• 제목/요약/키워드: Heterotopic

검색결과 108건 처리시간 0.023초

쥐모델에서의 이소성의 심장이식 (Heterotopic Heart Transplantation in the Rat Model)

  • 정원상;전양빈;전순호;김혁;이철범;김영학;지행옥;서정국;공구
    • Journal of Chest Surgery
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    • 제31권5호
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    • pp.531-535
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    • 1998
  • 국내에서 심장, 폐이식이 각 대학병원에서 점차 확산 시행되고는 있으나, 이에 따른 기초실험이 뒷받침되지 않고, 큰 동물에서는 많은 실험비용이 들어 보다 적은 동물을 이용하게 되었으나 이 방법은 현미경하의 미세수술기법의 발달과 더불어 발전하게 되었다. 본 연구는 현미경하의 미세수술기법으로 쥐모델에서 복부의 대동맥과 하공정맥에 다른 쥐의 공여심장의 대동맥과 폐동맥을 각각 문합술로 연결하는 방법으로 이식하여 동종이형의 장기이식에 따른 거부반응과 면역억제제를 투여하여 그에 따른 생존율을 비교하고자 하였다. 체중 150∼250 gm의 흰쥐의 심장을 공여 및 이식하는 바, 이소성의 심장이식후 면역억제제를 투여하지 않은 군과 면역억제제를 투여한 군으로 나누고, 각 군에서 복부에 이식된 심장의 박동을 매일 만져보고서 만져지지 않을 경우는 이식된 심장이 거부반응에 따른 것으로 판단하여 이의 생존율을 비교 검토하여본 바, 면역억제제를 투여하지 않은 군에서보다 투여한 군에서 오래 생존하여 동종이형의 이식에서 면역억제제를 투여하므로써 장기이식에 따른 장기성적을 향상시킴을 알 수 있었다.

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견봉쇄골 관절 탈구에서 Modified Phemister와 Modified Weaver-Dunn 술식을 이용한 수술적 치료 (The Surgical Treatment of Acromioclavicular Joint Dislocation using Modified Phemister and Modified Weaver-Dunn Operation)

  • 전철홍;이성호;이병창;조용우
    • Clinics in Shoulder and Elbow
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    • 제1권2호
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    • pp.180-185
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    • 1998
  • There has been considerable controversy as to the treatment method of dislocation of the acromioclavicular joint, so various operative treatment modalities have been suggested. We analyzed the results of 40 patients with acromio­clavicular dislocation, in whom twenty patients were treated by modified Phemister method and 20 patients by modified Weaver-Dunn method above follow-up two years. The purpose of this study was to compare the clinical results of two operative methods. According to Weitzman criteriae for clinical results, 12 cases were excellent, six cases good and two cases fair in modified Phemister method. But in modified Weaver-Dunn method, ten cases were excellent, eight cases good, one case fair and one case poor. In radiological result, coracoclavicular distance was measured at preoperative, postoperative and last follow-up period. The modified Phemister method was 6.lmm, 1.5mm and 2.4mm respectively, and the modified Weaver-Dunn method 7.8mm, 2.lmm and 2.5mm respectively. The complications were two cases of heterotopic ossification, one case of inadequate fixation and one case of K-wire breakage in modified Phemister method, and two cases of early fixation loss and one case of heterotopic ossification in modified Weaver-Dunn method. We obtained that the clinical, functional and radiological results showed no significant difference in two methods. The modified Phemister method was effective treatment for old patients in acute injuries due to short operation time and simple technique. The modified Weaver-Dunn method, as a reconstructive operation that reduces various complications for young and active male patients, was also good for getting the stability of coraco­clavicular ligament through clavicular bony union.

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동종 심장이식의 병리조직학적 연구 (An Experimental Study on the Heterotopic Canine Heart Transplantation: Pathologic Observation)

  • 손광현;서경필;이영균
    • Journal of Chest Surgery
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    • 제2권2호
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    • pp.155-166
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    • 1969
  • Heterotopic abdominal homograft of canine heart was carried out in 20 pairs of dogs. Of these 12 cases were subjected as a control and 8 were subjected to immunosuppressive group. The dosage of immunosuppressive agent was 5mg/kg/day of Imuran [Azathioprine] for 3 days preoperatively, 10mg/kg on operative day and 5mg/kg/day postoperatively. For reducing the metabolic demand, the donor heart was preserved in 4degree heparinized saline solution for approximately I4 minutes. In the most of the cases, transplantation was performed with the technique of end-to-side aorto-aortic anastomosis and end-to-side pulmonary artery-inferior vena cava anastomosis at the infrarenal portion. Five out of 20 grafted dogs were survived more than one day. The longest survived 18 days in the control group and survive more than 60 days in the treated group. The survival cases were 3 out of 8[37. 5%] in the group of dogs treated with lmuran and 2`out of 12 [16.6%] in the group of non-treated. A prominent gross findings of the grafted heart was a minimal to moderate degree of dilatation of the heart with or without thrombosis in the cardiac chambers and/or anastomotic site. The case number 10, 15, and 19 showed moderate hypertrophy in grossly. The microscopic findings were as follows; 1. There were early hypersensitive histologic reactions such as interstitial edema, cellular infiltrations and early degenerative changes in the myocardium in the cases of 3 hour survival. 2. In the cases of more than 6 hours survival, organizing thrombosis of myocardial vessels, vasculitis,myocardial necrosis and lymphocyte, plasma cell, round cell infiltrations were noted. In the cases of more than 12 hours survival, the degree of these histologic changes especially in the non-treated group were more intensified than in the treated. 3. In the cases which survived more than one day, so called homograft specific histologic changes were milder in the immunosuppressive group compared with the control. 4. All the host hearts showed no evidence of pathologic findings histologically. Among the homologous canine cardiac transplantation tissue reaction, was milder and suvival time longer in the group treated with immunosuppressive drug.

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Short- to mid-term outcomes of radial head replacement for complex radial head fractures

  • Baek, Chung-Sin;Kim, Beom-Soo;Kim, Du-Han;Cho, Chul-Hyun
    • Clinics in Shoulder and Elbow
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    • 제23권4호
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    • pp.183-189
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    • 2020
  • Background: The purpose of the current study was to investigate short- to mid-term outcomes and complications following radial head replacement (RHR) for complex radial head fractures and to identify factors associated with clinical outcomes. Methods: Twenty-four patients with complex radial head fractures were treated by RHR. The mean age of the patients was 49.8 years (range, 19-73 years). Clinical and radiographic outcomes were evaluated for a mean follow-up period of 58.9 months (range, 27-163 months) using the visual analog scale (VAS) score for pain, the Mayo elbow performance score (MEPS), the quick disabilities of the arm, shoulder and hand (Quick-DASH) score, and serial plain radiographs. Complications were also evaluated. Results: At the final follow-up, the mean VAS score, MEPS, and Quick-DASH score were 0.6±1.1, 88.7±11.5, and 19.4±7.8, respectively. The mean range of motion was 132.7° of flexion, 4.7° of extension, 76.2° of pronation, and 77.5° of supination. Periprosthetic lucency was observed in six patients (25%). Heterotopic ossification was observed in four patients (16.7%). Arthritic change of the elbow joint developed in seven patients (29.2%). Capitellar wear was found in five patients (20.8%). Arthritic change of the elbow joint was significantly correlated with MEPS (P=0.047). Four cases of complications (16.6%) were observed, including two cases of major complications (one stiffness with heterotopic ossification and progressive ulnar neuropathy and one stiffness) and two cases of minor complications (two transient ulnar neuropathy). Conclusions: RHR for the treatment of complex radial head fractures yielded satisfactory short- to mid-term clinical outcomes, though radiographic complications were relatively high.

헤테로토피아 관점에서 본 필립스탁의 공간표현 특성 연구 (A Study on the Spatial Expression Characteristics of Philippe Starck from the Perspective of Heterotopia)

  • 서수미
    • 디지털융복합연구
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    • 제20권2호
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    • pp.375-381
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    • 2022
  • 본 연구의 목적은 4차 산업혁명의 시대와 함께 코로나19라는 감염병의 시대를 힘겹게 살아가고 있는 현대인들의 시대적인 배경 속에서 헤테로토피아적 관점에서 본 필립스탁의 공간표현 특성을 알아보고자 하는 것이다. 연구 방법으로는 은퇴 후 더욱 활발히 활동하는 2015년부터 현재까지 인테리어 공간의 완공작품을 중심으로 총 11곳을 선정하여 문헌 및 사례 연구를 통하여 공간표현 특성을 알아보고자 한다. 결과로는 공간만이 가지고 있는 서사성의 공간표현 특성이 가장 빈도가 높았으며, 장소를 표현하기 위한 시간의 중첩의 형태인 상상의 공간과 환상성의 특성이 상호연관이 있다는 것을 알 수 있었다. 서사성과 환상성, 상상의 공간 특성을 사용하는 필립스탁의 디자인 방법은 헤테로토피아적 특성을 충분히 나타낸다고 볼 수 있으며 새로운 공간의 설계 시 또 다른 디자인 방법론으로 사용할 수 있다고 본다.

진행성 골화성 섬유이형성증 - 성인 1례보고 - (Fibrodysplasia Ossificans Progressiva - A Case Report -)

  • 윤영식
    • 대한골관절종양학회지
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    • 제10권1호
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    • pp.50-55
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    • 2004
  • 진행성 골화성 섬유이형성증은 매우 드문 유전적 질환이기는 하나 영유아 초기에 경부나 두부의 종괴에 동반하여 나타나는 특징적인 양측성의 족부 모지의 선천성 기형으로 진단이 가능하다. 그러나 오진으로 인한 잘못된 치료와 그로 인한 합병증이 병의 진행을 더 악화시킬 수 있으며 불필요한 처치를 행할 수 있어 처음 진단에 주의를 요하는 질환이다. 이에 저자는 이질환의 자연적 경과와 더불어 잘못된 치료로 인해 발생한 성인에서의 양상을 보고하는 바이다.

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소아 장중첩증에 대한 복강경 수술의 경험 (Laparoscopic Surgery for Intussusception in Children)

  • 윤두환;남소현
    • Advances in pediatric surgery
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    • 제19권2호
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    • pp.66-72
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    • 2013
  • Intussusception is common cause of intestinal obstruction in children. Most of intussusceptions can be treated with non-operative reduction using air or barium. However, about 10% patients need operative treatment due to failure of reduction, peritonitis, and recurrence after reduction. We introduce our experience of laparoscopic surgery for intussusception. From April 2010 to March 2013, we reviewed 57 children who diagnosed intussusception. Twelve patients underwent an operation. The cause of operation was 7 of failure of air reduction and 5 of recurrence after air reduction. Median age was 21.5 months (range: 5.0~57.7 months) and 11 children (91.7%) underwent successful laparoscopic reduction. Median operating time was 50 minutes (range: 30~20 minutes) and median hospital days was 4.5 days (range: 3~8 days). One patient had a leading point as a heterotopic pancreas and underwent bowel resection through conversion. There was neither intra-operative nor postoperative complication. Laparoscopic reduction for intussusception can bring an excellent cosmetic effect with high success rate.

Surgical extraction of mandibular third molar in pterygomandibular space: a case report

  • Lee, Young-Kyu;Park, Sung-Soo;Myoung, Hoon
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제39권5호
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    • pp.242-245
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    • 2013
  • Impacted mandibular third molars are located between the second mandibular molar and mandibular ramus. However, ectopic mandibular third molars with heterotopic positions are reported in the subcondylar or pterygomandibular space. The usual cause of malposition is a cyst or tumor, and malposition without a pathology is rare. This case report described an impacted mandibular third molar in the pterygomandibular space without any associated pathology.

Nonsurgical treatment of stylohyoid (Eagle) syndrome: a case report

  • Taheri, Arman;Firouzi-Marani, Shahram;Khoshbin, Masoud
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제40권5호
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    • pp.246-249
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    • 2014
  • Eagle syndrome is a rare condition caused by elongation of the styloid process or calcification of the stylohyoid ligament. Patients with Eagle syndrome typically present with dysphagia, dysphonia, cough, voice changes, otalgia, sore throat, facial pain, foreign body sensation, headache, vertigo, and neck pain. Here we report a case in which the patient initially presented with sore throat, left-sided facial pain, and cough. This case report provides a brief review of the diagnosis and nonsurgical management of this rare syndrome.