• 수면정신생리
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• 제11권2호
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• pp.100-105
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• 2004

목 적：본 연구의 목적은 주요우울장애환자를 대상으로 Heart Rate Variability(HRV) 검사를 이용하여 비침습적으로 자율신경계의 기능, 심혈관조절체계 및 항상성을 측정하여 정상대조군과 비교해보고 생리학적, 임상적 의미를 고찰해보는 것이다. 방 법：DSM-Ⅳ의 진단기준에 의하여 주요우울장애로 진단받은 환자 30명과 정상대조군 30명을 대상으로 하였다. 검사는 SA-2000E 기기를 사용하여 HRV parameter를 측정한 후 시(time) 영역과 주파수(frequency)영역별로 분석하였다. 결 과：Heart rate(HR)는 환자군에서 유의하게 증가된 소견을 나타내었으며 the standard deviation of the NN interval(SDNN), the root square of successive differences(RMSSD)도 환자군에서 유의하게 낮은 소견을 보였다. Total power(TP) band, very low frequency(VLF：$0.003{\sim}0.04\;Hz$) band, low frequency(LF：$0.04{\sim}0.15\;Hz$) band, high frequency(HF：$0.15{\sim}0.4\;Hz$) band는 환자군에서 유의하게 낮은 수치를 보였고, LF/HF의 비는 유의한 차이를 나타내지 않았다. 결 론：우울증 환자는 심박수의 증가와 HRV의 감소를 보였으며, 교감 신경과 미주 신경의 불균형이 높은 심혈관계 사망률과 부분적으로 연관이 있는 것 같다. 우울증 환자들은 심장에서 자율신경기능의 이상을 나타내며 이렇게 교감/부교감 신경활성 조절능력이 저하되어 균형이 깨짐으로써 높은 심혈관계 사망률을 보인다고 할 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제39권4호
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• pp.359-364
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• 2006

Objectives: The object of this study is to assess the relationship between socioeconomic factors and the predicted 10-year risk of cardiovascular disease by using health risk appraisal of ischemic heart disease. Methods: The study population was taken from The 2001 Korea National Health and Nutrition Survey, and it consisted of 1,566 men and 1,984 women aged 30-59. We calculated 10-year risk using the risk function of ischemic heart disease as developed by Jee. The educational level and equivalized household income were dichotomized by a 12 years education period and the median income level. Occupation was dichotomized into manual/non-manual work. We stratified the population by age(10 years) and sex, and then we rated the risk differences according to socioeconomic factors by performing t-tests for each strata. Results: There were gradients of the predicted 10-year risk of ischemic heart disease with the educational level and the equivalized household income, and thet was an increasing tendency of risk differences with age. Manual workers didn't show significant risk difference from non-manual workers. Conclusions: There was definite relationship between low socioeconomic position and the predicted risk of ischemic heart disease in the future.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1169-1179
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• 1992

To determine the period and degree of full recovery of postoperative pulmonary function, the author performed seiral pulmonry function test with spirometry at preoperative period and 1st, 2nd, 3rd, 4th, 6th and 8th postoperative week in 64 patients who underwent chest surgery form 1990. 1. to 1990. 8. at Dep. of Thoracic & Cardiovascular surgery, Pusan National University Hospitcal, Pusan, Korea 28 patients underwent lung resection[Group A], 14 patients mediastinal and other thoracic surgery[Group B], and 22 patients heart surgery with cardiopulmonary bypass[Group C]. Al of them recovered normally and discharged without any complications. Their serial changes of pulmonary function test were compaired and its results was as follows; l. Over all mean recovery time of restrictive ventilatory function tests[ie, VC, ERV, IC, FEF1, FVC, FEF200-1200, MVV] were 4th & 6th postoperative week, and that of obstructive ventilatory function tests[ie., EFE25-75%, Vmax50] were 2nd postoperative week. 2. In patient who underwent lung resection surgery[Group A], FEF1 recovered in 4th~6th postoperative week and its ratio to preoperative value was 70% in pneumonectomy, and 75% in lobectomy. FVC recovered in 4th~6th postoperative week and its ratio to preoperative value was 65% in pneumonectomy, and 80% in lobectomy. MVV was recovered in 4th~8th postoperative week and recovery ratio was 80%, FEF200-1200 was recovered at 4th~6th postoperative week and its recovery ratio was 70%, FEF25-75% and Vmax50 was recovered in 2nd~4th postoperative week and recovered nearly to preoperative level. 3. In patient who underwent mediastinal and other thoracic surgery[Group B], FEV1 and FVC and recovered in 4th~6th postoperative week and the recovery ratio of FVC in blebectomy was 90%. MVV reached preoperative level in 4th~8th postoperative week. FEF200-1200, FEF25-75% and Vmax50 were recovered in 2nd~4th postoperative week and the recovery of FEF25-75% and Vmax50 in blebectomy was prominant. 4. In patient who underwent heart surgery[Group C], FEV1 and FVC were recovered in 4th~6th postoperative week. The recover ratio of FEF25-75% and Vmax50 was delaied to 6th~8th postoperative week From the above results we concluded that the recovery time of posoperative restrictive ventilatory disorder was 4th postoperative week and pulmonary complication would possibly occure during that period. So more intensive observations will be needed.

• Korean Journal of Acupuncture
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• 제33권4호
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• pp.176-182
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• 2016

Objectives : This study was designed to analyze the characteristic of heart rate variability(HRV) changes between Deficiency Pattern and Excess Pattern in Stroke Patients admitted to the hospital. Methods : We measured heart rate variability of stroke patients who were admitted to the Department of Korean Internal medicine, Stroke and Neurological Disorders Center from February 1, 2015 to May 30, 2016. We recruited a total of 28 stroke patients and heart rate variability tests were performed on the first day of admission, 2weeks after admission, and 4 weeks after admission. Results : VLF and LF/HF ratio significantly increased over time in Deficiency Pattern group compared with those in the Excess Pattern group. Conclusions : This results suggest that the parasympathetic function of Deficiency Pattern group is lower than that of the Excess Pattern group, resulting in imbalance of the autonomic nervous system.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.533-543
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• 2021

Myocardial fibrosis (MF) is the result of persistent and repeated aggravation of myocardial ischemia and hypoxia, leading to the gradual development of heart failure of chronic ischemic heart disease. Triptolide (TPL) is identified to be involved in the treatment for MF. This study aims to explore the mechanism of TPL in the treatment of MF. The MF rat model was established, subcutaneously injected with isoproterenol and treated by subcutaneous injection of TPL. The cardiac function of each group was evaluated, including LVEF, LVFS, LVES, and LVED. The expressions of ANP, BNP, inflammatory related factors (IL-1β, IL-18, TNF-α, MCP-1, VCAM1), NLRP3 inflammasome factors (NLRP3, ASC) and fibrosis related factors (TGF-β1, COL1, and COL3) in rats were dete cted. H&E staining and Masson staining were used to observe myocardial cell inflammation and fibrosis of rats. Western blot was used to detect the p-P65 and t-P65 levels in nucleoprotein of rat myocardial tissues. LVED and LVES of MF group were significantly upregulated, LVEF and LVFS were significantly downregulated, while TPL treatment reversed these trends; TPL treatment downregulated the tissue injury and improved the pathological damage of MF rats. TPL treatment downregulated the levels of inflammatory factors and fibrosis factors, and inhibited the activation of NLRP3 inflammasome. Activation of NLRP3 inflammasome or NF-κB pathway reversed the effect of TPL on MF. Collectively, TPL inhibited the activation of NLRP3 inflammasome by inhibiting NF-κB pathway, and improved MF in MF rats.

• Journal of Chest Surgery
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• 제13권4호
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• pp.364-374
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• 1980

Twenty-two patients were selected for evaluation of pre-and postoperative pulmonary function. These patients were performed open cardiac surgery with the extracorporeal circulation from March 1979 to July 1980 at the Department of Thoracic and Cardiovascular Surgery, Kyungbook National University Hospital. Patients were classified with ventricular septal defect 5 cases, atrial septal defect 5 cases, tetralogy of Fallot 5 cases, mitral stenosis 4 cases, rupture of aneurysm of sinus Valsalva 1 case, left atrial myxoma I case, and aortic insufficiency 1 case. The pulmonary function tests were performed and listed: [1] respiratory rate, tidal volume [TV], and minute volume[MV], [2] forced vital capacity [FVC] and forced expiratory volume[FEV 0.5 & FEV 1.0], [3] forced expiratory flow [FEF 200-1200 ml & FEF 25-75%]. [4] Maximal voluntary ventilation [MVV], [5] residual volume [RV] and functional residual capacity[FRC], measured by a helium dilution technique. Respiratory rate increased during the early postoperative days and tidal volume decreased significantly. These values returned to the preoperative levels after postoperative 5-6 days. Minute volume decreased slightly, but essentially unchanged. Preoperative mean values of the forced vital capacity, functional residual capacity and total lung capacity decreased [63.2%, 87.2% & 77.3% predicted, respectively], and early postoperatively these values decreased further [19.6%, 76.0% & 38.0% predicted], but later progressively increased to the preoperative levels. In residual volume, there was no decline in the preoperative mean values [100.9% predicted] and postoperatively the value rather increased [106.3-161.7% predicted]. Forced expiratory volume [FEV 0.5 & FEV 1.0] and forced expiratory flow [FEF 200-1200 ml & FEF 25-75%] also revealed significant declines in the early postoperative period. There was no significant difference in values of the spirometric pulmonary function tests, such as FEF 1.O and FEF 25-75% between successful weaning group [17 cases] extubated within 24 hrs post-operatively and unsuccessful weaning group [5 cases] extubated beyond 24 hrs. Static compliance and airway resistance measured for the two cases during assisted ventilation, however, any information was not obtained. Long term follow-up pulmonary function studies were carried out for 8 cases in 9 months post-operatively. All of the results returned to the pre-operative or to normal predicted levels except FVC, FEV 1.0, and FEF 25-75% those showed minimal declines compared to the pre-operative figures.

• 동의신경정신과학회지
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• 제19권3호
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• pp.45-54
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• 2008

Objective: To treat psychogenic headache patients, doctors have to amplify on the headache caused by emotional stress to patients, and assist the patients to cope with difficulties. So, we investigated HRV of the headache patients caused by Chiljungsang and would like to apply to the clinical treatment. Method: Our study measured time and frequency domain HRV indicies(5-min resting study) of 123 headache patients caused by emotional stress. Standardized tests of HRV allow a quantitative estimation of autonomic nervous system function. Results & Conclusions: 1. The study classed as aspects of the head pain showed the differences in RMS-SD(square root of mean squared difference of successive NN intervals) band, HF(high frequency) band significantly. 2. The male headache patients showed higher all the indicies except heart rate compared to the female patients, significantly in SDNN(standard deviation of NN interval), TP(total Power), HF band. 3. As the patients grow older, SDNN, RMS-SD band was lower and LF(low frequency) band, LF/HF ratio higher significantly. The beginning age lower, SDNN, RMS-SD band was higher significantly. The duration of the disease longer, LF band, LF/HF ratio was higher significantly.

• Journal of Chest Surgery
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• 제30권3호
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• pp.247-252
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• 1997

심장이식시에 가교 역할을 담당하거나 수술 후 심부전에 빠진 심장을 보조할 공압식 심실보조장치를 개발하여 동물실험을 시행하였다. 실험 에 이용한 심실보조장치는 소아용과 성 인용의 두 가지 종류로서 박동장이 각각 34cc와 70cc이다. 심실 재료는 폴리우레탄으로 제작하여 항혈전성을 높였다. 총 10마리의 동물실험을 시행하였다. 심실보조장치의 혈액펌프는 좌심방과 대동맥에 연결관을 이용하여 이식하였다. 심실보조장치의 평균 박출량은 펌프 박동수가 60회일 때 성 인의 경우 2.38 L/min였고 소아용의 경우 0.41 L/min였다. 생존시간은 최고 26시간이었다. 가장 큰 합병증은 출혈이었고 주 사망원인은 심부전 및 폐부전이었다. 심실보조장치 자체 에 대한 결함때문에 일어난 실패는 없었다. 현재까지의 실험 결과를 토대로 심실보조장치를 발전시키면 임상에서도 사용 가능할 것으로 보인다.

• Tuberculosis and Respiratory Diseases
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• 제46권3호
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• pp.386-393
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• 1999

연구배경 : 호흡곤란을 호소하는 폐질환 환자에 대하여 답차 및 자전거 운동을 시행하여 각각의 운동 부하 방법에 따른 심폐기능의 변화의 차이점을 알아 보고자 하였다. 방 법 : 호흡곤란을 동반한 남자 17명과 여자 4명을 대상으로 1주일 이상의 간격을 두고 무작위로 Sensor Medics사의 model No. 2900 자전거 작업계 (bicycle ergometer)와 Sensor Medics사의 Vmax29 treadmill을 이용하여 각각 incremental exercise를 실시하였다. 결 과 : 답차를 이용한 운동부하 폐기능 검사상 자전거 운동에 비하여 $VO_2max$, VEmax, 혐기성 역치값은 유의한 상승을 보였으며, 호흡 및 심박수 예비력은 유의한 감소를 보였다. 결 론 : 운동부하 검사 방법에 따라 호흡기 질환 환자에서 심폐기능 검사치의 유의한 차이를 보이므로 어떠한 운동 부하 방법을 사용하였는지에 따라 결과 해석에 고려가 필요할 것으로 사료된다.

• 대한간호학회지
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• 제29권6호
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• pp.1273-1283
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• 1999

This study was done to explore the effects of dance therapy on pulmonary and cognitive functions in the elderly. The design of this study was a non-equivalent pre-post test experiment. The subjects consisted of elderly persons living in a facility located in Kyoungi-Do. Fifty eight subjects had normal cognition, sensory function and resting blood pressure. They underwent tests of pulmonary and cognitive function as baseline data before dance therapy, and at 6th week and at the end of 12nd week after following dance therapy. Twenty seven elderly persons were assigned to the experimental group and participated with the dance therapy. This therapy was based on the Marian Chace's dance therapy and Korean traditional dance with music. The dance therapy consisted of 50 minutes session, 3 times a week for 12 weeks. One session consisted of warming-up, expression, catharsis, sharing and closing stage. the intensity of the dance therapy was at the 40% of age-adjusted maximum heart rates. Data were analyzed with mean, standard deviation, Chi-square test, unpaired t-test, repeated measures ANOVA, and Bonferroni multiple regression using SAS program. The results were as follows : 1. Pulmonary function(forced expiratory volume at one second and forced vital capacity) of the experimental subjects significantly increased over time more than that of the control subjects. 2. The experimental group had significantly higher score for pulmonary function than the control group at the 12nd week after dance therapy. 3. Cognitive function of the experimental subjects significantly increased over time more than that of the control subjects. 4. The experimental group had significantly higher score for cognitive function than the control group at the 6th week and 12nd week after dance therapy. The findings showed the dance therapy could be effective in improving the pulmonary and cognitive function of the elderly.