• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2021년도 학술발표회
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• pp.252-252
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• 2021

하천 합류부의 흐름거동은 단일 하천 흐름거동에 비해 복잡한 흐름 특성을 나타낸다. 하천의 본류와 지류가 만나는 합류지점에서는 유량비, 합류각의 변화에 따라 전단면(shear plane), 재순환류(recirculation zone)가 발생할 수 있다. 이러한 하천 합류부의 복잡한 흐름특성은 하상의 침식 또는 퇴적을 야기할 수 있고, 수심의 변화, 수생태 변화 등을 일으켜, 하천환경 변화에 영향을 미칠 수 있다. 따라서 본 연구에서는 2차원 흐름해석모형 HDM-2D를 이용하여 하천합류부에서 2차원 흐름 모의를 수행하였으며, 합류각의 변화에 따른 흐름특성 변화를 분석했다. HDM-2D 흐름모의 결과의 검증을 위해 90° 각도의 합류수로에 대한 Weber et al.(2001)의 실험결과를 이용했다. 그 결과, 합류지점 하류에서 발생하는 재순환류 및 수위하강, 유속의 변화 등의 수치모의결과가 실험결과와 유사한 변화를 나타냈다. 지류 합류 각도의 변화에 따른 하류 흐름변화를 비교하기 위해 3가지 합류부 각도(30°, 45°, 60°)에 대해 흐름모의를 수행했다. 합류지점의 흐름특성을 분석하기 위해 합류지점의 계산격자를 세밀하게 구성했다. 합류지점 하류에서 발생하는 재순환류의 길이와 최대 폭의 변화로부터 재순환류 발생면적을 계산하였으며, 합류각도의 변화에 따른 흐름특성을 비교 분석 하였다. 흐름모의 결과, 본류와 지류의 합류각이 30°일 때 합류부 내측의 재순환류가 거의 발생하지 않았으며, 합류각이 45°이상일 때 합류각 증가에 따라 재순환류의 폭과 너비가 증가하는 결과를 나타냈다. 또한 합류각 증가에 의해 재순환류 발생 면적이 증가함에 따라 합류부 하류의 수심이 더 큰 폭으로 감소하는 결과를 나타냈다.

• 생명과학회지
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• 제6권2호
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• pp.111-119
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• 1996

The production of interleukin-1(IL-1)and nitric oxide(NO) by cultured fibroblast cells of human nasal turbinate was revealed by biological assay respectively. The cells were incubated for various periods of time in the presence of staphyloccocal toxic shock syndrome toxin-1(TSST-1) and house dust mite(Dermatophagoides farinae, HDM), and the culture supernatants were harvested. There was a little difference in the activities of IL-1beta and the amount of NO produced by the cells when stimulated with 0.002-0.1$\mu$g/ml of TSSTO-1 and 0.02-1$\mu$g/ml of HDM. The shapes of the time course curves for the production of IL-1beta and NO by the cells were different. Groups stimulated with TSST-1 or HDM produced more IL-beta in 2 h than no exposure group(Control). A certain mixed group(TSST-1, 10ng+mite, 100 ng) continued to produce IL-1beta highly throughout the entire incubation period. The cells stimulated with TSST-1 or HDM produced more NO in 2 h and 6 h than that produced in the end of incubation(48 h). Also, the mixed groups were generally similar. There results suggest that induction of IL-1beta by a certain mixed condition(TSST-1+mite) in fibroblast cell in vivo may play a role in inflammation.

• Architectural research
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• 제9권2호
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• pp.37-45
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• 2007

The proliferation of the House Dust Mite(HDM) is affected by temperature, humidity, ventilation, etc. Measuring temperature and humidity was performed at the very location where dust samplings take place and where they live in reality together with temperature and humidity of the ambient of the room. There has been discussion over the key environment factor of HDM survival; absolute humidity or relative humidity. It seems that relative humidity is the more important determinant for the mite's survival through the analysis of previous studies. Temperature, humidity, ventilation rate and Der P1 were measured in 4 flats in London. Mite allergen was detected in every house. Levels of Der P1 varied between <100ng/g and 22,778ng/g. Flats with high relative humidity(>50%) and poor ventilation(<0.5ach) showed higher levels of mite allergen than flats with lower humidity and adequate air change rate. Questionnaire survey was conducted and the result helped to confirm the findings from monitoring of environmental factors and the dust sampling.

• Nutrition Research and Practice
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• 제17권5호
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• pp.1007-1018
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• 2023

BACKGROUND/OBJECTIVES: This study aimed to examine whether the tailored home-delivered meal (HDM) services included nutrition counseling impacts alleviating self-rated frailty among low-income older adults in Korea. SUBJECTS/METHODS: Pre- and post-test were implemented on May 27 and on November 25 in 2019 during 3 weeks, respectively, before and after the 6 months intervention program. Participants completed a questionnaire measuring frailty, malnutrition, food security, depression, and underlying diseases. Initially, 136 older adults were selected as participants for this study, they were recipients of a free meal program from 2 senior welfare centers in Seoul, the final sample size of those who completed the intervention program was 117 (female 70.9%, male 29.1%). Statistical analyses were conducted with IBM SPSS package program, paired t-test and χ² test to validate the test. RESULTS: There were statistically significant differences in the score of the Tilburg Frailty Indicator (TFI) before and after receiving the tailored HDM services (pre-test 9.46, post-test 2.8, P < 0.01). The differences in the score of TFI by 3 risk groups at the pre-test decreased as a result of receiving these services. CONCLUSIONS: The tailored HDM services alleviated the self-rated frailty of low-income older adults with limited mobility in a community setting. Based on the positive outcomes this study could be applied to developing social services for aging in place.

• 한국식품영양학회지
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• 제30권4호
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• pp.735-741
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• 2017

This study was conducted to investigate if the supplement formula may improve alcohol metabolism in healthy adult men. In a double-blinded, randomized, crossover study, subjects were administrated yeast extract mixtures (YEM, n=15), Hovenia dulcis mixtures (HDM, n=15), placebo (PLA, n=15), and control (CON, n=15) in an oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 week), subjects drank 450 mL, 20.1 percent alcohol after administered mixtures. Blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hours). Fifteen subjects completed the protocol and were included in the analysis. Plasma ethanol concentration was lower in YEM (10 percent) and the HDM (5 percent) groups. The area under the curves (AUC) and $C_{max}$ for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUC and $C_{max}$ for plasma acetaldehyde concentration were significantly decreased in the YEM (45 and 54 percent) and the HDM (35 and 53 percent) groups respectively, when compared with PLA (p<0.01). Together, these findings validate that YEM or HDM improved alcohol metabolism and hangover syndromes, leading to reduce alcohol concentration and acetaldehyde concentration without adverse effects.

• 대한토목학회논문집
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• 제34권2호
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• pp.645-654
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• 2014

현재 우리나라 일반국도의 포장관리시스템(PMS: Pavement Management System)은 세계은행(World Bank)이 주도한 HDM (Highway Development and Management)-4를 사용하여 유지보수 의사결정의 기초 자료로 사용하고 있으나, 과다한 입력변수와 모형의 불확실성 등으로 인해 국내 실정에 적합한 경제성 분석모형이 필요하게 되었으며, 대부분의 선진국의 경우에는 각 지역과 국가에 맞는 PMS 시스템을 구축하여 운영하고 있다. 따라서 본 연구에서는 우리나라 실정에 맞고 효율적인 국도의 도로 및 포장관리를 위한 의사결정시스템을 개발하기 위한 연구로써 시스템 개발에 필요한 구성요소, 공용성 모형 개발, 각 요소별 활용가능한 원단위, 기준 등의 지표 정의 및 종류, 특성들을 분석, 정리하고 경제성 평가를 통해 최적 의사결정을 위한 시스템(S/W) 개발을 목적으로 하였다. 포장관리를 위해 개발한 의사결정시스템의 구성요소는 크게 1)도로, 교통, 사회경제 지표 등의 DB, 2) 도로포장상태의 공용성 모형, 3)도로포장상태에 따른 차량속도변화 모형, 4)경제성 평가 모형, 5) 의사결정지원 시스템으로 구성되며, 개발된 시스템의 검증을 위해 사례 구간을 대상으로 한 분석결과도 함께 제시하였다. 그러나 장래 확률적 특성을 고려한 공용성 모형의 개발과 의사결정을 위한 지표 개발에 대해서는 추가적인 연구가 필요할 것으로 판단된다.

• 한국식품과학회지
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• 제13권3호
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• pp.176-180
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• 1981

국내의 산란노계와 브로일러로부터 생산(生産)된 수동발골육(HDM) 및 기계발골육(MDM)을 여러가지 비율(比率)로 배합(配合)하여 제조(製造)한 치큰 패티와 프랑크푸르트 소시지의 특성(特性), 보존성(保存性), 기호성(嗜好性)을 평가(評價)하였던 바 다음과 같은 결과(結果)를 얻었다. 1. HDM을 사용한 치큰 패티의 TBA시험에 의한 지방산패도는 냉동저장중 계속 증가하였으나 8주(週)까지는 보존성이 양호(良好)였다. 2. 치큰 패티의 색(色)과 기호성(嗜好性)에 있어 MDM을 50%까지 첨가한 것이 가장 우수하였고 50%까지도 양호(良好)하였으나 70%이상 첨가는 권장할 수 없었다. 3.프랑크푸르트 소시지의 제조에 있어 MDM을 50%까지 첨가한 것의 기호성이나 조직적 특성은 HDM으로만 만든 제품과 비등하게 양호(良好)하였으나 70% 이상 첨가한 것은 불량(不良)하였다. 4. MDM을 함유(含有)한 프랑크푸르트 소시지의 보존성(保存性)은 $4^{\circ}C$에서 4주까지 무난하였으며 저장 기간에 따른 TBA 값의 변화는 거의 없었다. 5. 결론적으로 치큰 패티나 프랑크푸르트 소시지등의 육제품(肉製品) 제조에 있어서 MDM을 총원료육의 $30{\sim}35%$까지 첨가하여도 조직이나 기호성이 우수한 제품을 생산(生産)할 수 있었다.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.675-685
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• 2018

Purpose: This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR. Methods: A total of 45 patients aged ${\geq}60years$ with HDM-induced AR who had ${\geq}3$ A/H ratio on skin prick test and/or ${\geq}0.35IU/L$ to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15). Rhinoconjunctivitis total symptom score (RTSS), rhinoscopy score, Korean rhinoconjunctivitis quality of life questionnaire, rhinitis control assessment test, asthma control test scores, and adverse reactions, were assessed at the first visit (V1) and after 1 year of treatment (V5); for immunological evaluation, serum levels of HDM-specific immunoglobulin A/IgE/IgG1/IgG4 antibodies and basophil response to HDMs were compared between V1 and V5 in both groups. Results: There were no significant differences in demographics, RTSS, skin reactivity to HDMs, or serum total/specific IgE levels to HDMs (P > 0.05, respectively) between the 2 groups. Nasal symptom score and RTSS decreased significantly at year 1 in the 2 groups (P < 0.05). There were no significant differences in percent decrease in nasal symptom score and RTSS at year 1 between the 2 groups (P > 0.05); however, rhinoscopic nasal symptom score decreased significantly in the SLIT-treated group (P < 0.05). Immunological studies showed that serum specific IgA levels (not specific IgE/IgG) and CD203c expression on basophils decreased significantly at V5 in the SLIT-treated group (P = 0.011 and P = 0.001, respectively), not in the control group. The control group required more medications compared to the treatment group, but there were no differences in adverse reactions. Conclusions: It is suggested that HDM-SLIT for 1 year could induce symptom improvement and may induce immunomodulation in elderly rhinitis patients.

• 전자공학회지
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• 제22권6호
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• pp.17-26
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• 1995

• 대한기계학회논문집A
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• 제30권2호
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• pp.164-170
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• 2006

To prevent the numerical instabilities in topology optimization, continuous approximation of material distribution (CAMD) is proposed to the homogenization design method (HDM) and the simple isotropic material with penalization (SIMP) method. The continuous FE approximation of design variables including high order elements is applied to the formulation of SIMP method. Numerical examples are presented to compare the efficiency of CAMD both in HDM and SIMP.