• 대한예방한의학회지
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• 제27권2호
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• pp.1-22
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• 2023

Objectives : The aim of this study was to introduce the development process of Korean medicine health aging program for the older that is suitable for applied at public health center. Methods : For the development of the draft of health promotion program, we conducted a literature review of previous studies through searching international and domestic databases. The opinions of several experts were also colleted. Results : The details of 8-week of Korean medicine healthy aging program are as follows: 8-week of taking herbal medicines (Yukmijihwang-tang or Palmijihwang-tang, or Jaeumganghwa-tang) based on counseling with Korean medicine doctor, qigong, acupuncture on head, abdominal hotpack, taking nuts, and health education Conclusions : This healthy aging program can help to develop the healthy lifestyle habits and increase the general health status of community seniors.

• 한국보건간호학회지
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• 제30권1호
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• pp.30-41
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• 2016

Purpose: This study was conducted to determine the effects of middle-aged women's social support, self-efficacy, and perceived health status on aging anxiety. Methods: Research subjects were 210 middle-aged women between 40 - 60 years living in G-city. Data were collected from July $21^{st}$ 2014 to August $8^{th}$ using a structured questionnaire and analyzed using t-test, One way ANOVA, and multiple regression analysis using the SPSS/WIN 21.0 program. Results: Aging anxiety showed statistically significant differences in religion (t=2.44, p=.015), satisfaction with married life (F=4.39, p=.014), type of leisure activity (F=8.09, p<.001), and number of friends (F=3.23, p=.024). Aging anxiety showed correlation with social support (r=-.21, p=.003), self-efficacy (r=-.46, p<.001), and perceived health status (r=-.33, p<.001). Factors affecting aging anxiety were self-efficacy (${\beta}=-.33$, p<.001), perceived health status (${\beta}=-.23$, p<.001), leisure activity type (${\beta}=-.16$, p=.010), and religious affiliation (${\beta}=-.17$, p=.038). The predictive power of these variables was 25% (F=18.63, p<.001). Conclusion: Nursing intervention strategies for improving self-efficacy, perceived health status, and leisure activity are required to relieve aging anxiety of middle-aged women.

• 지역사회간호학회지
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• 제26권4호
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• pp.372-379
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• 2015

Purpose: This research was conducted to examine the successful aging and identify factors influencing successful aging in the Korean elderly. Methods: The subjects were 4,507 elders and data were collected from the 4th Korean Longitudinal Study of Ageing in 2012. The data were analyzed using frequencies, weighted percentage, ${\chi}^2$ test, and logistic regression. Results: The results of this study showed that 19.6% of the participants were categorized to successful aging. The domains of the absence of disease and disability and maintaining physical and mental functioning showed a high rate of achievement, while the domain of active engagement with life showed a low rate of achievement compared to others. Successful aging was influenced by gender, age, subjective economic status, subjective health status, and family support, particularly spouse's support. Conclusion: Intervention programs to increase the prevalence of successful aging are required. Especially programs for strengthening spouse's support and enhancing subjective health status are required.

• BMB Reports
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• 제52권1호
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• pp.47-55
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• 2019

Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model, suggesting a direct link between SCs, longevity, and ARDs. Therefore, senotherapeutics, medicines targeting SCs, might be an emerging strategy for the extension of health span, and prevention or treatment of ARDs. Senotherapeutics are classified as senolytics which kills SCs selectively; senomorphics which modulate functions and morphology of SCs to those of young cells, or delays the progression of young cells to SCs in tissues; and immune-system mediators of the clearance of SCs. Some senolytics and senomorphics have been proven to markedly prevent or treat ARDs in animal models. This review will present the current status of the development of senotherapeutics, in relation to aging itself and ARDs. Finally, future directions and opportunities for senotherapeutics use will discussed. This knowledge will provide information that can be used to develop novel senotherapeutics for health span and ARDs.

• 한국보건간호학회지
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• 제29권3호
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• pp.426-440
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• 2015

Purpose: This qualitative study aimed to understand older adults' perspectives on successful aging and develop a model of a successful aging process, within the Korean socio-cultural context. Methods: This study used a Grounded Theory approach. Through theoretical sampling, 14 participants were selected from older adults at a public health center and a volunteer institution in Gyeonggi Province, South Korea. Results: The basic social process identified was "expanding the aging self", which was preceded by three phases, namely, adjusting to the changes, developing the valuable self, and embracing the environment. Participants used 2-3 strategies for successful aging in each phase. For adjusting to the changes, participants used strategies such as "adopting a positive attitude", "accepting the changes", and "being at the center of life". To develop the valuable self, "re-identifying capacities", "having something to do", and "advancing to a healthy lifestyle" were used. Participants embraced their environments with "sharing with others" and "embracing younger generations". The causal condition for expanding the aging self was the changes in participants' physical, mental, or psychosocial situations. Conclusion: These findings suggest a theoretical foundation for the development of potential nursing interventions to promote self-care management and the interpersonal relationship for successful aging among Korean elderly individuals.

• 대한예방한의학회지
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• 제17권2호
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• pp.79-88
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• 2013

Objectives : This study investigated the relationship between smoking and health factors including stress resistance, stress index, fatigue and vaso-aging degree. Methods : The subjects were 19,953 persons who had received health examination by Korean Medicine and submitted questionnaires about smoking history, for 8 months from March to November in 2011. The stress index and resistance, fatigue were measured by HRV(Heart Rate Variability). The vaso-aging degree were measured by APG(Accelerated Photoplethysmograph). Results : Regarding the relationship between smoking and stress index and resistance, fatigue and vaso-aging degree were significant differences(p<0.05). Conclusions : This study suggests that smoking affects health factors including stress, fatigue and avaso-aging degree.

• Molecules and Cells
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• 제45권11호
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• pp.763-770
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• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.335-344
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• 2019

Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects of caloric restriction (CR) on LCN2-mediated inflammation and oxidative stress in the BAT of high-fat diet (HFD)-fed mice. Mice were fed a HFD for 20 weeks and then either continued on the HFD or subjected to CR for the next 12 weeks. CR led to the browning of the white fat-like phenotype in HFD-fed mice. Increased expressions of LCN2 and its receptor in the BAT of HFD-fed mice were significantly attenuated by CR. Additionally, HFD+CR-fed mice had fewer neutrophils and macrophages expressing LCN2 and iron-positive cells than HFD-fed mice. Further, oxidative stress and mitochondrial fission induced by a HFD were also significantly attenuated by CR. Our findings indicate that the protective effects of CR on inflammation and oxidative stress in the BAT of obese mice may be associated with regulation of LCN2.

• 한국언론정보학보
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• 제61권
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• pp.159-179
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• 2013

본 연구는 고령사회로 진입한 한국 사회에서 미디어가 어떻게 '잘 나이 들기(Aging Well)'에 대한 의미를 구성해내는지 고찰해보고자 하였다. 구체적으로 TV 건강프로그램이 어떠한 모습으로 노화를 그려내고 있으며, 노화 과정을 재현하는 방식의 사회문화적 의미는 무엇인가라는 질문에 답하고자 하였다. 이를 위해 KBS <비타민>에 대한 텍스트 분석을 진행한 결과, <비타민>은 정보의 오락화를 추구하는 과정에서 노화된 몸을 희화화시켜 조소의 대상으로 재현하고 있으며, 노화방지를 하지 못한 출연자가 실패자로 낙인찍히는 과정을 보여주어 노화에 대한 공포심을 강화하고 있다. 이 과정에서 노화된 몸을 수명이 다한 기계로 의미화 하고 측정 가능한 노화 지수를 만들어 그 기준에 미치지 못한 노년은 의료전문가와 의료 기술의 도움이 필요함을 강조한다. 과거에는 질병으로 간주되지 않았던 노화를 의료의 영역으로 끌어들여 치료의 대상으로 삼는 '노화의 의료화' 담론은 의료전문가의 통제권을 강조하고 사회문제를 개인화시키는 결과를 확산시키고 있다.

• 대한화장품학회지
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• 제45권2호
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• pp.185-198
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• 2019

인체 조직은 노화 현상을 겪으면 산화로 인한 손상이 진행되어 구조적인 변화가 일어나고 물성 저하를 겪는다. 피부가 겪는 노화 과정은 잘 알려져 있고 많은 평가가 수행되고 있지만 상대적으로 모발(머리카락)의 노화에 의한 평가는 잘 진행되어 있지 않아 모발의 노화를 케어하는 연구가 어려운 실정이다. 이에 본 연구는 모발의 노화 현상을 케어할 효능 기작을 적용할 수 있도록 노화된 모발 샘플을 제작하고 물성을 평가하여 안티에이징 효능을 확인하는 것을 목적으로 진행하였다. 먼저 내인성 노화가 진행된 모발의 지질량을 외인성 노화를 진행시킨 시료들과 비교한 결과, 펌 1회 처리 모발이 60대의 모발 지질량과 가장 유사함을 발견하였고, 이 모발을 통해서 원자 현미경으로 나노 스케일의 거칠기와 매크로 스케일의 인장강도를 평가하여 내인성 노화 모발과 유사한 물성 값을 가지고 있음을 확증하였다. 실제로 펌 처리를 통해 외인성으로 노화시킨 모발에 카르보디이미드와 펩타이드 결합을 적용하여 DSC로 구조적 변화와 거칠기 및 인장강도를 확인한 결과, 외인성 요인으로 노화된 모발을 에이징 이전의 상태의 물성 쪽으로 개선시키는 효과를 확인할 수 있었다. 뿐만 아니라 내인성 노화에 의해서 소실 된 내부 구성 성분을 프로폴리스를 이용하여 보강한 경우에도 외인성 노화가 유도된 모발의 물성이 에이징 이전 상태의 물성으로 회복되는 안티 에이징 효능이 발생함을 확인하였다. 본 연구에서 사용한 외인성 노화 유발 모발 시료 및 평가는 모발의 외인성 노화 연구에 유용하게 적용될 수 있음을 최초로 확인하였다.