• 대한방사선방어학회:학술대회논문집
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• 2010.04a
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• pp.48-51
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• 2010

• Corrosion Science and Technology
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• v.3 no.2
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• pp.39-46
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• 2004

Development and application of structural health monitoring system in Korea have become active since the early 1990's. In earlier applications, health monitoring systems were installed in several existing bridges in order to collect initial field data by full scale load capacity test for design verification and subsequently monitor long-term performance and durability of the bridge as part of an inspection and maintenance program. Recently, modem and integrated monitoring systems have been introduced in most of the newly constructed long-span bridges since the design stage. This paper outlines the progresses and applications of monitoring systems in Korea for both existing and newly constructed bridges and describes their aims and characteristics.

• BMB Reports
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• v.52 no.1
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• pp.47-55
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• 2019

Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model, suggesting a direct link between SCs, longevity, and ARDs. Therefore, senotherapeutics, medicines targeting SCs, might be an emerging strategy for the extension of health span, and prevention or treatment of ARDs. Senotherapeutics are classified as senolytics which kills SCs selectively; senomorphics which modulate functions and morphology of SCs to those of young cells, or delays the progression of young cells to SCs in tissues; and immune-system mediators of the clearance of SCs. Some senolytics and senomorphics have been proven to markedly prevent or treat ARDs in animal models. This review will present the current status of the development of senotherapeutics, in relation to aging itself and ARDs. Finally, future directions and opportunities for senotherapeutics use will discussed. This knowledge will provide information that can be used to develop novel senotherapeutics for health span and ARDs.

• Smart Structures and Systems
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• v.20 no.2
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• pp.197-205
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• 2017

The dynamic performance of railway bridges under high-speed trains draws the attention of bridge engineers. The vibration issue for long-span bridges under high-speed trains is still not well understood due to lack of validations through structural health monitoring (SHM) data. This paper investigates the correlation between bridge acceleration and train speed based on structural dynamics theory and SHM system from three foci. Firstly, the calculated formula of acceleration response under a series of moving load is deduced for the situation that train length is near the length of the bridge span, the correlation between train speed and acceleration amplitude is analyzed. Secondly, the correlation scatterplots of the speed-acceleration is presented and discussed based on the transverse and vertical acceleration response data of Dashengguan Yangtze River Bridge SHM system. Thirdly, the warning indexes of the bridge performance for correlation scatterplots of speed-acceleration are established. The main conclusions are: (1) The resonance between trains and the bridge is unlikely to happen for long-span bridge, but a multimodal correlation curve between train speed and acceleration amplitude exists after the resonance speed; (2) Based on SHM data, multimodal correlation scatterplots of speed-acceleration exist and they have similar trends with the calculated formula; (3) An envelope line of polylines can be used as early warning indicators of the changes of bridge performance due to the changes of slope of envelope line and peak speed of amplitude. This work also gives several suggestions which lay a foundation for the better design, maintenance and long-term monitoring of a long-span high-speed bridge.

• Structural Monitoring and Maintenance
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• v.3 no.3
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• pp.259-276
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• 2016

Historically the UK has been a pioneer and early adopter of experimental investigation techniques on new and operation structures, a technology that would now be descried as 'structural health monitoring' (SHM), yet few of these investigations have been enduring or carried out on the long span or tall structures that feature in flagship SHM applications in the Far East.

• Structural Engineering and Mechanics
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• v.17 no.5
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• pp.655-670
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• 2004

This paper aims to evaluate the effect of typhoons on fatigue damage accumulation in steel decks of long-span suspension bridges. The strain-time histories at critical locations of deck sections of long-span bridges during different typhoons passing the bridge area are investigated by using on-line strain data acquired from the structural health monitoring system installed on the bridge. The fatigue damage models based on Miner's Law and Continuum Damage Mechanics (CDM) are applied to calculate the increment of fatigue damage due to the action of a typhoon. Accumulated fatigue damage during the typhoon is also calculated and compared between Miner's Law and the CDM method. It is found that for the Tsing Ma Bridge case, the stress spectrum generated by a typhoon is significantly different than that generated by normal traffic and its histogram shapes can be described approximately as a Rayleigh distribution. The influence of typhoon loading on accumulative fatigue damage is more significant than that due to normal traffic loading. The increment of fatigue damage generated by hourly stress spectrum for the maximum typhoon loading may be much greater than those for normal traffic loading. It is, therefore, concluded that it is necessary to evaluate typhoon induced fatigue damage for the purpose of accurately evaluating accumulative fatigue damage for long-span bridges located within typhoon prone regions.

• Journal of Sasang Constitutional Medicine
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• v.14 no.3
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• pp.7-16
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• 2002

Purpose The goal of this study tried to provide aging and life span in Sasang Constitutional Medicine. Methods It was researched Master Dong-Mu's documentary records about aging and the life span represented by ${\ulcorner}$Dongyi Soose Bowon Sasang Chobongyun${\lrcorner}$ and ${\ulcorner}$Dongyi Soose Bowon${\lrcorner}$ published in 1901. Results & conclusion 1. A principal of regimen according to Sasang Constitutional Medicine isn't medicational method but non-medicational method. There are control mind and upright oneself. 2. Dong-Mu's the views of the span of life represented by 'Inherent vitality' that a term means health promoting and forecasting length of the life. He also emphasizied a natural power of recovery from damaged vitality. 3. Greed is reduced one's lifetime. It is originated by bias for 'joy-anger -sorrow-pleasure'. The other example is 'Liquor-Sex-Property- Authority'. 4. The way of prolonging lifetime what managed small visceral intestines through constitutional upright oneself. This is found on pathology, care of health and constitutional 'Knowledge and Deed'.

• Smart Structures and Systems
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• v.11 no.6
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• pp.637-662
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• 2013

The Jiangyin Bridge is a suspension bridge with a main span of 1385 m over the Yangtze River in Jiangsu Province, China. Being the first bridge with a main span exceeding 1 km in Chinese mainland, it had been instrumented with a structural health monitoring (SHM) system when completed in 1999. After operation for several years, it was found with malfunction in sensors and data acquisition units, and insufficient sensors to provide necessary information for structural health evaluation. This study reports the SHM system upgrade project on the Jiangyin Bridge. Although implementations of SHM system have been reported worldwide, few studies are available on the upgrade of SHM system so far. Recognizing this, the upgrade of original SHM system for the bridge is first discussed in detail. Especially, lessons learned from the original SHM system are applied to the design of upgraded SHM system right away. Then, performance assessment of the bridge, including: (i) characterization of temperature profiles and effects; (ii) recognition of wind characteristics and effects; and (iii) identification of modal properties, is carried out by making use of the long-term monitoring data obtained from the upgraded SHM system. Emphasis is placed on the verification of design assumptions and prediction of bridge behavior or extreme responses. The results may provide the baseline for structural health evaluation.

• Research in Community and Public Health Nursing
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• v.8 no.2
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• pp.178-196
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• 1997

The purpose of this study is to identify the kind, the frequency, and the type of Stress Management Program(SMPs) throughout life-span used foreign, recent research. The period of this study was from July 1 to Dec. 10, 1997. The data were collected through Medline using two concepts: stress management programs and life-span. The number of these research were 106 and thirty-one experimental researches that were tested the effectiveness of SMPs throughout life span were selected. The data were analysed by the kind, frequency, and life-span. The results were as follows: 1. The kind and frequency of SMP : The total number of the kind of SMP were twenty-two. The most used SMP was relaxation therapy, 22 out of 31. The second biofeedback was 10, the third, cognitive behavior program was 9, the fourth, nutrition and diet, and education were 7. The others were coping skill(4), cognitive therapy(4), breathing(4), imagery(3), autogenic training(3), sleep and rest(2), meditation(2), information(2), desensitization(2), hypnosis(2), behavior therapy(1), time management (1), visualization(I), yoga(I), diversion(1), and problem solving skill. 2. Throughout life-span: Most SMPs were applied to adolescents, young adults, and middle-adults. Other subjects could not be found under the schooler. 3. The type of SMPs : 28(90.3%) out of 31 research used combined-SMP : two-combined SMP, 5: three-combined SMP, twelve: four-combined SMP, seven: five-combined SMP. 4. Afterward, further study such as meta-analysis are needed in order to identify effective ness of the SMPs.

• The Journal of Health Technology Assessment
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• v.6 no.2
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• pp.133-141
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• 2018

Objectives: In the past, the pharmaceutical drug heparin was mostly used as the anticoagulant for continuous renal replacement therapy (CRRT), but the duration time is long to have the risk of a bleeding adverse effect, and in that case the drug therapy Nafamostat mesilate was utilized instead, as it is more safe in this case, with a short half-life and is increasing in use to permit lower concerns for bleeding incidents. However, there are insufficient number of large-scale studies on the comparison of Nafamostat mesilate and heparin. Methods: In this study, a systematic review are used to compare the bleeding risk of Nafamostat mesilate and Heparin, as subjected to patients and procedures for measuring risks performed with a CRRT, and the filter life span is to be evaluated as well in this patients. Results: As a result of literature review search, a total of 6 studies were included in systematic review. The reducing risk of bleeding and filter life span was analyzed. The retrospective cohort studies confirm that Nafamostat mesilate is less at risk of bleeding than heparin. And a cohort study confirms that Nafamostat mesilate is longer filter lifespan than heparin and randomized controlled trial studies show that Nafamostat mesilate is longer filter lifespan than not using the anticoagulants. Conclusion: Nafamostat mesilate is considered to be a good therapeutic option because it has a longer filter life span as well as the advantage of reducing bleeding.