• The Korean Journal of Physiology and Pharmacology
• /
• v.19 no.5
• /
• pp.451-460
• /
• 2015

Sirtuin 1 (SIRT1) is a mammalian $NAD^+$-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation contributes to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO) mice were fed a high-fat diet (HFD) or normal diet (ND) for 12 weeks. Metabolic parameters and markers of hepatic steatosis and inflammation in liver were compared in WT and KO mice. SIRT1 deletion enhanced HFD-induced changes on body and liver weight gain, and increased glucose and insulin resistance. In liver, SIRT1 deletion increased the acetylation, and enhanced HFD-induced nuclear translocation of nuclear factor kappa B (NF-${\kappa}B$), hepatic inflammation and macrophage infiltration. HFD-fed KO mice showed severe hepatic steatosis by activating lipogenic pathway through sterol regulatory element-binding protein 1 (SREBP-1), and hepatic fibrogenesis, as indicated by induction of connective tissue growth factor (CTGF), alpha-smooth muscle actin (${\alpha}$-SMA), and collagen secretion. Myeloid-specific deletion of SIRT1 stimulates obesity-induced inflammation and increases the risk of hepatic fibrosis. Targeted induction of macrophage SIRT1 may be a good therapy for alleviating inflammation-associated metabolic syndrome.

• Nuclear Engineering and Technology
• /
• v.55 no.3
• /
• pp.1031-1035
• /
• 2023

Neutron is an indirectly ionizing particle without charge, which is normally measured by detecting reaction products. Neutron detection system based on measuring gadolinium-converted gamma-rays is a good way to monitor the neutron because the representative prompt gamma-rays of gadolinium have low energies (79, 89, 182, and 199 keV). Low energy gamma-rays and their high attenuation coefficient on materials allow the simple design of a detector easier to manufacture. Thus, we designed a cadmium zinc telluride detector to investigate feasibility of simultaneous detection of gamma-rays and neutrons by using the Monte-Carlo simulation, which was divided into two parts; first was gamma-detection part and second was gamma- and neutron-simultaneous detection part. Consequently, we confirmed that simultaneous detection of gamma-rays and neutrons could be feasible and valid, although further research is needed for adoption on real detection.

• Journal of dental hygiene science
• /
• v.22 no.4
• /
• pp.233-240
• /
• 2022

Background: In modern society, rapid changes in the medical environment have required medical staff to access various information and be competent in active and effective problem-solving through collegial interactions. In line with these changes, universities are aiming to connect education. This study aimed to provide basic data of connected-convergence education by survey the awareness and needs of college students in health-related fields. Methods: This study included 122 college students from the health field. A survey regarding "the awareness and need of connected-convergence education" was conducted and general characteristics of the participants were collected from June to July 2022. Results: The awareness of connected-convergence education was low at 19.7%, but the intention to participate was high at 74.6%. Subject requirements were 18.0% for medical psychology, 13.5% for communication and counseling, 13.5% for medical artificial intelligence technology convergence, and 10.4% for sports health management. In the group showing high satisfaction with the major curriculum, the demand for connected education was also high. For efficient operation, it was investigated that it was necessary to secure specialized training courses, recognition of liberal arts credits, the right to register for courses equal to those of major students, and secure dedicated classrooms. Conclusion: Although the awareness and experience of connected-convergence education among the participants were low, the intention to participate was high. As such a plan to revitalize the university curriculum was required. It is timely to discuss the nurturing of convergence-type talents and multidisciplinary thinking skills. It is meaningful to provide basic data necessary for connected-convergence education in health-related fields at university. Universities should strive to enhance job competency in the health field by providing connected-convergence education based on student demands.

• Journal of the Korea Convergence Society
• /
• v.10 no.1
• /
• pp.71-78
• /
• 2019

This Convergence study aimed to analyze the oral health education, oral health awareness and oral health knowledge of early childhood education' students. Questionnaire survey on the of five universities early childhood education' 314 students in Daegu and Gyeongbuk provinces. Average score of oral health awareness was 3.62, which was high female students, 3rd grade, athlete, high case on oral health condition perception and childhood oral health education experience. Oral health knowledge correct answer of 15 items was average 9.63, which was higher female students, 3rd grade, nonsmokers, have received childhood oral health education, responded to the need for childhood oral health education. Regression analysis showed that Y (oral health awareness) = 2.350 + 0.242 (exercise) +0.387 (oral health education) +0.134 (childhood oral health education experience) +0.067 (oral health knowledge). In order to promote infants oral health of department of Early Childhood Education, it would be necessary to develop the systematic programs to perform the childhood oral health education.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2014.04a
• /
• pp.708-711
• /
• 2014

국민소득 증가와 고령화 사회에 진입하면서 다양한 의료소비가 의료서비스산업에 영향을 미치고 있으며, 이러한 사회 구조 및 환경변화에 따라 새로운 질병에 대한 대응 또한 절실히 요구되고 있다. 질병 예측을 위한 연구는 기후변화와 질병, 건강행태와 질병, 사회적 위치와 질병 등 질병에 영향을 주는 많은 요인들이 있다. 그러나 이러한 요인들을 통합, 분석 활용하는 데는 해결해야 할 문제들이 많이 있다. '정부3.0 공공데이터 개방 정책' 을 통해 질병에 관련된 자료가 공개 되면서 본 연구에서는 2010년부터 2012년까지의 질병에 영향을 주는 공공데이터를 연도별로 통합하여 지리정보시스템(GIS)기반 데이터베이스를 구축하고 활용 할 수 있게 하였다. 향후 기후변화에 민감한 질병을 찾기 위해 해당기관의 자료를 활용하여 월별로 데이터베이스를 구축하고, 이를 기반으로 의료서비스의 활성화 및 효율성에 기여 할 수 있다.

• Journal of the Korean Society of Safety
• /
• v.36 no.5
• /
• pp.92-92
• /
• 2021

• Journal of the Korea Convergence Society
• /
• v.11 no.3
• /
• pp.95-100
• /
• 2020

The purpose of the Convergence study is to identify the factors of health-related quality of life for the elderly and provide the basic data needed to improve the quality of life for the elderly. The objects of the study were 1,367 people aged 65 or older living in Korea out of the original data for the 7th National Health and Nutrition Survey by the Korea Centers for Disease Control and Prevention (Year 2017). Multiple regression analyses was performed by using the SPSS/PC 21.0 statistical program for the purpose of the study. According to the study, mental health and then physical activity were the most influential factors in health-related quality of life. Based on these results, we found that health education is highly important to provide customized health care services and to build the correct lifestyle in order to improve the quality of health-related life. Therefore, follow-up research is needed to identify the effectiveness of developing and applying diverse programs to enhance mental health and physical activity of the elderly in the future.

• Journal of Convergence for Information Technology
• /
• v.9 no.9
• /
• pp.201-209
• /
• 2019

A convergence study of oral health beliefs and subjective oral health awareness-knowledge factors of some university students was conducted on 216 students agreed from April 1 to June 14, 2019. Satistical analysis was performed with the mean and standard deviation, t-test, one-way ANOVA, and Pearson's correlation test. The oral health beliefs were 3.87 and oral health knowledge, oral health importance measured by 5-point, oral health interest and oral health status are 11.9, 1.50, 2.36, 2.67 respectively. The need for constant oral health education so that changes in oral health beliefs of university students and subjective oral health awareness-perception ability can be improved. Oral health education programs should be developed to suit the characteristics of university students.

• Journal of the Korean Society of Industry Convergence
• /
• v.25 no.2_2
• /
• pp.219-232
• /
• 2022

The aim of this study is to provide the dynamic convergence index that reflected the inherent characteristics of the convergence phenomenon and utilized the nationally-funded R&D projects data, thereby suggesting useful information about the direction of the national convergence R&D strategy. The dynamic convergence index that we suggested was made of two indicators: persistency and diversity. From a time-series perspective, the persistency index, which measures the degree of continuous convergence of multidisciplinary nationally-funded R&D projects, and the diversity index, which measures the degree of binding with heterogeneous research areas. We conducted the empirical experiment with 151,248 convergence R&D projects during the 2015~2021 time period. The results showed that convergence R&D projects in both public health and life sciences appeared the highest degree of persistency. It was presumed that the degree of persistency has increased again due to the COVID-19 pandemic. Meanwhile, the degree of diversity has risen with combining with disciplinary such as materials, chemical engineering, and brain science areas to solve social problems including mental health, depression, and aging. This study not only provides implications for improving the concept and definition of dynamic convergence in terms of persistency and diversity for national convergence R&D strategy but also presented dynamic convergence index and analysis methods that can be practically applied for directing public R&D programs.

• Journal of the Korea Convergence Society
• /
• v.11 no.9
• /
• pp.425-432
• /
• 2020

This study was to identify the educational needs for mental health nursing among undergraduate nursing students, prioritizing the areas where require extensive convergence learning via simulation. One hundred and forty students completed the survey where data accrued from between March-May 2020. The educational needs for mental health nursing and nursing care schizophrenia patients were assessed using a self-reporting questionnaire, which included 19 and 15 items, respectively. Additional three essay questions were used to obtain information regarding previous simulation education experience. Higher educational needs in nursing care for schizophrenia were identified and the highest-priority need is communication skills. Factors, including realistic experience with standardized patients, teamwork, and feedback from the lecturers, affect positive experiences in mental health nursing simulation. The findings suggest that educational programs to improve communication skills are necessary for better mental health nursing competency. Well-designed and convergence based simulation programs providing real-like clinical experience would ensure optimal learning outcomes.