• Molecules and Cells
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• 제38권2호
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• pp.156-162
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• 2015

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3' untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

• The Korean Journal of Physiology and Pharmacology
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• 제22권1호
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• pp.63-70
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• 2018

Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.

• 감성과학
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• 제22권3호
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• pp.55-64
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• 2019

Stroke is a health problem experienced by many elderly people around the world. Stroke has a devastating effect on quality of life, causing death or disability. Hemiplegia is clearly an early sign of a stroke and can be detected through patterns of body balance and gait. The goal of this study was to determine various feature vectors of foot pressure and gait parameters of patients with stroke through the use of a wearable sensor and to compare the gait parameters with those of healthy elderly people. To monitor the participants at all times, we used a simple measuring device rather than a medical device. We measured gait data of 220 healthy people older than 65 years of age and of 63 elderly patients who had experienced stroke less than 6 months earlier. The center of pressure and the acceleration during standing and gait-related tasks were recorded by a wearable insole sensor worn by the participants. Both the average acceleration and the maximum acceleration were significantly higher in the healthy participants (p < .01) than in the patients with stroke. Thus gait parameters are helpful for determining whether they are patients with stroke or normal elderly people.

• Journal of Korea Artificial Intelligence Association
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• 제1권1호
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• pp.17-21
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• 2023

The primary objective of this research is to utilize machine learning models to analyze factors tailored to each dataset for predicting mental health conditions. The study aims to develop appropriate models based on specific datasets, with the goal of accurately predicting mental health states through the analysis of distinct factors present in each dataset. This approach seeks to design more effective strategies for the prevention and intervention of depression, enhancing the quality of mental health services by providing personalized services tailored to individual circumstances. Overall, the research endeavors to advance the development of personalized mental health prediction models through data-driven factor analysis, contributing to the improvement of mental health services on an individualized basis.

• Molecules and Cells
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• 제40권7호
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• pp.476-484
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• 2017

C-X-C chemokine receptor 4 (CXCR4) stimulates cancer metastasis. NF-${\kappa}B$ regulates CXCR4 expression in cancer cells, and O-GlcNAc modification of NF-${\kappa}B$ promotes its transcriptional activity. Here, we determined whether CXCR4 expression is affected by O-GlcNAcylation of NF-${\kappa}B$ in lung metastasis of cervical cancer. We found elevated levels of O-linked-N-actylglucosamine transferase (OGT) and O-GlcNAcylation in cervical cancer cells compared to those in non-malignant epithelial cells and detected increased expression of NF-${\kappa}B$ p65 (p65) and CXCR4 in cervical cancer cells. Knockdown of OGT inhibited the O-GlcNAcylation of p65 and decreased CXCR4 expression levels in HeLa cells. Thiamet G treatment increased O-GlcNAcylated p65, which subsequently enhanced CXCR4 expression levels. Inhibition of O-GlcNAcylation by 6-Diazo-5-oxo-L-norleucine (DON) treatment decreased p65 activation, eventually inhibiting CXCR4 expression in HeLa cells. Lung tissues from mice engrafted with OGT-knockdown HeLa cells (shOGT) exhibited lower expression of Ki-67 and HPV E6 and E7 oncogenes compared to lung tissues from mice engrafted with control HeLa cells (shCTL). In addition, lung tissues from mice engrafted with shOGT cells exhibited lower p65 and CXCR4 immunoreactivity compared to tissues from mice engrafted with shCTL cells. Taken together, our data suggest that p65 O-GlcNAcylation promotes lung metastasis of cervical cancer cells by activating CXCR4 expression.

• 웰빙융합연구
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• 제4권4호
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• pp.1-14
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• 2021

Purpose: This study aims to measure the level of satisfaction with the overall education of current students, who are major consumers of education by department at the Health Care Convergence University, and to establish development strategies such as improving education quality and satisfaction by deriving problems and improvements. Research design, data and methodology: This study drew conclusions through secondary data analysis based on data surveyed by the Educational Performance Management Center of a university in the academic year of 2020. The target of the education consumer satisfaction survey was 470 students of the College in the academic year 2020. Frequency analysis and correlation analysis were applied to the data using the statistical package program SPSS 25 version. Results: In the major curriculum satisfaction survey, the department with the highest score was optics and optics, 4.11, and the department with the lowest score was medical IT, 3.29. Conclusions: The department with the highest correlation in the correlation analysis result of the demand survey by department was the Department of Medical Management and the Department of Medical IT, with a correlation coefficient r=0.984, and the lowest correlation in the correlation analysis result of the demand survey by department was the Department of Medical IT and Dental Hygiene, with a correlation coefficient r= -0.085.

• 대한방사선기술학회지:방사선기술과학
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• 제42권4호
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• pp.291-299
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• 2019

The International Electrotechnical Commission (IEC) has regulated the definition and requirements of the exposure index (EI). In this study, we calculated the EI of several image receptors in digital radiography system of two different manufacturers according to the method as per IEC, and evaluated the relationship with incident air kerma. To calculate the EI, w e obtained the characteristics curve of each image receptor by increasing the incident air kerma at RQA 3, 5, 7 and 9, respectively. As a result, there was no significant difference in the EI values between different image receptors of the same manufacturer, but EI values of different manufacturer was different despite the same air kerma was incident. Therefore, understanding the characteristics of the digital radiography systems is important in order to use EI as a tool for measuring and managing the radiation dose.

• 대한의용생체공학회:의공학회지
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• 제38권4호
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• pp.205-210
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• 2017

The convergence healthcare industry in Korea has been stalled due to conflicts between stakeholders as well as a supplier-centered industry structure. This situation is caused by the structural contradiction in which the Korean industry has a prolonged conflict structure among stakeholders due to a strong regulation and an institutional inertia from the viewpoint of the sociotechnical system. Therefore, it is necessary to identify new system management plan that enhances social acceptability such as laws, customs and ideas while reducing conflicts between stakeholders. In this study, mainly adapting the stakeholder-oriented autopoiesis and focusing on publicness of healthcare, we propose the rationale and direction for policy making to harmonize various systems within the convergence healthcare industry.

• Perspectives in Nursing Science
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• 제5권1호
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• pp.59-71
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• 2008

e-Health/u-Health has generally been considered as an expansion of current medical and medical relevant segments. However. as e-Health/u-Health has been known to have typical attributes and characteristics of services supporting a physically and mentally well-balanced life of its users, we can rationally assume that e-Health/u-Health can be not only an expansion of the existing medical field but also a result of the complex and sophisticated convergence among diverse industries such as the ICT industry. traditional care-relevant segments, etc. Thus, in this study, we carefully and cautiously consider e-Health/u-Health in accordance with both possible scenarios: 1) an expansion of a typical industry, and 2) a result of a convergence among various industries. The advent of new technologies, rapid development of current technologies, and convergence trends in various fields are creating dramatic innovations in the next generation health services market. Consumerism as a characteristic of c-Health/u-Health can be expected to find a solution of the existing healthcare service problems. In the initial phase. mainly due to the absence of a vanguard, as well as to various legalistic and regulative limitations, the role of the government would be immensely critical for the successful early settlement of the e-Health/u-Health industry. Both the government and private sector need to practice continuous and effective public education and publicity mainly to increase the overall recognition and usability of e-Health/u-Health services. Nursing as a unique professional discipline should be well aware of the new paradigm shift of the healthcare market, and make maximum use of the possibility of this trend to the advent of the professional nursing's new role.

• International journal of advanced smart convergence
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• 제8권3호
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• pp.87-94
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• 2019

IoT-based services are being released in accordance with the aging population and the demand for well-being pursuit needs. In addition to medical device companies, companies with ideas ranging from global ICT companies to startup companies are accelerating their market entry. The areas where these services are most commonly applied are health/medical, life/safety, city/energy, automotive and transportation. Furthermore, by expanding IoT technology convergence into the area of life care services, it contributes greatly to the development of service models in the public sector. It also provides an important opportunity for IoT-related companies to open up new markets. By addressing the problems of life care services that are still insufficient. We are providing opportunities to pursue the common interests of both users and workers and improve the quality of life. In order to establish IoT-based digital life care services, it is necessary to develop convergence technologies using cloud computing systems, big data analytics, medical information, and smart healthcare infrastructure.