• Development and Reproduction
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• v.23 no.2
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• pp.129-138
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• 2019

In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. $NAD^+$-dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseases. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity.

• International Journal of Contents
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• v.9 no.1
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• pp.42-48
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• 2013

This research explores the convergence of health care expenditure in Korea with different income groups and the world level by applying different concepts of convergence, including growth rates, trends, differences as well as rationality and statistical variation of health care expenditure. The empirical evidence shows that, in general, the health care expenditure in Korea seems to be on the right track in terms of both level and difference, given the fact that convergence exists with the expenditures of the high income group and the world level. It is also worth mentioning that the Korean public health care system has been performing much better than its private health care counterpart. Such a result suggests that the private health care system has to be more elaborately and systematically managed through the establishment of an operational policy to stimulate an increase in private health care expenditure.

• Journal of Convergence for Information Technology
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• v.9 no.3
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• pp.120-127
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• 2019

A study on the factors affecting oral health beliefs of some high school third graders on oral health promotion behavior After the oral health education on November 21, 2017, 160 students who explained and agreed on the study purpose and method were final analyzed. Oral health belief and oral health promotion behavior according to general characteristics were analyzed with t-test, one-way ANOVA, and the correlation with Pearson's correlation test. The convergence factors affecting oral health promotion were performed multiple regression analysis. The convergence factors affecting oral health promotion were performed multiple regression analysis. Oral health belief was the highest with 3.61 points, with 4.06 points of benefit, while oral health promotion with 3.25 points. Convergence factors affecting oral health improvement were shown as susceptibility (${\beta}=-0.210$), salienece(${\beta}=0.396$), seriousness(${\beta}=0.306$), and barrier(${\beta}=-0.170$). To explore ways to change the oral health beliefs of high school students, the school district health education is very important, and various oral health education programs to promote oral health promotion should be developed.

• Journal of the Korea Convergence Society
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• v.8 no.8
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• pp.267-281
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• 2017

Despite the recent importance of interdisciplinary convergence research, little has been studied on the detailed experience while conducting convergence research in Korea. To deeper understand challenges and overcoming in convergence research and to suggest an administrative system for it, by analyzing researchers experience and cognition while conducting their actual convergence research, in-depth interviews with 16 full-time faculty members with expertise in convergence research and research administration in a university and analyzed the interviews by using the paradigm model of grounded theory. The results show that the core phenomenon researchers experienced is that "convergence research is not being effectively conducted," and they experience growth in research through pursuing efforts and improving research atmosphere in various aspects. Based on these findings, we made several suggestions for promoting convergence research.

• Journal of the Korea Convergence Society
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• v.8 no.11
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• pp.167-175
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• 2017

The purpose of this study was to investigate the convergence factors affecting behavior of oral health improvement perceived by the subjective oral health awareness perception factors in some college students. The questionnaire was conducted from April 10, 2017 to April 30, 2013 for 300 students at S university and the and the 290 final data were used. Oral health knowledge, oral health importance measured by 5-point, oral health status and oral health interest are 11.46, 1.71, 2.78, 2.52 respectively. Significant differences from experience of oral health education for oral health knowledge, oral health importance, oral health interest have been observed. The convergence factors influencing acts of oral health promotion were oral health status(${\beta}=-0.188$) and oral health interest(${\beta}=-0.265$) the higer the oral health status and oral health interest, the better acts of oral health promotion. Therefore, effective oral health education programs should be developed to increase oral health knowledge and interest in oral health and to change behavior and attitude.

• Journal of the Korea Convergence Society
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• v.9 no.9
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• pp.135-142
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• 2018

The purpose of this study was to investigate the effect of subjective systemic health status and health behavior on the oral health-related quality of life through a convergence study. The data collected by a survey on adults living in Busan Metropolitan City were analyzed using SPSS 21.0 program. The oral health-related quality of life of the non-smoking group was higher than that of the smoking group, and the oral health-related quality of life was higher in the high group for the subjective systemic health status and health behavior than in the low group. Subjective systemic health status and health behavior both were found to have a positive (+) influence on oral health-related quality of life, and especially the subjective systemic health status had a greater influence. Therefore, as the improvement of oral health-related quality of life is expected through systemic health, it is considered that development of convergence education programs could be an important medium to educate the associated importance of systemic health and oral health.

• Korean Journal of Health Education and Promotion
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• v.33 no.2
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• pp.47-55
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• 2016

Objectives: We investigated whether the rate of depressive symptom is higher among family members of asthmatic patient compared to people who had no asthmatic family member. Methods: This study used data from the fourth and fifth Korea National Health and Nutrition Examination Survey (2007-2012). In this cross-sectional study, 15,987 men (mean age 46.4) and 20,906 women (mean age 47.4) were included. To compare the rate of depressive symptoms in individuals who had a family member with asthma and those who did not have, we analyzed data using survey logistic regression. Results: Diagnosed depression was reported by 3.0% of the study population, by 4.2% of asthmatic patient's family member, and by 3.0% of individuals who did not have a family member with asthma. Family members of asthmatic patient increased odds of diagnosed depression compared with those who did not had an asthmatic family member (odds ratio = 1.56, p = 0.008). Conclusions: To prevent depression among family members of asthmatic patient, health education for entire family of asthmatic patient need to be considered. Also, government and policy makers should give more attention to caregivers who had a family member with asthma.

• Oncology Reports
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• v.41 no.2
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• pp.1377-1386
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• 2019

Zinc finger protein 36 (ZFP36) is an AU-rich element protein that binds to 3'-untranslated regions and promotes the decay of target mRNAs. Downregulation of ZFP36 expression in turn results in stabilization of target mRNAs. A recent study indicated that downregulation of ZFP36 expression in human liver cancer is caused by epigenetic mechanisms. The purpose of the present study was to investigate the potential of resveratrol (Res) to induce ZFP36 expression. Promoter methylation was analyzed using methylation-sensitive restriction analysis. It was determined that Res treatment increased ZFP36 expression and decreased the mRNA levels of ZFP36 target genes in A549 lung cancer cells. Additionally, Res suppressed the expression of DNA (cytosine-5)-methyltransferase 1 and induced demethylation of the ZFP36 promoter. Collectively, the present results demonstrated that Res has anticancer activity through its epigenetic regulation of ZFP36 in non-small cell lung cancer.

• Molecules and Cells
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• v.38 no.11
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• pp.991-997
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• 2015

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of ARE-scontaining mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.

• Convergence Security Journal
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• v.15 no.3_2
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• pp.77-82
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• 2015

IT convergence has been approached from national strategic dimension with an aim to drive forward technology development and industrial advancement in other fields by taking the IT to the next advanced level, and has been the focus of intensive investment of research resources. Against this backdrop, IT convergence has emerged as a cutting-edge convergence industry that helps spur development of new growth engine being pushed forward at inter-ministerial level, as well as help turn the mainstay industries into high value-added industries and create new IT industry. Health-related convergence services have shifted its focus towards the exercise/sports and rehabilitation-oriented entertainment experiential industry away from conventional disease prevention and control-centric treatment/therapy technology industry. Thus, this study was intended to examine the trends of IT convergence technological development related to health exercise and present recommendation on the future course for development of major technologies and advancement of convergence industry, given the importance assigned to IT convergence.