Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer

수술 절제를 시행받은 제1기 비소세포폐암 환자에서의 Fascin 발현과 예후

  • Roh, Mee-Sook (Department of Pathology, Dong-A University College of Medicine) ;
  • Um, Su-Jung (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Choi, Youngmin (Department of Radiation Oncology, Dong-A University College of Medicine) ;
  • Kim, Ki-Nam (Department of Radiology, Dong-A University College of Medicine) ;
  • Choi, Pil Jo (Department of Thoracic Surgery, Dong-A University College of Medicine) ;
  • Lee, Soo-Keol (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Son, Choonhee (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Yang, Dookyung (Department of Internal Medicine, Dong-A University College of Medicine)
  • 노미숙 (동아대학교 의과대학 병리학교실) ;
  • 엄수정 (동아대학교 의과대학 내과학교실) ;
  • 최영민 (동아대학교 의과대학 방사선종양학교실) ;
  • 김기남 (동아대학교 의과대학 영상의학교실) ;
  • 최필조 (동아대학교 의과대학 흉부외과학교실) ;
  • 이수걸 (동아대학교 의과대학 내과학교실) ;
  • 손춘희 (동아대학교 의과대학 내과학교실) ;
  • 양두경 (동아대학교 의과대학 내과학교실)
  • Received : 2008.07.02
  • Accepted : 2008.07.28
  • Published : 2008.08.30
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Abstract

Background: Fascin is an actin-bundling protein that plays an important role in cellular motility. Fascin is normally expressed in the neuronal and mesenchymal cells and its expression is low or absent in the epithelia. However, an overexpression of fascin has been linked to the invasive behavior of some neoplasms such as breast, stomach and ovarian tumors. In this study, we evaluated the expression of fascin and its prognostic significance in stage I non-small cell lung cancer (NSCLC). Methods: Immunohistochemical staining for fascin was performed on the paraffin-embeded tissue sections of 81 cases of resected NSCLC. Staining of more than 5% of the tumor cells was recorded as positive immunoreactivity. Results: Fascin expression was seen in 73% (59/81) of the cases and this was more frequently seen in squamous cell carcinoma than in adenocarcinoma (93% vs 42%). There were no significant correlations of fascin immunoreactivity with tumor recurrence and overall survival. Conclusion: The expression rate of fascin was relatively high in NSCLC, but this was without prognostic significance. The exact clinical role of fascin should be defined through further investigations.

연구배경: Fascin은 세포 운동에 관여하는 액틴 결합 단백질로서 정상적인 상피세포에는 증가되어 있지 않으며, 일부 악성종양에서 fascin이 증가되어 있다는 보고가 있다. 본 연구는 비소세포폐암 환자의 조직에서 fascin 발현을 조사하고 fascin이 예후 인자로 역할을 하는지를 알아보고자 하였다. 방 법: 제 1기 비소세포폐암으로 근치적 절제수술을 받고 추적조사가 가능했던 환자 81명의 조직에서 fascin 발현을 면역조직화학 염색 방법으로 조사하였다. 결 과: Fasin 발현은 전체 81예 중 59예(73%)에서 양성이었다. Fascin 발현 정도에 따른 5년 생존율은 fascin 발현 음성군에서 68%, fascin 저발현군에서 76%, fascin고발현군에서 79%으로 각 군간에 유의한 차이가 없었다(p=0.86). 결 론: Fascin발현이 비소세포폐암으로 근치적 수술을 받은 환자에서 예후 인자로서 역할을 하는지 알아보았으나 통계학적으로 유의한 관련성이 없었다.

Keywords

References

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