• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3759-3762
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• 2016

Background: Breast cancer risk assessment is a helpful method for estimating development of breast cancer at the population level. Materials and Methods: In this cross-sectional study, participants consisted of a group of 3,847 volunteers ($mean{\pm}SD$ age: $463{\pm}7.59$ years) in a convenience sample of women referred to health centers affiliated to Tehran University of Medical Sciences in Tehran, Iran. The risk of breast cancer was estimated by applying the National Cancer Institute's online version of the Gail Risk Assessment Tool. Results: Some 24.9% of women reported having one first-degree female relative with breast cancer, with 8.05% of them having two or more first-degree relatives with breast cancer. The mean five-year risk of breast cancer for all participants was $1.61{\pm}0.73%$, and 9.36% of them had a five-year risk of breast cancer >1.66%. The mean lifetime risk of breast cancer was $11.7{\pm}3.91%$. Conclusions: The Gail model is useful for assessing probability of breast cancer in Iranian women. Based on the their breast cancer risk, women may decide to accept further screening services.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.153-163
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• 1994

P450s are a superfamily of heme-containing monooxygenases and important in the metabolism of numerous physiological substrates and foreign compounds. It has been established that tilers are at least 30 distinct human isoforms of P450. Four families containing numerous individual P450s are mainly responsible for metabolizing foreign compounds, A cDNA expression system in which individual human P450s are synthesized in cultured human hepatoma (Hep G2) cells infected with a recombinant vaccinia virus containing human P450 cDNA has been constructed.

• Environmental Analysis Health and Toxicology
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• v.24 no.1
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• pp.9-16
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• 2009

Effects of salinity and standard toxic metals on fertilization and embryo development rates were investigated in the sea urchin, Hemicentrotus pulcherrimus. Spawning was induced by injecting $1{\sim}2$ mL of 0.5 M KCl into the coelomic cavity. Males released white or cream-colored sperms and females released yellow or orange-colored eggs. The fertilization rate was below 30% when salinity was 20 psu and lower, but was almost above 90% when salinity was 25 psu and higher. The embryo development rate was below 60% when salinity was 25 psu and lower, but was above 80% when salinity was between 30 and 35 psu. The fertilization and embryo development rates in the control condition(not including Cu and Cd) were greater than 90%, but decreased a high negative correlation with the increasing of Cu(r=-0.80, r=-0.78) and Cd(r=-0.90, r=-0.82) concentrations, respectively. The fertilization and embryo development rates were significantly inhibited in the addition of Cu($EC_{50}$=17.30 ppb, $EC_{50}$=10.32 ppb) and Cd($EC_{50}$=364.57 ppb, $EC_{50}$=244.04 ppb), respectively. These results suggest that salinity concentrations for successful fertilization and normal embryogenesis of H. pulcherrimus are above 25 psu and 30 psu, respectively, and the biological assays of fertilization and embryo development rates using H. pulcherrimus are useful methods for the ecological toxicity test of marine pollution elements.

• Journal of Pharmacopuncture
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• v.26 no.1
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• pp.77-85
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• 2023

Objectives: The coronavirus disease 2019 has deteriorated mental health, particularly in mothers with elementary school children. Although the country has developed several health promotion programs to preserve mental health, no program has incorporated Korean medicine. Thus, this study focuses on developing vital Korean medicine mental health care programs. Methods: The program follows the Korean medicine health promotion program principles. Guidelines, reports, research, and previous programs were analyzed to form interventions and lecture content. Results: Pellets, hot packs, meditation, lavender oil, and green tea were selected as final intervention strategies. Mental health-related guidelines were analyzed to produce stress management lecture materials. In addition, an operational methods and evaluation tool manual was created. Conclusion: We designed a health promotion program capitalizing on Korean medicine to improve mental health. This program will be assessed and accordingly improved through practical applications.

• Mass Spectrometry Letters
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• v.4 no.1
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• pp.18-20
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• 2013

Headspace solid phase micro-extraction gas chromatography/flame ionization detection (HS-SPME-GC/FID) method was compared with headspace gas chromatography/mass selective detection (HS-GC/MS). Organic solvent-spiked urine as well as urine samples from workspace was analyzed under optimal condition of each method. Detection limit of each compound by HS-SPME-GC/FID was $3.4-9.5{\mu}g/L$, which enabled trace analysis of organic solvents in urine. Linear range of each organic solvent was $10-400{\mu}g/L$, with fair correlation coefficient between 0.992 and 0.999. The detection sensitivity was 4 times better than HS-GC/MS in selected ion monitoring (SIM) mode. Accuracy and precision was confirmed using commercial reference material, with accuracy around 90% and precision less than 4.6% of coefficient of variance. Among 48 urine samples from workplace, toluene was detected from 45 samples in the range of $20-324{\mu}g/L$, but no other solvents were found. As a method for trace analysis, SPME HS GC/FID showed high sensitivity for biological monitoring of organic solvent in urine.

• Child Health Nursing Research
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• v.16 no.3
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• pp.184-194
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• 2010

Purpose: The purpose of this research was to develop an interpersonal caring program "Muldan Dongsan" for vulnerable adolescents in mental health clinics and to identify the effect of this program. Methods: The interpersonal caring program was composed of group interpersonal caring (one time per week for two weeks, for a total of 8 hr) and individual interpersonal caring (1-2 times per day for 2 weeks). For this research, a non-synchronized quasi-experimental model including nonequivalent experimental and control groups was used. The experimental group was made up of 17 students and the control group, of 22 students. The data were collected from May 11 to July 25, 2009 and the collected data were analyzed using the SPSS/WIN 17.0 program. Results: The interpersonal caring program "Muldan Dongsan' was effective for mental health, including self-esteem, hope, and quality of life for vulnerable adolescents. Conclusion: The positive findings on the effectiveness of the interpersonal caring program "Muldan Dongsan" and the participants' high satisfaction with this program indicate that it can be utilized actively as a specific nursing intervention program for adolescents at school and in the community.

• Korean Journal of Health Education and Promotion
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• v.17 no.2
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• pp.35-56
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• 2000

This study is research on physical health and mental health(physical and mental symptom at school) in perceived school environment among adolescents. The study subjects ere selected by senior high school students in seoul and random sampling. The 3,060 subjects were selected 18 schools. The duration for survey was for Nov. 25-Dec. 13, 1998. The reliability of Questionnaire was Cronbach's $\alpha=0.95$. This study used multiple regression through Factor Analysis in SPSS programs. The major findings of this study are as follows: (1) All of Multiple Regression Models were significant. (p<0.001). (2) Physical Mental health is related to gender, personal environment, and economic status. (3) Physical Health is related to perceived school environmental variable (therapeutic teacher-student relationships, classrom climate, and school life satisfaction) among adolescents. (4) Mental Health is related to perceived school environment variables(therapeutic teacher-student relationships, classroom climate, school life satisfaction, teachers' climate, and classmates' attitudes) among adolescents. This study could be used as the basis for the development of educational program, counseling, teacher in-service training, student teacher training and the establishment of educational and health policy.

• Journal of Korean Public Health Nursing
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• v.21 no.2
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• pp.252-261
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• 2007

Purpose: To analyze the trends of study related with case management in Korean nursing in order to present the direction for future research. Methods: This article reviewed 15 studies from 7 nursing Journals and dissertations published in Korea from 1995 to 2006. The studies were examined according to the research topics, research subjects and methods and research results. Results: Only 15 articles related to case management were published in nursing journals between 1995 and 2006, most of which were from 2001 to 2003. The majority of the articles (53.3%) was experimental designs and their subjects were mostly adults (72.7%). The major topic of the articles was the effects of nursing interventions, followed by development for case management model, applying program for CM and developing case management strategies. Conclusion: This study suggests the need for further research in various areas of case management and the development of case management theory related to nursing.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.47-49
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• 2003

Development of drug delivery systems has been recognized as one of portfolios to gain a competitive edge in pharmaceutical industry over 30 years. The application of drug delivery technologies offers pharmaceutical companies and patients several therapeutic benefits, including improving efficacy and adverse effect profiles, enhancing patient compliance and potentially regenerating unsuccessful drugs. (omitted)

• Journal of Genetic Medicine
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• v.2 no.1
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• pp.11-15
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• 1998

This paper reports 3 cases with 46,XX sex reversed male. Three 46,XX hypogonadal subjects showed complete sex reversal and had normal phallus and azoospermia. We studied them under clinical, cytogenetic and molecular aspects to find out the origin of the sex reversal. Patients had markedly elevated serum follicle-stimulating hormone (FSH) and lutenizing hormone (LH) and decreased or normal range of serum testosterone. The testicular volumes were small (3-8ml). Testicular biopsy showed Leydig cell hyperplasia and atrophy of seminiferous tubules. We obtained the results of normal 46,XX, and the presence of Y chromosome mosaicism was ruled out through XY dual fluorescent in situ hybridization (FISH). By using polymerase chain reaction (PCR), we amplified short arm (SRY, PABY, ZFY and DYS14), centromere (DYZ3), and heterochromatin (DYZ1) region of the Y chromosome. PCR amplification of DNA from these patients showed the presence of the sex-determining region of the Y chromosome (SRY) but didn't show the centromere and heterochromatin region sequence. The SRY gene was detected in all the three patients. Amplification patterns of the other regions were different in these patients; one had four amplified loci (PABY+, SRY+, ZFY+, DYS14+), another had two loci (SRY+, ZFY+) and the other had two loci (PABY+, SRY+). We have found that each patient's translocation elements had different breakpoints at upstream and downstream of the SRY gene region. We conclude that the testicular development in 46,XX male patients were due to insertion or translocation of SRY gene into X chromosome or autosomes.