• Journal of Preventive Medicine and Public Health
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• 제47권1호
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• pp.36-46
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• 2014

Objectives: To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history. Methods: We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged ${\geq}65$ years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria: previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period <90 days. We categorized the daily levothyroxine doses into 4 groups: ${\leq}50{\mu}g/d$, 51 to $100{\mu}g/d$, 101 to $150{\mu}g/d$, and > $150{\mu}g/d$. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status. Results: Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the > $150{\mu}g/d$ group, compared with the 51 to $100{\mu}g/d$ group, was 1.56 (95% CI, 1.03 to 2.37) in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the > $150{\mu}g/d$ group, compared with the 51 to 100 ${\mu}g/d$ group, was 1.93 (95% CI, 1.14 to 3.26). Conclusions: While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.

• 한국산학기술학회논문지
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• 제12권3호
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• pp.1234-1243
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• 2011

본 연구의 목적은 지역사회획득 폐렴 입원 환자의 재원일수의 변이를 분석하기 위해 중증도 모형을 개발하였다. 2004~2006년 퇴원손상환자 조사자료 중 지역사회획득 폐렴환자 5,353건을 연구대상으로 하였으며, 재원일수의 차이분석은 t검정, 분산분석을 실시하였고, 중증도 보정 재원일수 예측 모형은 데이터마이닝 기법을 이용하였다. 여자에 비해 남자, 연령이 많을수록, 의료급여, 응급실 경유 환자의 재원일수가 긴 반면, 병원사망 여부에 따라서는 유의한 차이가 없었다. 개발된 의사결정나무 모형을 이용하여 예측 재원일수를 산출하고 표준화한 값을 비교한 결과 타지역 진료여부에 따라서 재원일수의 차이는 없는 반면, 보험유형과 지역별로 재원일수의 변이가 존재하는 것으로 나타났다. 환자 특성과 중증도를 통제하고 나타난 재원일수의 변이는 공급자 요인으로 설명될 수 있는데, 진료행태나 의료자원에 대한 후속 연구가 필요한 것으로 보인다. 본 연구는 행정 데이터를 이용하여 중증도 모형을 개발하고 변이를 확인하였다는 점에서 활용의 효용성을 높이는 데 기여할 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제43권6호
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• pp.523-534
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• 2010

Objectives: We assessed impact of performance reporting information about the readmission rate, length of stay and cost of hip hemiarthroplasty. Methods: The data are from a nationwide claims database, National Quality Improvement Project database, of Health Insurance Review & Assessment Service in Korea. From January 2006 to April 2008, we received information of length of stay, readmission within 30 days, cost of 22 851 hip hemiarthroplasty episodes. Each episodes has retained the diagnoses of comorbidities and demographics. We used time-series analysis to assess the shifting of patients selections, between high volume (over 16 operations in a year) and low volume institutions, after performance reporting (December 2007). The changes of quality (readmission, length of stay) and cost were evaluated by multilevel analysis with adjustment of patient's factors and institutional factors after performance reporting. Results: As compared with the before performance reporting, the proportion of patients who choose the high volume institution, increased 3.45% and the trends continued 4 months at marginal significance (p = 0.059). After performance reporting, national average readmission rate, length of stay were decreased by 0.49 OR (95% CI=0.25 - 0.95) and 10% (${\beta}$=-0.102, p<0.01) and cost was not changed (${\beta}$=-0.01, p=0.27). The high volume institutions were more decreased than low volume in length of stay. Conclusions: After performance reporting, readmission rate, length of stay were decreased and the patient selections were marginally shifted from low volume institutions to high volume institutions.

• 보건행정학회지
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• 제26권2호
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• pp.135-147
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• 2016

Background: The voluntary diagnosis-related groups (DRG)-based payment system was introduced in 2002 and the government mandated participation in the DRG for all hospitals from July 2013. The main purpose of this study is to examine the independent effect of mandatory participation in DRG on various outcomes of patients. Methods: This study collected 1,809,948 inpatient DRG data from the Health Insurance Review and Assessment database which contains medical information for all patients for the period 2007 to 2014 and examined patient outcomes such as length of stay (LOS), total medical cost, spillover, and readmission rate according to hospital size. Results: LOS of patients decreased after DRGs (large hospitals: adjusted odds ratio [aOR], 0.87; 95% confidence interval [CI], 0.78-0.97; small hospitals: aOR, 0.91; 95% CI, 0.91-0.92). The total medical cost of patients increased after DRGs (large hospitals: aOR, 1.22; 95% CI, 1.14-1.30; small hospitals: aOR, 1.22; 95% CI, 1.21-1.23). The results reveals that spillover of patients increased after DRGs (large hospitals: aOR, 1.27; 95% CI, 0.70-2.33; small hospitals: aOR, 1.18; 95% CI, 1.16-1.20). Finally, we found that readmission rates of patients decreased significantly after DRGs (large hospitals: aOR, 0.28; 95% CI, 0.26-0.29; small hospitals: aOR, 0.59; 95% CI, 0.56-0.63). Conclusion: The DRG payment system compared to fee-for-service payment in South Korea may be an alternative medical price policy which can reduce the LOS. However, government need to monitor inappropriate changes such as spillover increase. Since this study also is the results based on relatively simple surgery, insurer needs to compare or review bundled payment like new DRG for expansion of various inpatient-related diseases including internal medicine.

• Journal of Acupuncture Research
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• 제27권2호
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• pp.43-49
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• 2010

Objectives : Among young generation, the prevalence of spinal disorders is known to be increasing. This study aimed to analyze the clinical data of spinal disorder in young ages in Korea. Methods : Number of patient, kinds of disorder, and medical cost were analyzed for patients(7~18 years) underwent spinal disorders using computerized database of Health Insurance Review and Assessment Service(HIRAS) from 2004 to 2008. We included dorsopathies as spinal disorder according to Korean Classification of Diseases(KCD) and excluded spinal disorder caused by trauma. We compared the data of traditional Korean medicine treatment with that of western medical care. Results : 4.8% of the children and adolescents had medical treatment with spinal disorder in 2008. The claim number and medical cost for both traditional Korean medicine and western medicine treatment are increasing 1.8 and 1.3 times respectively over 5 years. Total medical spent of western clinic was 2.1 times than those of traditional Korean clinic. The most common spinal disorder was dorsalgia(31.8%) and scoliosis(13.5%) in western clinics while back pain(29.0%) and neck pain(10.8%) in oriental clinic. Conclusions : We first reported the clinical tendency of spinal disorder in Korean children adolescents from 2004 to 2008. This study will support the development of a strategy for traditional Korean medicine-based prevention or treatment of spinal disorders in young generation.

• Annals of Coloproctology
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• 제34권6호
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• pp.299-305
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• 2018

Purpose: Inflammatory bowel disease (IBD) in Korea has been increasing in recent years, but accurate statistics about operations for IBD are lacking. The purpose of this study was to investigate the trends and current status of IBD surgeries in Korea. Methods: Using a national database from the Korea Health Insurance Review and Assessment Service, we analyzed data from patients who underwent surgery for Crohn disease and ulcerative colitis from January 2009 to October 2016. Results: The mean number of patients who underwent surgery for Crohn disease was 791.8 per year. Colorectal surgery, small bowel surgery, and anal surgery were performed fairly often (31.2%, 29.4%, 39.4%, respectively), and laparoscopic surgery continued to increase, recently exceeding 30%. About 50% of Crohn patients used biologics before and after surgery, and those patients also underwent a relatively high rate of anal surgeries (44.2%). The mean number of patients who underwent surgery for ulcerative colitis was 247.6 per year. Colorectal surgery accounted for more than half of all operations, and laparoscopic surgery has been increasing rapidly, having been performed in about 60% of patients in recent years. The incidence of colorectal cancer in patients with ulcerative colitis was very high and increased rapidly during the study period, reaching about 80%. Conclusion: The number of patients undergoing laparoscopic surgery for IBD in Korea has increased significantly. Biologics are actively used by patients with Crohn disease, with a high proportion of anal surgeries required. Many of the surgical indications for ulcerative colitis have shifted into colorectal cancer.

• 대한소아치과학회지
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• 제49권2호
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• pp.206-216
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• 2022

이 연구의 목적은 코로나 바이러스 감염증-2019 팬데믹 이후 소아청소년의 치과 이용 실태를 조사하고 성인과 비교하여 파악하는 것이다. 건강보험심사평가원에서 제공하는 2017년 1월부터 2020년 12월까지 20세 미만의 소아청소년 및 20세 이상의 성인의 주상병과 치료코드별 치과 내원 횟수 자료를 사용했다. 연도별 인구수 변화가 내원 횟수에 미치는 영향을 줄이기 위해 인구수 1000명당 치과 내원 횟수를 이용해 분석하였다. 치수 및 근단주위조직의 질환 주상병으로 인한 치과 내원 횟수가 팬데믹 이후 모든 연령에서 감소했고, 치수치료에 해당하는 치료 코드로 인한 치과 내원 횟수는 0 - 4세군을 제외하고 감소했다. 수복치료에 해당하는 치료코드로 인한 치과 내원 횟수는 팬데믹 이후 0 - 19세군에서 감소했다. 2020년 신규확진자 수와 치료 코드의 치과 내원 횟수 변화율을 월별로 비교했을 때, 우리나라 대유행이 있던 2월과 8월 이후 치수치료 및 수복치료는 점차 감소했다. 치은염 및 치주질환 주상병으로 인한 치과 내원 횟수는 팬데믹 이후 모든 연령군에서 증가했다. 소아청소년의 수복치료로 인한 내원 횟수 감소율은 성인보다 컸다. 팬데믹 이후 Multi-visit 치수치료로 인한 치과 내원 횟수 감소율은 1-visit 치수치료보다 컸다. 이 연구를 통해 코로나 바이러스 감염증-2019 전파 이후 소아청소년들의 치과 내원 횟수를 파악하고 성인과 비교해볼 수 있다.

• 한국콘텐츠학회논문지
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• 제22권9호
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• pp.561-569
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• 2022

우리나라 신장암 발생을 소득 수준에 따라 확인하고 병기별로 분석하여 소득 수준에 따른 지연된 진단 정도의 차이를 확인하기 위하여 2015년부터 2017년까지 중앙암등록자료 및 국민건강보험공단, 건강보험심사평가원 데이터베이스를 연계하여 국가 단위 신장암 코호트를 구축하여 병기별, 소득수준별 신장암 발생률을 산출하였다. 연구 기간 중 우리나라 신장암 발생률은 모든 소득 분위에서 증가하나 의료보장인구에서만 감소하는 양상을 보였다. 신장암 발생률은 인구 10만 명 당 7.35 명이었고 이 중 83.54%가 국한 및 국소 신장암으로 소득 상위 20%에서 인구 10만 명 당 21.46명의 높은 발생률을 보였다. 그 중 국한 및 국소 신장암이 18.37명으로 소득 수준이 높을수록 국한 및 국소 신장암 발생률이 높은 것으로 확인된 반면 소득 수준이 낮을수록 원격 전이된 상태로 신장암을 진단받을 위험이 높음(소득 하위 20% adj.OR 1.807, 95% CI 1.411-2.222)을 확인하였고 의료보장인구에서는 병기 미상으로 진단받을 위험비가 1.926(95% CI 1.317, 2.816)으로 관찰되었다. 소득 수준이 높을수록 조기에 암을 진단하는 빈도가 높지만 소득 수준이 낮을수록 전이 신장암으로 진단받거나 병기 미상으로 진단받을 위험이 높아 소득 수준에 따른 건강 불평등이 관찰되었다.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.977-986
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• 2008

목 적 : 사회적 관점에서 로타바이러스의 사회적 비용을 추계하고자 하였다. 방 법 : 로타바이러스 연간 발생 환자수는 2002년 7월에서 2004년 6월까지 정읍지역에서 보고된 5세 미만 인구 1,000명당 입원 환자 11.6명, 외래 환자는 1,000명당 45.3명을 1년 단위로 환산하여 적용하였으며 의료비 자료는 건강보험심사평가원에 로타바이러스(A08.0)로 청구된 자료를 이용하였다. 2006년 12월부터 2007 년 5월까지 환자 보호자 조사를 실시하여 직접 비의료비 및 간접 비용을 산출하는 근거로 사용하였다. 결 과 : 2005년 5세 미만 아동 중 로타바이러스 감염으로 외래 이용한 환자수는 55,030명, 입원 환자수는 14,092명으로 추정하였다. 의료 비용은 110억원으로 전체의 82.8%를 차지했고, 교통비 및 기저귀 사용 등으로 인한 직접 비의료비는 16억원, 간호에 따른 작업 손실 비용은 6억 8000만원으로 로타바이러스 감염으로 인한 총 사회적 비용은 약 132억원 8천만원으로 집계되었다. 결 론 : 로타바이러스 감염은 의료비 뿐 아니라 비의료비와 간접 비용의 추가적인 지출을 가져오며 이는 사회적으로 큰 손실이 될 것이다. 그러나 본 연구에서는 보수적 추정을 하였으며 추후 연구에서 로타바이러스 감염이 보호자의 삶의 질과 건강수준의 저하에 미치는 영향을 비용 항목에서 충분히 고려할 필요가 있다.

• 한국임상약학회지
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• 제19권1호
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• pp.1-17
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• 2009

Adverse drug reactions (ADR) caused by inappropriate prescription are responsible for major socioeconomic loss. Drug-drug interactions (DDI) has been recognized as a major part of ADRs and, therefore, healthcare professionals should prevent possible DDIs to minimize preventable ADRs. This study aimed to examine DDI information in drug information references and Korea Food & Drug Administration (KFDA) drug labeling information. Drug ingredients from the formulary of Health Insurance Review and Assessment Service in Korea (HIRA) were included for the study. DDI information source used for the study were Micromedex Drugdex and Drug Information Facts (DIF) with the DDI severity level of "moderate" or more. The DDI information in KFDA drug labeling were collected and compared. Drug ingredients were classified with KFDA Drug Classification and ATC Classification of WHO for the analysis. Among the total 1,355 drug ingredients satisfying inclusion criteria, 738 ingredients involved at least one DDI, which was described in Micromedex and/or DIF. Drug Ingredients of 176 involved DDI only described in KFDA drug labeling, but not Micromedex nor DIF. Drug ingredients of 35 which DDIs were described in Micromedex or DIF did not have DDI based on KFDA drug labeling. Micromedex and DIF retrieved 7,582 and 3,071 DDIs, respectively 57.6% and 58.5% of DDIs were also described in KFDA drug labeling. Central nervous system (CNS) drugs, cardiovascular system (CVS) drugs and the antiinfectives appeared to have higher frequency of DDIs among all drug classes. The highest number of DDIs with high severity level ("contraindicated" or "major") were the DDIs of CNS drugs. The antiinfectives are the second drug group having serious DDIs. The DDI pairs of the CNS drug and the antiinfective had the highest contraindication risk (13.6%). DDI information from Micromedex and DIF were not consistent with the result that only 465 ingredients' DDIs are common in both literature (total DDI numbers were 715 vs 488, respectively). And 1,652 DDI information are common in both references among 7,582 vs 3,071 DDIs, respectively. Only 55.2% of DDI information in the database contained in the KFDA drug labeling. Prescribers and pharmacists should pay attention to the drugs for CV system, CNS and infections because of higher risk of possible DDIs compared to other drug classes. KFDA drug labeling is not likely to be recommended as a good information source for DDI due to significant inconsistency of information. Drug information providers should be aware that DDI information from different sources are not consistent and therefore multiple references should be used.