
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    • v.9 no.1
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    • pp.97-106
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    • 2008
  • This study investigated the relationships between eating disorder risk, body image perception, weight control, and dietary habits in Korean women. Body shape perception, the Eating Attitude Test (EAT-26) and dietary habit information were collected by a self-administered questionnaire to 373 adult women and the data were analyzed by the Chi-square test. 31.4% of the women were classified in the eating disorder group by a score of over 20 points on the EAT-26. Compared to the normal group, more women in the eating disorder risk group perceived that a thin body shape was the ideal body shape and were dissatisfied with their body shape. This group was also more interested in weight control and more likely to try weight control methods. The eating disorder risk group was more likely to skip meals and snacks than the normal group. In addition, they had a greater appetite and a higher frequency of overeating than the normal group. Over 30% of the Korean women surveyed were categorized at high risk of eating disorders. They were more likely to overestimate body weight and shape and tried to control their weight by inappropriate methods. To prevent eating disorders in adult women, nutrition education programs should incorporate strategies to change inaccurate self-body image and to disseminate information about healthy weight control methods.

Classification of Microsatellite Alterations Detected in Endoscopic Biopsy Specimens of Gastric Cancers (단순반복염기서열의 변이 형태에 따른 위암 내시경 조직의 유전자형 분류)

  • Choi Young Deok;Choi Sang Wook;Jeon Eun Jeong;Jeong Jeong Jo;Min Ki Ouk;Lee Kang Hoon;Lee Sung;Rhyu Mun Gan
    • Journal of Gastric Cancer
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    • v.4 no.2
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    • pp.109-120
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    • 2004
  • Purpose: Individual gastric cancers demonstrate complicated genetic alterations. The PCR-based analysis of polymorphic microsatellite sequences on cancer-related chromosomes has been used to detect chromosomal loss and microsatellite instability. For the purpose of preoperative usage, we analyzed the correspondance rate of the microsatellite genotype between endoscopic biopsy and surgical specimens. Materials and Methods: Seventy-three pairs of biopsy and surgical specimens were examined for loss of heterozygosity and microsatellite instability by using 40 microsatellite markers on eight chromosomes. Microsatellite alterations in tumor DNAs were classified into a high-risk group (baselinelevel loss of heterozygosity: 1 chromosomal loss in diffuse type and high-level loss of heterozygosity: 4 or more chromosomal losses) and a low-risk group (microsatellite instability and low-level loss of heterozygosity: 2 or 3 chromosomal losses in diffuse type or $1\∼3$ chromosomal losses in intestinal type) based on the extent of chromosomal loss and microsatellite instability. Results: The chromosomal losses of the biopsy and the surgical specimens were found to be different in 21 of the 73 cases, 19 cases of which were categorized into a genotype group of similar extent. In 100 surgical specimens, the high-risk genotype group showed a high incidence of nodal involvement (19 of 23 cases: $\leq$5 cm; 23 of 24 cases: >5 cm) irrespective of tumor size while the incidence of nodal involvement for the low-risk genotype group depended on tumor size (5 of 26 cases: $\leq$5 cm; 18 of 27 cases: >5 cm). Extraserosal invasion was more frequent in large-sized tumor in both the high-risk genotype group ($\leq$5 cm: 12 of 23 cases; >5 cm: 23 of 24 cases) and the low-risk genotype group ($\leq$5 cm: 7 of 26 cases; >5 cm: 16 of 27 cases). The preoperative prediction of tumor invasion and nodal involvement based on tumor size and genotype corresponded closely to the pathologic tumor stage (ROC area >0.7). Conclusion: An endoscopic biopsy specimen of gastric cancer can be used to make a preoperative genetic diagnosis that accurately reflect the genotype of the corresponding surgical specimen.

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Thrombocytopenia in Moderate- to High-Risk Sutureless Aortic Valve Replacement

  • Thitivaraporn, Puwadon;Chiramongkol, Sarun;Muntham, Dittapol;Pornpatrtanarak, Nopporn;Kittayarak, Chanapong;Namchaisiri, Jule;Singhatanadgige, Seri;Ongcharit, Pat;Benjacholamas, Vichai
    • Journal of Chest Surgery
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    • v.51 no.3
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    • pp.172-179
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    • 2018
  • Background: This study aimed to compare preliminary data on the outcomes of sutureless aortic valve replacement (SU-AVR) with those of aortic valve replacement (AVR). Methods: We conducted a retrospective study of SU-AVR in moderate- to high-risk patients from 2013 to 2016. Matching was performed at a 1:1 ratio using the Society of Thoracic Surgeons predicted risk of mortality score with sex and age. The primary outcome was 30-day mortality. The secondary outcomes were operative outcomes and complications. Results: A total of 277 patients were studied. Ten patients (50% males; median age, 81.5 years) underwent SU-AVR. Postoperative echocardiography showed impressive outcomes in the SU-AVR group. The 30-day mortality was 10% in both groups. In our study, the patients in the SU-AVR group developed postoperative thrombocytopenia. Platelet counts decreased from $225{\times}10^3/{\mu}L$ preoperatively to 94.5, 54.5, and $50.1{\times}10^3/{\mu}L$ on postoperative days 1, 2, and 3, respectively, showing significant differences compared with the AVR group (p=0.04, p=0.16, and p=0.20, respectively). The median amount of platelet transfusion was higher in the AVR group (12.5 vs. 0 units, p=0.052). Conclusion: There was no difference in the 30-day mortality of moderate-to high-risk patients depending on whether they underwent SU-AVR or AVR. Although SU-AVR is associated with favorable cardiopulmonary bypass and cross-clamp times, it may be associated with postoperative thrombocytopenia.

Alcohol Consumption and the Coronary Heart Disease-Related Risk Factors in Korean Adults;the Third Korea National Health and Nutrition Examination Survey (KNHANES III), 2005 (한국인에서 알코올 섭취가 관상동맥질환 관련 위험요인에 미치는 영향;국민건강영양조사 제3기 (2005년))

  • Park, Sung-Hee;Kang, Young-Hee;Park, Hyun-Young
    • Journal of Nutrition and Health
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    • v.41 no.3
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    • pp.232-241
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    • 2008
  • Moderate alcohol consumption has been known to be associated with reduced risk for coronary heart disease (CHD). We assessed the association between alcohol consumption and CHD-related risk factors [hypertension, diabetes mellitus (DM) , high total cholesterol, high triglyceride (TG), low HDL-cholesterol (HDL-C), and high LDL-cholesterol (LDL-C)] in Korean. After excluding those with extreme intake values, the number of final subjects included in the analysis was 4,662 Korean adults aged over 20 years (1,961 men, 2,701 women) who participate in the 2005 Korean National Health and Nutrition Examination Survey. The subjects were divided into four or five groups; none-alcohol consumption group, moderate alcohol consumption group (<15 or 15.0-29.9 g/d), heavy alcohol consumption group (30-69.9 g/d or ${\geq}$ 70 g/d in men, ${\geq}$ 30 g/d in women). Odds ratios (ORs) were estimated from logistic regression adjusting for potential covariates. Alcohol consumption was inversely associated with low HDL-C in both men and women. However, heavy alcohol intake (${\geq}$ 70 g/d) significantly increased risk for hypertension, DM, and hypertriglyceridemia in men. The frequency of alcohol intake was also associated with CHD risk. The risk for low HDLC was decreased with alcohol consumption (${\geq}$ 1 times/wk), but frequent alcohol intake (${\geq}$ 4 times/wk) increased the risk for hypertension. This study revealed that moderate alcohol consumption has protective effect on CHD-related risk factors in Korean population.

Failure Modes and Effects Analysis for Electric Power Installations of D University (D대학 수변전설비의 고장모드 영향 분석)

  • Park, Young Ho;Kim, Doo-Hyun
    • Journal of the Korean Society of Safety
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    • v.31 no.5
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    • pp.7-15
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    • 2016
  • The purpose of this paper is to carry out Failure Modes and Effects Analysis (FMEA) and use criticality in order to determine risk priority number of the components of electric power installations in Engineering college building of D university. In risk priority number, GROUP A had 7 failure modes; more specifically, Transfomer had 4 modes, Filter(C)(1 mode), LA(1 mode), and CB(MCCB)(1 mode), and thus 4 components had failure modes. In terms of criticality, high-grade group a total of 16 failure modes, and 7 components-LA(1 mode), CB(MCCB)(1 mode), MOF(2 modes), PT(1 mode), Transformer(7 modes), Cable(3 modes), and Filter(C)(1 mode)-had failure modes. Comparison of risk priority number and criticality was made. The components which had high risk priority number and high criticality were Transformer, Filter(C), LA, and CB(MCCB). The components which had high criticality were MOF and cable. In particular, Transformer(RPN: 4 modes, Criticality: 7 modes) was chosen as an intensive management component.

Self-rated Health as a Sex-based Risk Factor for Compulsion (성별에 따른 강박증상의 위험요인으로서 주관적 건강상태)

  • Kim, Yunyoung;Hyun, Hye-Sun;Jang, Eunsu
    • The Korean Journal of Health Service Management
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    • v.13 no.4
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    • pp.243-252
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    • 2019
  • Objectives: This study aimed to determine whether the self-rated health (SRH) could be a risk factor for compulsion. Methods: Data related with compulsion and SRH information were collected from 532 young adults aged over 20 years in South Korea. The distribution of the high and low SRH groups was analyzed using the chi-square test, whereas difference in quality of life (QoL) was analyzed using the t-test. Logistic regression was used to analyze the odds ratio (OR). Results: In the high and low-SRH groups, 44 (28.8%) and 23 (31.5%) men and 24 (10.4%) and 21 (27.6%) women, respectively, were at risk for compulsion (p<.001). For women, the compulsion scores of the low and high-SRH groups, respectively, were 15.8±9.53 and 9.9±8.47 (t=5.071, p<.001). The low-SRH group had higher ORs compared with the high-SRH group among women (OR 3.277, 95% confidence interval 1.699 - 6.321, p<.001) in the original model, and this phenomenon was significant even after adjusting for age and residence type. Conclusions: Low SRH may be a risk factor for compulsion. Further research for improving SRH by developing preventive measures against compulsion is necessary.

Effects of a supportive program on uncertainty, anxiety, and maternal-fetal attachment in women with high-risk pregnancy (고위험 임부를 위한 지지적 프로그램이 불확실성, 불안, 태아 애착에 미치는 효과)

  • Kim, Hyun Jin;Chun, Nami
    • Women's Health Nursing
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    • v.26 no.2
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    • pp.180-190
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    • 2020
  • Purpose: The purpose of this study was to identify the effects of a supportive program on uncertainty, anxiety, and maternal-fetal attachment in high-risk pregnant women. Methods: The participants were 59 high-risk pregnant women admitted to the maternal-fetal intensive care unit. The control group (n=30) received usual treatment and antenatal care, while the experimental group (n=29) received an additional supportive program. Uncertainty, anxiety, and maternal-fetal attachment were measured in both groups prior to the intervention and at 3 days and 10 days after the intervention (or at discharge). Data were analyzed with the t-test, chi-square test, repeated-measures analysis of covariance, and the Greenhouse-Geisser correction in SPSS version 23.0. Results: A supportive program including information provision, nutritional care, emotional care, and exercise care was developed from the literature. All variables except women's length of stay were found to be homogeneous the between experimental and control groups in the pre-test. Length of stay was calculated as a covariate for testing hypotheses. There was a significant difference in state anxiety over time between the two groups, while there were no differences in uncertainty or maternal-fetal attachment. Conclusion: This supportive program was identified as an effective nursing intervention on state anxiety in high-risk pregnant women during their stay in the maternal-fetal intensive care unit. It is suggested that nurses could apply this program to alleviate high-risk pregnant women's state anxiety, and that this program could be modified to be more effective on uncertainty and maternal-fetal attachment in high-risk pregnant women.

Organic solvent exposure for the chronic kidney disease: updated systematic review with meta-analysis

  • Chaeseong Lim;Hyeoncheol Oh
    • Annals of Occupational and Environmental Medicine
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    • v.35
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    • pp.11.1-11.17
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    • 2023
  • Background: Studies on the relationship between organic solvent exposure and chronic kidney disease (CKD) have presented inconsistent results. Definition of CKD has changed in 2012, and other cohort studies have been newly published. Therefore, this study aimed to newly confirm the relationship between organic solvent exposure and CKD through an updated meta-analysis including additional studies. Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search was conducted on January 2, 2023 using Embase and MEDLINE databases. Case-control and cohort studies on the relationship between organic solvent exposure and CKD were included. Two authors independently reviewed full-text. Results: Of 5,109 studies identified, a total of 19 studies (control studies: 14 and cohort studies: 5) were finally included in our meta-analysis. The pooled risk of CKD in the organic solvent exposed group was 2.44 (1.72-3.47). The risk of a low-level exposure group was 1.07 (0.77-1.49). The total risk of a high-level exposure group was 2.44 (1.19-5.00). The risk of glomerulonephritis was 2.69 (1.18-6.11). The risk was 1.46 (1.29-1.64) for worsening of renal function. The pooled risk was 2.41 (1.57-3.70) in case-control studies and 2.51 (1.34-4.70) in cohort studies. The risk of subgroup classified as 'good' by the Newcastle Ottawa scale score was 1.93 (1.43-2.61). Conclusions: This study confirmed that the risk of CKD was significantly increased in workers exposed to mixed organic solvents. Further research is needed to determine the exact mechanisms and thresholds. Surveillance for kidney damage in the group exposed to high levels of organic solvents should be conducted.

A Randomized Controlled Trial To Motivate Worksite Fecal Occult Blood Testing (암위험사정이 직장인의 혈변검사에 미친 영향에 관한 실험연구)

  • 이정렬
    • Journal of Korean Academy of Nursing
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    • v.20 no.3
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    • pp.300-306
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    • 1990
  • Colorectal cancer is second only to lung cancer as a cause of death due to cancer in the united States. Studies have shown that fecal occult blood(FOB) tests are effective in detecting colorectal cancer in its early stages. To motivate worksite FOB testing, a randomized controlled trial was conducted. Employees 40 years or older from three federal agencies in Washington State were randomized to a control group(n=139) which received a letter stating the availability of the FOB test at the worksite clinic or to an intervention group(n=139) which received the letter about facts on colorectal cancer and a Colorectal Cancer Risk Appraisal. The Colorectal Cancer Risk Appraisal included a feedback on an individual's risk of developing colorectal cancer compared to his / her peers in terms of ‘normal’, ‘moderate’, or ‘high’ risk status. After 3 months, a follow-up questionnaire was sent to all participants to measure the effectiveness of the intervention. In the analysis of the three major outcomes, two possible confounding factors(dietary fat and family history of colorectal cancer) were controlled by logistic regression. Based on a review of the worksite clinic records, the Intervention group had 4.3% higher compliance rate with the FOB test during the follow-up period compared to the control group(p=.10). The largest effect of the intervention was on the employees' intention to get a FOB test within the next year(62.6% in the intervention group vs. 36.2% in the control group, OR=3.18, p<.001). In the final Multivariate logistic model, the employees who were more likely to intend to get a FOB test within the next year were in the intervention group ; were at ‘moderate’ or ‘high’ risk of colorectal cancer ; knew more about the availability of the FOB test at the worksite clinic ; and had a FOB test during the last three years.

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Risk Stratification for Serosal Invasion Using Preoperative Predictors in Patients with Advanced Gastric Cancer

  • Park, Sung-Sil;Min, Jae-Seok;Lee, Kyu-Jae;Jin, Sung-Ho;Park, Sunhoo;Bang, Ho-Yoon;Yu, Hwang-Jong;Lee, Jong-Inn
    • Journal of Gastric Cancer
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    • v.12 no.3
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    • pp.149-155
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    • 2012
  • Purpose: Although serosal invasion is a critical predisposing factor for peritoneal dissemination in advanced gastric cancer, the accuracy of preoperative assessment using routine imaging studies is unsatisfactory. This study was conducted to identify high-risk group for serosal invasion using preoperative factors in patients with advanced gastric cancer. Materials and Methods: We retrospectively analyzed clinicopathological features of 3,529 advanced gastric cancer patients with Borrmann type I/II/III who underwent gastrectomy at Korea Cancer Center Hospital between 1991 and 2005. We stratified patients into low-(${\leq}40%$), intermediate-(40~70%), and high-risk (>70%) groups, according to the probability of serosal invasion. Results: Borrmann type, size, longitudinal and circumferential location, and histology of tumors were independent risk factors for serosal invasion. Most tumors of whole stomach location or encircling type had serosal invasion, so they belonged to high-risk group. Patients were subdivided into 12 subgroups in combination of Borrmann type, size, and histology. A subgroup with Borrmann type II, large size (${\geq}7$ cm), and undifferentiated histology and 2 subgroups with Borrmann type III, large size, and regardless of histology belonged to high-risk group and corresponded to 25% of eligible patients. Conclusions: This study have documented high-risk group for serosal invasion using preoperative predictors. And risk stratification for serosal invasion through the combination with imaging studies may collaboratively improve the accuracy of preoperative assessment, reduce the number of eligible patients for further staging laparoscopy, and optimize therapeutic strategy for each individual patient prior to surgery.