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http://dx.doi.org/10.22246/jikm.2018.39.2.97

A Study of the Co-Administration of Herbal and Western Medicines to Hospitalized Patients with Osteoarthritis  

Kim, Dong-hyun (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Lee, Da-eun (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Noh, Ji-won (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Ahn, Young-min (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Ahn, Se-young (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Lee, Byung-cheol (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.39, no.2, 2018 , pp. 97-106 More about this Journal
Abstract
Objectives: The combined use of herbal and Western medicine is increasing. However, herbal medicine is highly likely to interact with Western medicine making it important to understand the effects of co-administration. This study investigates the ratio of patients who take Western medicine with herbal medicine, the types of medicines commonly prescribed together, and the results of hospital examinations. Methods: We investigated patients who were hospitalized at Kyung Hee University Korean Medical Hospital for at least one day from January 1, 2010 to December 31, 2017. There were some inclusion criteria. First, we chose patients aged 19 and over. Second, we chose patients who were diagnosed with osteoarthritis (OA) with diagnosis codes M13, M15, M17 according to KCD-7. Third, patients had liver function tests, renal function tests, and general hematology tests performed at least two times during hospitalization. Results: Among a total of 131 OA patients, 32 (24.4%) patients were treated with herbal-Western medicine combination therapy. The most commonly prescribed herbal medicine was Daegalwhal-tang, and the most commonly prescribed Western medicine was celecoxib. In the laboratory findings, all liver function tests, renal function tests, and general hematology tests showed no difference compared to admission day. There were also no differences between herbal medicine single treatment and herbal-Western medicine combination treatment. Conclusions: From these results, we suggest that herbal medicine single treatment and herbal-Western medicine combination treatment for OA patients does not cause adverse effects.
Keywords
herbal medicine; adverse effect; osteoarthritis; drug interaction; combined prescription rate;
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1 Jeong SH, Kim SJ, Seo IB. Anti-pathogenetic and Curative Effects of Taeganghwal-tang (Daqianghuo-tang) on the Collagen-Induced Arthritis in Wistar Rats. Journal of Oriental Rehabilitation Medicine 2004;14(3):79-101.
2 National Health Insurance Service. 2011. Statistical annual report of Health Insurance.
3 Moon YH, Park YJ. Original Articles ; Studies on the Anti - inflammatory and Analgesic Activities of Ohjuksan. Natural product sciences 1994;25(3):258-63.
4 Park JK, Chae WS. Studies on the Effects of Administration per oral and Aqua - acupuncture with Ojucksan Extract Granule on the pain to mice. Journal of Korean acupuncture & moxibustion medicine society 1992;9(1):273-91.
5 Lee NH, Ha HK, Lee HY, Jung DY, Choi JY, Lee JK, et al. Analysis of Studies on Ojeok-san for Establishment of Evidence Based Medicine. Herbal formula science 2008;16(2):1-9.
6 Yun EH, Jang MG, Hwang JH. Adverse Event Study on Ojeok-san Extract Powders RCT in Low Back Pain Patients. Journal of Korean Acupuncture & Moxibustion society 2010;27(4):195-202.
7 Park SI, Park JY, Park MJ, Yim SV, Kim BH. Effects of Ojeok-san on the Pharmacokinetics of Celecoxib at Steady State in Healthy Subjects. Basic Clin Pharmacol Toxicol 2018.
8 Wang Y, Simpson JA, Wluka AE, Teichtahl AJ, English DR, Giles GG, et al. Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study. Arthritis Res Ther 2009;11(2):31.   DOI
9 Johnson VL, Hunter D. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol 2014;28(1):5-15.   DOI
10 Leyland KM, Judge A, Javaid MK, Diez-Perez A, Carr A, Cooper C, et al. Obesity and the relative risk of knee replacement surgery in patients with knee osteoarthritis:a prospective cohort study. Arthritis Rheumatol 2016;68(4):817-25.   DOI
11 da Costa BR, Reichenbach S, Keller N, Nartey L, Wandel S, Juni P, Trelle S. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 2016;387(10033):2093-105.   DOI
12 Turini ME, DuBois RN. Cyclooxygenase-2:a therapeutic target. Annu Rev Med 2002;53:35-57.   DOI
13 Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study. A randomized controlled trial: celecoxib long-term arthritis safety study. JAMA 2000;284(10):1247-55.   DOI
14 Graham DJ, Campen D, Hui R, Spence M, Cheetham C, Levy G, et al. Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study. Lancet 2005;365(9458):475-81.   DOI
15 Roberts E, Delgado Nunes V, Buckner S, Latchem S, Constanti M, Miller P, et al. Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann Rheum Dis 2016;75(3):552-9.   DOI
16 Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibitied by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA 2002;99(21):13926-31.   DOI
17 Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin CW, Day RO, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ 2015;350:1225.   DOI
18 Shin HY, Jeong HJ, Na HJ, Hong SH, Lee SK, Lee KN, et al. Daeganghwal-tang inhibits the stem cell factor-induced migration and inflammatory cytokines secretion in mast cells. J Ethnopharmacol 2003;85(1):157-61.   DOI
19 Cherniack EP, Senzel RS, Pan CX. Correlates of use of alternative medicine by the elderly in an urban population. J Altern Complement Med 2001;7(3):277-80.   DOI
20 Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014;4:177.
21 Awortwe C, Makiwane M, Reuter H, Mull er C, Louw J, Rosenkranz B. Critical evaluation of causality assessment of herb-drug interactions in patients. Br J Clin Pharmacol 2018;84(4):679-93.   DOI
22 Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease?. Best Pract Res Clin Rheumatol 2010;24(1):15-26.   DOI
23 Elders MJ. The increasing impact of arthritis on public health. J Rheumatol 2000;60:6-8.
24 National Health Insurance Service. 2016. Statistical annual report of Health Insurance.
25 Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res(Hoboken) 2012;64(4):465-74.   DOI
26 McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage 2014;22(3):363-88.   DOI
27 Derry S, Moore RA, Rabbie R. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev 2012.
28 Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343(8900):769-72.   DOI
29 Tachjian A, Maria V, Jahangir A. Use of herbal products and potential inter actions in patients with cardiovascular disease. J Am Coll Cardiol 2010;55(6):515-25.   DOI
30 FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001;345(6):433-42.   DOI
31 Adriane FB, Ernst E. Herb-drug interactions: Review and assesment of report reliability. Br J Clin Pharmacol 2001;52(5):587-95.   DOI
32 Shin HT, Lee SD. Effects of Kidney Function in Blood of Drug Users(Herbal and Western) in Koreans. The Journal of Oriental Medical Preventive 2004;8(2):157-69.
33 Jarvholm B, Lewold S, Malchau H. Age, bodyweight, smoking habits and the risk of severe osteoarthritis in the hip and knee in men. Eur J Epidemiol 2005;20(6):537-42.   DOI
34 Park BJ. Herbal Diet of Obese with Osteoarthristis. Journal of society of Korean medicine for obesity research 2004;4(1):201-11.
35 Lee JS, Lee SD. Effects of Liver Function in Blood of Drug Users(Herbal and Western) in Koreans. The Journal of Oriental Medical Preventive 2004;8(1):59-74.
36 Kim TS, Kim CY, Min JY, Choi YG, Kang DH. The Effects of Use of Sasang-Bang with Western Medicine on Liver and Kidney Function. Journal of Sasang constitutional medicine 2004;16(3):70-5.
37 Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J 1966;2(5512):497-9.   DOI
38 Boyd EM, Bereczky GM. Liver necrosis from paracetamol. Br J Pharmacol Chemother 1966;26(3):606-14.   DOI
39 Lee WM. Etiologies of acute liver failure. Semin Liver Dis 2008;28(2):142-52   DOI
40 Bachman M, Pfeilschifter J, Muhl H. A Prominent Role of Interleukin-18 in Acetaminophen Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation. Front Immunol 2018;8(9):161.
41 Kennon-McGill S, McGill MR. Extrahepatic Toxicity of Acetaminophen: Critical Evaluation of the Evidence and Proposed Mechanisms. J Clin Transl Res 2018 Jan 15;3(3).
42 Park JK, Choi SY, Koh KW, Yu JS, Kim TH, Sohn DK, et al. Combined utilization with herbal products and prescribed drugs: A result from health examinee-based national survey. Korean journal of health policy and administration 2006;16(1):1-16.