• Journal of Nutrition and Health
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• 제31권7호
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• pp.1139-1150
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• 1998

본 연구에서는, 무분별하게 사용되고 있는 민간요법의 과학적인 접근의 일환으로 인슐린 비의존형 당뇨환자를 대상으로 당뇨치료약물을 복용하는 당뇨군과 당뇨치료약물을 복용하지 않는 당뇨군 그리고 정상군으로 나누어 각군 모두에게 누에분말을 복용시켜 혈당 및 혈중 당화헤모글로빈, 인슐린, 그리고 혈중 지질농도에 미치는 영향을 관찰하여 요약하면 다음과 같다. 1) 신장, 체중, BMI, 둔부둘레는 세군간에 차이가 없었다. 허리둘레는 기존의 당뇨치료약물과 누에분말을 동시에 투여받는 당뇨군에서 다른 두 군에 비해 유의적으로 높아 WHR은 당뇨치료 약물을 동시에 복용한 당뇨군>누에분말만 복용한 당뇨군>정상군의 순으로 나타났다. 누에분말을 투여받는 동안 체중의 변화는 관찰되지 않았다. 2) 당뇨군과 정상군 사이에 열량 및 열량구성비에는차이가 없었으며, 연구 진행동안의 유의적인 변화도 관찰되지 않았다. 실험기간동안 총열량 섭취량은 남자의 경우, 권장량의 87.7%, 여자의 경우, 권장량의 86.2% 를 섭취하고 있었다. 하루동안 누에분말로 공급된 단백질 함량은 0.279이었으며 식이로의 단백질섭취는 남녀 각각 권장량의 97.5%. 108.3%를 섭취하고 있었다. 총 열량구성비는 남자의 경우 탄수화물 단백질. 지방이 68 : 15 : 17, 여자의 경우 69 : 16 : 15이었다. 3) 당뇨치료 약물을 누에분말과 동시에 복용한 당뇨군에서 누에분말 복용후 공복시 혈당이 7.4%, 식사후 2시간의 혈당이 19.4% 감소하는 경향이었고, 누에분말만 섭취한 당뇨군은 누에분말 복용후 혈당이 공복시 9.7%, 식사후 2시간시 23.4%의 감소경향을 나타냈다. 공복시와 식사후 2시간의 혈당 모두 누에분말 섭취후에도 정상범위보다 다소 높았으나, 혈당감소율(%)은 당뇨치료약물을 동시에 복용한 당뇨군에 비해 누에분말만 섭취한 당뇨군에서 큰 경향이었다. 정상군의 혈당에 는 큰 변화가 없었다. 4) 당뇨치료 약물을 동시에 복용한 당뇨군이 누에분말만 복용한 당뇨군에 비해 당화 헤모글로빈이 낮았고 정상군은 더 낮았다. 4주동안 누에분말 복용 후 당화헤모글로빈의 변화는 관찰되지 않았다. 5) 본 연구 대상자들의 공복시 인슐린 농도는 당뇨치료 약물을 동시에 복용한 당뇨군에서 누에분말만 복용한 당뇨군과 정상군에 비해 높았다. 누에분말 복용에 따른 공복시 인슐린 농도의 유의적인 변화는 관찰되지 않았다. 6) 누에분말 복용에 따른 각 군간의 혈중 지질 농도의 유의적인 변화가 관찰되지 않았다. 혈중 중성지방의 농도는 당뇨치료 약물을 동시에 복용한 당뇨군의 경우 8.5%, 누에분말만 섭취한 당뇨군의 경우 9.0% 그리고 정상군은 3.4%가 감소되는 경향을 나타내었다.

• 대한한의학회지
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• 제27권1호
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• pp.165-183
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• 2006

Objectives : We implemented the Artemisia Extract Moxibustion Method and had the clinical tests for the diabetes with it. Methods : We implemented Artemisia extract made by extracting the vasodilator and antioxidant compounds from Artemisia-CH2C12 fraction and the moxibustion method constructed with DC Power supply, controller, Artemisia pad. single and multiple heating terminal with PTC(Positive Temperature Coefficient) thermistor. And we performed to estimate the efficiency on the questionnaire and the clinical tests with 23 cases of the diabetics. Results : We have estimated the improvement over 60% the symptoms that were the upper and lower limbs pain, frequent urination, spontaneous perspiration, thirst, decrease of body weight, and malaise after the moxibustion treatment on 5 cases among 23 cases. And the 19 cases took the biochemical check-up after the moxibustion treatment. From the results of biochemical check-up, the average HbAlc of before treatment was 8.400%, and after treatment 7.632%. The average HbAlc was decreased significantly after treatment (P<0.001). And the average urinary blood of before treatment was 0.73 and after treatment 0.27. The average urinary blood was decreased significantly after treatment (P<0.001). In addition the average FBS before treatment was 182.64 mg/dl, after treatment 161.77 mg/dl. Conclusions : We could estimate that our proposed moxibustion method was a significant treatment method for the diabetes.

• 한국콘텐츠학회논문지
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• 제15권11호
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• pp.338-346
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• 2015

본 연구는 동기강화면담이 공복혈당장애 환자의 건강증진생활양식, 행동변화단계, 당화혈색소값에 미치는 효과를 확인하기위해 시도되었다. 2011년 12월부터 2012년 3월까지 U시 동구보건소에 내소하는 공복혈당장애를 가진 대상자로 실험군 27명 과 대조군 33명으로 무작위 배정하여 실험군에게 연구자가 개발한 동기강화면담 프로그램을 실시하였다. 면담프로그램은 1대1 면담 1회와 전화상담 1회로 이루어졌으며 MET I, II 프로그램을 응용하여 연구자가 개발한 후 전문가 내용타당도를 검증받았다..프로그램 적용후 효과검정을 위해 실험전후 대상자의 건강증진생활양식, 변화단계는 설문지 조사하였고 채혈을 통해 당화혈색소를 측정하였다. 수집된 자료는 SPSS WIN 20.0을 이용하여 빈도와 백분율, 평균과 표준편차, $x^2$ test, t-test로 분석하였다. 연구결과, 변화단계점수는 두 집단 간 유의한차이가 있어(t=-20.224, p=.000) 동기강화면담의 긍정적인 효과를 확인하였고, 건강증진생활양식(t=-1.297, p=.200)과 당화혈색소값(t=.794, p=.431)에 대해서는 두집단간 유의한 차이가 없었다. 따라서, 본 연구의 동기강화면담프로그램은 공복혈당장애 환자의 행위변화단계를 인식전단계에서 인식단계로 변화되는데 효과가 있었으므로 간호현장에서 건강관리 중재프로그램을 시행하기위한 준비단계에 효과적으로 적용되기를 기대한다.

• Journal of Preventive Medicine and Public Health
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• 제57권5호
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• pp.471-479
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• 2024

Objectives: The use of qualitative healthcare services or its discrepancy between different income levels of the type 2 diabetes (T2D) patients has seldom been studied concurrently. The present study is unique that regarding T2D patients of early stages of diagnosis. Aimed to assess the utilization of qualitative healthcare services and influence of income levels on the inequality of care among newly diagnosed patients with T2D. Methods: A retrospective cohort study of 7590 patients was conducted by the National Health Insurance Service National Sample Cohort 2.0 from 2002 to 2015. Insured employee in 2013 with no history of T2D between 2002 and 2012 were included. The standard of diabetes care includes hemoglobin A1c (HbAlc; 4 times/y), eyes (once/y) and lipid abnormalities (once/y). Multivariate logistic regression analysis was performed to examine the difference between income levels and inequality of care. Results: From years 1 to 3, rates of appropriate screening fell from 16.9% to 14.1% (HbA1c), 15.8% to 14.5% (eye), and 59.2% to 33.2% (lipid abnormalities). Relative to income class 5 (the highest-income group), HbA1 screening was significantly less common in class 2 (year 2: odds ratio [OR], 0.78; 95% confidence interval [CI], 0.61 to 0.99; year 3: OR, 0.79; 95% CI, 0.69 to 0.91). In year 1, lipid screening was less common in class 1 (OR, 0.84; 95% CI, 0.73 to 0.98) than in class 5, a trend that continued in year 2. Eye screening rates were consistently lower in class 1 than in class 5 (year 1: OR, 0.73; 95% CI, 0.60 to 0.89; year 2: OR, 0.63; 95% CI, 0.50 to 0.78; year 3: OR, 0.81; 95% CI, 0.67 to 0.99). Conclusions: Newly diagnosed T2D patients have shown low rate of HbA1c and screening for diabetic-related complications and experienced inequality in relation to receiving qualitative diabetes care by income levels.

• Nutritional Sciences
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• 제8권1호
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• pp.35-41
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• 2005

Controlling dietary behaviors and health-related lifestyle habits is important to manage non-insulin dependent diabetes mellitus (NIDDM). If NIDDM is not treated properly, the prevalence of macro-vascular complications (MC) may increase. The goal of NIDDM therapy is to maintain normal concentrations of blood glucose and lipid profiles by having regular meals, controlling alcohol drinking, quitting smoking, and performing physical exercise regularly. This study was performed to investigate the dietary and health-related lifestyle habits and blood parameters of NIDDM patients of both genders and compared these characteristics between the patients with and without MC. Our results show that the subjects with MC compared to without MC and the female patients than the males controlled their diets more regularly, tended to regulate the number of meals better, and smoke less than those without MC. Although plasma lipid profiles were not significantly different between the genders and between the subjects with and without MC, the men had higher blood glucose and plasma tHcy concentrations than the women and plasma tHcy concentration was higher in the female subjects without MC. These results imply that the male patients of NIDDM without MC might have more problems in maintaining their blood glucose. In addition, smoking may be the most important life-style factor influencing some blood parameters like blood glucose, HbAlc, and total cholesterol in the NIDDM patients.

• 한국건강관리협회지
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• 제2권3호
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• pp.73-96
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• 2004

Along with a development of medical technology, a variety of tests, such as laboratory tests, x-ray and endoscopies are being used in health screening tests. As the tests determine the quality of health screening, test items and methods should be carefully selected. This study was to get hold of the test items of major health screening programs in Korea Most of the health screening programmes focused upon detection of risk factors and diagnosis of life - style related diseases (diabetes, hypertension, cardiovascular diseases, hypercholesterolemia, overweight, drinking, smoking, cerebrovascular diseases, osteoporosis) ,cancers (stomach, cervix, lung, breast, liver, colon, prostate, ovary, pancreas, thyroid, esophagus) , infectious diseases (hepatitis, tuberculosis, sexually-transmitted diseases, parasites) , chronic obstructive respiratory diseases, chronic renal diseases (bacteriuria hematuria, proteinuria) , anemia, glaucoma, hearing loss, Alzheimer disease, stress, early psychiatric diseases. The health screening tests were basic physical examination, basic laboratory tests (CBC, urinalysis, liver function tests, lipid tests, glucose, HbAlc, uric acid, electrolytes, serological tests (HBsAg, HBs-Ab, HCV-Ab, HIV-Ab, VDRL) EKG, x-ray (chest PA, CT) , endoscopy (gastroscopy, colonoscopy) , sonography(abdomen, thyroid, pelvis, breast) ,cytology (cervix) , bone density, tumor markets (NMP22, alpha-FP, CEA, CA-19-9, CA12S, PSA) and eye tests. Advanced technologies, like CT, PET, MRI, MRT/Angio, molecular testings) were widely used in hospital health screening programmes .In summary, a variety of tests were utilized in health screening in Korea. Those tests were utilized by stages or according to sex and age in most of health screening programmes, however a few program used tests to excess disregarding health screening subjects.

• 한국임상약학회지
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• 제16권1호
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• pp.46-51
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• 2006

Dyslipidemia is an important CHD risk factor in diabetic patients. We conducted this study to assess the pattern of dyslipidemia in type 2 diabetes patients, to examine the demographic and clinical factors associated with dyslipidemia and to evaluate attaining within the lipid target goals and treatment strategies. A retrospective analysis was conducted among patents diagnosed type 2 diabetes at outpatient clinic in endocrinology between January 2003 and December 2004. Clinical history and physical examination were reviewed and laboratory data including blood glucose, HbAlc, lipid levels were recorded sequentially at least 1 year. In 882 patients with type 2 diabetes, 437 patients (49.6%) have dyslipidemia and 73% of them (319 patients) received lipid-lowering agents. 244 patients (94 males, 150 females, mean age 60 years old) were susceptible to analyses. The most frequent pattern of dyslipidemia is high LDL level and high TG levels (28%). Metabolic syndrome and macrovascular complication were significant negative independent association with lipid levels within the target goals (p<0.05). Only 15.2% (19 males, 18 females) attained within the lipid tar- get goals. Patients with diabetic dyslipidemia need maximization of lipid-lowering agents, increasing the fibric acid derivatives prescription and the effort to correction of low HDL and/or high TG.

• 한국보건간호학회지
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• 제16권2호
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• pp.346-353
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• 2002

The purpose of this study was to identify clinical characteristics of type 2 diabetic patients with microalbuminuria. The subjects were 390 out type 2 diabetic patients from beginning of March through the end of April in 2001, who visited at the endocrine center at Kangnam St. Mary's Hospital of Catholic University in Seoul. The patients' clinical laboratory data were assessed at medical record review. The data were analyzed using for t-test and $\chi^2$ test. The results were as follows : 1. There were no significant differences in age, body mass index, family history of diabetes and hypoglycemic agents between normoalbuminuria group and microalbuminuria group. 2. The level of systolic blood pressure and creatinine of microalbuminuria group were higher than those of normoalbuminuria group. There were no significant differences in HbAlc, fasting blood glucose, 2-hour postprandial blood glucose, diastolic blood pressure, total cholesterol, triglyceride, high density lipoprotein cholesterol, lipoprotein(a) and blood urea nitrogen between normoalbuminuria group and microalbuminuria group.

• 대한임상검사과학회지
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• 제46권4호
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• pp.143-149
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• 2014

Pulse wave velocity (PWV) is used to non-invasively estimate the severity of arteriosclerosis by measuring the patient's arterial stiffness comparing with each normal reference range according to their ages. Increased arterial stiffness is closely related to both atherosclerosis and arteriosclerosis, which have been known for causes of cardiovascular disease and stroke, also negatively affects the prognosis and the re-occurrence in patients with stroke. The study is focused on how brachial-ankle pulse wave velocity (baPWV) is related to cardiovascular disease risk factors in patients with acute stroke. There were 114 subjects, 69 males and 45 females, all in their 60's and had PWV test for acute stroke. The results are as follows: the group with increased arterial stiffness showed significant increase in HbAlc, total cholesterol, RSBP (resting systolic blood pressure), CSBP (central systolic blood pressure) and CDBP (central diastolic blood pressure). Cross tabulation test showed that there was a significant relationship only between the group with increased arterial stiffness and diabetes mellitus (DM). Therefore, it might be useful for preventing re-occurrence and making a favorable prognosis to promptly adjust DM and hypertension-related risk factors in patients with acute stroke.

• Food Science and Biotechnology
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• 제18권1호
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• pp.172-178
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• 2009

Fermented ginseng (FG) is an ethanol extract of ginseng radix processed with $\beta$-galactosidase. It was hypothesized that FG may exert anti-hyperlipidemic and anti-diabetic activities through modulating AMP-activated protein kinase (AMPK) in HepG2 human hepatoma cells. In this study, we showed that AMPK phosphorylation was stimulated by FG. These effects were abolished by pretreatment with an AMPK inhibitor, compound C. In addition, FG regulated the expression of genes associated with lipogenesis and lipolysis, thus causing suppression of hepatic triglyceride accumulation. In vivo study using db/db mice, FG reduced fasting plasma glucose, HbAlc, and insulin resistance index, when compared to diabetic control. FG also increased the phospho-AMPK and glucose transporter 4 (GLUT4) expressions in liver and skeletal muscle, respectively. In liver, expressions of lipogenic gene were decreased whereas expressions of lipolytic genes were induced, when compared to diabetic control. Taken together, we may suggest that FG ameliorates hyperglycemia and hyperlipidemia through activation of AMPK and could be developed as a health functional food or therapeutic agent for type 2 diabetic patients.