• 대한임상약리학회:학술대회논문집
• /
• 1998.12a
• /
• pp.68-68
• /
• 1998

• 대한임상약리학회:학술대회논문집
• /
• 1998.12a
• /
• pp.52-52
• /
• 1998

• 대한임상약리학회:학술대회논문집
• /
• 1999.12a
• /
• pp.44-44
• /
• 1999

• Korean Journal of Clinical Pharmacy
• /
• v.15 no.2
• /
• pp.100-104
• /
• 2005

건강한지원자에서 세프라딘 250 mg 캡슐을 오전 09:00시와 오후22:00시에 경구투여하여 세프라딘의 약물동태학적 주기변화 (생체리듬)를 검토하였다. 혈장중 세프라딘의 농도는 두 투여시간에서 유의성 있는 차이를 보여주었다. 혈장농도곡선하면적 (AUC)은 오후 때 보다 오전 투여시에 유의성 있게 증가되었으며, 생물학적반감기$(t_{1/2})$는 오후 때 보다 오전 투여시에 더 연장되었다. 전신청소를 $(CL_t)$은 오후 때 보다 오전 투여시 유의성 있게 감소되었다.

• 한국생물공학회:학술대회논문집
• /
• 2002.04a
• /
• pp.103-106
• /
• 2002

A gradient LC/MS system was constructed and applied for separation of biological samples. For example, a rapid and simple analytical method without pretreatment based on gradient ${\mu}LC/MS$ with a disposable microcolumn has been developed to determine B group vitamins in urine. Urine samples were directly injected to the disposable home-made microcolumn. The microcolumn can be emptied after being used for a series of urine samples, and repacked with fresh stationary phase. An overdose of vitamin pills were swallowed by healthy volunteers and the urine samples were taken 1,2,3,5, and 8 hours after swallowing. Vitamins immediately showed up in urine, hit the maximum, and disappeared swiftly. This technique is expected to have some application for clinical purposes.

• Journal of Pharmaceutical Investigation
• /
• v.17 no.3
• /
• pp.127-133
• /
• 1987

Dissolution characteristics and urinary excreted amount of commercially available three brands of sulfisoxazole tablets were investigated in order to elucidate the in vitro-in vivo correlations and relative bioavailability in humans. All the tablets tested met the K.P. IV and the USP XXI specifications for tablet weight variation, content uniformity, disintegration and dissolution. The disintegration and dissolution rate constants of sulfisoxazole tablets in pH 2.0 HCl-KCl buffer were reduced more significantly (p<0.05) than those in diluted HCl $(1{\rightarrow}12.5)$ and pH 6.5 phosphate buffer. It seemed to be attributed to the pH dependent solubility of sulfisoxazole. We could see that the relative bioavailability of brand B to sulfisoxazole powder was about 90% and that its value was higher than those of other two brands from the urinary excretion data obtained from eight healthy male volunteers by means of Latin square cross over design. No useful correlation was observed between the in vitro and in vivo studies in this experiment.

• Microbiology and Biotechnology Letters
• /
• v.24 no.2
• /
• pp.254-260
• /
• 1996

To investigate the effects of lactic acid bacteria administration on fecal microflora and putrefactive metabolites in human being, Lactobacillus acidophilus and Bifidobacterium longum powder (1.5 $\times$ 10$^{9}$ cells, respectively) was administrated to six healthy volunteers (average 28 years old) twice a day for 2 weeks. During the administration of lactic acid bacteria, the numbers of bifidobacteria, lactobacilli, and enterococci in feces were increased significantly, whereas those of Staphylococcus and lecithinase-negative Clostridium were decreased considerably. In addition, a number of anaerobic Bacteroides were increased. However, the contents of fecal ammonia and putrefactive metabolites (indole, skatole, p-cresole) were not changed during the administration.

• Archives of Plastic Surgery
• /
• v.32 no.6
• /
• pp.706-709
• /
• 2005

The absence of the nipple-areolar complex(NAC) in men are seldom stated, as a result of trauma, burn, mastectomy, or after the correction of extreme bilateral gynecomastia. A total of 50 healthy men aged 21 to 27 years were examined. We recorded the configuration (dimensions and shape) and the location of the NAC with respect to fixed skeletal anatomic landmarks. Of the 50 subjects examined, 44 had oval and 6 had a round NAC. The mean diameter for a round NAC was 24.3 mm. The center of the NAC was in the fourth intercostal space in 41 volunteers and in the fifth intercostal space in 9 of the subjects. To localize the NAC on the chest wall, at least three reproducible measurements proved to be necessary, composed of a horizontal line(distance from the midsternal line to the nipple, A), a medial oblique line(distance from the sternal notch to the nipple, B) and a lateral oblique line(distance from the acromioclavicular joint to the nipple, C). Using these three parameters, we recommend that the appropriate location can be calculated derived from the circumference of the chest.

• Analytical Science and Technology
• /
• v.8 no.4
• /
• pp.545-551
• /
• 1995

Five acid hydrazides as precolumn fluorescence derivatization reagents for carboxylic acids in HPLC, which have the benzofuran or benzothiazole moiety conjugated to a furan, thiophene or oxazoline ring, were synthesized and examined in view of reactivity, separability and sensitivity. Of these hydrazides, 2-(5-hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole (BTOH) was most favorable. The detection limit of lauric acid as a model acid was 0.1 pmol per $10-{\mu}l$ injection volume at S/N=3, which was roughly equal to that of an analogous compound, 2-(5-hydrazinocarbonyl-2-furyl)-5,6-dimethoxybenzothiazole. The reagent allowed rapid assays of carboxylic acids ($C_{12:0}-C_{20:4}$) within 20 min with satisfactory scparability. The method was applied to the determination of fatty acids in human sera from healthy volunteers as well as from patients with diabetes or thyroid dysfunction.

• Journal of Pharmaceutical Investigation
• /
• v.14 no.4
• /
• pp.189-194
• /
• 1984

The present study was undertaken to evaluate the relative bioavailability of doxycycline hyclate and doxycycline-L-methylenelysine, a new synthetic derivative of doxycycline. Single doses, equivalent to 100mg of doxycycline hyclate, were administered orally to 10 healthy male volunteers. Serum concentrations were determined periodically over 12 hrs. by microbiological assay. Peak serum concentrations were reached within 4 hrs. Doxycycline hyclate $(1.38mcg.ml^{-1})$ gave 1.66 tines higher concentration than doxycycline-L-methylenelysine $(0.38mcg.\;ml^{-1})$. And the areas under the serum concentrationtime curves 0 to 12 hrs were $8.38mcg.hr.ml^{-1}$ (doxycycline hyclate) and $5.56mg\;hr.ml^{-1}$(doxycycline).