• The Korean Journal of Pharmacology
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• v.17 no.2
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• pp.31-36
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• 1981

Heavy metals which are present as trace elements in human body have been known to modify various enzymatic reaction. These metals can be essential or non-essential. Zinc, copper and calcium are essential in maintaining some biological processes, whereas non-essential metals such as cadmium, lead and mercury produce accumulatve toxic effect. Cadmium accumulated in pancreas can cause toxicity and damage of pancreatic cells, thereby influencing CHO metabolism. Lead compounds are known to produce toxic effects on the kidney, digestive system and brain fellowed by inhibition of activity of ${\rho}-aminolevulinic$ acid and biosynthesis of hemoproteins and cytochrome. Evidence has been accumulated that zinc not only acts as a cofactor in enzyme reaction but also prevents toxic effect induced by heavy metal such as copper and cadmium. To demonstrate the effect of heavy metals on pancreatic secretion, part of uncinate pancreas was taken and incubated in Krebs-Ringer bicarbonate buffer with heavy metals used. Additional treatment with CCK-OP was performed when needed. After incubation during different period of time, medium was analyzed for amylase activity using Bernfeld's method. The present study was attempted in order to elucidate the effect of several kinds of heavy metal on exocrine pancreatic secretion in vitro. The results obtained are as follows: 1) CCK-OP stimulated significantly amylase release from pancreatic fragments in vitro. 2) CCK-OP response of amylase release from pancreatic fragments was inhibited by treatmant with cadmium, especially high doses of cadmium. 3) CCK-OP response of amylase release from pancreatic fragments was inhibited when pretreated with $10^{-4}M$ copper chloride. 4) Lead chloride at the concentration of $10^{-3}M\;and\;10^{4}M$ stimulated the basal amylase release in vitro but CCK-OP response did not augment by lead chloride. 5) Zine chloride did not affect amylase release from pancreatic fragment in vitro. From the results mentioned above, it is suggested that CCK-OP response was inhibited it the amylase release from pancreatic fragments pretreated with cadmium and copper chloride.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2000.11a
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• pp.129-135
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• 2000

Four types of land use were selected for sampling and study with different characteristics of heavy metal contamination during the period from August 1998 to June 2000. A series of studies have been carried out concerning the physicochemical characteristics of the sediments settling down in a gully pot to evaluate the contamination of Pb, Zn, Cd, Co, Cr and Cu. An examination of six elements indicated that Zn, Cu and Pb were the heavy metals severely impacted by anthropogenic input in Seoul. An assessment of 60 volatile organic compounds (VOCs) in urban runoff and ground water was conducted based on samples collected from 31 sites and 12 wells, respectively, in Seoul City. The higher levels of alkyl benzenes in urban runoff indicated that Seoul areas were mainly contaminated through traffic sources.

• Animal cells and systems
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• v.7 no.3
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• pp.173-186
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• 2003

The transition metal cadmium is a serious occupational and environmental toxin. To inhibit cadmium-induced damage, cells respond by increasing the expression of genes that encode stress-responsive proteins. The metal-regulatory transcription factor 1 (MTF-1) is a key regulator of heavy-metal induced transcription of metallothionein-I and II and other genes in mammals and other metazoans. Transcriptional activation of genes by MTF-1 is mediated through binding to metal-responsive elements in the target gene promoters. Phosphorylation of MTF-1 plays a critical role in the cadmium-inducible transcriptional activation of metallothionein and other responses. Studies using inhibitors indicate that multiple kinases and signal transduction cascades, including those mediated by protein kinase C, tyrosine kinase and casein kinase II, are essential for cadmium-mediated transcriptional activation. In addition, calcium signaling is also involved in regulating metal-activated transcription. In several species, cadmium induces heat shock genes. Recently much progress has been made in elucidating the cellular machinery that regulates this metal-inducible gene expression. This review summarizes these recent advances in understanding the role of some known cadmium-responsive genes and the molecular mechanisms that activate metal-responsive transcription factor, MTF-1.

• Journal of Korean Society for Atmospheric Environment
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• v.18 no.E2
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• pp.57-68
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• 2002

Atmospheric dry deposition fluxes and size segregated concentrations of particulate metal elements were measured at four sites in Kunpo, a small city in the Seoul metropolitan area in Korea. At each site, aerosol samples were collected by dry deposition plates, a cascade impactor, and a coarse panicle rotary impactor during four sampling periods. At all sites, the average fluxes of metals measured during daytime were higher than nighttime fluxes due to higher wind speeds and higher ambient concentrations during daytime. The average fluxes of crustal elements (Al, Ca) were 1∼2 orders of magnitude higher than anthropogenic elements (As, Cd, Cu, Mn, Ni, Pb, and Zn). The daytime fluxes of Al and Ca were between 90 and 12000 $\mu\textrm{g}$ m$\^$-2/ day$\^$-1/, and the nighttime fluxes of Al and Ca were between 20 and 2200 $\mu\textrm{g}$ m$\^$-2/ day$\^$-1/. The daytime fluxes of Pb, a typical anthropogenic element, were between 20 and 160$\mu\textrm{g}$ m$\^$-2/ day$\^$-1/, and the nighttime fluxes of Pb were between ND and 100$\mu\textrm{g}$ m$\^$-2/ day$\^$-1/. Also the ambient metal concentrations during daytime were higher than nighttime. Based on a dust emission estimation study in Kunpo, it was found that dust emissions during daytime are higher than nighttime. The concentrations of crustal elements were higher than anthropogenic elements. The distributions of heavy metals were mainly in small particles (D$\_$p/ 9㎛). The fraction of crustal elements in the large particles (D$\_$p/> 9㎛) were higher than anthropogenic elements.

• Korean Journal of Soil Science and Fertilizer
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• v.28 no.2
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• pp.130-134
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• 1995

To investigate the influence of coal fly ash treatment on the heavy metal content in the infilteration water, 12t/10a/year of fly ash(Anthracite and Bituminous) were applicated at two paddy fields of different textured soils, clay loam and sandy loam, for 3 and 2 years, respectively. The infilteration waters were collected 30, 60 and 100cm of soil depth and the heavy metal contents were measured. In the paddy field of clay loam, the content of Zn in the infilteration water were increased with fly ash treatment and increasing soil depth, but it didn't show any significance. In the clay loam soil, successive application of fly ash for 3 years brought to increase Pb, Zn content in the infilteration water, Pb content was the highest at 100cm of soil depth, but the content of others were lower than non-treatment. In the paddy field of sandy loam, successive application of fly ash for 2 years increased Cd, Ni and Mn content in the infilteration water at anthracite ash application, but the contents of other elements were similar or lower than non-treatment.

• Journal of the East Asian Society of Dietary Life
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• v.19 no.1
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• pp.116-129
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• 2009

The study was conducted to evaluate consumer awareness of the risk elements associated with foods and their information search behavior regarding food safety. The data were collected from 504 adult consumers living in Seoul, Busan, Incheon, Daegu, Daejeon, and Gwangju through a self-administered questionnaire on August, 2006. Frequency analyses, t tests, one-way analysis of variance, and Duncan's multiple range comparison tests were conducted to analyze the responses using SPSS v. 14.0. The levels of recognition of consumers regarding each risk element were generally low. Many respondents answered that they obtained information regarding food safety from TV/radio/newspapers and family/relatives/friends/neighbors. The respondents also indicated that they had strong confidence in the information from family/relatives/friends/neighbors. Additionally, most respondents required information regarding heavy metal contamination, endoctrine disruptors, and avian influenza.

• Biomedical Science Letters
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• v.3 no.1
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• pp.37-42
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• 1997

The concentrations in women's hair of essential and toxic elements such as Zn, Ni, Fe, Mn, Cu, Cr, Pb and Cd in residential and factory areas in Pusan were determined, and all the elements were detected from all the samples. It was apparent that employees working in factory areas in Pusan were exposed directly to the essential and toxic heavy matals. This is based on the fact that average concentrations of Ni, Fe, Mn, Cu, Cr, Pb, and Cd in hair samples from women aged 10 to 29 in factory area, who were considered to be main members among women employees, were much higher than those of residential areas. That is, the highest concentrations found in the hair samples taken from women 10 to 29 years old living in factory areas were 110 times higher in Cr (in the women in their 20's), 92 times higher in Pb (in the women in their teens) and 23 times higher in Cd (in the women in their 20's) than those living in residential areas. Furthermore, it was suggested that the heavy metals may be accumulated gradually in human bodies as humans get older, based on the fact that the concentrations of Cr, Pb, and Cd in women living in residential areas were higher in older age groups, although the average contents of these elements in residents from residential areas were similar with those of several foreign countries.

• Journal of Korea Soil Environment Society
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• v.4 no.2
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• pp.113-125
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• 1999

Heavy metal elements were analysed to assess degrees of heavy metal contents for the plants, M. sinensis, A. vulgaris and G. oldhamiana, from the Baekdong serpentine area within the western part of Chungnam. The area was divided into two sites ; serpentine area (SP, consisting of serpentinite, SP) and non-serpentine area (NSP, containing amphibole schist, AS and gneiss, GN). Their host rocks(R) and top soils(S) were also collected from the each site. As the results of the study, the plants contain high concentration of Ni Cr, Co in the SP and Fe, Zn in the AS and GN. Plants from the AS of the NSP contain mainly high content in the most of elements. Averages of Ni, Co and Cr for the plants decreased in the order of SP, AS and GN. In the total element contents, M. sinensis and A. vulgaris decreased in the order of Fe > Ni or Cr > Zn > Co > As > Sc within the SP and in the order of Fe > Zn > Cr > Ni, within the GN. Comparing among the parts of plants, root parts were higher in the most of elements than the above grounds. In the relative element ratios of plants collected from the SP and GN (SP/GN) M. sinensis was lower than A. vulgaris in the most of elements, suggesting that the M. sinenis shows low absorption within the infertile serpentine soil and high absorption within the fertile gneiss soil. In the element contents of the top soils and their host rocks, the SP shows higher Ni, Co and Cr contents than the others. Their total contents decreased from SP to AS and GN, suggesting that the soils reflect the composition of their host rocks. Total element contents of the SP decreased in the order of Fe> Cr or Ni> Co> Zn> As> Sc and, for the GN, in the order of Fe> Zn> Cr> Ni> Co or Sc, respectively. In the relative element ratios, R/S of the SP decreased in the order of Cr> As> Fe> Sc> Co> Ni> Zn and for the GN, in the order of Sc> Fe> Ni> Zn> Cr> Co. Comparing with plants within the each site, their top soils were higher than the plants in the most of elements. and their increase and decrease trends for each element are similar. Differences of element contents between the top soils and plants decreased in the order of SP, AS and GN. Plants of the GN were moi-e similar to their soils than those of the others, suggesting that each plant species show different absorptions within the different soils. Comparing with the plants of GN, higher Ni, Co, Cr contents within those of the SP and their survival within the infertile serpentine soil suggest that the M. sinensis, A vulgaris and G. oldhamiana may be the tolerance species in the serpentine soil. Comparisons with the upper crust show that M. sinensis, and A. vulgaris within the SP show high Hi and Cr contents. suggestive of hyperaccumulation. Upper results with the previous studies for the contaminated soils developed as parent materials with the serpentinites suggest additional studies for ecological behaviors for the plant and degrees of accumulations for the elements need to know phytoextraction of the heavy metal elements within the soils.

• Journal of Energy Engineering
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• v.8 no.4
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• pp.499-504
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• 1999

본 논고에서는 석탄의 화학조성, 입도 및 광물질 종류들에 따라 중금속 선분들의 고온 거동을 해석하여 대규모 석탄화력발전소의 중금속화합물 배출규제기준결정과 관련된 기초자료를 제공하고자 시도하였다. 먼저 , Sb. Ca, Pb, Ni, As, Cr, Mg, Se, Be Co, Hg,Mn, Cd Ti, Zn 등 원소들의 휘발성을 석탄에 포함된 광물질의 고온거동을 조사하여 분석한 결과 중금속물질 배출정도는 광물질들의 고온상 기체/고체 분포 여부 및 광물질들의 고온에서의 변이 과정과 밀접한 관계가있는 것으로 인식되었다. 또한 , 반응후 중금속물질들의 비산재와 슬랙에의 존재분포를 입도별로 해석하였으며, 그 결과는 EF enrichment factor를 이용하여 해석하였다.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.55-55
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• 2009

FGB(Flexible Glasswool Backing) Submerged Arc Welding has been one of the main welding processes for one side butt welding in shipbuilding industries, which can efficiently improve the welding productivity by the addition of a supplementary filler metal into the molten weld pool. As recent ships have become larger in size, the application of high tensile and higher grade of steels has been continuously increased. Single pass FGB SA welding process accompanies such a high heat input when welding thick plates that the mechanical properties of weld metal can be dramatically degraded. This study has been performed in order to obtain high toughness and tensile properties of high heat input FGB SA welds, and to evaluate the effect of alloy elements on their mechanical properties. To complete welding 25mm-thick EH36 grade steel plate by single pass, 1.2mm diameter and 1.0mm long cut wires has been distributed in the groove before welding, and three different test coupons have been made using C-1.5%Mn, C-1.8%Mn-0.5%Mo, and C-1.4%Mn-1.7%Ni cut wires to investigate the influence of nickel(Ni) and molybdenum(Mo) on the mechanical properties of welds. Test results showed that the addition of Ni and Mo effectively promotes the formation of Acicular Ferrite(AF), while significantly reducing the amount of Grain Boundary Ferrite(GBF) in weld metal microstructures, which resulted in a beneficial effect on low temperature impact toughness and strength.