• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.66 no.9
• /
• pp.1379-1384
• /
• 2017

To guarantee safety and reliability, RAMS(Reliability Availability Maintainability and Safety) activity for a communication software in train communication network is studied. In this paper, preliminary hazard analysis in RAMS activities is studied for the communication software. Preliminary hazard analysis is done through library for communication software that the specification is defined by IEC 61375. The hazards are defined, then causes and consequence for each hazard are defined. The total 36 preliminary hazards are classified. For high severity hazards are changed to acceptable level by upgrading of system requirement specification.

• Journal of the Speleological Society of Korea
• /
• no.77
• /
• pp.53-58
• /
• 2007

From the computer or the library the use of the place about lower the case which gives a damage to the different person occurs with four three anger backs. It became from the hazard which manages the library place efficiently it used the AVR and a RF communication to make a system.

• Transactions of the Korean hydrogen and new energy society
• /
• v.34 no.4
• /
• pp.381-387
• /
• 2023

The risk assessment (safety assessment) must be performed to verify the risks during operation and installation of the hydrogen system and to ensure safe design and operation. Among them, hazard and operability study (HAZOP), a qualitative risk assessment, is most often used to discover risk factors and secure safety. However, in HAZOP performance, there is a difference in the level of evaluation results depending on the level and experience of the evaluator, and there is a high possibility that subjective results will be derived. This study aims to develop a risk factor library that can list and provide information on potential risk factors in order to solve these problems when performing HAZOP, reduce risk factors that are omitted or overlooked.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.5
• /
• pp.2369-2374
• /
• 2014

Background and Aim: Selumetinib is a promising and interesting targeted therapy agent as it may reverse radioiodine uptake in patients with radioiodine-refractory differentiated thyroid cancer. We conduct this metaanalysis to compare the efficacy and safety of selumetinib with current therapies in patients with advanced cancer. Methods: An electronic search was conducted using PubMed/ Medicine, EMBASE and Cochrane library databases. Statistical analyses were carried out using either random-effects or fixed-effects models according to the heterogeneity of eligible studies. Results: Six eligible trials involved 601 patients were identified. Compared with current therapies, treatment schedules with selumetinib did not improve progression free survival (hazard ratio, 0.91; 95%CI 0.70-1.17, P= 0.448), but did identify better clinical benefits (odds ratio, 1.24; 95%CI 0.69-2.24, P = 0.472) and less disease progression (hazard ratio, 0.72; 95%CI 0.51-1.00, P = 0.052) though its impact was not statistically significant. Sub-group analysis resulted in significantly improved progression free survival (hazard ratio, 0.61; 95%CI 0.49-0.57, P = 0.00), clinical benefits (odds ratio, 3.04; 95%CI 1.60-5.77, P = 0.001) and reduced disease progression (hazard ratio, 0.35; 95%CI 0.18-0.67, P = 0.001) in patients administrated selumetinib. Dermatitis acneiform (risk ratio, 9.775; 95%CI 3.143-30.395, P = 0.00) and peripheral edema (risk ratio, 2.371; 95%CI 1.690-3.327, P = 0.00) are the most frequently observed adverse effects associated with selumetinib. Conclusions: Compared with current chemotherapy, selumetinib has modest clinical activity as monotherapy in patients with advanced cancer, but combinations of selumetinib with cytotoxic agents in patients with BRAF or KRAS mutations hold great promise for cancer treatment. Dermatitis acneiform and peripheral edema are the most frequently observed adverse effects in patients with selumetinib.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.13
• /
• pp.5573-5578
• /
• 2015

Background: A systematic review and meta-analysis were performed to compare the post-recurrence survival with hepatic re-resection versus transarterial chemoembolization (TACE) for recurrent hepatocellular carcinoma (HCC) after initial resection. Materials and Methods: All relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Subgroup analysis was performed according to country. Sensitivity analysis was performed in studies which clearly reported the recurrent regions, in moderate/high-quality studies, in studies published in full-text form, and in studies published after 2005. Results: In total, twelve papers were included in our study. Five and seven of them were of moderate- and poor-quality, respectively. The overall meta-analysis demonstrated a statistically significantly higher post-recurrence survival in the hepatic re-resection group than in those undergoing TACE (HR=0.64, 95%CI=0.52-0.79, P<0.0001). Heterogeneity was statistically significant and statistical significance remained in the subgroup analysis. Sensitivity analyses were also consistent with the overall analysis. Conclusions: Hepatic re-resection might provide a better post-recurrence survival than TACE for recurrent HCC after initial resection. However, considering the low quality of published studies and the potential bias of treatment selection, further randomized trials should be warranted to confirm these findings.

• International Journal of Internet, Broadcasting and Communication
• /
• v.16 no.2
• /
• pp.237-246
• /
• 2024

In recent years, the frequent occurrence of fire accidents in university libraries has posed significant threats to the safety of students' lives and property, alongside negative social impacts. Accurately analyzing the factors affecting evacuation during library fires and proposing optimized measures for safe evacuation is thus crucial. This paper utilizes a specific university library as a case study, simulating fire evacuation scenarios using the Pathfinder software, to assess and validate evacuation strategies and propose relevant optimizations. Pathfinder, developed by Thunderhead Engineering in the United States, is an intuitive and straightforward personnel emergency evacuation assessment system, offering advanced visualization interfaces and 3D animation effects. This study aims to construct evacuation models and perform simulation analysis for the selected university library using Pathfinder. The library's structural layout, people flow characteristics, and the nature of fire and smoke spread are considered in the analysis. Additionally, evacuation scenarios involving different fire outbreak locations and the status of emergency exits are examined. The findings underscore the importance of effective evacuation in fire situations, highlighting how environmental conditions, individual characteristics, and behavioral patterns significantly influence evacuation efficiency. Through these investigations, the study enhances understanding and optimization of evacuation strategies in fire scenarios, thereby improving safety and efficiency. The research not only provides concrete and practical guidelines for building design, management, and emergency response planning in libraries but also offers valuable insights for the design and management of effective evacuation systems in buildings, crucial for ensuring occupant safety and minimizing loss of life in potential hazard situations

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.7
• /
• pp.4195-4198
• /
• 2013

Background and Objective: Though researched for years, the prognostic role of hypoxia-inducible factor 1 alpha (HIF-$1{\alpha}$) in gastric cancer is still controversial. We thus undertook a systematic review to assess the relationship. Method: A systematically literature search of Pubmed, Embase, Web of Science, China Biological Medicine Disc and Cochrane Library was undertaken in February 2013, and the reference lists of articles were retrieved. Results: 12 trials (1,555 participants) were included to assess the association between HIF-$1{\alpha}$ expression and survival. Summary hazard ratios (HRs) were calculated. HIF-$1{\alpha}$ expression was significantly correlated with poor overall survival of gastric cancer patients (HR=1.34, 95%CI: 1.13-1.58; P=0.0009), but not with poor disease free survival of gastric cancer patients (HR=1.67, 95%CI: 0.99-2.82; P=0.06). Conclusion: HIF-$1{\alpha}$ was associated with poor OS, but not DFS, especially for Asian patients. But studies evaluating relationships of HIF-$1{\alpha}$ with OS and DFS in non-Asian gastric cancer patients appear needed.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.8 no.4
• /
• pp.347-353
• /
• 2010

Source terms of metal waste comprising a spent fuel assembly are relatively important when the spent fuel is pyroprocessed, because cesium, strontium, and transuranics are not a concern any more in the aspect of source term of permanent disposal. In this study, characteristics of radiation source terms for each structural component in spent fuel assembly was analyzed by using ORIGEN-S with a assumption that 10 metric tons of uranium is pyroprocessed. At first, mass and volume for each structural component of the fuel assembly were calculated in detail. Activation cross section library was generated by using KENO-VI/ORIGEN-S module for top-end piece and bottom-end piece, because those are located at outer core with different neutron spectrum compared to that of inner core. As a result, values of radioactivity, decay heat, and hazard index were reveled to be $1.40{\times}10^{15}$ Bequerels, 236 Watts, $4.34{\times}10^9m^3$-water, respectively, at 10 years after discharge. Those values correspond to 0.7 %, 1.1 %, 0.1 %, respectively, compared to that of spent fuel. Inconel 718 grid plate was shown to be the most important component in the all aspects of radioactivity, decay heat, and hazard index although the mass occupies only 1 % of the total. It was also shown that if the Inconel 718 grid plate is managed separately, the radioactivity and hazard index of metal waste could be decreased to 20~45 % and 30~45 %, respectively. As a whole, decay heat of metal waste was shown to be negligible in the aspect of disposal system design, while the radioactivity and hazard index are important.

• Journal of the Korean Society of Hazard Mitigation
• /
• v.10 no.3
• /
• pp.61-69
• /
• 2010

Disasters have been diversifying and the scale of disaster has been increasing worldwide due to the global warming and urbanization. Consequently, it is essential to establish the systematic disaster management because the scale of damages has been rapidly increasing. Nowadays, the importance of the standardized disaster management have been realized internationally due to the 9.11 terror and Tsunami. Also, the activities of research and development to utilize and establish the disaster management standards have been increasing. This study mainly focused on generating an efficient operating manual to support the systematic disaster management of the central administration office based on disaster management standard in South Korea. Firstly, the activities and status of disaster management performed by the central administration office were investigated. Accordingly, libraries of work, functions, organizations, references and behavior for disaster management were designed. Then, a method to make the efficient operation manual based on the constructed libraries was presented to maximize the efficiency of disaster management. This emergency operation manual could support the systematic disaster management by defining the work, function, references and the codes of conduct. Thus, central administration office would be able to define methods and procedures from preparation to recovery through the utilization of the operation manual.

• Proceedings of the Korean Institute Of Construction Engineering and Management
• /
• 2008.11a
• /
• pp.521-524
• /
• 2008

The main goal of construction projects from the past has been enhancing efficiency by reducing cost and time. Compared to this, it is true that for a long time not much attention was paid to safety management. For this reason, safety management is much behind cost and time management but nevertheless, not much improvement has been made. The current safety management is only focused on managing after an occurrence based on knowledge like safety standards and rules. Even though safety accident is reducing in domestic construction projects, the extent of a accident is getting greater because construction projects are getting more complex and sophisticated. Moreover, the actual loss due to accident is increasing and the severeness of a hazard is getting worse. Therefore, to improve the current conditions of safety management, we propose a more effective safety management program. This program is a safety managing method using virtual reality. Property, entity, safety library is applied and finally, aims to continuously manage and prevent rather than deal with an accident/disaster after it happens.