• Clean Technology
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• v.13 no.4
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• pp.237-243
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• 2007

Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dimethyl ether (DME) and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing DME as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of DME and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the DME composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature.

• Ocean Systems Engineering
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• v.2 no.1
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• pp.17-31
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• 2012

This study investigated the behavior of a non-isothermal $CO_2$ bubble formed through a leak process from a high-pressure source in a deep sea. Isenthalpic interpretation was employed to predict the state of the bubble just after the leak. Three modes of mass loss from the rising bubble were demonstrated: dissolution induced by mass transfer, condensation by heat transfer and phase separation by pressure decrease. A graphical interpretation of the last mode was provided in the pressure-enthalpy diagram. A threshold pressure (17.12 bar) was identified below which the last mode was no longer present. The second mode was as effective as the first for a bubble formed in deep water, leading to faster mass loss. To the contrary, only the first mode was active for a bubble formed in a shallow region. The third mode was insignificant for all cases.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.573-573
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• 2012

High quality $VO_2$ thin films were successfully grown on GaN substrate by optimizing oxygen partial pressure during the growth using RF sputtering technique. The $VO_2$ thin film grown on GaN substrate exhibited an unusual metal insulator transition behavior, which was known to be observed only either in doped sample or under uniaxial stress. Raman spectra also confirmed that metal insulator transition occurred from monoclinic M1 to rutile R phase via monoclinic M2 phase with increasing temperature. We believe that large lattice mismatch between $VO_2$ and GaN substrate may cause M2 phase to be thermodynamically stable. Optical transmittance and its electrical switching behavior were carefully investigated to elucidate the underlying physics of its metal insulator transition behavior. This study may lead to a unique opportunity to better understand the growth mechanism of M2 phase dominant $VO_2$ thin films.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.05a
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• pp.302-308
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• 2004

• Clean Technology
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• v.13 no.1 s.36
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• pp.34-45
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• 2007

Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing dichloromethane as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of dichloromethane and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the dichloromethane composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature. The second half of this work is focused on the particle formation of the simvastatin drug by a supercritical anti-solvent recrystallization process in a cylindrical high-pressure vessel equipped with an impeller. Microparticles of the simvastatin drug were prepared as functions of pressure (8 MPa to 12 MPa), temperature (303.15 K, 313,15 K), feed flow rate of carbon dioxide, and stirring speed (up to 3000 rpm), in order to observe the effect of those process parameters on the size and shape of the drug microparticles recrystallized.

• Journal of Korean Society for Atmospheric Environment
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• v.23 no.E1
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• pp.10-15
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• 2007

The gas hydrates are probably most sensitive to climate change since they are stable only under specific conditions of high pressure and low temperature. One of the main factors responsible for formation of gas hydrates is the saturation of the gases with water vapor. Quantitative phase equilibrium data and understanding of the roles of water component in the phase behavior of the heterogeneous water-hydrocarbon-hydrate mixture are of importance and of engineering value. In this study, the water content of ethylene gas in equilibrium with hydrate and water phases were analyzed by theoretical and experimental methods at temperatures between 274.15 up to 291.75 K and pressures between 593.99 to 8,443.18 kPa. The experimental and theoretical enhancement factors (EF) for the water content of ethylene gas and the fugacity coefficients of water and ethylene in gas phase were determined and compared with each other over the entire range of pressure carried out in this experiment. In order to get the theoretical enhancement factors, the modified Redlich-Kwong equation of state was used. The Peng-Robinson equations and modified Redlich-Kwong equations of state were used to get the fugacity coefficients for ethylene and water in the gas phase. The results predicted by both equations agree very well with the experimental values for the fugacity coefficients of the compressed ethylene gas containing small amount of water, whereas, those of water vapor do not in the ethylene rich gas at high temperature for hydrate formation locus.

• Journal of computational fluids engineering
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• v.13 no.4
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• pp.126-134
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• 2008

We developed a three dimensional Navier-Stokes code based on the level set method to simulate two phase flows with high density ratio. The Navier-Stokes equations with consideration of the surface tension effects are solved by using SIMPLE algorithm on a non-staggered grid. The present code is validated by simulating two test problems. First one is to simulate a rising bubble inside a cube. The thickness of the interface of the bubble is shown to affect the pressure distribution around the interface. As the thickness decreases, the pressure field around the interface becomes more oscillatory. As the bubble rises, a ring vortex is shown to form around the interface and the bubble eventually develops into an ellipsoidal shape. Merge of two bubbles inside a container is secondly tested to show the robustness of the present code for two phase flow simulation. Numerical results show stable and reliable behavior during the process of merging of two bubbles. The velocity and pressure fields around the interface of bubbles are shown oscillation free during the merging of two bubbles.

• Journal of the Korean Society for Marine Environment & Energy
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• v.19 no.1
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• pp.52-61
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• 2016

To inject huge amount of $CO_2$ for CCS application, high pressure pipeline transport is accompanied. Rapid depressurization of $CO_2$ pipeline is required in case of transient processes such as accident and maintenance. In this study, numerical analysis on the depressurization of high pressure $CO_2$ pipeline was carried out. The prediction capability of the numerical model was evaluated by comparing the benchmark experiments. The numerical models well predicted the liquid-vapor two-phase depressurization. On the other hands, there were some limitations in predicting the temperature behavior during the supercritical, liquid phase and gaseous phase expansions.

• Transactions of the Korean Society of Automotive Engineers
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• v.7 no.8
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• pp.1-6
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• 1999

An experimental study was carried out to investigate the global spray behavior and spray characteristics of high-pressure fuel injector in the direct-injection goasoline enginet. The atomization characteristics of fuel spary such as mean droplet size, mean velocity , and velocity distribution were measured by the phase Doppler particle analyzer. The spray tip penetration and spray width were investigated by the result fo visualizaiton experiment. The quantitiative spary characteristics of injector spray were measured under various sparay conditions and ambient pressures. The results of experiment show that the increase in ambient pressure have influence on the spray tip penetration and spray development process. Also, the influence of injection pressure and measuring location on the mean velocity and droplet size distribution were discussed.

• Journal of ILASS-Korea
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• v.6 no.2
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• pp.16-21
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• 2001

This paper describes the macroscopic behavior and atomization characteristics of the high-pressure gasoline swirl injector in direct-injection gasoline engine. The global spray behavior of fuel injector was visualized by shadowgraph technique. The atomization characteristics of gasoline spray such as mean diameter and mean velocity of droplets were measured by the phase Doppler particle analyzer system. The macroscopic visualization and experiment of particle measurement on the fuel spray were investigated at 7 and 10 MPa of injection pressure under different spray cone angle. The results of this work show that the geometry of injector was more dominant over the macroscopic characteristics of spray than the fuel injection pressure and injection duration. As for the atomization characteristics, the increase of injection pressure resulted in the decrease of fuel droplet diameter and the atomization characteristics differed as to the spray cone angle. The most droplets had under $25{\mu}m$ diameter and for the large droplets(upper $40{\mu}m$) as the spray grew the atomization presses were very slow. Comparison results between the measured droplet distribution and the droplet distribution functions revealed that the measured droplet distribution is very closed to the Normal distribution function and Nukiyama-Tanasawa's function.