• Title/Summary/Keyword: Herbal medicine prescription

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Compilation of 104 Experimental Theses on the Antitumor and Immuno-activating therapies of Oriental Medicine (한의학의 항종양 면역치료에 관한 연구 -1990년 이후 발표된 실험논문을 중심으로-)

  • Kang Yeon Yee;Kim Tai Im;Park Jong Ho;Kim Sung Hoon;Park Jong Dai;Kim Dong Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.1-24
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    • 2003
  • This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.

Morphological Analysis Study for the Development of DB on the Manufacture Process of Prescription and Medicinal Food (처방 및 약선요리 제조 과정의 데이터베이스 구축을 위한 형태소 분석 연구)

  • Kim, Thae-Yul;Hwang, Su-Jung;Kim, Ki-Wook;Lee, Byung-Wook
    • Journal of Korean Medical classics
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    • v.29 no.2
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    • pp.79-90
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    • 2016
  • Objectives : Treatment using foods has already been recorded since the time of Zhou Dynasty of China. Modifications in the cooking process of medicinal food or manufactural process of herbal medicines are accompanied by the alterations in the ingredients that affect the actual efficacies of medicinal food or herbal medicine, and may have marked effects on the patients including the difficulties that may be experienced in consuming the food or taking the medicine. Therefore, systemic management is essential in such processes. Accordingly, management of such knowledge system must be standardized and conveniently administered by grafting IT technology. This study aims to overcome the problem of the failure of the knowledge system on the material-oriented medicinal herbs to apply the knowledge on the cooking process that impart marked influence on the actual efficacies of the medicinal herbs. Methods : Therefore, analysis of the cooking process or manufacturing processes of prescriptions was executed by using the morphological analysis method in natural language. In this study, we aimed to make data structure of the terminologies that represent manufacture process of prescription and medicinal food. The data structure is combinations of smallest unit in natural language. We made the database by analyzing morpheme of the natural language to express the manufacture process of prescription and medicinal food. Results & Conclusions : As the results, we can express making process of Cheonjin-won, Guseon-wangdogo and Sanyagbaegboglyeongtalagjuk in DB. It was concluded that the development of DB through the extraction of a total of 15 types of concepts including 'order', 'action' and 'continuous action', etc. was helpful in systematization of the knowledge on medicinal herbs including the manufacturing process.

Comparative Evaluation of Metals in Frequent Using Herbal Medicinal Prescriptions according to the Consuming Area (다용(多用)한약처방중 사용지역별 일부 금속농도의 비교)

  • Kim, Kee D.;Seo, Yong Chan;Lee, Sundong
    • Journal of Society of Preventive Korean Medicine
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    • v.18 no.1
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    • pp.53-65
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    • 2014
  • The concentration of 5 metals such as As, Cd, Co, Cr and Pb in 5 frequent using herbal medicinal prescriptions in Korea were analyzed according to the consuming area. The ready prepared 5 prescription samples were obtained from Korean regional hospitals nationwide. All the sample were well powdered and pre-treated to being a solution, and then analyzed by ICP/MS. As was detected the highest concentration of 0.55 mg/kg in Ojeoksan of Gyunggi-do, the lowest was 0.01 mg/kg of Sipjeondaebotang of Seoul C. The highest concentration of Co was found to be in Bojoongikgitang of Seoul B and the lowest was also detected in Bojoongikgitang of Seoul A. Cd concentration, Ojeoksan of Chungcheong-do, Bojoongikgitang of Seoul B and yookmijihwangtang of Chungcheong-do showed the low level of 0.1 mg/kg. In turn, the highest level of Cr was 5.59 mg/kg in Ojeoksan of Gyunggi-do B. The lowest concentration of Cr was 0.04 mg/kg in Sipjeondaebotang of Seoul C and the highest was 0.94 mg/kg in Samooltang of Gangwon-do. Finally, the lowest concentration of Pb was 0.00 mg/kg in Sipjeondaebotang of Chungcheong-do and the highest was 0.134 mg/kg in Ojeoksan of Jeju-do. As a result it seems that the same prescription can not guaranteed the safety from toxic metals since those metal concentrations are dramatically varied according to the area where the each prescribed medicine available.

Hyeongok's Bobee-tang was Combined according to the Theory for Properties and Tastes of Herbal Medicines (현곡(玄谷) 보비탕(補脾湯)의 구성한약과 그 기미배오(氣味配伍) 분석)

  • Eom, Hyun-Sup;Seo, Bu-Il;Kim, Gyeong-Cheol;Shin, Soon-Shik
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.2
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    • pp.277-281
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    • 2008
  • The objectives of this study lie in theoretical establishment of Bobee-tang for curing the asthenic syndrome of spleen through analyzing the component medicines and combination principles of Hyeongok's Bobee-tang, and furthermore, maximizing the clinical use of Bobee-tang. This study analyzed the component medicines and combination principles of Hyeongok's Bobee-tang based on the theory for properties and tastes of herbal medicines from the ${\ulcorner}$Yellow Emperor's Canon of Internal Medicine${\lrcorner}$, the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's Bobee-tang is an odd prescription, composed of 7 kinds of ingredients : No.1 Radix Ginseng (2don;7.5 g), No.2 Rhizoma Atractylodis Macrocephalae (1don;3.75 g), No.3 Carapax Et Plastrumtestudinis (1don), No.4 Concha Ostreae (1don), No.5 Cortex Cinnamomi (1don), No.6 Rhizoma Zingiberis Praeparatae (1don), and No.7 Radix Glycyrrhizae (1don). First, to cure the asthenic syndrome of the spleen, the methods of invigorating the spleen and the heart, and purging the liver should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's Bobee-tang is combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

The study of Achyranthis Bidentatae Radix & Dipsaci Radix in Bang-Yak-Hap-Pyun (방약합편중(方藥合編中) 우슬(牛膝) 및 속단(續斷)을 포함하는 처방(處方)에 대한 고찰(考察))

  • Han, Jeu-Won;Oh, Min-Suck
    • Journal of Haehwa Medicine
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    • v.14 no.1
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    • pp.179-186
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    • 2005
  • In oriental medicine, Achyranthis Bidentatae Radix & Dipsaci Radix are frequently used materials for strenthing lumbar and knees. Bang-Yak-Hap-Pyun(方藥合編) is widely used for clinical herbal prescription book. In Bang-Yak-Hap-Pyun, Achyranthis Bidentatae Radix is used 1g~8g. and Dipsaci Radix is used 1g~3.2g. The most important fact is that the prescription used chyranthis Bidentatae Radix & Dipsaci Radix at the same time is only 1(Man-Geum-Tang-the ratio of Achyranthis Bidentatae Radix & Dipsaci Radix is 1:1). The number of prescription Achyranthis Bidentatae Radix & Dipsaci Radix in Bang-Yak-Hap-Pyun is total 19. 14 in sang-tong(上統), 2 in jung-tong(中統), 3 in ha-tong(下統). The group of mostly used disease is about lumbar and knees. The ratio of Achyranthis Bidentatae Radix in Bang-Yak-Hap-Pyun is 3.88%~25%. And the ratio of Dipsaci Radix is 8.33%~12.5%. The mostly quoted medical literature what prescription included Achyranthis Bidentatae Radix & Dipsaci Radix in Bang-Yak-Hap-Pyun is Dong-Yi-Bo-Gam and Gyung-Ak-Jun-Su Sin-Bang-Pal-Jin.

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Analysis on the herbal combinations in Korean medicine for atopic dermatitis (아토피 치료 처방의 본초 활용 분석)

  • Kim, An-Na;Kim, Sang-Kyun;Seo, Jin-Soon;Kim, Sang-Hyun;Kim, Young-Eun;Jang, Hyun-Chul
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.2
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    • pp.82-97
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    • 2016
  • Objective : The aim of this study was to search and analyze the herbal combinations in formulas used to treat atopic dermatitis in Korean medicine. Methods : Articles on the atopy were searched for from among those registered on the OASIS up to December, 2015. After the articles were reviewed, information on both internal and external formulas for atopy was constructed. Then, the herbal combination in the formulas was analyzed by using frequency distribution, network analysis, and data mining. Results : The combination of 'Saposhnikovia Radix - Schizonepetae Spica' and 'Scutellariae Radix - Phellodendri Cortex ' was mostly used in both internal and external formulas to treat atopy in articles. By using the network analysis and data mining, twelve combinations including ' (Saposhnikovia Radix, Ponciri Fructus Pericarpium) - (Platycodi Radix, Schizonepetae Spica) ' were discovered. Five effective combinations were also searched for external formulas.Conclusions : This study could help researchers to analyze the formulas in various ways. Moreover, the herbal combination in atopy formulas could be used to search for atopy formulas in other databases or make a new prescription.

A Korean Medicine Literature Review on Acne External Medicines (여드름 외용제에 관한 한의학 문헌 고찰)

  • Lee, Won Yung;Kim, Dong Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.31 no.3
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    • pp.153-158
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    • 2017
  • As social interest in acne treatment has grown, various external preparations have been developed and studied. So, we investigated the external prescription which can treat acne in medical classics, then reviewed and divided it by dynasty. The data for analysis of Herbal formula was taken from 'medicine Dictionary of traditional Chinese medicine prescriptions(中醫方劑大辭典)'. 31 external medicines were searched, 3 were before song(宋) dynasty, 11 were Song(宋) dynasty, 11 were Yuan(元) dynasty, 7 were Ming(明) dynasty and 7 were Qing(淸) dynasty. The recipe and usage were only making them pill(丸) and paste(膏) using grinded medicinal herbs, then rubbing to face. As the age developed, unique manufacturing process(i.e fermentation method), and usage(i.e time-based usage, herbal medicine extracts for wash) were proposed. The external application with oriental medicine for acne used with Angelicae Gahuricae Radix(n=12), Bletillae Rhizoma(n=8), Syzygii Flos, Saposhnikoviae Radix(n=7) and so on. In particular, Bletillae Rhizoma was searched with high frequency in this study, but it was not included or studied in patent composition. The results of this study will provide basic data for future experiments and clinical studies.

A Study of External Treatments for the Atopic Dermatitis (소아 아토피성 피부염의 외치법에 대한 고찰)

  • Chang, Gyu-Tae;Kim, Jang-Hyun;Park, Bo-Kyoung
    • The Journal of Pediatrics of Korean Medicine
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    • v.17 no.1
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    • pp.71-86
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    • 2003
  • Objectives : The aim of this study was to investigate the classification methods of the external treatments of atopic dermatitis for Children. Methods: We surveyed the oriental medical book concerning the atopic dermatitis for Children. Results : 1. The oriental herbal medications for the atopic dermatitis used with Ryuhwang(硫?), WoongHwang(雄黃), KyoungBun(輕粉), WhangBaek(黃栢), SeokGo(石膏) and so on. 2. The frequently used type of external prescription is solid or liquid. 3. The external preparations were frequently painted or washing with to the lesion of dermatitis. For the wet type of atopic dermatitis, the solid prescription were sprinkled on the lesion or irrigated with the liquid. For the dry type, the mixed prescription of the solid and liquid were painted on the lesion.

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[ ${\ulcorner}$ ]Standard Principles for the Designing of Prescriptions - The Theory for Monarch, Minister, Adjuvant and Dispatcher${\lrcorner}$ ("방제구성의 표준적 규격 - 군신좌사(君臣佐使)")

  • Kim Do-Hoy;Seo Bu-il;Kim Bo-Kyung;Kim Gyeong-Cheol;Shin Soon-Shik
    • Herbal Formula Science
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    • v.11 no.2
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    • pp.1-18
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    • 2003
  • The Theory for Monarch, Minister, Adjuvant and Dispatcher (or the Theory of Principal, Assistant, Adjuvant and Guiding Korean Oriental Herbal Medicines) has served as a standard principle for newly developed prescription formulas as well as established ones. Despite its significance, however, this theory hasn't been thoroughly studied and covered in the academic journals of Korean Oriental Herbal Medicines (KOHM) yet. This paper inquires into the origin of the theory while presenting the definitions and functions of Principal, Assistant, Adjuvant, and Guiding KOHM. In the end, the recommended doses and number of the KOHM comprising each of Principal, Assistant, Adjuvant, and Guiding KOHM are suggested. The compatibility theory of Principal, Assistant, Adjuvant, and Guiding KOHM can be traced back to the Warring States Period during which it was recorded in the treatise of the various schools of thoughts and their exponents. The theory was firmly established as a full system in ${\ulcorner}Shinnong's\;Pharmacopoeia{\lrcorner}\;and\;{\ulcorner}Yellow\;Emperor's\;Cannon\;of\;Internal\;Medicine{\lrcorner}$. While ${\ulcorner}Shinnong's\;Pharmacopoeia{\lrcorner}$ focuses on the classification of the properties of KOHM, ${\ulcorner}Yellow\;Emperor's\;Cannon\;of\;Internal\;Medicine{\lrcorner}$ mainly deals with the principles for writing prescriptions. In this regard, it is ${\ulcorner}Yellow\;Emperor's\;Cannon\;of\;Internal\;Medicine{\lrcorner}$ that systemized the Theory of Principal, Assistant, Adjuvant, and Guiding KOHM in a real sense. Principal KOHM aims at the causes of diseases and treat main symptoms. The doses are greater than Assistant, Adjuvant and Guiding KOHM. With their comprehensive effects, Principal KOHM is a leading ingredient of any prescription formula. Assistant KOHM are similar to Principal KOHM in its natures and flavors. Although its natures, flavors as well as efficacies may slightly differ from those of Principal KOHM, Assistant KOHM strengthens the therapeutic effects, jointly working with Principal KOHM. They mainly treat accompanying diseases and symptoms. Adjuvant KOHM is divided into two types: facilitator and inhibitor. Facilitators with the similar properties to those of Principal and Assistant KOHM help strengthen the therapeutic effects. Since they usually treat accompanying symptoms or secondary accompanying symptoms (minor accompanying symptoms), there are two kinds of facilitators. (1) The first kind of facilitators assists Principal KOHM, targeting accompanying symptoms. (2) The second ones supporting Assistant KOHM are for accompanying or secondary accompanying symptoms (or minor accompanying symptoms). Inhibitors counteract and thereby complement Principal and Assistant KOHM. Some of them inhibit the side effects or toxicity of Principal KOHM for the sake of the safety of the whole prescription formula while the others generate induced interactions. Guiding KOHM can be used for two purposes: guiding and mediating. The Guiding KOHM for the former purpose leads the other KOHM in a prescription formula to the lesion. But, the Guiding KOHM for mediating coodinate and harmonize all the ingredients in a prescription formula. The number of KOHM for those Principal, Assistant, Adjuvant and Guiding KOHM and their doses are different, depending on the types of prescriptions: classical prescriptions, prescriptions after ${\ulcorner}$Treatise of Cold-Induced Diseases${\lrcorner}$ and prescriptions of Sasang Constitutions Medicines. In the case of the prescriptions after ${\ulcorner}$Treatise of Cold-Induced Diseases${\lrcorner}$, it is highly recommended to follow the view of ${\ulcorner}$Thesaurus of Korean Oriental Medicine Doctors in Chosun Dynasty${\lrcorner}$ for the number of KOHM to be used. For the doses, however, ${\ulcorner}$Elementary Course for Medicine${\lrcorner}$, is found to be more accurate. The most appropriate number of KOHM per prescription is 11-13. To be more specific, for one prescription formula, it is recommended to administer one kind of KOHM for Principal KOHM, 2-3 for Assistant KOHM, 3-4 for Adjuvant KOHM and 5 for Guiding KOHM. As for the proportion of the doses, when 10 units are to be administered for Principal KOHM in a formula, the doses for the other three should be 7-8 units for Assistant KOHM, 5-6 for Adjuvant KOHM and 3-4 for Guiding KOHM. The doses of the KOHM added to or taken out of the prescription correspond to those of Adjuvant and Guiding KOHM.

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A Study of the Co-Administration of Herbal and Western Medicines to Hospitalized Patients with Osteoarthritis (골관절염 환자의 한약 양약 투여 현황 및 안전성 연구)

  • Kim, Dong-hyun;Lee, Da-eun;Noh, Ji-won;Ahn, Young-min;Ahn, Se-young;Lee, Byung-cheol
    • The Journal of Internal Korean Medicine
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    • v.39 no.2
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    • pp.97-106
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    • 2018
  • Objectives: The combined use of herbal and Western medicine is increasing. However, herbal medicine is highly likely to interact with Western medicine making it important to understand the effects of co-administration. This study investigates the ratio of patients who take Western medicine with herbal medicine, the types of medicines commonly prescribed together, and the results of hospital examinations. Methods: We investigated patients who were hospitalized at Kyung Hee University Korean Medical Hospital for at least one day from January 1, 2010 to December 31, 2017. There were some inclusion criteria. First, we chose patients aged 19 and over. Second, we chose patients who were diagnosed with osteoarthritis (OA) with diagnosis codes M13, M15, M17 according to KCD-7. Third, patients had liver function tests, renal function tests, and general hematology tests performed at least two times during hospitalization. Results: Among a total of 131 OA patients, 32 (24.4%) patients were treated with herbal-Western medicine combination therapy. The most commonly prescribed herbal medicine was Daegalwhal-tang, and the most commonly prescribed Western medicine was celecoxib. In the laboratory findings, all liver function tests, renal function tests, and general hematology tests showed no difference compared to admission day. There were also no differences between herbal medicine single treatment and herbal-Western medicine combination treatment. Conclusions: From these results, we suggest that herbal medicine single treatment and herbal-Western medicine combination treatment for OA patients does not cause adverse effects.