• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7509-7515
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• 2013

To assess the risk of cancers associated with sleep duration using meta-analysis of published cohort studies, we performed a comprehensive search using PubMed, Embase and Web of Science through October 2013. We combined hazard ratios (HRs) from individual studies using meta-analysis approaches. A random effect dose-response analysis was used to evaluate the relationship between sleep duration and cancer risk. Subgroup analyses and sensitivity analyses were also performed. Publication bias was evaluated using Funnel plots and Begg's test. A total of 13 cohorts from 12 studies were included in this meta-analysis, which included 723, 337 participants with 15, 156 reported cancer outcomes during a follow-up period ranging from 7.5 to 22 years. The pooled adjusted HRs were 1.06 (95% CI: 0.92, 1.23; P for heterogeneity =0.003) for short sleep duration, 0.91 (95% CI: 0.78, 1.07; P for heterogeneity <0.0001) for long sleep duration. In subgroup analyses stratified by cancer type, long duration of sleep showed an inverse relation with hormone-related cancer (HR=0.79; 95% CI: 0.65, 0.97; P for heterogeneity =0.009) and a greater risk of colorectal cancer (HR=1.29; 95% CI: 1.09, 1.52; P for heterogeneity =0.346). Further meta-analysis on dose-response relationships showed that the relative risks of cancer were 1.00 (95% CI: 0.99, 1.01; P for linear trend=0.9151) for one hour of sleep increment per day, and 1.00 (95% CI: 0.98, 1.01; P for linear trend=0.7749) for one hour of sleep increment per night. No significant dose-response relationship between sleep duration and cancer was found on non-linearity testing (P=0.5053). Our meta-analysis suggests a positive association between long sleep duration and colorectal cancer, and an inverse association with incidence of hormone related cancers like those in the breast. Studies with larger sample size, longer follow-up times, more cancer types and detailed measure of sleep duration are warranted to confirm these results.

• Journal of Ecology and Environment
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• v.38 no.4
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• pp.505-515
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• 2015

The objectives of this study were to determine the effects of stream nutrient regime, N:P ratios and suspended solids on fish tolerance/trophic compositions and stream ecosystem health, based on multi-metric model, during 2008-2013. Also, stream ecosystem health was evaluated in relation to chlorophyll-a (CHL) as a measure of algal productivity or indicators of trophic state to water chemical parameters. Total number of sampled fish species were 50 and showed a decreasing trend from 2008 to 2013. The minnow of Zacco platypus, based on the catch per unit effort (CPUE), was the most dominant species (25.9%) among the all species. Spatial heterogeneity was evident in the fish tolerance guilds that showed the dominance of sensitive species (89%) in the headwaters (S1) and the dominance of tolerant species (57%) in the urban. These conditions were directly influenced by concentrations of nutrients and organic matter (COD). The N:P ratios, as a barometer of water pollution, had a negative linear function (R² = 0.40, P < 0.01) with CHL, and the ratios had an important role in changes of COD concentration (R² = 0.40, P < 0.01). Under the circumstances, the N:P ratio directly influenced the relative proportions of fish trophic/tolerance compositions. According to the regression analysis of omnivore (O_m) and insectivore sp. (I_n) on total nitrogen and total phosphorus, nitrogen had no significant influences (P > 0.05) to the two compositions, but phosphorus influenced directly the two guilds [slope (a) = -32.3, R² = 0.25, P < 0.01 in the I_n; a = 40.7, R² = 0.19, P < 0.01 in the O_m]. Such water chemistry and fish trophic guilds determined the stream ecosystem health, based on the multi-metric fish model.

• Biomolecules & Therapeutics
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• v.24 no.3
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• pp.207-243
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• 2016

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments, as well as repetitive and restrictive behaviors. The phenotypic heterogeneity of ASD has made it overwhelmingly difficult to determine the exact etiology and pathophysiology underlying the core symptoms, which are often accompanied by comorbidities such as hyperactivity, seizures, and sensorimotor abnormalities. To our benefit, the advent of animal models has allowed us to assess and test diverse risk factors of ASD, both genetic and environmental, and measure their contribution to the manifestation of autistic symptoms. At a broader scale, rodent models have helped consolidate molecular pathways and unify the neurophysiological mechanisms underlying each one of the various etiologies. This approach will potentially enable the stratification of ASD into clinical, molecular, and neurophenotypic subgroups, further proving their translational utility. It is henceforth paramount to establish a common ground of mechanistic theories from complementing results in preclinical research. In this review, we cluster the ASD animal models into lesion and genetic models and further classify them based on the corresponding environmental, epigenetic and genetic factors. Finally, we summarize the symptoms and neuropathological highlights for each model and make critical comparisons that elucidate their clinical and neurobiological relevance.

• Journal of Chest Surgery
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• v.51 no.4
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• pp.254-259
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• 2018

Background: Primary spontaneous pneumothorax (PSP) affects patients without clinically apparent lung disorder found in tall and thin young male. Scoliosis refers to curves exceeding $10^{\circ}$ Cobb angle observed through chest X-ray and affects 2% to 4% of adolescents. Both conditions are commonly encountered in primary health care setting. The aim of this study is to access the correlation of thoracic scoliosis and PSP in adolescent. Methods: A retrospective analysis was conducted for patients diagnosed for PSP in Konyang University Hospital between January 2010 and March 2017. Chest X-rays of 222 patients and 155 normal control (NC) cases were reviewed to measure the Cobb angle. Greater than $10^{\circ}$ of Cobb angle is diagnosed as scoliosis. Results: Scoliosis in patient with PSP has higher incidence than that of NC group (p<0.001). Median value of Cobb angle is $12.9^{\circ}$ in PSP group and $14.7^{\circ}$ in NC group. Directional relationship between scoliosis and pneumothorax in PSP group is also observed; 40.5% cases are ipsilateral and 59.5% are contralateral. Conclusion: PSP patients tend to have thoracic scoliosis more commonly compared with normal healthy adolescent. Scoliosis may contribute to heterogeneity of alveolar pressure which exacerbates subpleural bleb formation that can cause pneumothorax. The causal relationship is unclear and further studies are needed in the future.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.335-335
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• 2012

기후변화에 의한 미래 수문량 전망에 대한 연구는 전지구 모델 결과를 바탕으로 이루어진다. 현재 전지구 모델의 모의 결과 생산된 강우 자료는 기상청에서 제공되며, 제공된 자료는 기상청 관측 지점에 국한되어 있다. 어떤 유역의 확률홍수량 전망은 유역내 강우 지점의 확률강우량을 강우-유출 모형인 HEC-1에 입력하여 추정할 수 있다. 한강 유역과 같은 대유역의 확률홍수량을 구하기 위해서는 유역내 기상청 관측 지점만으로는 지점수가 부족하기 때문에 국토해양부나 수자원공사 관할의 지점 자료를 활용한다. 하지만 이러한 대유역의 미래 확률홍수량을 전망하고자 하는 경우에 제공되는 전지구 모델 결과가 기상청 지점에 국한되어 있어 다른 지점의 확률강우량을 산정하는 데 어려움이 있다. 본 연구에서는 이러한 문제를 보완하기 위해 지역빈도해석을 이용하여 미래 전망 자료가 없는 지점들의 확률강우량을 추정하였다. 지역빈도해석을 수행하기 위해서는 관측 자료가 있는 유역내 지점들의 특성치(site characteristics)를 바탕으로 지역을 구분하고, Hosking and Wallis(1997)가 제안한 이질성 척도(heterogeneity measure)를 근거로 구분된 지역의 수문학적 동질성 여부를 검토하며, 각 지역에 대한 성장곡선(growth curve)를 추정한다. 지역별로 추정된 성장곡선에 지점의 연최대값 평균을 곱하면 그 지점의 확률강우량을 추정할 수 있다. 따라서 미래 기간의 지역별 성장곡선과 지점의 연최대값 평균을 전망할 수 있으면, 미래 기간의 지점별 확률강우량을 산정할 수 있고, 이를 바탕으로 확률홍수량도 전망할 수 있다. 이를 위해 본 연구에서는 전지구 모델에서 모의된 강우 자료를 바탕으로 미래 기간의 성장곡선을 추정하고, 과거 대비 미래 기간의 지속기간별 연최대값 평균의 비율을 산정하여 모의 자료가 없는 지점에 적용함으로써 미래 기간의 연최대값 평균을 산정하였으며, 이를 바탕으로 미래 기간의 확률강우량을 산정하도록 하였다. 이 기법의 신뢰도를 검증하기 위해 관측 자료를 두 기간으로 구분하여, 이 기법을 적용하여 추정한 확률강우량과 관측 자료로부터 산정한 확률강우량을 비교하였다.

• Journal of Korea Trade
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• v.23 no.5
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• pp.27-44
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• 2019

Purpose - The purpose of this paper is to analyze the net effect of the green total factor productivity (GTFP) of China's manufacturing industry from the China-Korea Free Trade Area (China-Korea FTA) quantitatively. Design/methodology - Firstly, the Global Malmquist-Luenberger (GML) index based on the SBM directional distance function is used to measure the GTFP of China's manufacturing and analyze the driving force for its growth. Secondly, the regression discontinuity quantitative analysis is used to determine the impact of the China-Korea FTA on China's manufacturing GTFP. Findings - Our main findings can be summarized as follows: the China-Korea FTA has promoted the GTFP of China's manufacturing with an effect evaluation mainly resulting from green technology progress. And there is industry heterogeneity in the policy effect on the manufacturing GTFP due to the China-Korea FTA. Namely, policy promotion from the China-Korea FTA is more effective on the GTFP of equipment manufacturing than it is on those of other industries. Originality/value - First, an evaluation and analysis of the GTFP development of China's manufacturing that employs GML index based on SBM directional distance function. Second, a quantitative estimate of China-Korea FTA's net effect on China's manufacturing industrial GTFP that uses regression discontinuity analysis, which is considered to be the closest method to natural experiments and superior to other causal inference methods. Third, an in-depth discussion of the practical steps that China's manufacturing can take to improve GTFP development and integrate China-Korea FTA construction into economic development.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.2
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• pp.35-40
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• 2022

Objectives: Restricted and repetitive behaviors (RRBs) are a core symptom in the diagnosis of autism spectrum disorder (ASD). The complexity of behavioral patterns has called for the creation of phenotypically homogeneous subgroups among individuals with ASD. The purpose of this study was 1) to investigate the different types of RRBs and 2) to explore whether subgroups created by RRBs would show unique levels of functioning in toddlers and young children with ASD. Methods: A total of 313 children with ASD, aged 12-42 months were included in the analysis. The Autism Diagnostic Interview-Revised was used to obtain information on the different types of RRBs by grouping 15 items into six categories. The Vineland Adaptive Behaviors Scale, a parent-reported questionnaire, was used to measure adaptive functioning. A portion of the children were analyzed separately for verbal-related RRBs based on their expressive language level. Two-step cluster analysis using RRB groups as features was used to create subgroups. Analysis of covariance while covarying for age and language was performed to explore the clinical characteristics of each cluster group. Results: Sensory-related RRBs were the most prevalent, followed by circumscribed interests, interest in objects, resistance to change, and repetitive body movements. A subset of the children was analyzed separately to explore verbal-related RRBs. Four cluster groups were created based on reported RRBs, with multiple RRBs demonstrating significant delays in adaptive functioning. Conclusion: Heterogeneity of RRBs emerges at a young age. The different patterns of RRBs can be used as valuable information to determine developmental trajectories with better implications for treatment approaches.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.1
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• pp.1-10
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• 2022

Background: Inferior alveolar nerve block (IANB) is known to have a lower success rate for anesthesia in patients with irreversible pulpitis. This calls for supplementary techniques to effectively anesthetize such patients. This systematic review aimed to evaluate the published literature for determining the success rate of anesthesia induction using post-IANB intraligamentary (IL) injection in the mandibular teeth of patients with symptomatic irreversible pulpitis. The review question was, "What is the success rate of IL injection in the mandibular teeth of patients with irreversible pulpitis as a supplementary technique for endodontic treatment?" Methods: A thorough search of electronic databases and manual searches were performed. The protocol of the review was framed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO) with a proper criterion for inclusion and exclusion of studies. The included studies were analyzed using the Cochrane Collaboration "Risk of Bias" tool. A meta-analysis that included a comparison of primary nerve block and supplemental IL injection was performed. The success rate was evaluated using the combined risk ratio (RR) with a random risk model. A funnel plot was created to measure publication bias. Results: After all analyses, four studies were included. In the forest plot representation, RRs were 3.56 (95% CI: 2.86, 4.44), which were in favor of the supplemental IL injections. Statistical heterogeneity was found to be 0%. These values suggest that supplemental IL injections provide better success rates for anesthesia. Conclusion: According to the pooled qualitative and quantitative analyses, supplemental IL injections increased anesthetic efficacy.

• Journal of Korea Trade
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• v.25 no.2
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• pp.95-110
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• 2021

Purpose - This paper intends to conduct theoretical analysis and empirical test on the action mechanism of South Korea-China trade and South Korea's FDI to China on green total factor productivity, so as to provide a new perspective and ideas for the improvement of China's green total factor productivity and promote the high-quality development of China's economy Design/methodology - This paper uses the data of 30 provinces, autonomous regions and municipalities in China from 2004 to 2017 as the research sample, adopts the GML index method of SBM Directional Distance Function to measure GTFP, and analyzes the influence of South Korea-China trade and FDI from South Korea on China's GTFP. Findings - Trade is conducive to promoting technological progress, which has a significant promotion effect on China's green total factor productivity. While FDI has a significant inhibitory effect on China's green total factor productivity, which verifies the "pollution haven" hypothesis. In addition, such influence has certain regional overall heterogeneity. Trade has a more significant promoting effect on GTFP in eastern coastal areas, while FDI has a more significant inhibitory effect on GTFP in central and western inland areas. The interaction between trade and FDI is conducive to the improvement of green total factor productivity, indicating that the benign mechanism of trade and FDI has been formed. Urbanization, industrial structure, human resource level and investment in science and technology are all conducive to the improvement of GTFP. Originality/value - Through theoretical analysis and empirical test on the action mechanism of South Korea-China trade and South Korea's FDI on green total factor productivity, this paper provides a solid theoretical foundation for the further development of China-South Korea economic and trade cooperation in the future.

• Asia Marketing Journal
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• v.15 no.1
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• pp.155-168
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• 2013

This study describes consumers' movie choices in conjunction with other group members and attempts to reassess the effect of the online word of mouth (WOM) source in a joint decision context. The tendency of many people to go to movies in groups has been mentioned in previous literature but there is no modeling research that studies movie choice from the group decision perspective. We found that ignoring the group movie-going perspective can result in a misunderstanding, especially underestimation of genre preference and the impact of the WOM variables. Most of the studies to measure online WOM effects were done at the aggregate level, and the role of online WOM variables(volume vs valence) is mixed in the literature. We postulate that group-level analysis might offer insight to resolve these mixed understanding of WOM effects in the literature. We implemented the study via a random effect model with group-level heterogeneity. Romance, drama, and action were selected as genre variables; valence and volume were selected as online WOM variables. A choice-based conjoint survey was used for data collection and the models was estimated via Bayesian MCMC method. The empirical results show that (i) both genre and online WOM are important variables when consumers choose movies, especially as group, and (ii) the WOM valence effect are amplified more than the volume effect does as individuals are engaged in group decision. This research contributes to the literature in several ways. First, we investigate movie choice from a group movie-going perspective that is more realistic and consistent with the market behavior. Secondly, the study sheds new light on the WOM effect. At group-level, both valence and volume significantly affect movie choices, which adds to the understanding of the role of online WOM in consumers' movie choice.