• Clinical and Experimental Reproductive Medicine
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• v.24 no.3
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• pp.399-405
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• 1997

Progesterone is necessary for successful pregnancy and had immunosuppressive properties. Peripheral blood mononuclear cells (PBMC) from many women with unexplained recurrent spontaneous abortion responded to trophoblast extract in vitro by prolifertion and releasing soluble, heat-labile factors that are toxic to mouse embryos (embryotoxic factors). Accumulating evidence suggests that T Helper (Th)-1 type immunity to trophoblast is correlated with embryotoxic factor production and is associated with pregnancy loss, while Th2-type immunity is associated with successful gestation. The objective of this study was to determine whether progesterone can inhibit Th1-type cytokine secretion (IFN-${\gamma}$, TNF-${\alpha}$) by trophoblast-activated peripheral blood mononuclear cells from 23 nonpregnant women (age 25-35) with unexplained recurrent abortion (median 5, range 3 to 15)who otherwise produce embryotoxic factors in response to trophoblast. We also determined whether progesterone affected Th2-type cytokines (IL-4, IL-10) in this system in vitro and if IL-10 (1,500 pg/mL) could inhibit Th1-type immunity to trophoblast. IFN-${\gamma}$ was detected in 17 of 23 (74%) trophoblast stimulated PBMC culture supernatants ($77.94{\pm}23.79$ pg/mL) containing embryotoxic activity. TNF-${\alpha}$ was detected in 19 (83%) of these same supernatants ($703.15{\pm}131.36$ pg/mL). In contrast, none of the supernatants contained detectable levels of IL-4 or IL-10. Progesterone ($10^{-5}$, $10^{-7}$, $10^{-9}$M) inhibited Th1-type immunity in a dose dependent manner, but had no effect on Th2-type cytokine secretion. The inhibitory effects of progesterone were abrogated with RU486, but did not affect Th2-type cytokine secretion in trophoblast-activated cell cultures. IL-10, like progesterone also inhibited Th1-type cytokine secretion but had no effect on Th2-type cytokines. These data suggest that therapies designed to suppress Th1-type cytokine secretion in women with recurrent abortion who have evidence of Th1-type immunity to trophoblast may be efficacious in preventing pregnancy loss and should be tested in appropriately designed clinical trials.

• International Journal of Highway Engineering
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• v.12 no.3
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• pp.93-101
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• 2010

As the number of indispensable needs of clean energy increases due to the green new deal revolution, the possibility of heat energy harvesting from the surrounding infrastructures such as a railroad or highway was verified. In order to find more efficient usage of a heat source, the possibility of transforming heat into electricity were confirmed using Bi-Te type thermoelectric element, and electrical quality were tested with experiments of different heat source and environmental change in the surrounding infrastructures. After careful experiments, the possibility of collecting thermal energy and findings of the heat temperature change in infrastructrue are verified with a result of obtaining almost 20.82W in 70 celcius($^{\circ}C$) temperature differences and $1m^2$ surface area. Consequently, the ratio of heat temperatiure change and transforming surface area is the most crucial factor in the harvesting heat energy, and reducing thermal loss and improving thermal convection as well as transformation efficiency of thermoelectric element is required to get more efficient and durable generation.

• Journal of Embryo Transfer
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• v.23 no.4
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• pp.257-261
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• 2008

The objective of present study was to investigate the effect of seasons on reproductive performance of Hanwoo and Holstein heifers. Heat stress in summer or cold stress in winter stress to Hanwoo and Holstein heifers may bring reproduction failure, which would pose an important economic loss, even around Daegwallyeong region located in high mountainous area. Seasonal differences in the serum levels of LH, FSH and progesterone ($P_4$) in response to environmental factors (hot and cold) out of 20 pubertal Hanwoo heifers in Daegwallyeong, Gangwon Province and 20 non-lactating Holstein heifers in Chonan city of Republic of Korea at 2-3 years of age were compared. Blood samples for hormonal analysis were from jugular vein after detection of estrus repeatedly over four seasons within four-week intervals (Spring: May to June, Summer: July to August, Autumn: October to November and Winter: January to February). In Hanwoo heifer population, averages of LH and FSH concentration in spring and in summer were greater compared to those in winter (p<0.05). LH or FSH levels tended to be greater (p=0.06) in spring and less (p=0.09) in winter compared to the levels in autumn. Only in summer, cattle seemed to show lower LH or FSH secretion (p<0.05). Similar to the results in Hanwoo heifers, the serum concentrations of LH and FSH in Holstein heifers decreased further by heat stress in summer when P 4 levels were high during luteal phase. The results demonstrate significant effect of summer heat on reproduction of Hanwoo or Holstein heifers. Although parameters indicating the extent of heat stress were not measured in this study, we suggest that serum hormone levels could be considered as successful indicators of summer heat stress condition for Hanwoo and Holstein heifers even under rather cool summer climate.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.31-36
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• 2001

As a part of micro engine development feasibility estimation was done through fabrication and test of down scaled combustor and MEMS fabricated spark electrode. In an experimental observation of the down scaled combustion phenomena where flame propagation was observed by optical method and pressure change in combustor which gives the information about the reaction generated thermal energy was recorded and analyzed. Optimal combustor scale was derived to be about 2mm considering increased heat loss effect and thermal energy generation capability. Through the fabrication and discharge test of MEMS electrode effects of electrode width and gap was investigated. Electrode was fabricated by thick PR mold and electroplating. From the result discharge voltage characteristic in sub millimeter scale electrode having thickness of $40{\mu}m$ was obtained. From the result base technology for design and fabrication of micro engine was obtained.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.05a
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• pp.458-463
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• 1997

A transient natural circulation behavior during a LOCA at hot-standby operation is evaluated for YGN Units 3/4. The plant initial condition is determined within the EOP limitation as suitable to hot-standby mode and the transient scenario is prepared as relevant to evaluation of transient natural circulation. A 0.4% cold leg break with loss of off-site power is calculated with RELAP5/MOD3.2, whose predictability has been verified for SBLOCA natural circulation test, S-NC-8B. Through one hour transient analysis, it is found that the plant has its own decay heat removal capability by natural circulation following a LOCA, at hot-standby mode. Additional calculation is performed to investigate an effect of HPSI flow on natural circulation.

• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.5
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• pp.112-117
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• 2007

With the Euro-4 regulation coming into effect, the domestic car industry is forced to look for newer options to reduce NOX in the exhaust. EGR(Exhaust Gas Recirculation) Cooler is an effective method for the reduction of NOX form a diesel engine. High efficiency, low pressure loss and compactness are desirable features of an EGR Cooler. The cooling performance of EGR depends on the shape of tubes and the location of the entrance and exit. This paper reports the computational work conducted to estimate the performance of EGR cooler with three different cross section tubes and a triangular spiral tube. Three dimensional computation results show that the triangular tube is more effective than circular and rectangular tube. The most effective geometry is a triangular spiral tube with offset inlet and outlet locations.

• 한국연소학회:학술대회논문집
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• 1999.10a
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• pp.231-240
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• 1999

The temperature distribution in double-concentric diffusion flames have been investigated experimentally by rapid insertion technique. Using a fine thermocouple and rapid insertion mechanism, the temperature has been measured before soot particles attach the thermocouple junction which can affect the temperature signal by changing the radiation heat loss. For double-concentric diffusion flames, the temperature at the axis is higher than that of normal coflow diffusion flames because of the inverse diffusion flame at the center of the flame. However, it is almost same at the periphery on which the inverse flame does not have an effect.

• Elastomers and Composites
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• v.32 no.1
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• pp.20-28
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• 1997

This study have Investigated the effect of various factors related to the physical properties of vulcanizated rubber compounds. rubber type, carbon black type and carbon black loading were selected as main factors and evaluation were tested by tables of orthogonal arrays with 3 factors and 3 levels. rubber types have affected cure time, tensile strength, and $T_g$ as main factor and carbon black loading have affected viscosity, scorch time, maximum torque, hardness, 300% modulus, rebound, heat build-up, $0\;&\;60^{\circ}C$ tangent delta, PICO and CUT/CHIP loss as main factor but the effects of carbon black type have affected only bound rubber content.

• Solar Energy
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• v.4 no.2
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• pp.51-57
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• 1984

The aim of the study is to the thermal performance of TAP (Thermosiphoning Air Panel) which is easily applicable to existing building as well as new building. TAP is one of the advantageous means of passive solar system, with a view to reducing the energy consumption of existing and new building. The instantaneous thermal efficency of a thermo siphoning collector depends primarily on the heat loss coefficient of the collector, the effectiveness of heattransfer between the absorber and the air, the average air temperature in the collector, the ambient air temperature, and the transmitted solar radiation. Because the important design variables are interrelated, it is, difficult to determine the effect of design decisions based on intuition. Therefore economical and effective TAP can be used easily, TAP had been designed and analyzed.

• Journal of the Korean Ceramic Society
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• v.32 no.10
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• pp.1162-1168
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• 1995

Systematic studies of the effects of additives and processing variables on the sintered density and the effect of crystalline forms of starting powders on the microstructure of pressureless sintered silicon carbide are described. Oxide additives were effective for the densification of SiC up to 96% of theoretical density at temperature as low as 185$0^{\circ}C$. Use of embedding powder increased the sintered density, up to 98% of theoretical density, by decreasing the weight loss during sintering. Composite type duplex microstructure has been developed due to the $\beta$longrightarrow$\alpha$ phase transformation of SiC by sintering at 185$0^{\circ}C$ and heat treatment at 195$0^{\circ}C$ for 1h.