• 제목/요약/키워드: High recurrence rate

검색결과 441건 처리시간 0.037초

Increased Hypermethylation of Glutathione S-Transferase P1, DNA-Binding Protein Inhibitor, Death Associated Protein Kinase and Paired Box Protein-5 Genes in Triple-Negative Breast Cancer Saudi Females

  • Hafez, Mohamed M.;Al-Shabanah, Othman A.;Al-Rejaie, Salim S.;Al-Harbi, Naif O.;Hassan, Zeinab K.;Alsheikh, Abdulmalik;Theyab, Abdurrahman I. Al;Aldelemy, Meshan L.;Sayed-Ahmed, Mohamed M.
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권2호
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    • pp.541-549
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    • 2015
  • Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with higher metastatic rate and both local and systemic recurrence compared to non-TNBC. The generation of reactive oxygen species (ROS) secondary to oxidative stress is associated with DNA damage, chromosomal degradation and alterations of both hypermethylation and hypomethylation of DNA. This study concerns differential methylation of promoter regions in specific groups of genes in TNBC and non-TNBC Saudi females in an effort to understand whether epigenetic events might be involved in breast carcinogenesis, and whether they might be used as markers for Saudi BCs. Methylation of glutathione S-transferase P1 (GSTP1), T-cadherin (CDH13), Paired box protein 5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-${\beta}$ ($RAR{\beta}1$) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin-fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), TNBC (80) and non-TNBC (100). The relationships between methylation status, and clinical and pathological characteristics of patients and tumors were assessed. Higher frequencies of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 hypermethylation were found in TNBC than in non-TNBC. Hypermethylation of GSTP1, CDH13, ID4, DAPK, HIN-1 and PAX5 increased with tumor grade increasing. Other statistically significant correlations were identified with studied genes. Data from this study suggest that increased hypermethylation of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 genes in TNBC than in non-TNBC can act as useful biomarker for BCs in the Saudi population. The higher frequency of specific hypermethylated genes paralleling tumor grade, size and lymph node involvement suggests contributions to breast cancer initiation and progression.

뇌성 마비를 동반한 악안면 기형 환자의 치험례 (TREATMENT OF DENTOFACIAL DEFORMITY PATIENT WITH CEREBRAL PALSY)

  • 김기호;박성연;이충국
    • 대한장애인치과학회지
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    • 제2권1호
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    • pp.39-44
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    • 2006
  • Cerebral palsy(CP) is one of the most common motor disease, due to brain injury during fetal and neonatal development which results in neuromotor paralysis and associated neuromuscular symptoms. Features of CP include motor disability due to the lack of muscle control, often accompanied by sensory disorders, mental retardation, speech disorders, hearing loss, epilepsy, behavior disorders, etc. There are increasing chances of treatment of dental patients with cerebral palsy, as the occurrence of CP is increasing with the decrease in infant mortality and an increase in immature birth and premature birth and also, there is a trend to pursue of higher quality of life. Reports on the relationship between CP and maxillofacial deformity are uncommon, but it is well known that the unbalance and discontrol of the facial muscles, lip, tongue and the jaws leads to malocclusion and temporomandibular joint disorders, and statistics show that class 2 relationship of the jaws and open bite is frequently reported. However, it is difficult to perform maxillofacial deformity treatment, which consists of orthodontic treatment, maxillofacial surgery and muscle adaptation training, due to difficulties in communication and problems of muscle adaptation caused by difficulties in motor control which leads to a high recurrence rate. This case report is to trearment of maxillofacial deformity in CP patient. A 26 year old female patient came to the department with the chief complaint of prognathism of the mandible and facial asymmetry. According to the past medical history, she was diagnosed as cerebral palsy 1 week after birth, classified as GMFC, classII accompanied with left side torticollis. The patient's intelligence was moderate, and there were no serious problems in communication. For two years time, the patient underwent lingual frenectomy, pre-operation orthodontic treatment and then bimaxillary orthognathic surgery to treat mandibular prognathism and facial asymmetry followed by rehabilitatory exercise of facial muscle. After 6 months of follow up, there was a good result. This is to report to the typical signs and symptoms of DFD in CP patient and the limitation of the usual method of the treatment of DFD in CP patient with literature review.

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수술 절제를 시행받은 제1기 비소세포폐암 환자에서의 Fascin 발현과 예후 (Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer)

  • 노미숙;엄수정;최영민;김기남;최필조;이수걸;손춘희;양두경
    • Tuberculosis and Respiratory Diseases
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    • 제65권2호
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    • pp.105-109
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    • 2008
  • 연구배경: Fascin은 세포 운동에 관여하는 액틴 결합 단백질로서 정상적인 상피세포에는 증가되어 있지 않으며, 일부 악성종양에서 fascin이 증가되어 있다는 보고가 있다. 본 연구는 비소세포폐암 환자의 조직에서 fascin 발현을 조사하고 fascin이 예후 인자로 역할을 하는지를 알아보고자 하였다. 방 법: 제 1기 비소세포폐암으로 근치적 절제수술을 받고 추적조사가 가능했던 환자 81명의 조직에서 fascin 발현을 면역조직화학 염색 방법으로 조사하였다. 결 과: Fasin 발현은 전체 81예 중 59예(73%)에서 양성이었다. Fascin 발현 정도에 따른 5년 생존율은 fascin 발현 음성군에서 68%, fascin 저발현군에서 76%, fascin고발현군에서 79%으로 각 군간에 유의한 차이가 없었다(p=0.86). 결 론: Fascin발현이 비소세포폐암으로 근치적 수술을 받은 환자에서 예후 인자로서 역할을 하는지 알아보았으나 통계학적으로 유의한 관련성이 없었다.

PU.1 Is Identified as a Novel Metastasis Suppressor in Hepatocellular Carcinoma Regulating the miR-615-5p/IGF2 Axis

  • Song, Li-Jie;Zhang, Wei-Jie;Chang, Zhi-Wei;Pan, Yan-Feng;Zong, Hong;Fan, Qing-Xia;Wang, Liu-Xing
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권9호
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    • pp.3667-3671
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    • 2015
  • Invasion and metastasis is the major cause of tumor recurrence, difficulty for cure and low survival rate. Excavating key transcription factors, which can regulate tumor invasion and metastasis, are crucial to the development of therapeutic strategies for cancers. PU.1 is a master hematopoietic transcription factor and a vital regulator in life. Here, we report that, compared to adjacent non-cancerous tissues, expression of PU.1 mRNA in metastatic hepatocellular carcinoma (HCC), but not primary HCC, was significantly down-regulated. In addition, levels of PU.1 mRNA in metastatic hepatoma cell lines MHCC97L and MHCC97H were much lower than in non-metastatic Hep3B cells. Transwell invasion assays after PU.1 siRNA transfection showed that the invasion of hepatoma cell lines was increased markedly by PU.1 knockdown. Oppositely, overexpression of PU.1 suppressed the invasion of these cells. However, knockdown and overexpression of PU.1 did not influence proliferation. Finally, we tried to explore the potential mechanism of PU.1 suppressing hepatoma cell invasion. ChIP-qPCR analysis showed that PU.1 exhibited a high binding capacity with miR-615-5p promoter sequence. Overexpression of PU.1 caused a dramatic increase of pri-, pre- and mature miR-615-5p, as well as a marked decrease of miR-615-5p target gene IGF2. These data indicate that PU.1 inhibits invasion of human HCC through promoting miR-615-5p and suppressing IGF2. These findings improve our understanding of PU.1 regulatory roles and provided a potential target for metastatic HCC diagnosis and therapy.

ST 분절 급상승 심근경색 환자들의 단기 재발 사망 예측 (Short-term Mortality Prediction of Recurrence Patients with ST-segment Elevation Myocardial Infarction)

  • 임광현;류광선;박수호;손호선;류근호
    • 한국컴퓨터정보학회논문지
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    • 제17권10호
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    • pp.145-154
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    • 2012
  • 현대 사회는 서구화된 식생활 패턴과 흡연, 비만 등의 원인으로 인해 심혈관계 질환들이 급증하고 있다. 특히, 급성심근경색은 심혈관계 질환으로 인한 사망의 대부분을 차지하고 있다. 이러한 추세에 따라 해외 선진국에서는 임상생리학적 오류를 줄이기 위해서 자국민의 데이터를 기반으로 급성심근경색의 발병 및 질병에 영향을 미치는 위험인자를 찾는 연구가 활발히 진행되고 있다. 하지만 한국인에 적합한 급성심근경색 예후 진단 예측 시스템이 미비한 실정이다. 따라서 이 논문에서는 KAMIR(Korea Acute Myocardial Infarction Registry) 데이터베이스에서 제공 받은 급성심근경색 환자의 예후 데이터를 기반으로 ST분절 급상승 심근경색 재발 환자들의 단기 사망률 예측모델을 찾고자 한다. 실험을 통해 로지스틱 회귀 분석에 의해 추출된 속성 집합을 적용하였을 때 기존의 원시 데이터 보다 높은 정확도를 얻을 수 있었으며, 인공신경망의 경우 다른 분류기법들보다 높은 성능을 보였다. 이를 통해 ST 분절 급상승 심근경색 재발 환자들의 단기 사망률을 예측함으로써 향후 고위험군 환자들의 관리에 도움을 줄 수 있을 것으로 기대한다.

상대정맥을 침범한 흉부종양의 수술적 치료 (Superior Vena Cava Resection and Reconstruction in Thoracic Malignancy)

  • 한국남;강창현;김영태;전상훈;성숙환;김주현
    • Journal of Chest Surgery
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    • 제43권3호
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    • pp.273-279
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    • 2010
  • 배경: 상대정맥을 침범한 흉부 종양의 수술은 종양의 병기가 진행된 상태로 인하여 수술적 치료에 대한 보고가 흔하지 않았다. 본 연구에서는 상대정맥 침범 종양의 수술적 치료 결과에 대한 후향적 고찰을 시행하고자 하였다. 대상 및 방법: 2000년 5월부터 2009년 5월까지 상대정맥을 침범한 흉부 종양으로 본원에서 상대정맥의 부분 혹은 완전 절제술을 받은 환자 18명을 대상으로 하였고 성별은 남자 10명, 여자 8명, 수술 당시 평균 연령은 56.6세였다. 결과: 수술 방법은 Polytetrafluoroethylene (PTFE)도관을 이용한 재건술이 9예, 일차봉합이 6예, 첩포 성형술이 3예에서 시행되었다. 재원기간 중앙값은 14.5일(6~61), 추적 관찰기간 중앙값은 23개월(1~88)이었다. 전체 악성 종양 환자의 3년 생존율은 58.0%, 생존기간의 중앙값은 24.5개월이었다. 폐암, 종격동 종양에 따른 생존율과 무병율의 차이는 뚜렷하지 않았다. 상대정맥 재건술을 시행한 환자 중 1명에서 주도관인 상대정맥 도관의 폐쇄가 발생하였고 3명에서 부도관인 무명정맥 도관의 폐쇄가 발생하였다. 결론: 상대정맥을 침범한 폐암과 종격동 종양은 수술적 절제로 효과적으로 치료될 수 있었으며, 여러 가지 수술 후 합병증에도 불구하고 좋은 장기 생존율을 보여 이러한 환자 군에서 적극적인 수술적 치료가 고려되어야 한다고 판단된다.

무릎관절의 미만형 색소 융모 결절성 활액막염에서 관절경을 이용한 육안적 활액막 전 절제술 후 방사선치료: 증례보고 (Combined Arthroscopic Gross Total Synovectomy and Radiotherapy for Diffuse Pigmented Villonodular Synovitis of the Knee: A Report of 2 Cases)

  • 장세경;김재화;하두회;강혜운;정소영;신현수
    • Radiation Oncology Journal
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    • 제24권3호
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    • pp.201-206
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    • 2006
  • 색소 융모 결절성 활액막염(pigmented villonodular synovitis, PVNS)은 병인이 밝혀지지 않은 증식성 질환으로, 병변의 범위에 따라 국소형과 미만형으로 분류되며, 조직학적으로 양성이지만 파괴적인 성향을 보이므로 연골의 파괴나 주위 조직으로 광범위한 침윤이 가능한 질환이다. 활액막 절제술이 일차적인 치료방법이지만 미만형인 경우에는 주위 조직을 침윤하는 성향 때문에 재발률이 높다. 재발이 반복된 후에는 수술적 절제가 어려워져서 병변부위의 절단이 필요하게 되므로, 광범위한 병변인 경우, 수술이 용이하지 않은 경우, 또는 불완전 절제가 시행된 경우 등에서 방사선치료를 시행하여 재발을 방지할 수 있다고 보고되고 있다. 저자들은 무릎관절의 미만형 색소 융모 결절성 활액막염으로 관절경을 이용한 육안적 활액막 전 절제술 후 방사선치료를 시행한 2예를 경험하였기에 문헌고찰과 함께 보고하고자 한다.

뇌졸중 환자를 위한 팀접근 재활프로그램의 효과 (The Effect of a Multidisciplinary Team Approach on the Rehabilitation of Stroke Survivors)

  • 조복희
    • 재활간호학회지
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    • 제6권2호
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    • pp.137-151
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    • 2003
  • The purpose of this study was to develop a multidisciplinary team approach program for stroke survivors, and to identify its effects on their rehabilitation. The team was composed of 7 members: a rehabilitation nurse, a physician, a physical therapist, an occupational therapist, a therapeutic recreational therapist, a nutritionist, and a researcher. A quasi-experimental study was performed with 36 subjects: 18 in the experimental group and 18 in the control group, using a noneqivalent control group pretest-posttest design. The experimental group participated 4 times in rehabilitation programsfocused on information and emotional support provided by the rehabilation team-and received telephone counseling from the researcher. The control group did not receive any treatment. The selection criteria for the subjects in this study were: (a) patients who were diagnosed as having had an ischemic stroke within the last year, (b) patients free of any communication disorder, (c) and those having a primary caregiver who could assist in filling out the form assessing the level of ADL. The data were collected from patients who had been discharged from a tertiary hospital, between October 1st, 1999 and September 30th, 2000. The data were analysed by $X^2$ test, Fisher's exact test, ANCOVA, Wilcoxon's rank sum test, and Wilcoxon's signed rank test using an SAS program. The results were as follows: 1. In terms of physical variables (blood pressure, grasp power, and ADL) 1) There was a significant difference in blood pressure between the two groups (systolic pressure P= .012, diastolic pressure P= .050). 2) There was also a significant difference in grasp power between the two groups (affected side : P= .012, unaffected side : P= .010). 3) There was no significant change in the level of ADL between the two groups. 2. In terms of psychosocial variables (depression, self-efficacy, self-esteem, and social activities) 1) There were no significant differences between the two groups. However, all four psychosocial variables showed a tendency to improve in the experimental group, while only two variables (depression and self-efficacy) showed a simalar tendency in the control group. 2) The level of social activities in the control group decreased significantly after a month (P= .050). 3. The level of life satisfaction improved in both groups, but no significant difference was found. Stroke has high recurrence rate and requires considerable follow-up care. The program used in this study was developed and designed for stimulting the rehabilitation process of stroke survivors. Through the program period of one month (meetings were held weekly), a positive effect was detected in physical variables, although the psychosocial variables did not improve significantly. In retrospect, a one month period may not be an adequate length of time to improve the psychosocial variables, as the stroke survivors were complicated cases, and most of them were elderly. Further research is therefore recommended by increasing the length of program, so that its effect can be more noticeable.

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법랑모세포섬유종에 의한 하악 제1대구치의 맹출 장애 (ERUPTION DISTURBANCE OF THE LOWER LEFT FIRST PERMANENT MOLAR CAUSED BY AMELOBLASTIC FIBROMA)

  • 김승혜;송제선;손흥규;최형준;이제호
    • 대한소아치과학회지
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    • 제37권1호
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    • pp.102-108
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    • 2010
  • 매복이란 맹출로 상에 물리적 장애물이 있거나, 치아의 비정상적 위치, 또는 공간 부족 등으로 인해 맹출이 정지되는 경우이다. 이는 과잉치, 치성 종양, 또는 낭성 병소의 존재와 연관되어 나타나기도 하는데, 법랑모세포섬유종은 이러한 매복을 일으킬 수 있는 치성 종양의 한 종류이다. 법랑모세포섬유종은 많은 경우 미맹출 치아나 매복치와 연관되어 나타나며, 병소의 크기 및 양상, 그리고 환자의 연령을 고려하여 보존적 절제술(conservative resection) 또는 완전 절제술(block resection)을 시행한다. 본 증례는 하악 좌측 제1대구치의 맹출 장애를 주소로 내원한 환아에서 외과적 노출술 및 변형된 halterman 장치를 사용한 교정적 견인을 통하여 양호한 결과를 얻었기에 보고하는 바이다. 매복의 원인이었던 법랑모세포섬유종의 비교적 높은 재발률 및 악성 전환 가능성을 고려하여 추후 장기적인 추적검사가 필요할 것으로 사료된다.

대내전근 천공지 도상 피판을 이용한 좌골부 연부조직결손의 재건 (Reconstruction of Ischial Soft Tissue Defects using Adductor Magnus Perforator Island Flap)

  • 김의식;박장완;황재하;김광석;이삼용
    • Archives of Plastic Surgery
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    • 제36권5호
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    • pp.559-564
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    • 2009
  • Purpose: Surgical reconstruction of an ischial soft tissue defect presents a challenging problem owing to a high rate of recurrence, especially paraplegic patients. Although various muscle, musculocutaneous and fasciocuta - neous flaps have been used in the reconstruction of ischial soft tissue defect, it is still debated which type of flaps are the best. We had performed a relatively durable adductor magnus perforator island flap based on the perforators originated from the first medial branch of the profunda femoris artery for coverage of ischial soft tissue defect where was not a region universally reconstructed by perforator flap. Methods: From August 2005 until January 2008, the adductor magnus perforator island flap had been used for resurfacing of the ischial soft tissue defects in a series of 6 patients (4 male and 2 female). Ages ranged from 26 to 67 years (mean, 47.5 years), and follow - up period from 13 to 26 months (mean, 16.7 months). Causes were 4 pressure ulcers, 1 cellulitis and 1 suppurative keratinous cyst. Results: The sizes of these flaps ranged from 12 to 18 cm in length and 7 to 9 cm in width. The flaps survived in all patients. Marginal loss over the distal area of the flap by infection was noted in one patient, which was treated successfully with a subsequent split - thickness skin graft. Average thickness of the flap was 0.94 cm, which was more thicker than other perforator flaps. Long term follow - up showed a good flap durability. Conclusion: In planning a reconstructive option of ischial soft tissue defect, the adductor magnus perforator island flap is a relatively large cutaneous flap with a durable thickness. With proper patient selection, careful vascular dissection and postoperative management, we recommend this flap is a good and suitable option for coverage of the ischial soft tissue defect.