Objectives: The purpose of this study was to investigate the associated factors of self-reported dry mouth in adults. Methods: A self-reported questionnaire was filled out by 249 adults in Seoul and Gyeonggi-do from June to October, 2014. The questionnaire consisted of general characteristics of the subjects, age, monthly income, smoking, alcohol drinking, and systemic diseases including systemic diseases, medication, oral health status, and stress. The question for dry mouth consisted of dryness in skin, eyes, lips, and nasal mucosa. The subjective dry mouth consisted of 6 questions measured by visual analogue scale(VAS). Cronbach's alpha was 0.881 in the study. Oral health related quality of life (OHIP-14) was adapted from Yoon. The questionnaire for OHIP-14 included functional limitation, physical pain, psychological disability, social disability, and experience in hadicap measured by Likert 5 scale. Cronbach's alpha was 0.885 in the study. Data was analyzed for a t-test, one-way ANOVA and multiple regression analysis by using SPSS(SPSS 18.0, USA) program. Results: There were positive correlations between oral health-related quality of life and self-reported dry mouth (functional limitation r=0.288, physical pain r=0.219, psychological discomfort r=0.193, physical disability r=0.280, psychological disability r=0.205, social disability r=0.224 and handicap r=0.270). In the multiple regression analysis, variation of self-reported dry mouth were positively associated with dry eyes{very often(${\beta}=0.305$)), sometimes(${\beta}=0.186$)}, dryness on lips{very often(${\beta}=0.247$), sometimes(${\beta}=0.177$)}, handicap(${\beta}=0.152$), physical disability(${\beta}=0.128$) and alcohol drinking(1-2 times/week)(${\beta}=0.116$) (p<0.001). Conclusions: Self-reported dry mouth may cause deterioration of the entire body dryness(dryness on eyes and lips), low oral health-related quality of life(handicap and physical disability) and alcohol drinking. Thus, It is necessary to develop oral health education programs to prevent and manage dry mouth in adults.