• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제46권4호
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• pp.220-227
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• 2020

Objectives: Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder. These patients lose their teeth at a young age and are in need of prosthetic rehabilitation. The aim of this systematic review was to assess the success of dental implant placement in these patients. Materials and Methods: An electronic search was performed in PubMed Central, Scopus, and Web of Science using the keyword "Papillon-Lefèvre syndrome" AND "dental implant" OR "prosthodontics". Articles reporting implant placement in patients with PLS until July 2019 were included. Results: Assessment of the included 11 articles reporting 15 cases showed 136 implant placements in these patients. Implant failure occurred in 3 patients (20 implants). The peri-implantitis and failure rate was higher in the maxilla. Meta-analysis showed the probability of failure to be 7% (95% confidence interval [CI] 0%-31%) for maxillary implants and 2% (95% CI 0%-9%) for mandibular implants. The follow-up time ranged between 1 and 20 years. Healing after bone graft and implant placement in these patients was uneventful. Conclusion: Dental implants may be a viable treatment option for PLS patients. Implantation can help preserve alveolar bone if the patients' immunological and growing conditions are well-considered and proper oral hygiene and compliance with the maintenance program are continued.

• Journal of Periodontal and Implant Science
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• 제27권1호
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• pp.179-189
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• 1997

Teeth mobility is an important part of a periodontal examination, because it represents a function of the persisting height of the alveolar bone and the width of the periodontal ligament. The purpose of this study was to evaluate clinical difference in teeth mobility after treatment with the modified Widman flap and the undisplaced flap in humans. Twenty males with moderate periodontal disease were selected. The severity of periodontal disease was evaluated with sulcular bleeding index, pocket depth and attachment level and tooth mobility was measured with Periotest(Siemens Co., Germany) at the initial examination, 1, 2, 4, 6, 8 and 12 weeks following the modified Widman flap and the undisplaced flap operation using the split-mouth technique. The relation of mobility to clinical parameters was statistically analyzed by multiple regression and the change of teeth mobility according to healing process by independent t-test using SPSS program. The results were as follows: 1. There was a strong relationship between the Periotest value(PTV) and attachment level. 2. The change of teeth mobility in both flap procedures was increased significantly at 1 week post-op. and was decreased to preoperative level at 4 weeks post-op, in modified Widman flap and at 6 weeks post-op. in undisplaced flap. 3. The change of teeth mobility in premolar teeth group in undisplaced flap compared to modified Widman flap was generally increased but these changes were not statistically significant. The changes of teeth mobility in molar teeth group in undisplaced flap was increased significantly at 2 weeks post-op.. 4. The change of teeth mobility following undisplaced flap was increased significantly compared to that of modified Widman flap at 2 weeks post-op.

• 농촌계획
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• 제25권4호
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• pp.87-97
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• 2019

본 연구는 방과 후 농업 체험활동 프로그램이 초등학생의 정서지능과 회복탄력성 향상 및 우울감 감소에 미치는 영향을 알아보고자 실시하였다. 서울시 초등학교에 재학 중인 4-6학년(11-13세) 초등학생 총 30명이 본 연구에 참여하였다. 참여에 동의한 30명의 학생 중 농업체험 프로그램에 참여를 희망한 18명은 실험군으로, 농업체험 프로그램에 참여를 희망하지 않은 학생 12명은 대조군으로 집단화 하였다. 실험군은 2018년 4월부터 7월까지, 총 12주간(주 1회, 회기당 60분)의 방과 후 활동으로 본 프로그램에 참여하였다. 초등학생의 정서적 건강 증진을 위해 사회정서학습 이론에 기반한 농업체험 프로그램을 설계하였다. 프로그램 실시 전과 후에 자기보고식 설문지를 이용해 정서지능, 우울, 회복탄력성을 측정하였다. 그 결과, 농업 체험활동 프로그램에 참여한 초등학생의 정서지능이 향상되었고(P=0.031), 우울감이 감소된(P=0.011) 반면 대조군에서는 유의한 차이가 나타나지 않았다(P>0.05). 회복탄력성은 실험군과 대조군에서 모두 실험 전후 유의한 차이가 없었다(P>0.05). 본 농업체험 프로그램에 참여한 아동들은 프로그램에 대해 높은 만족감을 보고하였다. 따라서 본 연구에서 사회 정서학습이론을 적용한 농업체험 프로그램이 초등학교 고학년 학생의 정서지능 향상과 우울감 감소에 효과적인 것으로 나타났다. 추후, 표본수를 확대하여 농업 체험활동 프로그램의 효과 검증 연구가 추가적으로 필요할 것이라 생각되며, 다양한 지역의 초등학생들에게 확대 적용하는 연구도 필요할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제18권11호
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• pp.2919-2923
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• 2017

Objective: Anthocyanins belong to a class of flavonoids, exhibiting antioxidant and anti-inflammatory actions have been reported to have anti-cancer effects. Here, we investigated whether anthocyanins can inhibit cancer cell proliferation, invasion, and angiogenesis in human lung cancer A549 cells, which are critically involved in cancer metastasis. Methods: We used anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) which has been used in Korean folk medicine for the treatment of inflammatory diseases and cancers. We have performed cell proliferation assays, cell invasion assay, gelatin zymography, wound healing assay and western blotting to examine whether anthocyanins can inhibit cancer cell proliferation, invasion, and angiogenesis in A549 cells. Result: AIMs did not inhibit cancer cell proliferation on A549 cells. Also, AIMs suppressed cancer migration, and invasion by supressing MMP-2 and MMP-9 expression. The Immuno-blotting results also revealed that AIMs suppressed the proteins involved in cancer proliferation (COX-2, C-myc, cyclin D1), migration and invasion (MMP-2, MMP-9), anti-apoptosis (XIAP, and c-IAP2), adhesion and angiogenesis (ICAM-1, VEGF). Conclusion: This study demonstrates that the anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit cancer proliferation, cancer migration, and invasion that is involve in cancer-metastasis. This study provides evidence that AIMs might have anti-cancer effects on human lung cancer.

• Journal of Forest and Environmental Science
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• 제37권3호
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• pp.260-268
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• 2021

This study was conducted to grasp users' preferences and behavior of forest paths and to provide basic data for forest path construction in the future. Among forest path users, males and females over 20 years old were surveyed on forest path preferences, motives for visiting, using time and distance, companions, and sources for obtaining information on forest paths. A total of 587 people participated in the questionnaire, and cross-analysis was conducted simultaneously using the SPSS statistical program. In analyzing the preference of forest paths, it was found that male and the general public preferred trekking path for activities while female and foresters preferred forest path for relaxation and healing (p<0.05). As for the motives for visiting forest paths, the response that they visited for a walk/rest was the highest in gender, occupation, and age group. As for the number of annual visits, less than 5 was the highest in overall, and foresters tended to visit forest path more often than the general public, and the number of visits to the forest paths increased with age (p<0.01). The most common route to acquire information about forest paths is the Internet, while the Internet use is relatively low in those over 60s (p<0.05). The response ratio of accompanying their family in visiting forest paths were the highest, while the response in their 20s and 60s was the most in accompanying their friends (p<0.05).

• 인간식물환경학회지
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• 제23권2호
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• pp.159-170
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• 2020

The purpose of this study was to understand the current status of education and programs and to identify the items that urban residents need most for garden management. First of all, there were 45 sites (40.5%) with gardens operated by city and county local governments nationwide, and 41(91.1%) of them had dedicated staff (1.8 persons on average). The average area of gardens was 18,623 m², garden area per person was 20.27m², the average number of participants was 683, and the average period of use was 8.69 months. In addition to gardening activities, 14 (31.1%) out of 45 sites were operating small group meetings, with an average of 2.29 meetings and 67 participants. In the satisfaction survey after gardening activities, 88.9% of 18 sites were satisfied. According to the questionnaire about education and programs related to garden users, an average of four sessions were conducted per education. In terms of education, the contents were in the following order: basic education on garden cultivation (33.9%) > prior education on garden operation (28.9%) > pest control (14.0%) > eco-friendly management (11.6%) > pesticides and Positive List System (9.9%) > others (1.7%). Over 95% of the respondents were generally satisfied. Regarding the perception survey on which items are needed to develop garden management guidelines, the most necessary items were in the order of crop management (38.7%) > public garden etiquettes among users (27.9%) > pest control (14.4%) > weed management (13.5%) > activities using harvest (5.4%). The contents that are to be included in the guidelines were in the order of garden planning and crop selection (17.2%) > cultivation techniques and schedule (16.5%) > pest and soil management (15.7%) > introduction of garden crops and gardening models (12.7%) > garden etiquettes (10.7%). In establishing urban garden management plans by region, the results will have high utility value as the basic data for continuous garden operation by setting a direction that meets the regional characteristics as well as the needs of urban residents.

• IMMUNE NETWORK
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• 제21권4호
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• pp.30.1-30.12
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• 2021

High expression of mitofusin-2 (MFN2), a mitochondrial fusion protein, has been frequently associated with poor prognosis of patients with cervical cancer. Here, we aimed to identify the function of MFN2 in cervical cancer to understand its influence on disease prognosis. To this end, from cervical adenocarcinoma, we performed an MTT assay and quantitative RT-PCR (qRT-PCR) analysis to assess the effects of MFN2 on the proliferation and of HeLa cells. Then, colony-formation ability and tumorigenesis were evaluated using a tumor xenograft mouse model. The migration ability related to MFN2 was also measured using a wound healing assay. Consequently, epithelial-mesenchymal transition (EMT) of MFN2-knockdowned HeLa cells originating from adenocarcinoma. markers related to MFN2 were assessed by qRT-PCR. Clinical data were analyzed using cBioPortal and The Cancer Genome Atlas. We found that MFN2 knockdown reduced the proliferation, colony formation ability, migration, and in vivo tumorigenesis of HeLa cells. Primarily, migration of MFN2-knockdowned HeLa cells decreased through the suppression of EMT. Thus, we concluded that MFN2 facilitates cancer progression and in vivo tumorigenesis in HeLa cells. These findings suggest that MFN2 could be a novel target to regulate the EMT program and tumorigenic potential in HeLa cells and might serve as a therapeutic target for cervical cancer. Taken together, this study is expected to contribute to the treatment of patients with cervical cancer.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제30권3호
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• pp.17-24
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• 2024

Purpose: The medical care for children in Korea is needed more than previous time as the situation changed. However, there is a few useful research for the planning of the children's specialized public medical center. This study has been started to provide basic information for the planning of Korean children's specialized public medical center. Methods: Research and architectural documentation with field surveys to 5 of 14 children's specialized public medical center, data have been analyzed for characteristics of children's medical care. Results: The result of this study can be summarized into three points. The first one is that children's medical care can be categorized independent and integrated type according to connection with main hospital. Independent type has vertical or horizontal form from spatial composition. The second one is that spatial composition are allocated by typical service, outpatient, central, and inpatient ward zones. The outpatient zone has horizontal/vertical type, central zone has concentrated/separated type by spatial and treatment situation of medical center. The third one is that children's hospital school is the specific program and healing environment for children. Implications: It is necessary to make typical model for national wide medical care for children in Korea.

• 지역사회간호학회지
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• 제7권2호
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• pp.183-202
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• 1996

This study was designed out to develop a home health care service for nurses working in community care services. This study investigates actual conditions at welfare institutions related to health needs the demands of clients, and the state of home health care services we hope that this study will improve upon the current service system. In Korea home health care services are still developing and only new becoming a part of the health care supply system. The data was collected by recording the client home nursing assessments modified to the situation of UTMB home health agency. In this study 107 clients were selected for home care who needed care for physical and mental deficits. The study lasted from March to November of 1995 at one of the welfare service institutions in Chunchon city. The results show that those who most frequently needed care services were over 50 years old with a health deficit of 80.3%, followed by sex as women who needed care at 59.8%. 50.5% of the clients had very little education. 99.1% of the clients live with their family, and a medical diagnostic analysis reveals that 73.9% of the 5 year period of illnesses were the following : 38.8% - muscular -skeleton system disorder, 24.4% - hypertension and stroke, 25.7% sole disease of arthritis. For behavioral conditions 43.3% of the patients were without care services, 56.6% of the patients were taking treatment that 73.5% of those were taking medication. The most main complaint of patients were 22.4% of pain in the extremities, next were 16.8% of a limitation of body activities, 15.0% was lumbo-sacralgia. According to the investigator who was a senior student nurse, the following suggestions were made: 32.7% for curative medical services, 29.9% for physical exercise, 19.6% for emotional support. Consultation nursing services consisted of 67.2% for physical therapy, 11.2% for the maintaining healing, 9.4% for counseling. The patients at home, required assistance most frequently for muscular-skeleton problems under the category of physical systems (33.3%). But, on the other hand, 49.5% of the patients required care givers at home, 28.2% had a knowledge deficit, 21.0% had malnutrition, 18.4% had bad impaired communication. The character of health problems were devided into chronic disease(67.0%), accidents(I3.1%), and general disease(15.9%). 86% of the disabled client had an impairment of the physical system. Eating (86.9%) , Toileting(77.6%), and personal care showed much the same of ADL condition, the level and range of achievement of mobility, the most frequently self performed was 81.3% only in a room size area, and 40.2% were completely dependent when going out. Although there were a large number of home care services in th community at these welfare institutions, many clients needed a variety of curative services. As policy changes have gathered momentum, responsibility for the development of a more suitable program was demanded by the clients from the community.

• Archives of Plastic Surgery
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• 제46권4호
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• pp.336-343
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• 2019

Background Sternal rigid plate fixation (RPF) has been adopted in recent years in high-risk cases to reduce complications associated with steel wire cerclage, the traditional approach to sternal closure. While sternal RPF has been associated with lower complication rates than wire cerclage, it has its own complication profile that requires evaluation, necessitating a critical examination from a national perspective. This study will report the outcomes and associated risk factors of sternal RPF using a national database. Methods Patients undergoing sternal RPF from 2005 to 2016 in the American College of Surgeons-National Surgical Quality Improvement Program were identified. Demographics, perioperative information, and complication rates were reviewed. Logistic regression analysis was performed to identify risk factors for postoperative complications. Results There were 381 patient cases of RPF identified. The most common complications included bleeding (28.9%), mechanical ventilation >48 hours (16.5%), and reoperation/readmission (15.2%). Top risk factors for complications included dyspnea (odds ratio [OR], 2.672; P<0.001), nonelective procedure (OR, 2.164; P=0.010), congestive heart failure (OR, 2.152; P=0.048), open wound (OR, 1.977; P=0.024), and operating time (OR, 1.005; P<0.001). Conclusions Sternal RPF is associated with increased rates of three primary complications: blood loss requiring transfusion, ventilation >48 hours, and reoperation/readmission, each of which affected over 15% of the study population. Smokers remain at an increased risk for surgical site infection and sternal dehiscence despite RPF's purported benefit to minimize these outcomes. Complications of primary versus delayed sternal RPF are roughly equivalent, but individual patients may perform better with one versus the other based on identified risk factors.