• 대한의생명과학회지
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• 제12권4호
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• pp.435-438
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• 2006

In eukaryotes, ER stress induces UPR (unfolded protein response) via IRE1 activation which sends a molecular signal for XBP1 mRNA splicing in the cytosol. During this mRNA splicing, 23 nt removed in which contains PstI site and then resulting XBP1 product is not digested with PstI restriction enzyme. In this study, using this XBP1 mRNA splicing mechanism, the effect of heat shock on thyrocytes is studied, because heat shock response in the thyrocytes needs more study to understand thyroid physiology under alternative environments. ER inducible drugs (tunicamycin, DTT, $Ca^{2+}$ ionopore A23187, BFA) induce ER stress in the thyrocytes. From 3 hours after heat shock, ER stress is induced and which is reversible when heat shock is without. While $Ca^{2+}$ ionopore A23187 is reversible from ER stress by washing out the drug, thapsigagin is irreversible. Other ER inducible drugs are not so sensitive to ER stress repairing. XBP1 mRNA splicing in a cell is very available method to detect ER stress. It needs only a small quantity of total RNA and processing also very easy.

• 대한한의학방제학회지
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• 제10권1호
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• pp.157-167
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• 2002

This study was performed to investigate what effect the taste and quality of drugs would have on the cold and heat mechanisms of human body. We administered Hwangryeunhaedok-tang composed of bitter-tasted, cold-qualified drugs and Gungangbuza-tang composed of spice-tasted. hot-qualified drugs, respectively to the mice 1 hr before exposure to heat stress or cold stress. Plasma corticosterone level of mice was measured. The results were as follows: 1. The elevated corticosterone level in the mice exposed to heat stress was significantly decreased after administration of Gungangbuza-tang but there was no decrease after administration of Hwangryeunhaedok-tang. 2. The elevated corticosterone level in the mice exposed to cold stress was significantly decreased after administration of Hwangryeunhaedok-tang but there was mild decrease after administration of Gungangbuza-tang. 3. When the doses, 3g/kg and 1g/kg were administerd to mice exposed to heat stress. both dose showed significant decrease of corticosterone level and the dose. 3g/kg was more effective. However, in the mice exposed to cold stress, the dose, 3g/kg showed mild decrease and 1g/kg showed significant decrease. These data suggested that HW decreased the plasma corticosterone level in the mice exposed to cold stress and GB also decreased the plasma corticosterone level in the mice exposed to heat stress. In conclusion, our study revealed that the taste and quality of drugs controled the cold and heat mechanism of human body.

• Asian-Australasian Journal of Animal Sciences
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• 제31권2호
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• pp.263-269
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• 2018

Objective: Heat stress (HS) triggers oxidative stress and respiratory alkalosis in pigs. The objective of this experiment was to study whether a short-term supranutritional amount of dietary vitamin E (VE) can mitigate oxidative stress and respiratory alkalosis in heat-stressed pigs. Methods: A total of 24 pigs were given either a control diet (17 IU/kg VE) or a high VE (200 IU/kg VE; HiVE) diet for 14 d, then exposed to thermoneutral (TN; $20^{\circ}C$, 45% humidity) or HS ($35^{\circ}C$, 35% to 45% humidity, 8 h daily) conditions for 7 d. Respiration rate and rectal temperature were measured three times daily during the thermal exposure. Blood gas variables and oxidative stress markers were studied in blood samples collected on d 7. Results: Although HiVE diet did not affect the elevated rectal temperature or respiration rate observed during HS, it alleviated (all p<0.05 for diet${\times}$temperature) the loss of blood $CO_2$ partial pressure and bicarbonate, as well as the increase in blood pH in the heat-stressed pigs. The HS reduced (p = 0.003) plasma biological antioxidant potential (BAP) and tended to increase (p = 0.067) advanced oxidized protein products (AOPP) in the heat-stressed pigs, suggesting HS triggers oxidative stress. The HiVE diet did not affect plasma BAP or AOPP. Only under TN conditions the HiVE diet reduced the plasma reactive oxygen metabolites (p<0.05 for diet${\times}$temperature). Conclusion: A short-term supplementation with 200 IU/kg VE partially alleviated respiratory alkalosis but did not reduce oxidative stress in heat-stressed pigs.

• 설비공학논문집
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• 제27권10호
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• pp.515-519
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• 2015

Conjugate heat transfer analysis for an ethylene furnace was carried out based on numerical simulation. Detailed distributions of velocity vectors, chemical species, and temperature inside the furnace are presented and discussed. Von Mises stress and heat flux at the tube surface were also evaluated to elucidate mechanisms regarding failure of the tube. Maximum stress was found at the upstream elbow of the tube, which did not coincide with the location of maximum heat flux. This implies that thermal stress at a steady state would not be a dominant component of the stress. Degradation of the material, as well as the system arrangement, should be considered in order to accurately predict the lifetime of the tube material in the furnace.

• 대한한의학방제학회지
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• 제11권2호
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• pp.147-158
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• 2003

This study aimed to investigate the effect of each constituent-herb of Sagoonja-Tang on the plasma corticosterone level in mice exposed to heat stress. Each formula(0.5g/kg, 1.0g/kg) was injected intragastrically to mice exposed to forced hot water swimming(42$^{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 15 minutes after the heat stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group didn't show significant changes. 3. Atractylodis group showed significant decrease at 0.5g/kg dose(P<0.05). But it showed slightly increase at 1.0g/kg dose. 4. Poria group didn't show significant changes. 5. Glycyrrhizae group showed slightly increase, but insignificant. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level in mice exposed to heat stress.

• 한국기계가공학회지
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• 제17권3호
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• pp.16-21
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• 2018

The effect of heat treatment on the fatigue crack growth behavior in welded joints between the heat-affected zone (HAZ) of SA 508 Cl.3 low-alloy steel and HAZ of AISI 316L stainless steel is investigated. When the crack propagates across SA 508 Cl.3 or AISI 316L SS and HAZ into the weldment, the fatigue crack growth rate (FCGR) in the HAZ region does not change or decrease despite the increase in stress intensity factor ${\Delta}K$. The residual stress at the HAZ region is more compressive than that at the base Δ materials and weldment. The effect of the welding residual stress on the crack growth behavior is determined by performing a residual stress relief heat treatment at $650^{\circ}C$ for 1h and subsequent furnace cooling. The FCG behavior in the HAZ region in the as-welded specimen and the residual stress relief heat-treated specimen is discussed in terms of the welding residual stress.

• Journal of Mechanical Science and Technology
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• 제16권9호
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• pp.1054-1064
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• 2002

Numerical prediction of welding-induced residual stresses using the finite element method has been a common practice in the development or refinement of welded product designs. Various researchers have studied several thermal models associated with the welding process. Among these thermal models, ramp heat input and double-ellipsoid moving source have been investigated. These heat-source models predict the temperature fields and history with or without accuracy. However, these models can predict the thermal characteristics of the welding process that influence the formation of the inherent plastic strains, which ultimately determines the final state of residual stresses in the weldment. The magnitude and distribution of residual stresses are compared. Although the two models predict similar magnitude of the longitudinal stress, the double-ellipsoid moving source model predicts wider tensile stress zones than the other one. And, both the ramp heating and moving source models predict the stress results in reasonable agreement with the experimental data.

• 열처리공학회지
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• 제16권3호
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• pp.141-147
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• 2003

The effects of heat treatment on the fatigue life and welding residual stress of welded plates were investigated in this study. The plates were welded by flux cored arc welding process, and post weld heat treated at $600^{\circ}C$ for 1 hour. The residual stresses of welded plates before and after post weld heat treatment were measured by hole drilling method. To measure the fatigue life of welded plates, low cycle fatigue tests under strain control and high cycle fatigue tests under load control were performed respectively, by using cylindrical specimens containing weld metal and heat affected zone. The obtained result shows that the post weld heat treatment reduces the residual stress, and resultantly changes the fatigue life of welded plate. Goodman diagrammatic analysis has also been performed to study the effect of post weld heat treatment on the high cycle fatigue life.

• 한국자동차공학회논문집
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• 제4권5호
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• pp.187-196
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• 1996

In this study, 3-dimensional finite element model of a diesel engine cylinder head was made to accomplish heat transfer analysis and also thermal stress and deformation analysis. Heat release analysis and Nusselt-Reynolds correlations were applied to determine the convective boundary conditions which are required for heat transfer analysis to calculate temperature distribution. Thermal stress distribution was also investigated from heat transfer analysis results. Steady state temperature and heat flux were measured by using K-type thermocouples and then compared with numerical results to give a guarantee for the propriety of numerical analyses.

• Asian-Australasian Journal of Animal Sciences
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• 제7권3호
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• pp.397-400
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• 1994

The effect of xylazine administration on plasma cortisol, prolactin, glucose and packed cell volume (PCV) responses to immobilization and heat stress was investigated. Immobilization of rats for 2 hours by ligation of the fore and hind legs strongly caused approximately two-fold increase in plasma cortisol and prolactin levels. Plasma glucose and PCV were not significantly changed. Pretreatment of immobilized rats with xylazine (20 mg/kg body weight i.m.) resulted in approximately 20% reduction in both plasma cortisol and prolactin concentrations. A marked hyperglycemia and increase in the PCV value was observed. On the other hand, rats exposed to acute heat stress ($40^{\circ}C$, and 60% relative humidity) for 2 hours, also developed two fold increase in both plasma cortisol and prolactin concentrations and the pretreatment with xylazine caused a 20% reduction in the levels of both hormones. Plasma glucose level was not significantly changed in heat stressed rats but it was markedly increased after pretreatment with xylazine. PCV was significantly incrcased under heat stress and pretreatment with xylazine induced a pronounced elevation in this value. It was suggested that stimulation of cortisol and prolactin secretion in response to immobilization or heat stress can be partially reduced by an alpha 2-adrenergic agonist.