• Journal of Radiation Protection and Research
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• 제48권2호
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• pp.84-89
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• 2023

Background: Food consumption is one of the most important routes for radionuclide intake for the public; therefore, there is the need to have a comprehensive understanding of the amount of radioactivity in food products. Consumption of radionuclide-contaminated food could increase potential health risks associated with exposure to radiation such as cancers. The present study aims to determine radioactivity levels in some food products (milk, rice, sugar, and wheat flour) consumed in Mali and to evaluate the radiological effect on the public health from these radionuclides. Materials and Methods: The health impact due to ingestion of radionuclides from these foods was evaluated by the determination of activity concentration of radionuclides ²³⁸U, ²³²Th, ⁴⁰K, and ¹³⁷Cs using gamma spectrometry system with high-purity germanium detector and radiological hazards index in 16 samples collected in some markets, mall, and shops of Bamako-Mali. Results and Discussion: The average activity concentrations were 9.8±0.6 Bq/kg for ²³⁸U, 8.7±0.5 Bq/kg for ²³²Th, 162.9±7.9 Bq/kg for ⁴⁰K, and 0.0035±0.0005 Bq/kg for ¹³⁷Cs. The mean values of radiological hazard parameters such as annual committed effective dose, internal hazard index, and risk assessment from this work were within the dose criteria limits given by international organizations (International Commission on Radiological Protection and United Nations Scientific Committee on the Effects of Atomic Radiation) and national standards. Conclusion: The results show low public exposure to radioactivity and associated radiological impact on public health. Nevertheless, this study stipulates vital data for future research and regulatory authorities in Mali.

• Human Ecology Research
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• 제60권4호
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• pp.577-593
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• 2022

The purpose of this study is to investigate a student's career maturity during a career exploration program based on the ecological system perspective and to propose directions for the career maturation process to help H. Meister High School students to get jobs. A single-case 12-session career exploration program was applied to a first-year student at H. Meister High School in U. City for 90 minutes per session twice a week. To verify the effects of the program, this study conducted a pre-test and post-test of career maturity to analyze changes. In addition, the study qualitatively analyzed changes in the program activity sheets and process evaluation sheets per session. The results of the study are as follows: Firstly, the career exploration program based on the ecological system perspective conducted with the student at H. Meister High School improved the student's career maturity. Secondly, changes were observed in the scores in the sub-factors of career maturity between the pre-test and the post-test. Significant differences in the results of the analysis of the sub-factors of career maturity indicate that the program had a statistically positive impact on the career maturation process of the participant. In conclusion, as a result of the in-depth implementation of the program for 12 sessions, the participant expressed his desires which were clarified. In addition, a positive career maturation process appears to have taken place, owing to the self-directed program that led the participant to initiate plans and explore his career by himself. This study was conducted as a single case based on the ecological system perspective concerning career exploration and the career maturation process, but it will be necessary to expand the study to investigate the effects of group counseling, information exchange considering peer influences, common discussions on goal-setting, and other methods on the career maturation process.

• Nutrition Research and Practice
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• 제18권4호
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• pp.554-566
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• 2024

BACKGROUND/OBJECTIVES: Urban-rural inequities in health and mortality exist in Korea, a highly centralized developed country. The potential impact of multiple health-related lifestyle behaviors on mortality and difference between urban and rural areas is not fully understood. This study aimed to investigate the effect of high-risk health behaviors on all-cause mortality among residents living in urban and rural in Korea. SUBJECTS/METHODS: Cross-sectional analyses were conducted on 8,298 adults aged 40 yrs and older from the Korea National Health and Nutrition Examination Survey 2013-2015. High-risk behaviors were defined as having poor diet quality, current smoking, high-risk drinking, or insufficient physical activity. Mortality status was linked to the Cause of Death data followed up to December 31, 2019. The associations between all-cause mortality and high-risk behaviors were evaluated using Cox proportional hazard regression models adjusted for age, sex, education, income, and survey year. Population attributable fractions (PAFs) were calculated, and effect modification analysis was conducted. Participants were stratified by residential area (urban or rural). RESULTS: During the follow-up (median: 5.4 yrs), 313 deaths occurred. A higher proportion of rural residents than urban residents engaged in multiple high-risk behaviors (28.9% vs. 22.6%; P < 0.0001). As individual factors, a greater risk of mortality was associated with poor diet quality, current smoking, and inadequate physical activity, and these tendencies persisted in rural residents, especially for diet quality. Multiple high-risk behaviors were positively associated with a higher risk of mortality in Koreans living in urban and rural areas. PAF (95% confidence interval) was 18.5% (7.35-27.9%) and 29.8% (16.1-40.2%) in urban and rural residents, respectively. No additive or multiplicative effect of the region was observed. CONCLUSION: The higher prevalence of multiple high-risk lifestyle behaviors in rural residents may explain the higher mortality in rural areas compared to urban areas. Comprehensive public health policies to improve health-related behaviors in rural populations may be needed.

• 한국양식학회지
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• 제16권3호
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• pp.196-201
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• 2003

Sessile organisms such as the oyster Crassostrea gigas have been given much attention as a potential biomonitoring indicator to assess the impact of toxicants on aquatic organism. In this study, we exposed cells isolated from gill of oyster (Crassostrea gigas) to hydrogen peroxide in vitro. In addition oysters were in vivo exposed to pyrene and benzo(a)pyrene at various concentrations for 2 weeks. Comet assay was used to detect DNA single strand breaks and to investigate the application of this technique as a tool for aquatic biomonitoring. Hydrogen peroxide increased DNA single strand break with increasing concentration after 30 minutes exposure in vitro. Pyrene and benzo(a)pyrene caused DNA damage only at very high concentration (100 $\mu\textrm{g}$/L or 1000 $\mu\textrm{g}$/L) at two week exposure in vivo. DNA damage was relatively higher at hemocyte than at gill. It suggested that metabolized PAHs are transferred to hemolymph from digestive gland which have a relatively high enzyme activity, and attacked the DNA of hemocyte, while gill accumulated PAHs without degrading them to their metabolites due to low enzyme activity at gill. Both in vitro and in vivo exposure experiments showed that the comet assay is an effective tool on screening whether the organism are exposed to genotoxic contaminants.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.69-69
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• 2023

Safflower seeds, classified as a member of the Asteraceae family, a dicotyledonous plant, contain linoleic acid as a major component, known for its pharmacological effect of strengthening bones. Additionally, safflower seeds have been reported to have pharmacological effects on vascular diseases such as atherosclerosis. In this study, we investigated the anti-obesity effect of safflower seed extract by examining its impact on adipocyte differentiation using Oil Red O staining, triglyceride quantification, and GPDH activity measurement. The results showed that safflower seed extract significantly inhibited adipocyte differentiation. Furthermore, we confirmed that safflower seed extract improved body weight, liver weight, adipose tissue size, glucose, and triglyceride levels in a high-fat diet-induced mouse model. These findings suggest that safflower seed extract exhibits potent anti-obesity activity both in vitro and in vivo and has the potential to be developed as a material for future anti-obesity therapies.

• Nuclear Engineering and Technology
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• 제49권8호
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• pp.1752-1757
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• 2017

The aim of this study is to evaluate the radioactivity levels and radiological impacts of representative black sand samples collected from different locations in the Rashid area, Egypt. These samples were prepared and then analyzed using the high-resolution gamma ray spectroscopy technique with a high-purity germanium detector. The activity concentration ($A_c$), minimum detectable activity, absorbed gamma dose rate, external hazard index ($H_{ex}$), annual effective dose rate equivalent, radium equivalent, as well as external and internal hazard index ($H_{ex}$ and $H_{in}$, respectively) were estimated based on the measured radionuclide concentration of the $^{238}U$($^{226}Ra$) and $^{232}Th$ decay chains and $^{40}K$. The activity concentrations of the $^{238}U$, $^{232}Th$ decay series and $^{40}K$ of these samples varied from $45.11{\pm}3.1Bq/kg$ to $252.38{\pm}34.3Bq/kg$, from $64.65{\pm}6.1Bq/kg$ to $579.84{\pm}53.1Bq/kg$, and from $403.36{\pm}20.8Bq/kg$ to $527.47{\pm}23.1Bq/kg$, respectively. The activity concentration of $^{232}Th$ in Sample 1 has the highest value compared to the other samples; this value is also higher than the worldwide mean range as reported by UNSCEAR 2000. The total absorbed gamma dose rate and the annual effective dose for these samples were found to vary from 81.19 nGy/h to 497.81 nGy/h and from $99.86{\mu}Sv/y$ to $612.31{\mu}Sv/y$, which are higher than the world average values of 59 nGy/h and $70{\mu}Sv/y$, respectively. The $H_{ex}$ values were also calculated to be 3.02, 0.47, 0.63, 0.87, 0.87, 0.51 and 0.91. It was found that the calculated value of $H_{ex}$ for Sample 1 is significantly higher than the international acceptable limit of <1. The results are tabulated, depicted, and discussed within national and international frameworks, levels, and approaches.

• 한국전문물리치료학회지
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• 제21권4호
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• pp.56-66
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• 2014

For maintaining adequate psychometric properties when reducing the number of items from an instrument, item level psychometrics is crucial. Strategies such as low item correlation or factor loadings, using classical test theory, have traditionally been advocated. The purpose of this study is to describe the development of a new short form assessing the impact of low back pain on physical activity. Rasch measurement model has been applied to the International Classification of Functioning, Disability and Health Activity Measure (ICF-AM). One hundred and one individuals with low back pain aged 19-89 years (mean age: $48.1{\pm}17.3$) who live in the community were participated in the study. Twenty-seven items of lifting/carrying construct of the ICF-AM were analyzed. Ten items were selected from the construct to create a short form. Item elimination criteria include: 1) high or low mean square (out of the range: .6-1.4 for the fit statistics), 2) similar item calibrations to adjacent items, 3) person separation value, and item-person map for potential gap in person ability continuum. All 10 items of the short form fit to the Rasch model except one item (i.e., carrying toddler on back). Despite its high infit and outfit statistics (1.90/2.17), the item had to be reinstated due to potential gaps at the upper extreme of person ability level. The short form had a slightly better spread of person ability continuum compared to the entire set of item. The created short form separated individuals with low back pain into nearly 4 groups, while the entire set of items separated the individuals into 6 groups. The findings prompted multidimensional models for better explanation of the lifting/carrying domain. The item level psychometrics based on the Rasch model can be useful in developing short forms with rationally retained items.

• 환경영향평가
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• 제29권3호
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• pp.182-197
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• 2020

본 연구에서는 뉴트리아를 대상으로 원격무선추적을 이용하여 기초적인 행동권과 활동성을 분석하였다. 밀양시 미전천 하류부 습지에 서식하는 뉴트리아 3개체의 평균 행동권은 MCP 95%에서 0.043㎢, K 95%에서 0.085㎢로 확인되었고, 핵심공간인 K 50%에서는 0.018㎢로 나타났다. MCP 95%에서 수컷은 0.058㎢의 행동권을 나타내어 0.012㎢의 행동권을 나타낸 암컷에 비해 0.046㎢ 넓은 행동권을 보였고, 야간 행동권이 주간 행동권에 비해 0.015㎢ 넓게 나타났다. 일간 평균 이동거리는 수컷이 암컷보다 길었으며, 일일 최대 1,278m의 이동 거리가 확인되었다. 활동성은 오전 06시, 오후 10시, 오후 07시, 오전 01시, 오전 05시에 높게 나타났고, 일몰 전후부터 일출 전후까지 지속적으로 높은 활동성을 보인 반면, 낮 시간대에는 비교적 낮은 활동성을 보여 야행성 동물의 성향이 반영되어 나타났다. 뉴트리아의 행동권과 활동성에 관한 연구는 한국에 정착한 뉴트리아의 생태특성에 관한 이해와 함께 관리 시 포획트랩의 효과적 설치 및 운용 시기의 결정, 관리구역의 공간적 구획, 투입되는 관리자원의 규모 산정 등 침입외생물의 관리 개선 측면에서 유용하게 활용될 수 있다.

• BMB Reports
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• 제56권11호
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• pp.618-623
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• 2023

Most cancer cells utilize glucose at a high rate to produce energy and precursors for the biosynthesis of macromolecules such as lipids, proteins, and nucleic acids. This phenomenon is called the Warburg effect or aerobic glycolysis- this distinct characteristic is an attractive target for developing anticancer drugs. Here, we found that Phosphofructokinase-1 (PFK-1) is a substrate of the Protein Phosphatase 4 catalytic subunit (PP4C)/PP4 regulatory subunit 1 (PP4R1) complex by using immunoprecipitation and in vitro assay. While manipulation of PP4C/PP4R1 does not have a critical impact on PFK-1 expression, the absence of the PP4C/PP4R1 complex increases PFK-1 activity. Although PP4C depletion or overexpression does not cause a dramatic change in the overall glycolytic rate, PP4R1 depletion induces a considerable increase in both basal and compensatory glycolytic rates, as well as the oxygen consumption rate, indicating oxidative phosphorylation. Collectively, the PP4C/PP4R1 complex regulates PFK-1 activity by reversing its phosphorylation and is a promising candidate for treating glycolytic disorders and cancers. Targeting PP4R1 could be a more efficient and safer strategy to avoid pleiotropic effects than targeting PP4C directly.

• 환경영향평가
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• 제16권4호
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• pp.267-275
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• 2007

In this study, relationship between the air pollution of Siheung city and the relative contribution of automobiles to the city's pollution was evaluated for the first time. Then, new air pollution exposure index was developed through simulation. Using the newly developed index, two different urban development scenarios were compared to present a sustainable urban development plan to reduce air pollution from the land utilization point of view. According to the result of this simulation, air quality of the city was found to be affected significantly by human activities. More populated area showed worse level of air quality. Any development in the city resulted in more automobile activity and deterioration of air quality. This simulation result thus explains that a rapid increase of automobiles accompanied by the land development near local roadsides in the city is the major cause of air pollution in Siheung city. In this study, if urban activities are vigorous in an area with high air pollution, people are more likely to be exposed to air pollutant under the bad environmental conditions. On the other hand, if urban activities are less vigorous in an area with high pollution or if urban activities are vigorous in an area with less pollution, the environmental condition was positive. The APEI (Air Pollution Exposure Index) was developed based on these considerations. Scenarios 1 and 2 were compared and analyzed using APEI. In result, scenario 1 is the case in which land is developed and used in an environmentally favorable manner. From this study, it was proved that the impact of air pollution on human health can be minimized with proper land use. The result form the current study can be used as the basic information to solve problems from improper land utilization and air pollution (by road traffic). It also can be utilized to evaluate air pollution level according to land use and road characteristics and to help to choose the best location of land use to comply with the road function and status.