• 한국초등과학교육학회지:초등과학교육
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• 제26권3호
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• pp.329-340
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• 2007

This study is to find out how well elementary school gardens work as places of observation learning. We compared the tree species planted in elementary school gardens with those which appeared in the science textbooks of the 7th Korean National Curriculum. The number of tree species are 60 throughout all the grades, specifically; 43 in the third grade, 22 in the fifth grade, 16 in the first grade, 15 in the second grade, 8 in the sixth grade, and 5 in the fourth grade, respectively. Their frequency of appearance (hereafter referred to as 'appearance frequency') throughout all the grades is 175, and the maximum frequency is 62 in the third grade. Of particular note is the fact that the appearance frequency in one grade was very high, meaning that a repeat study will not be conducted. The total number of tree species counted in the study was 13,028 and consisted of 167 species in 52 families. Only 23% of the total planted tree species, that is, 38 tree species appeared in the textbooks, so the ratio of the practical usage of school gardens was revealed to be low. In the school gardens, there are only an average of about 16 tree species per school. The fewest number of species in one school was 9 and the most was 22. The native species were 74 and the non-native species were 93. This means that almost all the planted species do not relate to observation learning in the textbooks. The 22 tree species among 60 species in the textbooks were not planted in the gardens. In conclusion, the degree of utilization of almost all the elementary school gardens examined during this investigation was very low.

• 보건행정학회지
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• 제20권1호
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• pp.19-36
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• 2010

Fee for long-term care insurance in Korea are determined in proportion to resources utilized according to severity rather than based on categorization of beneficiaries in consideration of the characteristics of resource utilization. This adoption is based on the assumption that as beneficiaries of long-term care insurance, characteristically, demands social services rather than needs medical treatments, the characteristics of beneficiaries and the quality of utilized resources are comparatively homogenous. Therefore, the proposition is that the size of resource consumed by beneficiaries in the same grade is identical. However, even in the same grade, the level of utilized resources is different depending on the characteristic of beneficiaries. In this regard, this study is to examine whether there are differences in the volumes of utilized resources depending on the characteristics of beneficiaries even in the same grade. We analyzed time study data for 2003, 2005, 2006 which conducted by the Korea Institute for Health and Social Affairs. To look at differences in the volumes of utilized resources, we identified characteristics of beneficiaries that influence utilized resource volumes and categorized services provided by facilities into the rehabilitation treatment category, the problematic behavior category, and the physical malfunction category. Then, we examined each service in consideration of service difficulty levels and wage weights. The result of examination showed that differences in utilized resource volumes exist in all three grades depending on the characteristics of beneficiaries. Especially, in the first grade with a high level of seriousness, utilized resource volumes were different for those three service categories and the problematic behaviour category considered dementia was found to consume the largest volume of resources. Moreover, there was the inversion phenomenon of utilized resources volumes between the grades. This result indicates that utilized resource volumes are different even in the same grade depending on the characteristics of beneficiaries and it is required to consider case-mix for reflection of the volumes of utilized resources depending on the characteristics of beneficiaries.

• Ocean and Polar Research
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• 제32권2호
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• pp.137-144
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• 2010

There is a host of habitat assessment systems available to evaluate and grade tidal flat ecosystems in Korea. Nevertheless, we recognize the need to develop a better ecological scheme to improve reliability and accuracy given the importance of using an empirical approach in assigning grades to indicators and the limitation of current systems which evaluate tidal flats on a regional basis. A preferable system would be one that enables habitat mapping within a tidal flat, provides a diagnosis of ecological stress/health, has a high level of ecological relevance, communicability, and statistical robustness, and enables evaluation of diverse habitats within a tidal flat. The following points should be considered in framing such a system. Indicators should discriminate habitat quality into five to seven grades accomodating diverse characteristics and conservation value of a habitat, and the grading should be made from frequency distribution of indicators based on nationwide data.We suggest the following tasks in crafting such a system: i) The decision on selection of indicators should be made based on accuracy of assessment and practical application; ii) effects of physical habitat conditions on variability of indicators should be reflected; and, iii) further works on stress/health indicators should be addressed for adopting a multiple-indicator approach which reduces misdiagnosis.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7187-7191
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• 2013

Most of the exogenous and endogenous chemical compounds are metabolized by enzymes of xenobiotic processing pathways, including the phase I cytochrome p450 species. Carcinogens and their metabolites are generally detoxified by phase II enzymes like glutathione-S-transferases (GST). The balance of enzymes determines whether metabolic activation of pro-carcinogens or inactivation of carcinogens occurs. Under certain conditions, deregulated expression of xenobiotic enzymes may also convert endogenous substrates to metabolites that can facilitate DNA adduct formation and ultimately lead to cancer development. In this study, we aimed to test the association between deregulation of metabolizing genes and brain tumorigenesis. The expression profile of metabolizing genes CYP1A1 and GSTP1 was therefore studied in a cohort of 36 brain tumor patients and controls using Western blotting. In a second part of the study we analyzed protein expression of GSTs in the same study cohort by ELISA. CYP1A1 expression was found to be significantly high (p<0.001) in brain tumor as compared to the normal tissues, with ~4 fold (OR=4, 95%CI=0.43-37) increase in some cases. In contrast, the expression of GSTP1 was found to be significantly low in brain tumor tissues as compared to the controls (p<0.02). This down regulation was significantly higher (OR=0.05, 95%CI=0.006-0.51; p<0.007) in certain grades of lesions. Furthermore, GSTs levels were significantly down-regulated (p<0.014) in brain tumor patients compared to controls. Statistically significant decrease in GST levels was observed in the more advanced lesions (III-IV, p<0.005) as compared to the early tissue grades (I-II). Thus, altered expression of these xenobiotic metabolizing genes may be involved in brain tumor development in Pakistani population. Investigation of expression of these genes may provide information not only for the prediction of individual cancer risk but also for the prevention of cancer.

• Environmental Analysis Health and Toxicology
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• 제28권
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• pp.18.1-18.8
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• 2013

Objectives As public concern on possible harmful effects of mobile phone in children has been raised, information of epidemiological characteristics of mobile phone use in children and adolescents will be essential for public health policy. Methods Using three databases (n=21,693) collected from 2008 to 2011, we examined characteristics of mobile phone ownership and use, and socioeconomic positions (SEP) in Korean children and adolescents. Results The ownership rate and the amount of mobile phone use were higher in females than males, in higher school grades than lower grades, and at 2011 than 2008. The average age of first mobile phone ownership was shown to decrease from 12.5 years in currently high school students to 8.4 years in currently elementary school students at 2011. More than 90% of children in the 5th grade owned a mobile phone. More children owned a mobile phone in lower SEP communities than in higher SEP. Children with parents educated less than those with parents educated more were more likely to own and use mobile phone. Conclusions Considering the epidemiological characteristics of mobile phone use, precautionary measures to prevent unnecessary exposure to mobile phones are needed in children and adolescents.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1251-1254
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• 2016

Background: Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, shows geographical variation with respect to the age, sex, site and habits of the population. The histolopathologic grade of the tumor is closely related to its tissue of origin. This study was conducted to establish the prevalence of OSCC in relation to patient sex, age, habits and sites of lesions. Materials and Methods: A total of 130 cases of histopathologically diagnosed OSCC were selected for the study, out of which 66, 38 and 26 were well (WD), moderately (MD)and poorly differentiated (PD), respectively. Sections were stained with haematoxylin and eosin and graded according to a modified Borders's system. Then statistically analyzed different grades of OSCC for correlations with other variables. Results: In our study the majority cases of OSCC were found in the 5th to 7th decades of life, males acconting for 53%. The most common site was the buccal mucosa and most cases had habit of tobacco use either in the form of chewing or smoking or both. When the different grades of OSCC were compared with different sites a statistically significant value was observed (P=0.029). Conclusions: The incidence of high grade PD is very much less in female patients but in males such lesions were common. In our location population the buccal mucosa is the most common site due to the tobbaco habits of the patients and majority cases of the buccal mucosa are WD whereas in tongue, floor of the mouth and palate PD are common.

• 한국임상수의학회지
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• 제5권1호
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• pp.1-7
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• 1988

An observational study was conducted to evaluate the effect of anterior pituitary gonadtropin on super-ovulation in donors, embryo quality, development stage of embryo, transfer location, corpus luteum quality of recipient, ease of transfer and induced versus natural estrus on pregnancy rates. The data were collected from 451 non-surgical transfers of fresh and frozen bovine embryos. 1. The average number of CL, formed in ovaries which were stimulated with follicular stimulating hormone, and/or APG, were 11. 1${\pm}$1.21, 12.3${\pm}$1.84, respectively. The numbers of embryos recovered were 8.2${\pm}$1.35, 8.7${\pm}$ 1.39, and the numbers of transferable embryos were 6.4${\pm}$0.98. 6.6${\pm}$1.01. respectively. 2 There was no effect of spontaneous versus prostaglandin-induced estrus of recipients on pregnany rates of either fresh (61.5% vs. 59.5%) or previously frozen(54.5% vs. 58.5%) embryos. 3. There were significant differences(p<0.05) in pregnancy rates for embryo grade 1(63.6%), grade 2 (45.4%) and grade 3 (30.4％) in fresh group and for grade-1 (60.5%), grade-2 (47.8%) and grade-3 (18.1%) in previously frozen embryos. 4. The recipients transfered with embryo morulae were found to have a lower (p<0.05) pregnancy rates than those transfered with embryos of blastocyst in be th fresh and previously frozen embryos. 5. There was no significant difference between transfer locations in pregnancy rates using both fresh and frozen embryos. 6. Attempts to select recipients for high pregnancy rates on the basis of corpus luteum (CL) quality were performed. CL were classified into 3 quality grades, on the basis of size and prominence. Quality grades 1 and 2 group had higher (p<0.05) pregnancy rates than grade-3 group using both fresh and frozen embryos. 7 Ease of transfer was ranked to a scale of one to three on the basis of increasing difficulty (time required). Transfers ranted as ease score 1 and 2 had significantly higher (P<0.05) pregnancy pregnancy rates (45.8%, 66.6%) than ease score 3 (27.7%, 31.8%) using both fresh and frozen embryos respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.189-195
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• 2016

Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cancer subtype with a maximum propensity for regional spread. Our objective was to study if p53 expression might have any correlation with aggressive patterns of invasion within oral tongue cancers as well as with the histologically identified degree of oral tongue dysplasia. p53 immunoexpression was studied using immunohistochemistry in early staged OTSCCs (n=155), oral tongue dysplasias, (n=29) and oral tongue normal specimens (n=10) and evaluated for correlations with histological and clinicopathological parameters. Our study (n=194) showed a pattern of p53 expression increasing with different grades of tongue dysplasia to different grades of invasive OTSCC (p=0.000). Among the OTSCC tumours, positive p53 expression was seen in 43.2% (67/155) and a higher p53 labelling index was significantly associated with increased Bryne's grade of the tumour invasive front (p=0.039) and increased tumour depth (p=0.018). Among the OTSCC patients with tobacco habits, (n=91), a higher p53 labelling index was significantly associated with increased risk of local recurrence (p=0.025) and with lymphovascular space involvement (p=0.014). Evaluation of p53 through varying degrees of dysplasia to oral tongue cancer indicates that p53 expression is linked to aggressive features of oral tongue cancers and tongue precancers entailing a closer monitoring in positive cases. Among the OTSCCs, p53 expression is associated with tumour aggressiveness correlating with increased grading of invasive tumour front and tumour depth.

• 한국학교수학회논문집
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• 제18권3호
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• pp.281-309
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• 2015

본 연구는 또래교수 학습법을 활용한 수학 교수학습과정에서 집단별로 수학 성적이 다른 또래학습자의 3개의 집단에서 각 담론의 공통점과 차이점을 분석하여 이 학습법을 활용하고자 하는 교수자에게 교수학적 시사점을 제공하고자 한다. 이러한 목적 달성을 위해 수학 성적 최상(A) 상(B) 중(C) 하(D)위 집단에서 연구 참여자를 각각 한명씩 선정하여 수학 학업 성취도가 가장 높은 학생이 또래교수자가 되고, 나머지 3명의 학생들이 또래학습자가 되어 A-B, A-C, A-D의 3개의 집단을 구성하였다. A-B, A-C, A-D의 각 집단별 의사소통을 통해 자신의 생각을 설명하는 기회를 가지도록 하였으며, 이를 촬영한 비디오 자료와 사전 사후 활동지를 분석한 질적 사례 연구를 실시하였다. 담론 전사본과 활동지를 열 네개의 문제에 대하여 구조화된 자료를 비교 대조하여 세 집단에서 보이는 공통점과 차이점에 대하여 분석하였다. 본 연구는 또래교수자에게 또래교수 학습법이 어떤 도움을 주고 있는지에 대한 구체적인 장면을 제시하고 있으며, 또래학습자의 성적 차이가 집단 별로 다를 때 수학적 담론의 특징이 다양하게 나타나는 것을 보여준다. 따라서 또래교수의 집단 구성을 할 때 성적의 차이를 고려하여 구성할 필요가 있음을 제안하여 또래교수의 집단 구성 방법에 실질적인 도움을 줄 수 있을 것으로 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3355-3360
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• 2015

Background: Zinc transporters have been considered as essential regulators in many cancers; however, their mechanisms remain unknown, especially in gliomas. Isocitrate dehydrogenase 1(IDH1) mutation is crucial to glioma. This study aimed to investigate whether zinc transporters are correlated with glioma grade and IDH1 mutation status. Materials and Methods: IDH1 mutation status and mRNA expression of four zinc transporters (ZIP4, ZIP9, ZIP11, and ZnT9) were determined by subjecting a panel of 74 glioma tissue samples to quantitative real-time PCR and pyrosequencing. The correlations between the expression levels of these zinc transporter genes and the grade of glioma, as well as IDH1 mutation status, were investigated. Results: Among the four zinc transporter genes, high ZIP4 expression and low ZIP11 expression were significantly associated with higher grade (grades III and IV) tumors compared with lower grade (grades I and II) counterparts (p<0.0001). However, only ZIP11 exhibited weak correlation with IDH1 mutation status (p=0.045). Samples with mutations in IDH1 displayed higher ZIP11 expression than those without IDH1 mutations. Conclusions: This finding indicated that zinc transporters may interact with IDH1 mutation by direct modulation or action in some shared pathways or genes to promote the development of glioma. Zinc transporters may play an important role in glioma. ZIP4 and ZIP11 are promising molecular diagnostic markers and novel therapeutic targets. Nevertheless, the detailed biological function of zinc transporters and the mechanism of the potential interaction between ZIP11 and IDH1 mutation in gliomagenesis should be further investigated.